SlideShare a Scribd company logo
DRUGS
AND
SPORTS
SHREYA GUPTA
HALL OF FAME
OR
HALL OF SHAME ?
MARIA SHARAPOVA, 2016
Suspended for two years in
2016 for doping.
Sharapova claimed she was
unaware that a drug she
had been using for a
decade—meldonium, which
helps increase blood and
oxygen flow—had become a
banned substance as of
2016.
LANCE ARMSTRONG, 2012
His seven Tour de France
titles (from 1999 to 2005)
were revoked in 2012 after
years of suspicion
culminated in the exposure
of an elaborate,
multifaceted doping
scheme (PEDs) within
Armstrong's U.S. Postal
Service team.
FLOYD LANDIS, 2006
He was stripped of his
2006 Tour de France title
for testing positive for
synthetic testosterone.
RUSSIAN TEAM, 2012, 2014
2016
Russia has been accused of
running a state-backed,
systematic doping
programme for years.
As a result the Russian
Olympic athletes competed
as neutral “Olympic
Athletes from Russia”
(OAR), and banned from
using their national flag or
anthem in 2018
Pyeongchang Olympics
MARTINA HINGIS, 2007
Having initially retired in
2003 at the age of 22,
Hingis tested positive for
cocaine in 2007 at
Wimbledon in her
comeback year.
She was suspended from
tennis for two years.
SHOAIB AKHTAR, 2006
In 2006, Pakistan
Cricket Board (PCB)
found Shoaib Akhtar guilty
of using the steroid
nandrolone, used to aid
recovery from injury, increase
muscle size, strength and
power and increase
aggression.
DIEGO MARADONA, 1994
‘The Fallen Angel’,
He was tested positive for
Ephedrine at soccer
World Cup in the US in
1994 and was excluded
from the tournament
NARSINGH YADAV, 2016
India wrestler was slapped
a four-year ban after testing
positive for
methandrostenolone just
weeks before 2016 Rio
Olympics.
Controversy on his ban is
still ongoing.
KHUMUKCHAM SANJITA
CHANU, 2018
Her sample tested
positive for testosterone,
resulting in immediate
provisional suspension by
the International
Weightlifting Federation
(IWF)
DRUGS
AND
SPORTS
• Drug abuse : Risk factor model, Reasons for abuse
• Drug abuse in sports: Introduction
• History of Doping
• Indian Statistics
• Reasons for Doping
• Mechanisms of Doping
• 2019 list of Prohibited Substances and Methods
• Anti-Doping Agencies
FLOW OF PRESENTATION
• Adverse Effects of Doping
• Testing and Investigative Procedure of athletes
• Sample Testing Protocol
• Therapeutic Use Exemption
• Designer drugs: Role in sports and Detection
• Sports Medicine
• Role of Sports Pharmacology
FLOW OF PRESENTATION
DRUG ABUSE
• Defined as the intentional, non-therapeutic use of a drug
product or substance, even once, to achieve a desired
psychological or physiological effect.
(https://www.fda.gov/downloads/drugs/guidances/ucm198650.pdf)
• Persistent or sporadic excessive drug use inconsistent with
or unrelated to acceptable medical practice
(https://www.who.int/substance_abuse/terminology/abuse/en/)
• Substance Abuse and Mental Health Services
Administration USA, estimated 21 million Americans age
12 or older (7.8 percent of the population) required
treatment for substance abuse in 2016.
CONTINNUM OF DEPENDENCE
First Use/
Social use
Regular
Use
Risky Use
Dependence
Substance
Use
Disorder
Genes
RISK FACTOR MODEL
To fit in: Teens use drugs
“because others are doing it
”they think others are doing it—
and fear not being accepted in a
drug- using social circle
To feel better: depression,
social anxiety, stress-related
disorders, and physical pain.
Stress plays a significant role in
starting and continuing drug
use
DRUG ABUSE IN YOUTH
To feel good: Abused drugs
interact with the
neurochemistry of the
brain to produce feelings of
pleasure and euphoria
To experiment: Motivation
to seek new experiences,
particularly those
perceived as thrilling or
daring.
DRUG ABUSE IN YOUTH
DRUG ABUSE IN YOUTH
To do better: Ours is a very competitive
society, pressure to perform athletically
and academically can be intense. Using
illegal or prescription stimulants for
enhancing or improving performance is
prevelant
DRUG ABUSE IN SPORTS
• Doping, defined as use of drugs or other substances for
performance enhancement.
• Drug abuse in athlete population involves doping in an
effort to gain competitive advantage.
• Alternatively, may involve use of substances such as
alcohol or marijuana without the intent of performance
enhancement, since athletes may develop substance use
disorders just as any non-athlete may.
• Most frequently detected doping agents (WADA regulated
dope-testing laboratories): Anabolic steroids, Stimulants
and Cannabinoids
3rd CEN
BC
• Brandy and wine concoctions, hallucinogenic mushrooms and sesame seeds to
enhance performance.
1904
• Illegal drugging of racehorses in the Olympics
1920s
• Mixtures of strychnine, heroin, cocaine, and caffeine were commonly used by
higher level athletes
1930
• Amphetamine replaced strychnine as the stimulant of choice for athletes.
• Use of PEDs in the Tour de France was common practice
1950s
• Soviet Olympic team first used male hormones to increase strength and power.
HISTORY OF DOPING
1967
• International Olympic Committee (IOC) medical commission established a list of
prohibited substances in 1967 and introduced anti-doping testing of athletes in
the 1972 Munich Games.
1970s
• Anabolic steroids were added to the IOC’s prohibited substances list in 1976.
resulting in a marked increase in the number of doping-related disqualifications
in the late 1970s,
1980s
• IOC identified and banned blood doping in 1986
1990s
• Erythropoietin was included in the IOC’s list of prohibited substances in 1990
1999
• IOC took the initiative and convened the First World Conference on Doping in
Sport in Lausanne in February 1999. Following the proposal of the Conference,
the World Anti-Doping Agency (WADA) was established later in 1999.
HISTORY OF DOPING
INDIAN STATISTICS
• India ranks 6th in the latest doping violation report
published by WADA in 2018
• India had 69 Anti-Doping Rule Violations (ADRV), the
same as Russia, which has been under international
scrutiny for a while.
• Athletics : 21 offenders
• Weightlifting and powerlifting : 14 each
• Kabaddi : 9 offenders
• Wrestling: 5 offenders
Source: https://timesofindia.indiatimes.com/sports/more-sports/others/india-joint-
6th-in-list-of-doping-violations-in-wada-report/articleshow/63943916.cms
• Pressure to perform
• Speed up injury healing process
• Ignorance and accidental consumption
• Push natural performance limits
• Repeated failures
REASONS FOR DOPING
MECHANISMS OF DOPING
1. STRENGTH ENHANCE
• Weight lifting, wresting
• Anabolic agents, eg.
Clenbutrol, testosterone,
nandrolone
2. OUTPUT OF ENERGY
• 100m sprint
• Amphetamine,
cocaine, ephedrine
3. HAND STEADINESS
• Shooting, archery
• Beta-blockers
4. BODY PLIANCY
• Gymnastics
• Growth hormone
MECHANISMS OF DOPING
5. ENDURANCE
• Cycling, marathon
• Erythropoietin
6. WEIGHT REDUCTION
• Boxers, jockeys
• Diuretics
MECHANISMS OF DOPING
2019
LIST OF PROHIBITED
SUBSTANCES &
METHODS
• The Prohibited List is a cornerstone of the World Anti-Doping
Code
• Updated annually following an extensive consultation process
facilitated by WADA.
• Valid from 1 January to 31 December, 2019.
• List is followed by NADA as well
• Available : https://www.wada ama.org/en/content/what-is-
prohibited/prohibited-at-all-times/anabolic-agents
2019 LIST OF PROHIBITED SUBSTANCES
2019 LIST OF PROHIBITED SUBSTANCES
3 subcategories:
1. Substances and methods banned all the time
(in and out of competition)
2. Substances banned in competition
3. Substances banned in particular sports
1.1 Substances Prohibited at all times
NON-APPROVED SUBSTANCES
ANABOLIC AGENTS
PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES &
MIMETICS
BETA-2 AGONISTS
HORMONE AND METABOLIC MODULATORS
DIURETICS AND MASKING AGENTSS5
S1
S2
S3
S4
S0
CATEGORY DEFINITION EXAMPLES
S0 : NON
APPROVED
SUBSTANCES
No current approval by
any governmental
regulatory health
authority for human
therapeutic use
• Drugs under pre-clinical or clinical
development or discontinued
• Designer drugs
• Substances approved only for
veterinary use
S1: ANABOLIC
AGENTS
• Anabolic
Androgenic
Steroids (AAS)
• Others
Exogenous: substance
which is not ordinarily
produced by the body
naturally.
Endogenous: substance
ordinarily produced by
the body naturally.
• 1-Androstenediol/dione
• 1-Androsterone, 1-Testosterone
• Danazol
• Norethandrolone
• Oxabolone
• Clenbuterol
• SARMs, e.g. andarine, enobosarm
• Tibolone
• Zeranol, Zilpaterol
1.1 Substances Prohibited at all times
1.1 Substances Prohibited at all times
CATEGORY DEFINITION EXAMPLES
S2: PEPTIDE
HORMONES,
GROWTH FACTORS,
RELATED
SUBSTANCES, AND
MIMETICS
1. EPO and like agents:
• Erythropoietin-Receptor
Agonists
• Hypoxia-inducible factor (HIF)
activating agents
• TGF-beta (TGF-β) inhibitors
• Innate repair receptor agonists
2. Peptide Hormones and their
Releasing Factors
• Chorionic Gonadotrophin (CG)
• Luteinizing Hormone (LH)
• Corticotrophins
• Growth Hormone , its
fragments and releasing
factors
3. Growth Factor Modulators
• Darbepoetins (dEPO)
• Argon, Cobalt, xenon
• Daprodustat
• Molidustat
• Luspatercept, Sotatercept
• Asialo EPO
• Carbamylated EPO (CEPO)
• Buserelin, deslorelin
• Corticorelin
• Sermorelin,
Tesamorelin(GHRH)
• Ghrelins(GHS)
• FGFs, HGF, IGF-1, PDGF, VEGF
CATEGORY DEFINITION EXAMPLES
S3: BETA-2
AGONISTS
All selective and non-selective beta-2
agonists, including all optical isomers,
EXCEPT:
• inhaled salbutamol max. 1600 mcg
in 24 hrs
• Inhaled formoterol max. 54mcg in
24 hrs
• Inhaled salmeterol max. 200 mcg
in 24 hrs
• Fenoterol
• Formoterol
• Indacaterol
• Olodaterol
• Salbutamol
• Salmeterol
• Terbutaline
• Vilanterol
S4: HORMONE
AND
METABOLIC
MODULATORS
• Aromatase inhibitors
• SERMs & anti-estrogenic
substances
• Agents preventing activin receptor
IIB activation
• Metabolic modulators
• Androstenol. Androstenone
• Letrozole
• Raloxifene, Tamoxifen
• Fulvistrant
• Anti-activin receptor IIB Ab
(e.g.Bimagrumab)
• Insulins, insulin-mimetics
• Meldonium, Trimetazidine
1.1 Substances Prohibited at all times
CATEGORY DEFINITION EXAMPLES
S5: DIURETICS AND
MASKING AGENTS EXCEPT:
• Drospirenone; pamabrom; and
ophthalmic use of carbonic
anhydrase inhibitors (e.g.
dorzolamide, brinzolamide);
• Local administration of
felypressin in dental
anaesthesia.
• Desmopressin
• Probenecid
• Plasma expanders
• Acetazolamide;
• Amiloride
• Bumetanide
• Canrenone
• Chlortalidone
• Etacrynic acid
• Furosemide
• Indapamide
• Metolazone
• Spironolactone
• Thiazides
• Vaptans
1.1 Substances Prohibited at all times
MANIPULATION OF BLOOD AND BLOOD COMPONENTS
• Administration or reintroduction of any quantity of autologous,
allogenic (homologous) or heterologous blood, or red blood cell
products of any origin into the circulatory system.
• Artificially enhancing the uptake, transport or delivery of oxygen:
Perfluorochemicals; efaproxiral (RSR13) and modified haemoglobin
products, e.g. haemoglobin-based blood substitutes and
microencapsulated haemoglobin products, excluding supplemental
oxygen by inhalation.
• Any form of intravascular manipulation of the blood or blood
components by physical or chemical means.
1.2 Prohibited Methods
CHEMICAL AND PHYSICAL MANIPULATION
• Tampering, or Attempting to Tamper, to alter the integrity and
validity of samples collected during Doping Control. Including, but
not limited to: Urine substitution and/or adulteration.
• Intravenous infusions and/or injections of more than a total of
100 mL per 12 hour period except for those legitimately received
in the course of hospital treatments, surgical procedures or clinical
diagnostic investigations.
1.2 Prohibited Methods
1.2 Prohibited Methods
GENE AND CELL DOPING
• Use of polymers of nucleic
acids or nucleic acid
analogues.
• Use of gene editing agents
to alter genome sequences
and/or the transcriptional,
post-transcriptional or
epigenetic regulation of
gene expression.
• Use of normal or
genetically modified cells.
2. Substances Prohibited In-Competition
STIMULANTS
NARCOTICS
CANNABINOIDS
GLUCOCORTICOIDS
S6
S8
S9
S7
2. Substances Prohibited In-Competition
CATEGORY EXAMPLES
S6: STIMULANTS • Amfetamine
• Benfluorex
• Cocaine
• Benzylpiperazine
• Modafinil
• Fenfluramine
S7: NARCOTICS • Buprenorphine
• Dextromoramide
• Diamorphine (heroin)
• Fentanyl
• Hydromorphone
• Methadone
• Morphine
• Nicomorphine
• Oxycodone
• Oxymorphone
• Pentazocine
• Pethidine
• Sibutramine
• Strychnine
• Ephedrine
(> 10 micrograms/ml)
• Pseudoephedrine
(> 150 micrograms/ml)
CATEGORY EXAMPLES
S8: CANNABINOIDS • Natural cannabinoids, e.g. Cannabis, Hashish and
Marijuana
• Synthetic cannabinoids e.g. Δ9-Tetrahydrocannabinol
(THC) Cannabimimetics
S9:
GLUCOCORTICOIDS
• Betamethasone
• Budesonide
• Cortisone
• Deflazacort
• Dexamethasone
• Fluticasone
• Hydrocortisone
• Methylprednisolone
• Prednisolone
• Prednisone
• Triamcinolone
2. Substances Prohibited In-Competition
BETA BLOCKERS ( increase precision)
Archery*
Automobile
Billiards (all disciplines)
Darts
Golf
Shooting*
Skiing/Snowboarding
Underwater sports
*Also prohibited Out-of-Competition
3. Substances Prohibited in Particular Sports
ANTI- DOPING
AGENCIES
WORLD ANTI-DOPING AGENCY
• The World Anti-Doping Agency (WADA) was established in
1999, HQ WADA: Montreal, Canada
• International independent agency composed and funded
equally by the sport movement and governments of the
world.
• Its key activities include scientific research, education,
development of anti-doping capacities, and monitoring
of the World Anti-Doping Code (Code) – the document
harmonizing anti-doping policies in all sports and all
countries.
WORLD ANTI-DOPING AGENCY
• The Code sets forth specific antidoping rules and principles
to be followed by the various anti doping organizations in
respective countries.
• Works in conjunction with six International Standards in
various technical areas, namely:
 Prohibited List
 Testing and investigations
 Laboratories
 Therapeutic Use Exemptions (TUEs)
 Protection of Privacy and Personal Information
 Code Compliance by Signatories
NATIONAL ANTI DOPING AGENCY
• National Anti Doping Agency was established by
Government of India as a Registered Society in 2005
• On 7th March 2008, the National Anti Doping Agency,
India (NADA) accepted the World Anti-Doping Code.
The primary functions of NADA are as under:
• To implement the Anti Doping Code to achieve
compliance by all sports organizations in the Country.
• To coordinate dope testing program through all
participating stakeholders.
• To promote anti doping research and education to
inculcate the value of dope free sports.
• To adopt best practice standards and quality systems
to enable effective implementation and continual
improvement of the program.
NATIONAL ANTI DOPING AGENCY
Doping is defined as the occurrence of one/ more
of the Anti-doping rule violations:
• Presence of a Prohibited Substance or its Metabolites or
Markers in an Athlete’s Sample
• Use or Attempted Use by an Athlete
• Evading, Refusing or Failing to Submit to Sample Collection
• Failure to file athlete whereabouts information & missed
tests
• Tampering or Attempted Tampering with any part of
Doping Control
NATIONAL ANTI DOPING AGENCY
• Possession of a Prohibited Substance or a Prohibited
Method
• Trafficking or Attempted Trafficking
• Administration or Attempted Administration to any
athlete In-Competition/ Out-of-Competition
• Assisting, encouraging, aiding, abetting, conspiring,
covering up or any other type of intentional complicity
NATIONAL ANTI DOPING AGENCY
ADVERSE EFFECTS OF DOPING
ANABOLIC AGENTS
General Side Effects:
Greasy skin and acne
Infertility
Hypertension
Liver and kidney dysfunction
Aggressive behaviour
Tumour
Male specific Effects:
Breast development
Testicular atrophy
Diminished testosterone production
Diminished sperm production
Impotence
Alopecia
Prostate cancer
Female specific Effects:
Male pattern hair growth and
baldness
Menstruation disturbances
Decreased size of breast
Deeper voice (hoarseness)
a
Side Effects of EPO:
Increased viscosity of blood
Hypertension
Myocardial infarction
Cerebral infarction
Pulmonary embolism
Convulsions
Side Effects of hGH:
Acromegaly
Soft tissues swelling
Abnormal growth of organs
Arthropathies
Diabetes mellitus
Side Effects of hCG:
Menstrual disorders
Gynecomastia
Side Effects of insulin:
Hypoglycaemia
Nausea
Drowsiness
CNS disturbances
Side Effects of ACTH:
Insomnia
Hypertension
Diabetes mellitus
Stomach ulcers
Osteoporosis
HORMONES & RELATED PEPTIDES
• After consuming stimulants,
performance under severe
circumstances eg. long periods
and/or in the heat,
raises the athlete's body
temperature intensively,
making it difficult to cool down.
• Cardiovascular malfunction
may even lead to death
Loss of appetite
Insomnia
Euphoria
Hallucinations
Trembling
Restlessness, agitation
Hypertension
Palpitation, arrhythmias
Hyperthermia
STIMULANTS
OTHER SUBSTANCES
Side Effects of Narcotics:
Addiction
Loss of balance and coordination
Nausea and dizziness
Insomnia & depression
Decreased heart rate
Side Effects of Cannabinoid:
Impaired balance and coordination
Loss of concentration
Increase in heart rate
Increased appetite
Drowsiness, Hallucination
Side Effects of Glucocorticoids:
Fluid retention
Hyperglycaemia
Systemic infections
Musculoskeletal disorders
When will an athlete be tested?
• Any sportsperson competing in national or international
events can be asked to give his/her blood and/or urine
samples at any point of time by anti-doping agency or
sports events committee during the event.
• Testing can be conducted in-competition and out-of-
competition. Usually athletes who bag the finishing
positions are tested.
• In addition, agency can randomly test any accredited
athlete, even when not participating in an event.
TESTING OF ATHLETES
Intelligence and Investigation Team is an important partner in
global anti-doping program in terms of:
• Investigating potential Anti-Doping Rule Violations
• Cooperating with law enforcement to shut down large scale
doping rings
• Curtailing the trafficking of prohibited substances
INVESTIGATIVE PROCESS
INVESTIGATIVE PROCESS
COLLECT: information from parent, officials, athletes.
interviews with the person making the claim. Seeking
out corroborating evidence without compromising the
confidentiality of the informant.
ANALYSE: Analyst assigned to the case along with a scientific
expert if necessary, to assess the quality of the information
and the source, determine the scope, accuracy and likelihood
of the allegations. Bulletin Report prepared
INVESTIGATE: Team coordination with internal WADA teams and
external partners like Anti-Doping Organizations, International
Federations and law enforcement. More interviews and analysis
conducted to further corroborate the claims
CONCLUDE: Determination of whether the case requires
additional follow-up or if the case is closed. At every step
along the way, the informant is updated and their identity
is kept confidential.
WADA accredited lab in India:
National Dope Testing Laboratory (NDTL)
Ministry of Youth Affairs & Sports
J.L.N. Stadium Complex, New Delhi
Head of the Laboratory: Dr. P. L. Sahu
Scientific Director
INVESTIGATIVE PROCESS
11 STAGES OF DOPING
CONTROL
Out of competition testing:
• Training Period
• Off Season
In Competition testing:
• Selection trial
• State level championship
• National Competition
• International Competition
SAMPLE TESTING PROTOCOL
Source: http://ndtlindia.com/sample-testing-protocol/
URINE SAMPLE TESTING PROTOCOL
Source: http://ndtlindia.com/sample-testing-protocol/
URINE SAMPLE TESTING PROTOCOL
No. Screening Equipment Sample
1. Erythropoietin Stimulating
Agents (ESAs) & its
Analogues
Electrophoresis Serum
2. Human Growth Hormone Luminometer Serum
3. Blood parameters Sysmex XT2000i Whole Blood
4. Blood Transfusion Flowcytometer
500
Whole Blood
5. Hemoglobin Based Oxygen
Carriers
ELISA Reader,
LC-MS/MS
Serum
BLOOD SAMPLE TESTING PROTOCOL
Source: http://ndtlindia.com/sample-testing-protocol/
• Number of Samples: 2 (“A” Sample and “B” Sample)
• Volume required: 2 x 3mL
THERAPEUTIC USE EXEMPTION (TUE)
• Athletes may at times need to use a prohibited medication
to treat a legitimate medical condition.
• A TUE is an exemption that allows an athlete to use,
for therapeutic purposes only, an otherwise prohibited
substance or method (of administering a substance).
• The World Anti-Doping Code International Standard for
Therapeutic Use Exemptions (ISTUE) is a mandatory
International Standard developed as part of the World Anti-
Doping Program.
An athlete may be granted a TUE if (and only if) he/she can
show, by a balance of probability, that each of the following
conditions is met by Prohibited Substance (PS) or Prohibited
Method(PM) in question . :
• Needed to treat an acute or chronic medical condition, such
that the athlete would experience a significant impairment to
health if it were to be withheld.
• No reasonable therapeutic alternative to its use
THERAPEUTIC USE EXEMPTION (TUE)
THERAPEUTIC USE EXEMPTION (TUE)
• Use is highly unlikely to produce any additional
enhancement of performance beyond what might be
anticipated by a return to the athlete’s normal state of
health following the treatment.
• The necessity for its use is not a consequence, wholly or
in part, of the prior Use (without a TUE) of another
prohibited substance or method.
DESIGNER DRUGS
• Molecules that are deliberately engineered to contain novel
modifications so that they may evade detection by targeted
drug surveillance procedures or evade current legislation.
• Produced with the intent of developing substances that
differ slightly from controlled substances in their chemical
structure while retaining their pharmacological effects.
• Examples:
1. Synthetic cathilones (stimulants): Mimic effects of cocaine,
methamphetamine, and MDMA
2. Tetrahydrogestrinone
3. Spice/ K2: Synthetic Marijuana
Use of highly targeted methods to
attain appropriate sensitivity to
detect known potent doping agents
But limited coverage with the
available methods
Emergence of DESIGNER DRUGS
specifically intended to evade
detection
DESIGNER DRUGS IN SPORTS
• Mass Spectrometry methods designed to provide more
generic detection of designer drugs.
• Alternative approaches such as the use of biomarkers,
ELISA methods targeted at steroid substructures and
receptor assays, are under investigation.
• While urine remains the primary matrix for testing,
understanding in vitro methods to study metabolism are
increasingly important.
DETECTION OF DESIGNER DRUGS
• Study of medicine pertaining to sportspersons
• Includes regular health assessment and management of
medical history of the people involved in sporting
activities and treatment of sports-related injuries.
• Athletes and sportspersons can prevent illness, injuries,
and incidences of doping through the basic knowledge of
sports science, exercise physiology, and pharmacokinetics
and pharmacodynamics of biologically active substances
that enter their body in the form of food or medicines
SPORTS MEDICINE
• The necessity of athletes to know the drug, its exact effect,
and the prescribed limit, led to the introduction of
pharmacology in sports.
• Inter-professional learning essential among the health-care
professionals to safeguard sportspersons from inadvertent
doping.
• Sport pharmacologists and sport pharmacists can work in
collaboration with other health-care professionals to help
this cause by communicating the hazards of inadvertent
drug abuse, improving health and professional outcomes.
ROLE OF SPORTS PHARMACOLOGY
CONCLUSION
THANK YOU
STOP DOPING
REFERENCES
• https://www.wada-ama.org/en/content/what-is-prohibited
• https://www.nadaindia.org/en/prohibited-list
• https://www.who.int/topics/substance_abuse/en/
• http://ndtlindia.com/sample-testing-protocol/
• Reardon, C. L., & Creado, S. (2014). Drug abuse in
athletes. Substance abuse and rehabilitation. 95–105.
• Malve HO. Sports pharmacology: A medical pharmacologist’s
perspective. Journal of pharmacy & bioallied sciences. 2018
Jul;10(3):126.
• Teale P, Scarth J, Hudson S. Impact of the emergence of
designer drugs upon sports doping testing. Bioanalysis. 2012
Jan;4(1):71-88.

More Related Content

What's hot

Doping in sports
Doping in sportsDoping in sports
Doping in sportsdrcorp
 
Performance Enhancing Drugs
Performance Enhancing DrugsPerformance Enhancing Drugs
Performance Enhancing Drugs
Catherine Lambert
 
Doping and its effects
Doping and its effectsDoping and its effects
Doping and its effects
munniradhika
 
DOPING IN SPORTS
DOPING IN SPORTSDOPING IN SPORTS
DOPING IN SPORTS
MuskanGupta23992
 
Drugs in sport
Drugs in sportDrugs in sport
Drugs in sport
StaceyFleming01
 
Doping
Doping Doping
Doping
Anjusha Joshi
 
anti doping law in sports
anti doping law in sportsanti doping law in sports
anti doping law in sports
PRADEEP KUMAR
 
Doping in sports
Doping in sportsDoping in sports
Doping in sports
Ankit Srivastava
 
Dope tests,drugs & athletes
Dope tests,drugs & athletesDope tests,drugs & athletes
Dope tests,drugs & athletes
SreelekshmiAS1
 
Doping in sports
Doping in sportsDoping in sports
Doping in sports
Muhammad Khan
 
Drugs In Sport
Drugs In SportDrugs In Sport
Drugs In Sport
Alex Lawless
 
Drug abuse in sports
Drug abuse in sportsDrug abuse in sports
Drug abuse in sports
Sathish Babu
 
Drugs and Sports
 Drugs and Sports Drugs and Sports
Drugs and Sports
JeanMelanieVincentHa
 
Blood Doping
Blood DopingBlood Doping
Blood Doping
pdhpemag
 
sports medicine
sports medicine sports medicine
sports medicine
PANFRAGGER
 
"DOPING IN SPORTS" CLASS- XI CBSE
                 "DOPING IN SPORTS"   CLASS- XI  CBSE                 "DOPING IN SPORTS"   CLASS- XI  CBSE
"DOPING IN SPORTS" CLASS- XI CBSE
Shivani Rawat
 
Doping
DopingDoping
Blood Doping in Athletics
Blood Doping in AthleticsBlood Doping in Athletics
Blood Doping in Athletics
Amir Junaid Shah
 

What's hot (20)

Doping in sports
Doping in sportsDoping in sports
Doping in sports
 
Performance Enhancing Drugs
Performance Enhancing DrugsPerformance Enhancing Drugs
Performance Enhancing Drugs
 
Doping and its effects
Doping and its effectsDoping and its effects
Doping and its effects
 
DOPING IN SPORTS
DOPING IN SPORTSDOPING IN SPORTS
DOPING IN SPORTS
 
Drugs in sport
Drugs in sportDrugs in sport
Drugs in sport
 
Doping ppt final
Doping ppt finalDoping ppt final
Doping ppt final
 
Doping
Doping Doping
Doping
 
anti doping law in sports
anti doping law in sportsanti doping law in sports
anti doping law in sports
 
Doping in sports
Doping in sportsDoping in sports
Doping in sports
 
Dope tests,drugs & athletes
Dope tests,drugs & athletesDope tests,drugs & athletes
Dope tests,drugs & athletes
 
Doping in sports
Doping in sportsDoping in sports
Doping in sports
 
Drugs In Sport
Drugs In SportDrugs In Sport
Drugs In Sport
 
Drug abuse in sports
Drug abuse in sportsDrug abuse in sports
Drug abuse in sports
 
Drugs and Sports
 Drugs and Sports Drugs and Sports
Drugs and Sports
 
Blood Doping
Blood DopingBlood Doping
Blood Doping
 
Drugs in sport
Drugs in sportDrugs in sport
Drugs in sport
 
sports medicine
sports medicine sports medicine
sports medicine
 
"DOPING IN SPORTS" CLASS- XI CBSE
                 "DOPING IN SPORTS"   CLASS- XI  CBSE                 "DOPING IN SPORTS"   CLASS- XI  CBSE
"DOPING IN SPORTS" CLASS- XI CBSE
 
Doping
DopingDoping
Doping
 
Blood Doping in Athletics
Blood Doping in AthleticsBlood Doping in Athletics
Blood Doping in Athletics
 

Similar to Drugs and Sports

25 drugs in sport i sr2002 2013 aj
25 drugs in sport i sr2002 2013 aj25 drugs in sport i sr2002 2013 aj
25 drugs in sport i sr2002 2013 ajMariama Malang
 
Doping and performance Enhancement for sports scientists
Doping and performance Enhancement  for sports scientistsDoping and performance Enhancement  for sports scientists
Doping and performance Enhancement for sports scientists
MeghanBale
 
DOPNIG PPT.pptx
DOPNIG PPT.pptxDOPNIG PPT.pptx
DOPNIG PPT.pptx
ShashiBhantiwari1
 
Sports Medicine and Doping.pptx
Sports Medicine and Doping.pptxSports Medicine and Doping.pptx
Sports Medicine and Doping.pptx
VikramSharma288
 
Drug abuse in sports
Drug abuse in sportsDrug abuse in sports
Drug abuse in sports
Ketan Patil
 
Psychological effects of doping and mindfulness.pptx
Psychological effects of doping and mindfulness.pptxPsychological effects of doping and mindfulness.pptx
Psychological effects of doping and mindfulness.pptx
Sidra Akhtar
 
Performance enhancing drugs
Performance enhancing drugsPerformance enhancing drugs
Performance enhancing drugs
Shenir Hosten
 
Sports law - anti-doping rules
Sports law - anti-doping rulesSports law - anti-doping rules
Sports law - anti-doping rules
dhidhisalo
 
Role of Physiotherapist in Doping Control
Role of Physiotherapist in Doping ControlRole of Physiotherapist in Doping Control
Role of Physiotherapist in Doping Control
drnidhimnd
 
IAL Biology Unit 5 June 2015 - Scientific Article
IAL Biology Unit 5 June 2015  - Scientific Article IAL Biology Unit 5 June 2015  - Scientific Article
IAL Biology Unit 5 June 2015 - Scientific Article
Sharmila Christy
 
Ial bio-scientific-article-wbi05-june-2015
Ial bio-scientific-article-wbi05-june-2015Ial bio-scientific-article-wbi05-june-2015
Ial bio-scientific-article-wbi05-june-2015Brindha Vasudevan
 
DOPE TESTING.pptx
DOPE  TESTING.pptxDOPE  TESTING.pptx
DOPE TESTING.pptx
Dr . Nishita Patel
 
PERFORMANCE ENHANCEMENT DRUGS AND DOPING.pdf
PERFORMANCE ENHANCEMENT DRUGS AND DOPING.pdfPERFORMANCE ENHANCEMENT DRUGS AND DOPING.pdf
PERFORMANCE ENHANCEMENT DRUGS AND DOPING.pdf
AshwiniShirahatti
 
3_Performance_Enhancing_Drugs.pptx
3_Performance_Enhancing_Drugs.pptx3_Performance_Enhancing_Drugs.pptx
3_Performance_Enhancing_Drugs.pptx
ArunRatta
 

Similar to Drugs and Sports (18)

25 drugs in sport i sr2002 2013 aj
25 drugs in sport i sr2002 2013 aj25 drugs in sport i sr2002 2013 aj
25 drugs in sport i sr2002 2013 aj
 
Doping and performance Enhancement for sports scientists
Doping and performance Enhancement  for sports scientistsDoping and performance Enhancement  for sports scientists
Doping and performance Enhancement for sports scientists
 
DOPNIG PPT.pptx
DOPNIG PPT.pptxDOPNIG PPT.pptx
DOPNIG PPT.pptx
 
It took the death of an athlete
It took the death of an athleteIt took the death of an athlete
It took the death of an athlete
 
Sports Medicine and Doping.pptx
Sports Medicine and Doping.pptxSports Medicine and Doping.pptx
Sports Medicine and Doping.pptx
 
Drug abuse in sports
Drug abuse in sportsDrug abuse in sports
Drug abuse in sports
 
Psychological effects of doping and mindfulness.pptx
Psychological effects of doping and mindfulness.pptxPsychological effects of doping and mindfulness.pptx
Psychological effects of doping and mindfulness.pptx
 
Performance enhancing drugs
Performance enhancing drugsPerformance enhancing drugs
Performance enhancing drugs
 
Sports law - anti-doping rules
Sports law - anti-doping rulesSports law - anti-doping rules
Sports law - anti-doping rules
 
Doping control 2014
Doping control 2014Doping control 2014
Doping control 2014
 
Timeline
TimelineTimeline
Timeline
 
Role of Physiotherapist in Doping Control
Role of Physiotherapist in Doping ControlRole of Physiotherapist in Doping Control
Role of Physiotherapist in Doping Control
 
IAL Biology Unit 5 June 2015 - Scientific Article
IAL Biology Unit 5 June 2015  - Scientific Article IAL Biology Unit 5 June 2015  - Scientific Article
IAL Biology Unit 5 June 2015 - Scientific Article
 
Ial bio-scientific-article-wbi05-june-2015
Ial bio-scientific-article-wbi05-june-2015Ial bio-scientific-article-wbi05-june-2015
Ial bio-scientific-article-wbi05-june-2015
 
DOPE TESTING.pptx
DOPE  TESTING.pptxDOPE  TESTING.pptx
DOPE TESTING.pptx
 
PERFORMANCE ENHANCEMENT DRUGS AND DOPING.pdf
PERFORMANCE ENHANCEMENT DRUGS AND DOPING.pdfPERFORMANCE ENHANCEMENT DRUGS AND DOPING.pdf
PERFORMANCE ENHANCEMENT DRUGS AND DOPING.pdf
 
Drugs in sportsaudiofinal
Drugs in sportsaudiofinalDrugs in sportsaudiofinal
Drugs in sportsaudiofinal
 
3_Performance_Enhancing_Drugs.pptx
3_Performance_Enhancing_Drugs.pptx3_Performance_Enhancing_Drugs.pptx
3_Performance_Enhancing_Drugs.pptx
 

More from Shreya Gupta

Critical appraisal of Meta Analysis
Critical appraisal of Meta AnalysisCritical appraisal of Meta Analysis
Critical appraisal of Meta Analysis
Shreya Gupta
 
PET in Drug Development
PET in Drug DevelopmentPET in Drug Development
PET in Drug Development
Shreya Gupta
 
Institutional Animals Ethics Committee
Institutional Animals Ethics CommitteeInstitutional Animals Ethics Committee
Institutional Animals Ethics Committee
Shreya Gupta
 
Ethnopharmacology
EthnopharmacologyEthnopharmacology
Ethnopharmacology
Shreya Gupta
 
Recent Advances in Pharmacotherapy of Inflammatory Bowel Disease
Recent Advances in Pharmacotherapy of Inflammatory Bowel DiseaseRecent Advances in Pharmacotherapy of Inflammatory Bowel Disease
Recent Advances in Pharmacotherapy of Inflammatory Bowel Disease
Shreya Gupta
 
Screening: Drugs Affecting Memory & Learning
Screening: Drugs Affecting Memory & LearningScreening: Drugs Affecting Memory & Learning
Screening: Drugs Affecting Memory & Learning
Shreya Gupta
 
Recent Advances in Obesity Pharmacotherapy
Recent Advances in Obesity PharmacotherapyRecent Advances in Obesity Pharmacotherapy
Recent Advances in Obesity Pharmacotherapy
Shreya Gupta
 
Recent Advances in Malaria Pharmacotherapy
Recent Advances in Malaria PharmacotherapyRecent Advances in Malaria Pharmacotherapy
Recent Advances in Malaria Pharmacotherapy
Shreya Gupta
 
Recent Advances in Management of Gram Negative Bacteria
Recent Advances in Management of Gram Negative BacteriaRecent Advances in Management of Gram Negative Bacteria
Recent Advances in Management of Gram Negative Bacteria
Shreya Gupta
 
Multi Omics Approach in Medicine
Multi Omics Approach in MedicineMulti Omics Approach in Medicine
Multi Omics Approach in Medicine
Shreya Gupta
 

More from Shreya Gupta (10)

Critical appraisal of Meta Analysis
Critical appraisal of Meta AnalysisCritical appraisal of Meta Analysis
Critical appraisal of Meta Analysis
 
PET in Drug Development
PET in Drug DevelopmentPET in Drug Development
PET in Drug Development
 
Institutional Animals Ethics Committee
Institutional Animals Ethics CommitteeInstitutional Animals Ethics Committee
Institutional Animals Ethics Committee
 
Ethnopharmacology
EthnopharmacologyEthnopharmacology
Ethnopharmacology
 
Recent Advances in Pharmacotherapy of Inflammatory Bowel Disease
Recent Advances in Pharmacotherapy of Inflammatory Bowel DiseaseRecent Advances in Pharmacotherapy of Inflammatory Bowel Disease
Recent Advances in Pharmacotherapy of Inflammatory Bowel Disease
 
Screening: Drugs Affecting Memory & Learning
Screening: Drugs Affecting Memory & LearningScreening: Drugs Affecting Memory & Learning
Screening: Drugs Affecting Memory & Learning
 
Recent Advances in Obesity Pharmacotherapy
Recent Advances in Obesity PharmacotherapyRecent Advances in Obesity Pharmacotherapy
Recent Advances in Obesity Pharmacotherapy
 
Recent Advances in Malaria Pharmacotherapy
Recent Advances in Malaria PharmacotherapyRecent Advances in Malaria Pharmacotherapy
Recent Advances in Malaria Pharmacotherapy
 
Recent Advances in Management of Gram Negative Bacteria
Recent Advances in Management of Gram Negative BacteriaRecent Advances in Management of Gram Negative Bacteria
Recent Advances in Management of Gram Negative Bacteria
 
Multi Omics Approach in Medicine
Multi Omics Approach in MedicineMulti Omics Approach in Medicine
Multi Omics Approach in Medicine
 

Recently uploaded

Ophthalmology Clinical Tests for OSCE exam
Ophthalmology Clinical Tests for OSCE examOphthalmology Clinical Tests for OSCE exam
Ophthalmology Clinical Tests for OSCE exam
KafrELShiekh University
 
24 Upakrama.pptx class ppt useful in all
24 Upakrama.pptx class ppt useful in all24 Upakrama.pptx class ppt useful in all
24 Upakrama.pptx class ppt useful in all
DrSathishMS1
 
Charaka Samhita Sutra Sthana 9 Chapter khuddakachatuspadadhyaya
Charaka Samhita Sutra Sthana 9 Chapter khuddakachatuspadadhyayaCharaka Samhita Sutra Sthana 9 Chapter khuddakachatuspadadhyaya
Charaka Samhita Sutra Sthana 9 Chapter khuddakachatuspadadhyaya
Dr KHALID B.M
 
BENIGN PROSTATIC HYPERPLASIA.BPH. BPHpdf
BENIGN PROSTATIC HYPERPLASIA.BPH. BPHpdfBENIGN PROSTATIC HYPERPLASIA.BPH. BPHpdf
BENIGN PROSTATIC HYPERPLASIA.BPH. BPHpdf
DR SETH JOTHAM
 
Couples presenting to the infertility clinic- Do they really have infertility...
Couples presenting to the infertility clinic- Do they really have infertility...Couples presenting to the infertility clinic- Do they really have infertility...
Couples presenting to the infertility clinic- Do they really have infertility...
Sujoy Dasgupta
 
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdf
ARTIFICIAL INTELLIGENCE IN  HEALTHCARE.pdfARTIFICIAL INTELLIGENCE IN  HEALTHCARE.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdf
Anujkumaranit
 
Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model SafeSurat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
Savita Shen $i11
 
Surgical Site Infections, pathophysiology, and prevention.pptx
Surgical Site Infections, pathophysiology, and prevention.pptxSurgical Site Infections, pathophysiology, and prevention.pptx
Surgical Site Infections, pathophysiology, and prevention.pptx
jval Landero
 
micro teaching on communication m.sc nursing.pdf
micro teaching on communication m.sc nursing.pdfmicro teaching on communication m.sc nursing.pdf
micro teaching on communication m.sc nursing.pdf
Anurag Sharma
 
heat stroke and heat exhaustion in children
heat stroke and heat exhaustion in childrenheat stroke and heat exhaustion in children
heat stroke and heat exhaustion in children
SumeraAhmad5
 
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptxMaxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Dr. Rabia Inam Gandapore
 
Charaka Samhita Sutra sthana Chapter 15 Upakalpaniyaadhyaya
Charaka Samhita Sutra sthana Chapter 15 UpakalpaniyaadhyayaCharaka Samhita Sutra sthana Chapter 15 Upakalpaniyaadhyaya
Charaka Samhita Sutra sthana Chapter 15 Upakalpaniyaadhyaya
Dr KHALID B.M
 
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfMANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
Jim Jacob Roy
 
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in StockFactory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
rebeccabio
 
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
kevinkariuki227
 
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTSARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
Dr. Vinay Pareek
 
BRACHYTHERAPY OVERVIEW AND APPLICATORS
BRACHYTHERAPY OVERVIEW  AND  APPLICATORSBRACHYTHERAPY OVERVIEW  AND  APPLICATORS
BRACHYTHERAPY OVERVIEW AND APPLICATORS
Krishan Murari
 
The Normal Electrocardiogram - Part I of II
The Normal Electrocardiogram - Part I of IIThe Normal Electrocardiogram - Part I of II
The Normal Electrocardiogram - Part I of II
MedicoseAcademics
 
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
bkling
 
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists  Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Saeid Safari
 

Recently uploaded (20)

Ophthalmology Clinical Tests for OSCE exam
Ophthalmology Clinical Tests for OSCE examOphthalmology Clinical Tests for OSCE exam
Ophthalmology Clinical Tests for OSCE exam
 
24 Upakrama.pptx class ppt useful in all
24 Upakrama.pptx class ppt useful in all24 Upakrama.pptx class ppt useful in all
24 Upakrama.pptx class ppt useful in all
 
Charaka Samhita Sutra Sthana 9 Chapter khuddakachatuspadadhyaya
Charaka Samhita Sutra Sthana 9 Chapter khuddakachatuspadadhyayaCharaka Samhita Sutra Sthana 9 Chapter khuddakachatuspadadhyaya
Charaka Samhita Sutra Sthana 9 Chapter khuddakachatuspadadhyaya
 
BENIGN PROSTATIC HYPERPLASIA.BPH. BPHpdf
BENIGN PROSTATIC HYPERPLASIA.BPH. BPHpdfBENIGN PROSTATIC HYPERPLASIA.BPH. BPHpdf
BENIGN PROSTATIC HYPERPLASIA.BPH. BPHpdf
 
Couples presenting to the infertility clinic- Do they really have infertility...
Couples presenting to the infertility clinic- Do they really have infertility...Couples presenting to the infertility clinic- Do they really have infertility...
Couples presenting to the infertility clinic- Do they really have infertility...
 
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdf
ARTIFICIAL INTELLIGENCE IN  HEALTHCARE.pdfARTIFICIAL INTELLIGENCE IN  HEALTHCARE.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdf
 
Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model SafeSurat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
 
Surgical Site Infections, pathophysiology, and prevention.pptx
Surgical Site Infections, pathophysiology, and prevention.pptxSurgical Site Infections, pathophysiology, and prevention.pptx
Surgical Site Infections, pathophysiology, and prevention.pptx
 
micro teaching on communication m.sc nursing.pdf
micro teaching on communication m.sc nursing.pdfmicro teaching on communication m.sc nursing.pdf
micro teaching on communication m.sc nursing.pdf
 
heat stroke and heat exhaustion in children
heat stroke and heat exhaustion in childrenheat stroke and heat exhaustion in children
heat stroke and heat exhaustion in children
 
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptxMaxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
 
Charaka Samhita Sutra sthana Chapter 15 Upakalpaniyaadhyaya
Charaka Samhita Sutra sthana Chapter 15 UpakalpaniyaadhyayaCharaka Samhita Sutra sthana Chapter 15 Upakalpaniyaadhyaya
Charaka Samhita Sutra sthana Chapter 15 Upakalpaniyaadhyaya
 
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfMANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
 
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in StockFactory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
 
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
 
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTSARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
 
BRACHYTHERAPY OVERVIEW AND APPLICATORS
BRACHYTHERAPY OVERVIEW  AND  APPLICATORSBRACHYTHERAPY OVERVIEW  AND  APPLICATORS
BRACHYTHERAPY OVERVIEW AND APPLICATORS
 
The Normal Electrocardiogram - Part I of II
The Normal Electrocardiogram - Part I of IIThe Normal Electrocardiogram - Part I of II
The Normal Electrocardiogram - Part I of II
 
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
 
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists  Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
 

Drugs and Sports

  • 2. HALL OF FAME OR HALL OF SHAME ?
  • 3. MARIA SHARAPOVA, 2016 Suspended for two years in 2016 for doping. Sharapova claimed she was unaware that a drug she had been using for a decade—meldonium, which helps increase blood and oxygen flow—had become a banned substance as of 2016.
  • 4. LANCE ARMSTRONG, 2012 His seven Tour de France titles (from 1999 to 2005) were revoked in 2012 after years of suspicion culminated in the exposure of an elaborate, multifaceted doping scheme (PEDs) within Armstrong's U.S. Postal Service team.
  • 5. FLOYD LANDIS, 2006 He was stripped of his 2006 Tour de France title for testing positive for synthetic testosterone.
  • 6. RUSSIAN TEAM, 2012, 2014 2016 Russia has been accused of running a state-backed, systematic doping programme for years. As a result the Russian Olympic athletes competed as neutral “Olympic Athletes from Russia” (OAR), and banned from using their national flag or anthem in 2018 Pyeongchang Olympics
  • 7. MARTINA HINGIS, 2007 Having initially retired in 2003 at the age of 22, Hingis tested positive for cocaine in 2007 at Wimbledon in her comeback year. She was suspended from tennis for two years.
  • 8. SHOAIB AKHTAR, 2006 In 2006, Pakistan Cricket Board (PCB) found Shoaib Akhtar guilty of using the steroid nandrolone, used to aid recovery from injury, increase muscle size, strength and power and increase aggression.
  • 9. DIEGO MARADONA, 1994 ‘The Fallen Angel’, He was tested positive for Ephedrine at soccer World Cup in the US in 1994 and was excluded from the tournament
  • 10. NARSINGH YADAV, 2016 India wrestler was slapped a four-year ban after testing positive for methandrostenolone just weeks before 2016 Rio Olympics. Controversy on his ban is still ongoing.
  • 11. KHUMUKCHAM SANJITA CHANU, 2018 Her sample tested positive for testosterone, resulting in immediate provisional suspension by the International Weightlifting Federation (IWF)
  • 13. • Drug abuse : Risk factor model, Reasons for abuse • Drug abuse in sports: Introduction • History of Doping • Indian Statistics • Reasons for Doping • Mechanisms of Doping • 2019 list of Prohibited Substances and Methods • Anti-Doping Agencies FLOW OF PRESENTATION
  • 14. • Adverse Effects of Doping • Testing and Investigative Procedure of athletes • Sample Testing Protocol • Therapeutic Use Exemption • Designer drugs: Role in sports and Detection • Sports Medicine • Role of Sports Pharmacology FLOW OF PRESENTATION
  • 15. DRUG ABUSE • Defined as the intentional, non-therapeutic use of a drug product or substance, even once, to achieve a desired psychological or physiological effect. (https://www.fda.gov/downloads/drugs/guidances/ucm198650.pdf) • Persistent or sporadic excessive drug use inconsistent with or unrelated to acceptable medical practice (https://www.who.int/substance_abuse/terminology/abuse/en/) • Substance Abuse and Mental Health Services Administration USA, estimated 21 million Americans age 12 or older (7.8 percent of the population) required treatment for substance abuse in 2016.
  • 16. CONTINNUM OF DEPENDENCE First Use/ Social use Regular Use Risky Use Dependence Substance Use Disorder
  • 18. To fit in: Teens use drugs “because others are doing it ”they think others are doing it— and fear not being accepted in a drug- using social circle To feel better: depression, social anxiety, stress-related disorders, and physical pain. Stress plays a significant role in starting and continuing drug use DRUG ABUSE IN YOUTH
  • 19. To feel good: Abused drugs interact with the neurochemistry of the brain to produce feelings of pleasure and euphoria To experiment: Motivation to seek new experiences, particularly those perceived as thrilling or daring. DRUG ABUSE IN YOUTH
  • 20. DRUG ABUSE IN YOUTH To do better: Ours is a very competitive society, pressure to perform athletically and academically can be intense. Using illegal or prescription stimulants for enhancing or improving performance is prevelant
  • 21. DRUG ABUSE IN SPORTS • Doping, defined as use of drugs or other substances for performance enhancement. • Drug abuse in athlete population involves doping in an effort to gain competitive advantage. • Alternatively, may involve use of substances such as alcohol or marijuana without the intent of performance enhancement, since athletes may develop substance use disorders just as any non-athlete may. • Most frequently detected doping agents (WADA regulated dope-testing laboratories): Anabolic steroids, Stimulants and Cannabinoids
  • 22. 3rd CEN BC • Brandy and wine concoctions, hallucinogenic mushrooms and sesame seeds to enhance performance. 1904 • Illegal drugging of racehorses in the Olympics 1920s • Mixtures of strychnine, heroin, cocaine, and caffeine were commonly used by higher level athletes 1930 • Amphetamine replaced strychnine as the stimulant of choice for athletes. • Use of PEDs in the Tour de France was common practice 1950s • Soviet Olympic team first used male hormones to increase strength and power. HISTORY OF DOPING
  • 23. 1967 • International Olympic Committee (IOC) medical commission established a list of prohibited substances in 1967 and introduced anti-doping testing of athletes in the 1972 Munich Games. 1970s • Anabolic steroids were added to the IOC’s prohibited substances list in 1976. resulting in a marked increase in the number of doping-related disqualifications in the late 1970s, 1980s • IOC identified and banned blood doping in 1986 1990s • Erythropoietin was included in the IOC’s list of prohibited substances in 1990 1999 • IOC took the initiative and convened the First World Conference on Doping in Sport in Lausanne in February 1999. Following the proposal of the Conference, the World Anti-Doping Agency (WADA) was established later in 1999. HISTORY OF DOPING
  • 24. INDIAN STATISTICS • India ranks 6th in the latest doping violation report published by WADA in 2018 • India had 69 Anti-Doping Rule Violations (ADRV), the same as Russia, which has been under international scrutiny for a while. • Athletics : 21 offenders • Weightlifting and powerlifting : 14 each • Kabaddi : 9 offenders • Wrestling: 5 offenders Source: https://timesofindia.indiatimes.com/sports/more-sports/others/india-joint- 6th-in-list-of-doping-violations-in-wada-report/articleshow/63943916.cms
  • 25. • Pressure to perform • Speed up injury healing process • Ignorance and accidental consumption • Push natural performance limits • Repeated failures REASONS FOR DOPING
  • 26. MECHANISMS OF DOPING 1. STRENGTH ENHANCE • Weight lifting, wresting • Anabolic agents, eg. Clenbutrol, testosterone, nandrolone 2. OUTPUT OF ENERGY • 100m sprint • Amphetamine, cocaine, ephedrine
  • 27. 3. HAND STEADINESS • Shooting, archery • Beta-blockers 4. BODY PLIANCY • Gymnastics • Growth hormone MECHANISMS OF DOPING
  • 28. 5. ENDURANCE • Cycling, marathon • Erythropoietin 6. WEIGHT REDUCTION • Boxers, jockeys • Diuretics MECHANISMS OF DOPING
  • 29.
  • 31. • The Prohibited List is a cornerstone of the World Anti-Doping Code • Updated annually following an extensive consultation process facilitated by WADA. • Valid from 1 January to 31 December, 2019. • List is followed by NADA as well • Available : https://www.wada ama.org/en/content/what-is- prohibited/prohibited-at-all-times/anabolic-agents 2019 LIST OF PROHIBITED SUBSTANCES
  • 32. 2019 LIST OF PROHIBITED SUBSTANCES 3 subcategories: 1. Substances and methods banned all the time (in and out of competition) 2. Substances banned in competition 3. Substances banned in particular sports
  • 33. 1.1 Substances Prohibited at all times NON-APPROVED SUBSTANCES ANABOLIC AGENTS PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES & MIMETICS BETA-2 AGONISTS HORMONE AND METABOLIC MODULATORS DIURETICS AND MASKING AGENTSS5 S1 S2 S3 S4 S0
  • 34. CATEGORY DEFINITION EXAMPLES S0 : NON APPROVED SUBSTANCES No current approval by any governmental regulatory health authority for human therapeutic use • Drugs under pre-clinical or clinical development or discontinued • Designer drugs • Substances approved only for veterinary use S1: ANABOLIC AGENTS • Anabolic Androgenic Steroids (AAS) • Others Exogenous: substance which is not ordinarily produced by the body naturally. Endogenous: substance ordinarily produced by the body naturally. • 1-Androstenediol/dione • 1-Androsterone, 1-Testosterone • Danazol • Norethandrolone • Oxabolone • Clenbuterol • SARMs, e.g. andarine, enobosarm • Tibolone • Zeranol, Zilpaterol 1.1 Substances Prohibited at all times
  • 35. 1.1 Substances Prohibited at all times CATEGORY DEFINITION EXAMPLES S2: PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES, AND MIMETICS 1. EPO and like agents: • Erythropoietin-Receptor Agonists • Hypoxia-inducible factor (HIF) activating agents • TGF-beta (TGF-β) inhibitors • Innate repair receptor agonists 2. Peptide Hormones and their Releasing Factors • Chorionic Gonadotrophin (CG) • Luteinizing Hormone (LH) • Corticotrophins • Growth Hormone , its fragments and releasing factors 3. Growth Factor Modulators • Darbepoetins (dEPO) • Argon, Cobalt, xenon • Daprodustat • Molidustat • Luspatercept, Sotatercept • Asialo EPO • Carbamylated EPO (CEPO) • Buserelin, deslorelin • Corticorelin • Sermorelin, Tesamorelin(GHRH) • Ghrelins(GHS) • FGFs, HGF, IGF-1, PDGF, VEGF
  • 36. CATEGORY DEFINITION EXAMPLES S3: BETA-2 AGONISTS All selective and non-selective beta-2 agonists, including all optical isomers, EXCEPT: • inhaled salbutamol max. 1600 mcg in 24 hrs • Inhaled formoterol max. 54mcg in 24 hrs • Inhaled salmeterol max. 200 mcg in 24 hrs • Fenoterol • Formoterol • Indacaterol • Olodaterol • Salbutamol • Salmeterol • Terbutaline • Vilanterol S4: HORMONE AND METABOLIC MODULATORS • Aromatase inhibitors • SERMs & anti-estrogenic substances • Agents preventing activin receptor IIB activation • Metabolic modulators • Androstenol. Androstenone • Letrozole • Raloxifene, Tamoxifen • Fulvistrant • Anti-activin receptor IIB Ab (e.g.Bimagrumab) • Insulins, insulin-mimetics • Meldonium, Trimetazidine 1.1 Substances Prohibited at all times
  • 37. CATEGORY DEFINITION EXAMPLES S5: DIURETICS AND MASKING AGENTS EXCEPT: • Drospirenone; pamabrom; and ophthalmic use of carbonic anhydrase inhibitors (e.g. dorzolamide, brinzolamide); • Local administration of felypressin in dental anaesthesia. • Desmopressin • Probenecid • Plasma expanders • Acetazolamide; • Amiloride • Bumetanide • Canrenone • Chlortalidone • Etacrynic acid • Furosemide • Indapamide • Metolazone • Spironolactone • Thiazides • Vaptans 1.1 Substances Prohibited at all times
  • 38. MANIPULATION OF BLOOD AND BLOOD COMPONENTS • Administration or reintroduction of any quantity of autologous, allogenic (homologous) or heterologous blood, or red blood cell products of any origin into the circulatory system. • Artificially enhancing the uptake, transport or delivery of oxygen: Perfluorochemicals; efaproxiral (RSR13) and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation. • Any form of intravascular manipulation of the blood or blood components by physical or chemical means. 1.2 Prohibited Methods
  • 39. CHEMICAL AND PHYSICAL MANIPULATION • Tampering, or Attempting to Tamper, to alter the integrity and validity of samples collected during Doping Control. Including, but not limited to: Urine substitution and/or adulteration. • Intravenous infusions and/or injections of more than a total of 100 mL per 12 hour period except for those legitimately received in the course of hospital treatments, surgical procedures or clinical diagnostic investigations. 1.2 Prohibited Methods
  • 40. 1.2 Prohibited Methods GENE AND CELL DOPING • Use of polymers of nucleic acids or nucleic acid analogues. • Use of gene editing agents to alter genome sequences and/or the transcriptional, post-transcriptional or epigenetic regulation of gene expression. • Use of normal or genetically modified cells.
  • 41. 2. Substances Prohibited In-Competition STIMULANTS NARCOTICS CANNABINOIDS GLUCOCORTICOIDS S6 S8 S9 S7
  • 42. 2. Substances Prohibited In-Competition CATEGORY EXAMPLES S6: STIMULANTS • Amfetamine • Benfluorex • Cocaine • Benzylpiperazine • Modafinil • Fenfluramine S7: NARCOTICS • Buprenorphine • Dextromoramide • Diamorphine (heroin) • Fentanyl • Hydromorphone • Methadone • Morphine • Nicomorphine • Oxycodone • Oxymorphone • Pentazocine • Pethidine • Sibutramine • Strychnine • Ephedrine (> 10 micrograms/ml) • Pseudoephedrine (> 150 micrograms/ml)
  • 43. CATEGORY EXAMPLES S8: CANNABINOIDS • Natural cannabinoids, e.g. Cannabis, Hashish and Marijuana • Synthetic cannabinoids e.g. Δ9-Tetrahydrocannabinol (THC) Cannabimimetics S9: GLUCOCORTICOIDS • Betamethasone • Budesonide • Cortisone • Deflazacort • Dexamethasone • Fluticasone • Hydrocortisone • Methylprednisolone • Prednisolone • Prednisone • Triamcinolone 2. Substances Prohibited In-Competition
  • 44. BETA BLOCKERS ( increase precision) Archery* Automobile Billiards (all disciplines) Darts Golf Shooting* Skiing/Snowboarding Underwater sports *Also prohibited Out-of-Competition 3. Substances Prohibited in Particular Sports
  • 46. WORLD ANTI-DOPING AGENCY • The World Anti-Doping Agency (WADA) was established in 1999, HQ WADA: Montreal, Canada • International independent agency composed and funded equally by the sport movement and governments of the world. • Its key activities include scientific research, education, development of anti-doping capacities, and monitoring of the World Anti-Doping Code (Code) – the document harmonizing anti-doping policies in all sports and all countries.
  • 47. WORLD ANTI-DOPING AGENCY • The Code sets forth specific antidoping rules and principles to be followed by the various anti doping organizations in respective countries. • Works in conjunction with six International Standards in various technical areas, namely:  Prohibited List  Testing and investigations  Laboratories  Therapeutic Use Exemptions (TUEs)  Protection of Privacy and Personal Information  Code Compliance by Signatories
  • 48. NATIONAL ANTI DOPING AGENCY • National Anti Doping Agency was established by Government of India as a Registered Society in 2005 • On 7th March 2008, the National Anti Doping Agency, India (NADA) accepted the World Anti-Doping Code.
  • 49. The primary functions of NADA are as under: • To implement the Anti Doping Code to achieve compliance by all sports organizations in the Country. • To coordinate dope testing program through all participating stakeholders. • To promote anti doping research and education to inculcate the value of dope free sports. • To adopt best practice standards and quality systems to enable effective implementation and continual improvement of the program. NATIONAL ANTI DOPING AGENCY
  • 50. Doping is defined as the occurrence of one/ more of the Anti-doping rule violations: • Presence of a Prohibited Substance or its Metabolites or Markers in an Athlete’s Sample • Use or Attempted Use by an Athlete • Evading, Refusing or Failing to Submit to Sample Collection • Failure to file athlete whereabouts information & missed tests • Tampering or Attempted Tampering with any part of Doping Control NATIONAL ANTI DOPING AGENCY
  • 51. • Possession of a Prohibited Substance or a Prohibited Method • Trafficking or Attempted Trafficking • Administration or Attempted Administration to any athlete In-Competition/ Out-of-Competition • Assisting, encouraging, aiding, abetting, conspiring, covering up or any other type of intentional complicity NATIONAL ANTI DOPING AGENCY
  • 53. ANABOLIC AGENTS General Side Effects: Greasy skin and acne Infertility Hypertension Liver and kidney dysfunction Aggressive behaviour Tumour Male specific Effects: Breast development Testicular atrophy Diminished testosterone production Diminished sperm production Impotence Alopecia Prostate cancer Female specific Effects: Male pattern hair growth and baldness Menstruation disturbances Decreased size of breast Deeper voice (hoarseness)
  • 54. a Side Effects of EPO: Increased viscosity of blood Hypertension Myocardial infarction Cerebral infarction Pulmonary embolism Convulsions Side Effects of hGH: Acromegaly Soft tissues swelling Abnormal growth of organs Arthropathies Diabetes mellitus Side Effects of hCG: Menstrual disorders Gynecomastia Side Effects of insulin: Hypoglycaemia Nausea Drowsiness CNS disturbances Side Effects of ACTH: Insomnia Hypertension Diabetes mellitus Stomach ulcers Osteoporosis HORMONES & RELATED PEPTIDES
  • 55. • After consuming stimulants, performance under severe circumstances eg. long periods and/or in the heat, raises the athlete's body temperature intensively, making it difficult to cool down. • Cardiovascular malfunction may even lead to death Loss of appetite Insomnia Euphoria Hallucinations Trembling Restlessness, agitation Hypertension Palpitation, arrhythmias Hyperthermia STIMULANTS
  • 56. OTHER SUBSTANCES Side Effects of Narcotics: Addiction Loss of balance and coordination Nausea and dizziness Insomnia & depression Decreased heart rate Side Effects of Cannabinoid: Impaired balance and coordination Loss of concentration Increase in heart rate Increased appetite Drowsiness, Hallucination Side Effects of Glucocorticoids: Fluid retention Hyperglycaemia Systemic infections Musculoskeletal disorders
  • 57. When will an athlete be tested? • Any sportsperson competing in national or international events can be asked to give his/her blood and/or urine samples at any point of time by anti-doping agency or sports events committee during the event. • Testing can be conducted in-competition and out-of- competition. Usually athletes who bag the finishing positions are tested. • In addition, agency can randomly test any accredited athlete, even when not participating in an event. TESTING OF ATHLETES
  • 58. Intelligence and Investigation Team is an important partner in global anti-doping program in terms of: • Investigating potential Anti-Doping Rule Violations • Cooperating with law enforcement to shut down large scale doping rings • Curtailing the trafficking of prohibited substances INVESTIGATIVE PROCESS
  • 59. INVESTIGATIVE PROCESS COLLECT: information from parent, officials, athletes. interviews with the person making the claim. Seeking out corroborating evidence without compromising the confidentiality of the informant. ANALYSE: Analyst assigned to the case along with a scientific expert if necessary, to assess the quality of the information and the source, determine the scope, accuracy and likelihood of the allegations. Bulletin Report prepared INVESTIGATE: Team coordination with internal WADA teams and external partners like Anti-Doping Organizations, International Federations and law enforcement. More interviews and analysis conducted to further corroborate the claims CONCLUDE: Determination of whether the case requires additional follow-up or if the case is closed. At every step along the way, the informant is updated and their identity is kept confidential.
  • 60. WADA accredited lab in India: National Dope Testing Laboratory (NDTL) Ministry of Youth Affairs & Sports J.L.N. Stadium Complex, New Delhi Head of the Laboratory: Dr. P. L. Sahu Scientific Director INVESTIGATIVE PROCESS
  • 61. 11 STAGES OF DOPING CONTROL
  • 62.
  • 63.
  • 64.
  • 65.
  • 66. Out of competition testing: • Training Period • Off Season In Competition testing: • Selection trial • State level championship • National Competition • International Competition SAMPLE TESTING PROTOCOL Source: http://ndtlindia.com/sample-testing-protocol/
  • 67. URINE SAMPLE TESTING PROTOCOL Source: http://ndtlindia.com/sample-testing-protocol/
  • 69. No. Screening Equipment Sample 1. Erythropoietin Stimulating Agents (ESAs) & its Analogues Electrophoresis Serum 2. Human Growth Hormone Luminometer Serum 3. Blood parameters Sysmex XT2000i Whole Blood 4. Blood Transfusion Flowcytometer 500 Whole Blood 5. Hemoglobin Based Oxygen Carriers ELISA Reader, LC-MS/MS Serum BLOOD SAMPLE TESTING PROTOCOL Source: http://ndtlindia.com/sample-testing-protocol/ • Number of Samples: 2 (“A” Sample and “B” Sample) • Volume required: 2 x 3mL
  • 70. THERAPEUTIC USE EXEMPTION (TUE) • Athletes may at times need to use a prohibited medication to treat a legitimate medical condition. • A TUE is an exemption that allows an athlete to use, for therapeutic purposes only, an otherwise prohibited substance or method (of administering a substance). • The World Anti-Doping Code International Standard for Therapeutic Use Exemptions (ISTUE) is a mandatory International Standard developed as part of the World Anti- Doping Program.
  • 71. An athlete may be granted a TUE if (and only if) he/she can show, by a balance of probability, that each of the following conditions is met by Prohibited Substance (PS) or Prohibited Method(PM) in question . : • Needed to treat an acute or chronic medical condition, such that the athlete would experience a significant impairment to health if it were to be withheld. • No reasonable therapeutic alternative to its use THERAPEUTIC USE EXEMPTION (TUE)
  • 72. THERAPEUTIC USE EXEMPTION (TUE) • Use is highly unlikely to produce any additional enhancement of performance beyond what might be anticipated by a return to the athlete’s normal state of health following the treatment. • The necessity for its use is not a consequence, wholly or in part, of the prior Use (without a TUE) of another prohibited substance or method.
  • 73. DESIGNER DRUGS • Molecules that are deliberately engineered to contain novel modifications so that they may evade detection by targeted drug surveillance procedures or evade current legislation. • Produced with the intent of developing substances that differ slightly from controlled substances in their chemical structure while retaining their pharmacological effects. • Examples: 1. Synthetic cathilones (stimulants): Mimic effects of cocaine, methamphetamine, and MDMA 2. Tetrahydrogestrinone 3. Spice/ K2: Synthetic Marijuana
  • 74. Use of highly targeted methods to attain appropriate sensitivity to detect known potent doping agents But limited coverage with the available methods Emergence of DESIGNER DRUGS specifically intended to evade detection DESIGNER DRUGS IN SPORTS
  • 75. • Mass Spectrometry methods designed to provide more generic detection of designer drugs. • Alternative approaches such as the use of biomarkers, ELISA methods targeted at steroid substructures and receptor assays, are under investigation. • While urine remains the primary matrix for testing, understanding in vitro methods to study metabolism are increasingly important. DETECTION OF DESIGNER DRUGS
  • 76. • Study of medicine pertaining to sportspersons • Includes regular health assessment and management of medical history of the people involved in sporting activities and treatment of sports-related injuries. • Athletes and sportspersons can prevent illness, injuries, and incidences of doping through the basic knowledge of sports science, exercise physiology, and pharmacokinetics and pharmacodynamics of biologically active substances that enter their body in the form of food or medicines SPORTS MEDICINE
  • 77. • The necessity of athletes to know the drug, its exact effect, and the prescribed limit, led to the introduction of pharmacology in sports. • Inter-professional learning essential among the health-care professionals to safeguard sportspersons from inadvertent doping. • Sport pharmacologists and sport pharmacists can work in collaboration with other health-care professionals to help this cause by communicating the hazards of inadvertent drug abuse, improving health and professional outcomes. ROLE OF SPORTS PHARMACOLOGY
  • 80. REFERENCES • https://www.wada-ama.org/en/content/what-is-prohibited • https://www.nadaindia.org/en/prohibited-list • https://www.who.int/topics/substance_abuse/en/ • http://ndtlindia.com/sample-testing-protocol/ • Reardon, C. L., & Creado, S. (2014). Drug abuse in athletes. Substance abuse and rehabilitation. 95–105. • Malve HO. Sports pharmacology: A medical pharmacologist’s perspective. Journal of pharmacy & bioallied sciences. 2018 Jul;10(3):126. • Teale P, Scarth J, Hudson S. Impact of the emergence of designer drugs upon sports doping testing. Bioanalysis. 2012 Jan;4(1):71-88.

Editor's Notes

  1. Based on a report from the World Anti-Doping Agency, the International Olympic Committee said, "all Russian athletes … are considered to be affected by a system subverting and manipulating the anti-doping system." Yet,the organization left it to the governing bodies of each sport to determine the eligibilityof individual athletes. As a result, 271 of 389 Russian athleteswere cleared for competition at the 2016 Summer Olympics in Brazil, reported CNN.  The International Paralympic Committee banned the entire Russian federationfrom competing at the Rio Paralympics.
  2. Even though Yadav was given the go-ahead by the National Anti-Doping Agency, he was not cleared by the World Anti-doping Agency.
  3. It was decided that countries like Russia, Kazakhstan, Azerbaijan, Armenia and Belarus will be given only two places each at Tokyo 2020. The new rules state that any nation with 20 or more doping violations from 2008 to 2020 will have just one man and one woman at the Games. Countries with 10-19 doping violations over that same period will be limited to two men and two women in Tokyo. At least nine more countries, including Bulgaria, Iran and India fall into that category.
  4. First Use The first step to addiction is trying the substance. It can be as fast as taking the first drink or smoking a cigarette. Or, people may have used drugs in the past without developing a dependency, but are now moving on to a more addictive substance. Part of the challenge is when the first exposure to drugs is through legal means. Opioids, for example, are often prescribed to patients as a way to deal with persistent pain. The first dose may relieve that pain temporarily, but over time as the body grows accustomed to the drug, relief no longer comes, sometimes prompting individuals to take more of the drug than is medically recommended or seeking a stronger dosage. Regular Use As people become regular users, they begin to display a pattern. Sometimes they may use only on the weekends or just at night while spending time with friends, but oftentimes these individuals will begin to show the signs of addiction as the substance becomes more important in their lives. Risky Use As use deepens, people may begin to exhibit dangerous behavior, such as driving while drunk or high. The substance in question may impact one’s ability to succeed at work or school. Relationships with friends or significant others may also begin to deteriorate. Dependence At this stage, the individual has developed a tolerance to the substance and needs a dangerous amount of it to feel good again. Furthermore, going without the substance for a certain amount of time can induce withdrawal symptoms, such as muscle cramps, vomiting or fevers. Cravings for the substance, both physical and psychological, can be intense. Substance Use Disorder At this point, individuals cannot function in daily life without their substance of choice. People with addiction may lose their job, drop out of school and even face homelessness. Despite these significant consequences, individuals will continue to abuse their substance.
  5. he term “doping” was introduced in English in 1889, when a potion containing opium was abused in horses
  6. he first actual drug testing of athletes occurred at the 1966 European Championships, and 2 years later the IOC implemented their first drug tests at both the Summer and Winter Olympics.24 Anabolic steroids became even more prevalent during the 1970s, and after a method of detection was found, they were added to the IOC’s prohibited substances list in 1976. This resulted in a marked increase in the number of doping-related disqualifications in the late 1970s,24 notably in strength-related sports, such as throwing events and weightlifting.
  7.  One representative study randomized male recreational athletes to growth hormone 2 mg/day subcutaneously, testosterone 250 mg weekly intramuscularly, a combination of the two treatments, or placebo.36 Female recreational athletes were randomized to growth hormone 2 mg daily or placebo. In both males and females, growth hormone was associated with significantly decreased fat mass, increased lean body mass, and improved sprint capacity (although with no change in strength, power, or endurance). Sprint capacity improvement was even greater when growth hormone and testosterone were coadministered to males.
  8. Growth Factors and Growth Factor Modulators, including, but not limited to: Fibroblast Growth Factors (FGFs); Hepatocyte Growth Factor (HGF); Insulin-like Growth Factor-1 (IGF-1) and its analogues; Mechano Growth Factors (MGFs); Platelet-Derived Growth Factor (PDGF); Thymosin-β4 and its derivatives e.g. TB-500; Vascular-Endothelial Growth Factor (VEGF); Growth Hormone fragments, e.g. AOD-9604 and hGH 176-191; Growth Hormone Releasing Hormone (GHRH) and its analogues, e.g. CJC-1293, CJC-1295, sermorelin and tesamorelin;Growth Hormone Secretagogues (GHS), e.g. lenomorelin (ghrelin) and its mimetics, e.g. anamorelin, ipamorelin, macimorelin and tabimorelin;GH-Releasing Peptides (GHRPs), e.g. alexamorelin, GHRP-1, GHRP-2 (pralmorelin), GHRP-3, GHRP-4, GHRP-5, GHRP-6, and examorelin (hexarelin).
  9. Agents preventing activin receptor IIB activation including, but not limited, to: Activin A-neutralizing antibodies;Activin receptor IIB competitors such as: Decoy activin receptors (e.g. ACE-031);Anti-activin receptor IIB antibodies (e.g. bimagrumab);Myostatin inhibitors such as: Agents reducing or ablating myostatin expression; Myostatin-binding proteins (e.g. follistatin, myostatin propeptide); Myostatin-neutralizing antibodies (e.g. domagrozumab, landogrozumab, stamulumab).
  10. Artificially enhancing the uptake, transport or delivery of oxygen: Perfluorochemicals; efaproxiral (RSR13) and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation.
  11. IN ADDITION TO THE CLASSES S0 TO S5 AND M1 TO M3 DEFINED ABOVE, THE FOLLOWING CLASSES ARE PROHIBITED IN-COMPETITION In-Competition: Unless provided otherwise in the rules of an International Federation or the ruling body of the Event in question, “In-Competition” means the period commencing twelve hours before a Competition in which the Athlete is scheduled to participate through the end of such Competition and the Sample collection process related to such Competition.
  12. Except: Clonidine; Imidazole derivatives for topical/ophthalmic use and those stimulants included in the 2019 Monitoring Program*. * Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol, and synephrine: These substances are included in the 2019 Monitoring Program, and are not considered Prohibited Substances. ** Cathine: Prohibited when its concentration in urine is greater than 5 micrograms per milliliter. *** Ephedrine and methylephedrine: Prohibited when the concentration of either in urine is greater than 10 micrograms per milliliter. **** Epinephrine (adrenaline): Not prohibited in local administration, e.g. nasal, ophthalmologic, or co-administration with local anaesthetic agents. ***** Pseudoephedrine: Prohibited when its concentration in urine is greater than 150 micrograms per milliliter.
  13. All glucocorticoids are prohibited when administered by oral, intravenous, intramuscular or rectal routes.
  14. P1 ALCOHOL Alcohol is a central nervous system depressant which slows down the actions of the brain and body. Combining alcohol with other drugs can magnify the effects of alcohol or of the other drugs which can be dangerous in many circumstances. Side Effects of Alcohol: Impaired judgment Loss of reflexes and muscular co-ordination slurred speech sleepiness and poor respiration
  15. Whereabout failure: Any  combination   of   three   missed   tests  and/or   filing  failures,   as   defined  in   the International Standard for Testing and Investigations, within a twelve­month period by an Athlete in a Registered Testing Pool. 
  16. Anabolic’ means ‘tissue building’ and ‘androgenic’ means ‘masculinizing Anabolic properties may affect accelerated growth of muscles and bones while the androgenic properties may affect development of male reproductive system and secondary male sexual characteristics such as hairiness and deep voice. Formation of proteins is promoted in genital organ, skin, skeleton and muscles. Used to improve physical and physiological capacity to train and reduce associated fatigue and recovery duration. Used by athletes involved in weightlifting, throwing and other sports involving strength parameters.
  17. S3 BETA-2-AGONISTS Beta-2-Agonists if taken into bloodstream are having anabolic effects and hence WADA prohibited the use of all Beta-2-Agonists by athletes with the exception of inhaled formoterol, salbutamol, salmeterol and terbutaline to treat and/or prevention of asthmatic athletes. An abbreviated therapeutic use exemption certificate is required for the use of inhaled Beta-2Agonists. S4 HORMONE ANTAGONISTS AND MODULATORS These substances may be illegally used by athletes to counteract undesirable side effects associated with anabolic steroid use such as gynecomastia. Side Effects of Hormone Antagonists and Modulators: Hot flushes Gastrointestinal disorders Fluid retention Venous thrombosis S5 DIURETICS AND OTHER MASKING AGENTS Masking agents are substances that have the potential to impair the excretion of prohibited substances to conceal their presence in urine or other doping control samples or to increase haematological parameters.
  18. ENHANCEMENT OF OXYGEN TRANSFER Blood doping may be illegally used to increase red blood cells in an attempt to improve the oxygen carrying capacity in endurance events. Side Effects of Blood Doping: Increased blood viscosity Clotting susceptibility Hypertension Vasoconstriction Kidney dysfunction Risk of cardiac arrest, brain stroke and pulmonary embolism M2 CHEMICAL AND PHYSICAL MANIPULATION Chemical and physical manipulations including catheterization without medical justification and masking agents are prohibited methods and should not be used by athletes. Side Effects of manipulations: Cystitis (bladder infection) and other dysfunctions and disorders depending upon the type of manipulation. M3 GENE DOPING Gene doping is banned by WADA in sports.
  19. Following the analysis, the team will produce a Bulletin Report, which will track the investigation going forward.
  20. Doping Control Officer (DCO): An official who has been trained and authorized by the ADO with delegated responsibility for the on-site management of a Sample Collection Session.
  21. Historically, dope-testing methods have been developed to target specific and known threats to the integrity of sport. Traditionally, the source of new analytical targets for which testing was required were derived almost exclusively from the pharmaceutical industry. More recently, the emergence of designer drugs, such as tetrahydrogestrinone that are specifically intended to evade detection, or novel chemicals intended to circumvent laws controlling the sale and distribution of recreational drugs, such as anabolic steroids, stimulants and cannabinoids, have become a significant issue. 1. These substances are often marketed as “bath salts,” “research chemicals,” “plant food,” “glass cleaner,” and labeled “not for human consumption,” in order to circumvent application of the Controlled Substance Analogue Enforcement Act. Marketing in this manner attempts to hide the true reason for the products’ existence—the distribution of a psychoactive/stimulant substance for abuse.