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Principles and application of genetics
and genomics to improve animal health
an online course at destination of swine professionals
Perle Boyer, Montserrat Torremorell,
Jack Dekkers
A collaborative effort
A collaborative effort
• Numerous and prestigious course contributors
Genetically Improving Resistance of Pigs to PRRS Virus
Infections
by Dr. Jack Dekkers and collaborators
• Justification:
– Veterinarians and health professions involved in genetic decisions
seldom are exposed to genetics during their training years
– Genetic selection and genomic programs are complex and require a
comprehensive understanding of the methods and strategies
employed by genetic companies to deliver genetic improvement, in
particular when the improvement relates to health.
• Overall Goal: To train veterinarians, geneticists and
industry stakeholders on basic concepts of genetic
selection and genomics and how to apply them to
improve animal health
Goals of the course
By the end of the class, the learner will be able to:
• Synthesize the epidemiologic and biological characteristics of an
infectious disease
• Explain the bases of a genetic improvement program and how a
program works
• Compare and contrast the various genetic selection tools and
approaches and how they can be used to improve health
• Recognize the limitations of genetic improvement of health due
to the pathogens’ biology and evolution
• Explain genetic approaches to control PRRSV infections
Course Design
• Completely online
• Self-paced
• 8 hours of content  25h-30h of learning
• Videos as well as interactive sliders
• Knowledge check to highlight major concepts
Module 1: Introduction to
infectious disease biology
Part 1:
Epidemiology
of infectious
diseases
Part 2: Control
and
prevention of
infectious
diseases
Part 3: Disease
modeling
Part 4: PRRSV
epidemiology
and control
Module 2: Genetics and
Genetic selection
Part 1: How
does genetic
material work?
Part 2: Genetic
variation
Part 3:
Quantitative
trait genetics
and response
to selection
Part 4: Use of
genomics in
genetic
improvement
Module 3: Genetic selection for
disease resistance
Part 1: Genetic
selection for disease:
basic concepts
Part 2: Impact of
genetic selection on
disease epidemiology
Module 4: Genetic selection
for PRRS
Part 1: Evidence for
a genetic
component to
PRRS
Part 2: Resistance
to PRRS in the
growing pig and the
reproductive female
Part 3: Other
technologies
Overall Structure
Preview of
the course
Preview of
the course
Preview of the course
Preview of
the course
Preview of
the course
Who should take this course?
• Swine practitioners and health professionals in the
swine industry
• Geneticists
• Researchers in swine health
• Graduate students
More information
• Opening of the course: Spring 2018
• Course webpage: z.umn.edu/geneticsgenomics
• Contact: pboyer@umn.edu
Funding
• This project was supported by the Agriculture and
Food Research Initiative Competitive Grant no 2013-
68004-20362 from the USDA National Institute of
Food and Agriculture
Thank you for your attention
pboyer@umn.edu
@umn_swine_group
umnswinenews.com

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Dr. Perle Boyer - Porcine reproductive and respiratory syndrome genetic resistance: an online class at destination of swine experts and professionals

  • 1. Principles and application of genetics and genomics to improve animal health an online course at destination of swine professionals Perle Boyer, Montserrat Torremorell, Jack Dekkers
  • 3. A collaborative effort • Numerous and prestigious course contributors
  • 4. Genetically Improving Resistance of Pigs to PRRS Virus Infections by Dr. Jack Dekkers and collaborators • Justification: – Veterinarians and health professions involved in genetic decisions seldom are exposed to genetics during their training years – Genetic selection and genomic programs are complex and require a comprehensive understanding of the methods and strategies employed by genetic companies to deliver genetic improvement, in particular when the improvement relates to health.
  • 5. • Overall Goal: To train veterinarians, geneticists and industry stakeholders on basic concepts of genetic selection and genomics and how to apply them to improve animal health
  • 6. Goals of the course By the end of the class, the learner will be able to: • Synthesize the epidemiologic and biological characteristics of an infectious disease • Explain the bases of a genetic improvement program and how a program works • Compare and contrast the various genetic selection tools and approaches and how they can be used to improve health • Recognize the limitations of genetic improvement of health due to the pathogens’ biology and evolution • Explain genetic approaches to control PRRSV infections
  • 7. Course Design • Completely online • Self-paced • 8 hours of content  25h-30h of learning • Videos as well as interactive sliders • Knowledge check to highlight major concepts
  • 8. Module 1: Introduction to infectious disease biology Part 1: Epidemiology of infectious diseases Part 2: Control and prevention of infectious diseases Part 3: Disease modeling Part 4: PRRSV epidemiology and control Module 2: Genetics and Genetic selection Part 1: How does genetic material work? Part 2: Genetic variation Part 3: Quantitative trait genetics and response to selection Part 4: Use of genomics in genetic improvement Module 3: Genetic selection for disease resistance Part 1: Genetic selection for disease: basic concepts Part 2: Impact of genetic selection on disease epidemiology Module 4: Genetic selection for PRRS Part 1: Evidence for a genetic component to PRRS Part 2: Resistance to PRRS in the growing pig and the reproductive female Part 3: Other technologies Overall Structure
  • 11. Preview of the course
  • 14. Who should take this course? • Swine practitioners and health professionals in the swine industry • Geneticists • Researchers in swine health • Graduate students
  • 15. More information • Opening of the course: Spring 2018 • Course webpage: z.umn.edu/geneticsgenomics • Contact: pboyer@umn.edu
  • 16. Funding • This project was supported by the Agriculture and Food Research Initiative Competitive Grant no 2013- 68004-20362 from the USDA National Institute of Food and Agriculture
  • 17. Thank you for your attention pboyer@umn.edu @umn_swine_group umnswinenews.com

Editor's Notes

  1. The main grant goal is to identify, validate and transfer genetic markers and biomarkers that are associated with superior response to, or with better ability to cope with, PRRSV infection. The deliverables will impact the industry through the implementation of marker-assisted selection for PRRSV resistance in breeding programs, resulting in improved breeding stock for producers. Specific objectives, covering integrated activities in research, extension and education, are: 1. Determine the nature and robustness of the effects of the identified associated genomic regions and biomarkers to co-infection with other pathogens and to PRRS vaccine. 2. Validate the effect of the identified genomic regions to disease challenge under field conditions. 3. Develop and implement strategies to educate industry stakeholders on the role of host genetics and on strategies to improve host resistance to the PRRS virus. 4. Develop and implement strategies to educate the next generation of industry leaders on the role and science of host genetics of resistance to infectious diseases.