The document discusses various drugs containing carboxylic acids, including their structures, uses, and side effects, with specific examples like aspirin and salicylic acid. It highlights additional formulations such as fusidic acid antibiotics and vitamin C products, detailing their therapeutic benefits and contraindications. Important precautions for use and references for further reading are also provided.

1. Drugs containingCarboxylic acid

2. Introduction are organic acids characterized by the presence of at least one carboxyl group. The general formula of a carboxylic acid is R-COOH

4. Examples for carboxylic acids included in some drug :1. Salicylic acid. 2.Fusidic acid.3. Citric acid. 4. Ascorbic acid.5. Benzoic acid. 6.Lactic acid. 7.Tartaric acid.

6. AspirinFor Example: 1- Aspocid. ( shewable tablets) 2- Rivo( tablets) 3- Rivoped( supp)4- aspocid buffer( eff) 5-Aspegic( vial) It is Acetyl salicylic acid which have many trade names in the Egyptian market

7. synthesis

9. 1- headache. ( the 1st drug in treatment of migraine) 2- pain( muscle, cramps ,skin irritation)3-prevention of heart attacks and strokes . 4-for fever and pains associated with common cold 5-for joint pain of acute rheumatic fever Indications

10. Side Effects :

11. Contraindications :1-Hypersensitivity to salicylates 2-Clients with asthma, hay fever3- Severe anemia4- history of blood coagulation defects, 5-in conjunction with anticoagulant therapy 6-In pregnancy, especially the last trimester as the drug may cause problems in the newborn child or complications during delivery.

12. 1-Use with caution during lactation. 2-gastric or peptic ulcers, 3- in cardiac disease. 4- in liver or kidney disease. Precautions

13. Heel Forte ointmentComposition;Salicylic acid 12 gUrea 8 gDose:A thin film of the ointment should be applied twice daily to cover the affected area completely

14. PROPERTIES :Salicylic acid has keratolyticproperty which causes the cornified tissues to swell, soften, macerate and desquamate. Urea moisturizes and softens severely dry, rough skinSOINDICATIONS : 1-Removal of callus and corns2-Smoothing of intensely rough heels3-Helps in treatment of warts

16. Examples for soaps containing carboxylic acids

18. Fawar Fruit

19. PRESENTATION FORM : SachetCOMPOSITION: Citric acid 16 gmFlavor and color to 100 gmSodium bicarbonate 56 gmTartaric acid 26.7 gmUSES: Antacids in the gastrointestinal system .

20. Eva Spotless Cream

21. Components:Special formula facial cream rich in lactic acid and lemon juice. USESthe ideal solution to deal with black spots and other problems of teenage skin and not only.

22. Cream gently removes the top layer of dead cells and cleans pores, preventing problems.

23. The cream also lightens the skin and contributes to the disappearance of freckles. Drugs containing fusidic acid:What is fucidic acid??fucidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections. Fusidic acid is often found in topical skin and eye preparations .

24. Structure:

25. Fusiderm ointment

26. Components:Each 100 gmFusidermointment containsSodium fusidate2 gmUSES:Fusidermis an antibiotic having a potent antimicrobial activity against many Gram-positive organisms such as, Streptococci, Corynebacteriumminutissimum and particularly Staphylococci, including the strains resistant to penicillin or other antibiotics.Fusiderm provides highly effective topical treatment in primary and secondary bacterial infections of the skin and has a unique ability to penetrate intact skin

27. Betafucin cream

28. COMPOSITION: Each gram contains :Fucidicacid 20 mg Betamethasone 1mg PROPERTIES:Betafucincream combines the potent topical antibacterial action of fusidic acid with the anti-inflammatory and antipruritic effect of betamethasone

29. VITACID C

30. Are effervescent granules of single vitamin ( ascorbic acid)COMPOSITION :1- sachets: each 4 gm sachet contain 500 mg ascorbic acid 2- 1 gm effervescent tablets contain 1 gm ascorbic acid

31. VITAMIN C PROPERTIES:1-Vitamin C is an essential co-enzyme for collagen formation2-tissue repair and synthesis of lipids and proteins. 3-It acts both as a reducing agent and as antioxidant.4-It is necessary for many physiologic functions e.g. metabolism of iron, carbohydrate and folic acid, resistance to infection, cellular respiration and preservation of blood vessel integrity.

32. 1-Prevention and treatment of scurvy. 2-Symptomatic relief of common cold and influenza 3-Pregnancy and lactation. 4-in certain diseases and conditions such as:hyperthyroidism, peptic ulcer, chronic illness and infections (whooping cough, pneumonia, sinusitis and rheumatic fever).History of hyper sensitivity to vitamin C

33. REFERENCES:1- Organic chemistry (5th Edition),Paula YurkanisBruice .2-2nd Edition Therapeutic drugs ,Colin Dollergy ,Vol 1.3- 2nd Edition therapeutic drugs,Colin Dollergy,vol2.4-Drug Index ,Master on therapeutic Drugs ,Dr. HeneinWely & Dr. UsamaTharwat.5- Mina El Bostany pharmacy .

34. BY:1- Aya Ahmed Saber 2- GehanEssamMahmood3- EmanAlaa El Shamy4-Eman Mohamed MostafaFaculty of pharmacy ASUPharmaceutical Chemistry department 1st Year Section 2