Treatment of a young female patient wit a combination of Invisalign and distalizing appliance. Well treated by one of our students under my supervision.
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
1. ORTHODONTIC CASE
PRESENTATION
D O N E B Y : D R . N O O R ALTAM I M I
S U P E RV I S E D B Y: D R . AH M A D AL TAR AW N E H
D R . R AG H D A S H AM M O U T
D R . AN WAR AL R AH A M N E H
D R . H AN A N AL H AB A R N E H
3. MEDICAL AND DENTAL HISTORY
Medical History: Denied any medical problems
Dental History: Heavily restored UR6, Amalgam on LL6 & UL6
Habits: No habits
17. SOFT TISSUE ASSESSMENT
• Upper lip length 17 mm
• Lower lip length 30 mm
• Upper lip thickness 12 mm
• Lower lip thickness 14 mm
18. SMILE ANALYSIS
• Buccal corridors: narrow
• The smile arc: Incisal
edges of upper anterior
teeth are not parallel to the
upper border of the lower
lip
20. GINGIVAL HEIGHT, CONNECTORS
Gingival level of lateral 0.5 mm lower to
central incisors
Gingival connectors between centrals almost equal
connectors between central and lateral
26. PERIODONTAL HEALTH AND
TEETH HEALTH
• Periodontal health:
poor oral hygiene, calculus formation on upper 6’s
• Multiple restorations
6 1 1 6
6
27. ANTERIOR SEGMENT
RELATIONSHIP
Class I incisor relationship
Upper midline shifted to R 2mm
Lower midline shifted to R 3mm
Overjet = 3 mm
Overbite = Deep 50% complete to tooth
UR2 in cross bite
28. BUCCAL SEGMENT RELATIONSHIP
• Molar relationship: L: Class I R: Class I
• Canine relationship: L: Class I R: Class II 1/2
33. Right side:2 mm Curve of
Spee
STUDY MODEL ANALYSIS
Left side:3 mm Curve of
Spee
34. STUDY MODEL ANALYSIS
Upper arch
• U shaped arch form
• Dental Asymmetry
• Intermolar width: 43mm
• Intercanine width: 32 mm
35. STUDY MODEL ANALYSIS
Lower arch
• U shaped arch form
• Dental Asymmetry
• Intermolar width 40 mm
• Intercanine width 25 mm
36.
37. SPACE ANALYSIS
• Upper Arch:
Space available (Arch circumference):76 mm
Space needed (MD teeth width) :70 mm
• Lower Arch:
Space available 66mm
Space needed 61mm
48. PANORAMIC RADIOGRAPH
All teeth are present including all 8’s except UR8
UR6 is heavily restored
Right side ramus length = 65
Left side ramus length = 63
49. PROBLEM LIST
Gingivitis with Calculus
C/C “Palatally positioned UR2”
Skeletal:
Mild Asymmetry, chin deviated to
right side.
Decreased lower facial height
Soft tissue:
Increased Frontonasal angle
Thin upper lip
Dental:
Mod-Severe crowding in upper and
lower
Shifted upper and lower midlines
Increased(deep complete) over bite
Class 2 ½ unit UR3
UR2 in cross bite
Buccally erupted UR3
Rotated upper molars
Impacted LR5
Mesially tipped LR6
Distally tipped LR5
50. DIAGNOSTIC SUMMARY
• A.M is a 13 year old male, Medically fit, with gingivitis and
calculus on upper 6s,complains of palatally positioned
UR2. He has a class I incisor relationship based on class I
skeletal pattern, reduced lower facial height, competent
lips, and a straight facial profile. O.J of 3 mm, deep
complete to the tooth O.B. Deep COS in lower arch
Mod- Severe crowding in upper arc anteriorly and lower
arch psteriorly. Midlines are not coincident, UR2 in
crossbite, LR5 is impacted. Molar relationship is class I on
both sides, canine relationship is class 1 on left side,1/2 unit
class 2 on right side.
51. TREATMENT AIMS
Improve oral hygiene and treatment of calculus
Address C/C: correct position of UR2
Skeletal:
Accept Mild Asymmetry
Improve Lower facial height
Soft tissue:
Improve smile esthetics
Dental:
Correct crowding in upper and lower arches
Correct Overbite
Correct buccal segment relationship on right side to class I
Bring LR5 into position
Correct angulation of upper and lower post teeth
Correct midline discrepancies
Correct Bolton discrepancy
52. TREATMENT PLAN
(Camouflage, Non-extraction case, space provided by
arch wires)
1. OHI.
2. Modified TPA (Zachrisson)
3. Upper and lower fixed appliance (MBT) slot 22” with bite
turbos on upper centals, open space for impacted LR5
4. Miniscrew on lower right retromolar area
5. Retention:
Upper: anterior bite plane (wear time at night until end of vertical
growth) and fixed retainer from 3-3
Lower: fixed retainer from 3-3
53. JUSTIFICATION (NON-EXTRACTION)
DENTAL:
CRITERIA VALUE NORMAL VALUE PRO/CON
NON-EXTRACTOION
Tooth size- arch length Upper :6 mm
excess
Lower: 5
8-11 mm crowding PRO
Curve of Spee L:3mm,R:2mm More than 6 severe PRO
Bolton discrepancy 90.7% If 4* more then extract PRO
Peck & Peck L1:75%
L2: 91%
L1:88-92 (if less extract)
L2: 90-95 (if less extract)
CON
PRO
Irregularity index .05 mm X>6.5 mm extract PRO
Incisor-Man. Plane angle 95˚ 85˚-95˚ PRO
Frankfurt-Man. Incisal
angle
69˚ 60˚-75˚ PRO
Upper incisor to NA 7mm, 34˚ 4mm anterior, (22-25) CON
Lower incisor to NB 3 mm, 23˚ 4 mm anterior ( 22-25) PRO
Lower incisor to A-pog 1 1-3 mm anterior to it PRO
55. JUSTIFICATION (NON-EXTRACTION)
SOFT TISSUE
CRITERIA VALUE NORMAL VALUE PRO/CON
NON-EXTRACTION
POSITION OF
UPPER LIP –E LINE
2 mm 2mm ±3 PRO
POSITION OF
LOWER LIP- E LINE
0 mm 2mm ±3 PRO
NASOLABIAL ANGLE 97˚ 90˚-115˚ PRO
UPPER LIP
MORPHOLOGY
13mm≠
8 mm
3 mm below sk A point
=
Vermilion to labial
surface of teeth ±1
CON
57. JUSTIFICATION
Camouflage:
Skeletal is class 1, wits 1, molars are class 1, problem is mainly concentrated in upper anterior
region , spaces can be gained by arch expansion in upper and lower arches, and molar
uprighting provides space in lower arch
• Expansion by arch wires:
Arch development
Correct angulation of lower teeth
Fixed Appliance
Alignment of teeth
Bodily movement
Correct cross bite , traction of impacted tooth and molar uprighting
Upper and lower arch coordination
• Bite turbos:
Reduction of deep overbite, dis-occlusion of upper and lower teeth
• Modified TPA (Zachrisson) :
Correct rotated upper molars
58. JUSTIFICATION
• Miniscrew on lower right retromolar area
help in uprighting lower molars and distalization
• MBT prescription slot 0.022:
Increased maxillary incisors labial crown torque
Increased lingual crown torque of LLS (to counteract the effect of RCOS during deep
OB correction)
Less anchprage demand
Provides better intercsupation
• Retention ( Upper and Lower fixed retainer ), Upper Anterior bite plane
Upper fixed retainer: maintain position of UR2
Upper Anterior bite plane as retainer : to maintian corrected deep bite until end of
vertical growth
Lower fixed retainer: prevent late anterior mandibular crowding
59. TREATMENT DETAILS AND
MECHANICS
1. Full records
2. Separators on all 6’s
3. Bands selection on all 6’s
4. Impression for Zachrisson type TPA
5. Cementation of lower bands
6. Cementation of TPA
60. TREATMENT DETAILS AND
MECHANICS
7.Direct bonding of upper and lower fixed appliance with
anterior bite turbos on upper centrals, Check OPG to
achieve the right teeth angulations.
Regarding bracket positioning
-Place brackets more incisally on upper anteriors
-Increase mesial angulation of upper canines
-Invert brackets on upper laterals
8.Alignment arch wire 0.014 Niti, 0.016*0.022 NiTi for
leveling
61. 10. On working arch wire 0.019*0.025 SS:
Open coil spring between UR1-UR3, LR4-LR6
Use piggyback 0.012 NiTi technique to bring UR2 into the
arch
Ligate btw UR3-UR6, UR1-UL2 to maintain space of UR2
Refer for exposure of LR5 (if didn’t erupt by itself after space provision-
note that the root is not fully formed yet)
TREATMENT DETAILS AND
MECHANICS
62. TREATMENT DETAILS AND
MECHANICS
11. Band all 7s to aid in correction of deep bite after they are fully erupted
12. Consider use of reverse curve of spee in lower arch
13. Midline correction can be achieved with correction of teeth
angulations and differential elastics
14. Finishing and detailing 0.017*0.025 TMA, consider reshaping of upper
anterior teeth
15. Upper impression for anterior bite plane (to be used until the end of
vertical growth)
16. Upper and lower fixed retention from 3-3 using multistranded SS
Normal upper thickness below A 3mm to outer border F12.5 +-1.6,14.8 +-1.4
Lower 13.6 +-1.4,15+-1.2
Ptn’s 8upper ,lower 7
Length sn-sto-gn
Zero merdian from N perp to F
Pog 0 +/- 2
Though canines are partially erupted
Calculated LR5 W MAG RATIO 6 ON CAST 1113.6…5 ON XRAY 8.1
Max ant excess
Total upper 92
Total lower 83.5
Anterior upper : 46
Anterior lower 34
Means lower > upper
Or upper < lower
Ya3ni mandible bigger than maxilla or maxilla smaller than mandible
Provides better intercsupation
Increased buccal root torque
Reduced lingual root torque of lower posterior teeth
Upper molar offset at 10 degree
Zero degree tip of upper molars
Why MBT less anchorage demand
Light force
The wagon wheel effect: because increasing the torque will cause the mesial tip of ULS to be reduced and this will reduce the anchorage demands
Reduced canine, premolar and molar tip compared to Roth
Increased molar root torque buccally, increase anchorage by cortical bone theory
Upper molar 10 degree offset, counteract the unwanted rotational movement during space closure in the upper arch and this might strengthen the anchorage
-Partial ligation of Distally inclined lower canines