Plato and Descartes both proposed dualist theories of mind and body, but differed in key ways. Plato viewed the soul as preexisting and immortal, being reincarnated through forms. He believed in obtaining knowledge through recollection. Descartes argued the mind and body are distinct substances that interact, and the immaterial mind proves immortal through the "I think therefore I am" argument. Both aimed to establish immortality, but Plato relied on religion while Descartes used rational empiricism.