The document outlines career pathways for research in the United Kingdom's National Health Service (NHS), including fellowships offered by the National Institute for Health Research (NIHR). It describes:
- The NIHR/HEE Integrated Clinical Academic Programme for non-medical healthcare professionals, which provides training awards to develop careers combining clinical research and leadership with clinical practice.
- The NIHR/HEE Masters in Clinical Research, an introduction to clinical academic research covering trial design, data management, and practical research experience.
- The various NIHR fellowship opportunities at different career levels, from Doctoral to Senior Research Fellowships, to support individuals' development as future research leaders.
Let's Talk Research Annual Conference - 24th-25th September 2014 (Dr Mal Palin)NHSNWRD
"NIHR Administered Personal Research Training Award": Dr Mal Palin's presentation reviewed opportunites given by the NIHR Trainees Coordinating Centre and presented the experiences of an existing award holder.
This presentation will help the U.G, P,G, students ,scholars and researcher and others to make a research proposal to conduct a research study in any area of their interest.
Let's Talk Research Annual Conference - 24th-25th September 2014 (Dr Mal Palin)NHSNWRD
"NIHR Administered Personal Research Training Award": Dr Mal Palin's presentation reviewed opportunites given by the NIHR Trainees Coordinating Centre and presented the experiences of an existing award holder.
This presentation will help the U.G, P,G, students ,scholars and researcher and others to make a research proposal to conduct a research study in any area of their interest.
Protocol writing in clinical research kamalKamal Perera
Perera P.K. Resource person: Workshop on Protocol Writing in Clinical Research: BMARI, Nawinna, Maharagama,Sri Lanka. Organized by: Bandaranaike Memorial Ayurvedic Research Institute (BMARI) Collaboration with World Health Organization 27th January 2015, at Bandaranaike Memorial Ayurvedic Research Institute, Nawinna, Sri Lanka.
Traditional Medicine (TM) has been subject to substantial debate with regard to the ethics governing research in this area. The controversies have generally revolved around the unreasonable harvesting of medicinal plants, ethical accountability of researchers towards local knowledge holders and the credibility of TM as a complementary and alternative mode of treatment.
This presentation stresses the importance of understanding the 6 ethical principles governing publication in TM journals:-
1. Sustenance
2. Scientific validation
3. Informed consent
4. Reporting standards
5. Proprietary issues
6. Ethical policies and declarations
The NIHR Research Design Service provides support to NHS staff and academics preparing research proposals for submission to peer-reviewed funding competitions for applied health or social care research.
EuroBioForum 2013 - Day 1 | Wolfgang EberleEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# NATIONAL PERSPECTIVES #
Belgium
Working across disciplines for our health benefit - From successful strategies for biotech and nanotech to Nanotech for Health in Flanders
Wolfgang Eberle
Funded Program Manager Life Science Technologies Imec
=======================================
http://www.eurobioforum.eu
Protocol writing in clinical research kamalKamal Perera
Perera P.K. Resource person: Workshop on Protocol Writing in Clinical Research: BMARI, Nawinna, Maharagama,Sri Lanka. Organized by: Bandaranaike Memorial Ayurvedic Research Institute (BMARI) Collaboration with World Health Organization 27th January 2015, at Bandaranaike Memorial Ayurvedic Research Institute, Nawinna, Sri Lanka.
Traditional Medicine (TM) has been subject to substantial debate with regard to the ethics governing research in this area. The controversies have generally revolved around the unreasonable harvesting of medicinal plants, ethical accountability of researchers towards local knowledge holders and the credibility of TM as a complementary and alternative mode of treatment.
This presentation stresses the importance of understanding the 6 ethical principles governing publication in TM journals:-
1. Sustenance
2. Scientific validation
3. Informed consent
4. Reporting standards
5. Proprietary issues
6. Ethical policies and declarations
The NIHR Research Design Service provides support to NHS staff and academics preparing research proposals for submission to peer-reviewed funding competitions for applied health or social care research.
EuroBioForum 2013 - Day 1 | Wolfgang EberleEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# NATIONAL PERSPECTIVES #
Belgium
Working across disciplines for our health benefit - From successful strategies for biotech and nanotech to Nanotech for Health in Flanders
Wolfgang Eberle
Funded Program Manager Life Science Technologies Imec
=======================================
http://www.eurobioforum.eu
Hide glossary Glossary Study record managers.docxtarifarmarie
Hide glossary
Glossary
Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Search for terms
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Accepts healthy volunteersA type of eligibility criteria that indicates whether people who do not have the condition/disease being studied can participate in that clinical study.
Active comparator armAn arm type in which a group of participants receives an intervention/treatment considered to be effective (or active) by health care providers.
Adverse eventAn unfavorable change in the health of a participant, including abnormal laboratory findings, that happens during a clinical study or within a certain amount of time after the study has ended. This change may or may not be caused by the intervention/treatment being studied.
Age or age groupA type of eligibility criteria that indicates the age a person must be to participate in a clinical study. This may be indicated by a specific age or the following age groups:
The age groups are: Child (birth-17)Adult (18-64)Older Adult (65+)AllocationA method used to assign participants to an arm of a clinical study. The types of allocation are randomized allocation and nonrandomized.
ArmA group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Arm typeA general description of the clinical trial arm. It identifies the role of the intervention that participants receive. Types of arms include experimental arm, active comparator arm, placebo comparator arm, sham comparator arm, and no intervention arm.
Baseline characteristicsData collected at the beginning of a clinical study for all participants and for each arm or comparison group. These data include demographics, such as age, sex/gender, race and ethnicity, and study-specific measures (for example, systolic blood pressure, prior antidepressant treatment).
Canceled submissionIndicates that the study sponsor or investigator recalled a submission of study results before quality control (QC) review took place. If the submission was canceled on or after May 8, 2018, the date is shown. After submission of study results, a study record cannot be modified until QC review is completed, unless the submission is canceled.
Certain agreementsInformation required by the Food and Drug Administration Amendments Act of 2007. In general, this is a description of any agreement between the sponsor of a clinical study and the principal investigator (PI) that does not allow the PI to discuss the results of the study or publish the study results in a scientific or academic journal after the study is completed.
CertificationA sponsor or investigator may submit a certification to delay submission of results information if they are applying for FDA approval of a new drug or device, or new use of an already approved drug or device. A sponsor or investigator who submits a certification can.
EVIDENCE-BASED PRACTICE IN NURSING.docxHaraLakambini
-Evidence-based Practice in Nursing
-Steps of Evidence-Based Practice
-Hierarchy of Evidence | Quantitative Questions
-Elements of Evidence-Based Practice
-Nursing Research
-Types of Research
-Rights of Human Subject
-Comparison of Nursing Process with Research Process Table
-Performance Improvement in Nursing
-Examples of Performance Improvement Models
-Relationship between Evidence-Based Practice, Research, and Performance Improvement
-Similarities and Differences among Evidence-Based Practice, Research, and Performance Improvement
Career In Clinical Research _ ProRelix Education (1).pdfTrishalaDeshmane1
Building a successful career in clinical research requires a strong foundation in science and medicine, specialized training in clinical research methodology, and a deep understanding of ethics and regulations
Efforts to place the patient at the center of medical research, spurred by the Affordable Care Act’s founding of the Patient Centered Outcomes Research Institute, have begun to change the way clinical research is conceptualized and conducted. Such efforts hold great promise, but also raise potential challenges for ethical oversight. How should oversight bodies approach the presence of patients in potentially unfamiliar research roles, such as investigator? What forms of patient involvement in research, if any, warrant increased scrutiny from oversight bodies? How do we keep the patient voice from being ‘captured’ by special interest groups? This symposium brought together a diverse group of patients and community members, policymakers, bioethicists, and regulatory officials to address these and other issues.
Hosted by Professor Priscilla Harries and Professor Carolyn Unsworth.
Including talks by Professor Desmond O'Neill, Dr Tadhg Stapleton, Ed Passant, Professor Priscilla Harries, Professor Carolyn Unsworth, Dr Carol Hawley, Dr Kate Radford, Dr Britta Lang and Dr Elizabeth White.
This event took place at Brunel University on 23/6/2016.
This was an event held at Brunel University
Monday June 16th 2014
Conference Organisers
Dr Priscilla Harries, Director of Occupational Therapy
Brunel Institute for Ageing Studies
Mr Brian Smith
Joint Lead Officer Crime and Disorder, Trading Standards Institute
The event was for professionals or organisations who work with adults at risk or are in a position to detect and prevent scams as well as researchers who are interested in research on financial abuse/ fraud and prevention of scams.
We plan to make this an annual event
The speakers were
Ms Marilyn Baldwin OBE – Think Jessica
Mr Nick Ellender, Former Chair of the London Safeguarding Adults Network - ‘Safeguarding from the Local Authority perspective’
Dr Cassandra Cross -Key note ‘Beyond money and borders: Seniors’ experiences of online fraud’
Chief Inspector Ronnie Megaughin and Mr Graham Vance, Financial Business Security Adviser at Scottish Business Resilience Centre – ‘Banks Detecting and Reporting Financial Harm’
DC Suzanne Grimmer, A/DS Hannah Nunn, A/D Jim Egley, Operation Amberhill Specialist Organised & Economic Crime Command – ‘Courier Fraud, Suspicious Activity Reports and the Little Book of Big Scams’
Brian Smith, Trading Standards - “At risk “ consumers being targeted by scammers; the Trading Standards response.
Lou Baxter, National Scam Team – The role of the National Trading Standards Scams Team
Maria Gray and Sam Falkner – Capability and Support Central Safeguarding Team - An Adult Protection Framework
Dr Priscilla Harries, Brunel University – Evidence based training tools
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Dr Beth Harris - NIHR Personal Research Training Awards for non-medical healthcare professionals-update
1. 25/03/2015
NIHR Personal Research Training
Awards for Non-Medical Healthcare
Professionals
NIHR Trainees Coordinating Centre
Dr Beth Harris
2. National Institute for Health Research
Established 2006 as a vehicle for
implementing Government’s
strategy for applied health
research
£1b annual spend
Vision:
To improve the health and wealth
of the nation through research
3. All submitted proposals must fall
within NIHR Remit
• NIHR supports training in clinical and applied health research, including
social care research.
• The proposal must have clear potential for benefitting patients and the
public within 5 years of its completion (but recognising the training
element of the research).
• The research can involve: patients; samples or data from patients;
people who are not patients; populations; health technology
assessment; or health services research.
• NIHR does not itself fund basic research or work involving animals
and/or animal tissue
4. NIHR Remit (2)
• If the work involves biomarkers:
- research that tests whether application of new knowledge can improve
treatment or patient outcomes, and has obvious potential benefit within
5 years, is within remit; This might include application of known
biomarkers, or other prognostic factors, to refine and test novel
therapeutic strategies.
- research that aims only to elucidate mechanisms underpinning
disease, or identify risk factors for disease or prognosis (including
search for biomarkers) is out of remit.
• NIHR is also prepared to support research into medical education.
5. Infrastructure
Clinical Research
Facilities, Centres &
Units
Clinical Research
Networks
Research
Research Projects &
Programmes
Research Management
Systems
Research Information
Systems
Systems
Patients
&
Public
Universities
Investigators &
Senior Investigators
Associates
Faculty
Trainees
Research Schools
NHS Trusts
The NIHR Health Research System
6. NIHRTCC Research Career Pathways Level of
Award
Undergraduate
ChairSenior/Pre-
Chair
PostDoctoral
(earlytosenior)
DoctoralPreDoctoral
------------------------- ------------------------------------------------------------------------------ --
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------------
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Non Medical/Dental
Health Professionals
HEE/NIHR Integrated
Clinical Academic
Programme
HEE/NIHR
Masters in
Clinical
Research
HEE/NIHR
Clinical
Doctoral
Research
Fellowship
HEE/NIHR
Senior Clinical
Lecturership
HEE/NIHR
Clinical
Lectureship
Methodologists
Research
Methods
Programme
NIHR Research
Methods Fellowship
and Internship
NIHR Masters
Studentship in Health
Economics or Medical
Statistics
Doctors and Dentists
NIHR Integrated
Academic Training
Programme
NIHR
Clinician
Scientist
Award
NIHR
In-Practice Fellowship
NIHR Academic
Clinical Fellowship
NIHR
Doctoral Research
Fellowship
NIHR
Post-
Doctoral
Fellowship
NIHR Career
Development
Fellowship
NIHR Senior
Research
Fellowship
NIHR Research Professorship
NIHRTransitional
Research
Fellowship
NIHRClinicalTrialsFellowship
NIHRKnowledgeMobilisationResearchFellowship
All Professions
NIHR Fellowships,
Professorships, Other Awards
NIHR
Clinical
Lectureship
7. NIHRTCC Research Career Pathways
------------------------------------------------------------------------------------------------------- --
--------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------
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Methodologists
Research
Methods
Programme
Level of
Award
Undergraduate
ChairSenior/Pre-
Chair
PostDoctoral
(earlytosenior)
DoctoralPreDoctoral
Non Medical
Healthcare
Professionals
HEE/NIHR Integrated
Clinical Academic
Programme
HEE/NIHR
Masters in
Clinical
Research
HEE/NIHR
Clinical
Doctoral
Research
Fellowship
HEE/NIHR
Senior Clinical
Lecturership
HEE/NIHR
Clinical
Lectureship
Doctors and Dentists
NIHR Integrated
Academic Training
Programme
NIHR
Doctoral Research
Fellowship
NIHR
Post-
Doctoral
Fellowship
NIHR Career
Development
Fellowship
NIHR Senior
Research
Fellowship
NIHRTransitional
Research
Fellowship
All Professions
NIHR Fellowships,
Professorships, Other Awards
8. NIHR Personal Research
Training Awards
• Career pathway to facilitate the development of
future research leaders.
• Funding the individual not just the research –
Training and Development
10. NIHR Fellowships Programme
• Salary
• Full tuition fees (for PhD)
• Research costs
• Full training and development
• Awards 3 years full time (part-time options of 75% or
60%) or up to 5 years for SRF
• Can be based at HEI or NHS Trust
• Annual competition for all levels
• Next launch – October 2015
11. Post Doctoral Research
Fellowship (NIHR PDF)
Early post doctoral Fellowship
(≤ 3 years WTE Post
Doctorate)
3 years FT (4 or 5 years PT)
Applicant:
PhD/MD or have submitted
Output from research
Evidence of commitment to
research career
Doctoral training award
3 years FT (4 or 5 years PT)
Applicant:
Some previous research experience
Some outputs from research
Evidence of commitment to research
career
Doctoral Research Fellowship
(NIHR DRF)
NIHR Fellowships
12. Senior Research Fellowship
(NIHR SRF)
Most senior NIHR Fellowship
5 years ( Chair)
Applicant:
Significant postdoctoral experience
Outstanding publication record
Independence
Leadership potential
Record of research capacity
development
Later postdoctoral award (≤ 7 yrs
WTE Post Doctorate)
3 years FT (4 or 5 years PT)
Applicant:
PhD/MD and postdoctoral experience
Significant output from research
Evidence of increasing independence
Experience of developing research
skills of others
Career Development Fellowship
(NIHR CDF)
NIHR Fellowships
13. NIHR Fellowships
Postdoctoral award (≤ 5 yrs WTE Post Doctorate)
18 months to 2 years FT or PT
Applicant:
PhD/MD and maybe postdoctoral experience
• Individuals from any scientific discipline wanting to
contribute to improving health or healthcare e.g. basic
scientists moving to applied health research
• Individuals wanting to change the focus of their research
e.g. clinically focused research to translational research
• Individuals who have had their research careers
interrupted e.g. career break, who can identify clear
training needs
• Proposed research must be within the NIHR remit
Transitional Research Fellowship
(NIHR TRF) new from 2013
21. HEE/NIHR Integrated Clinical
Academic Programme
Personal research training awards for non-medical healthcare
professionals who wish to develop careers that combine clinical
research and research leadership with continued clinical practice
and clinical development
22. HEE/NIHR Integrated Clinical
Academic Programme
Eligible Professions
• Midwife
• Music Therapist
• Nurse
• Operating Department
Practitioner
• Occupational therapist
• Orthoptist
• Orthotist and
Prosthetist
• Paramedic
• Podiatrist
• Pharmacist
• Pharmacy technician
• Physiotherapist
• Radiographer
• Speech and language
therapist
• Art therapist
• Clinical Psychologist
• Dental hygienist
• Dental nurse
• Dental therapist
• Dietician
• Drama therapist
• Healthcare Scientist
• Health Visitor
23. HEE/NIHR Integrated Clinical
Academic Programme
Applicants must belong to one of the eligible healthcare
professions and hold registration with the listed
professional body/council
Special dispensation to apply may be granted by the
funder if prospective applicants:
•Belong to a statutorily registered profession,
•are a graduate (or have equivalent experience),
•Provide NHS services in England
24. HEE Mandate
• Research funded by Health Education England (HEE) must fulfil one
of the priorities in its mandate from Government:
– Ensuring the best start in life for every child and young person (from
pregnancy through to adulthood)
– Delivering integrated care that meets the needs of people and their
families
– Improving the understanding of mental health conditions by all staff and
how this may effect their patients
– Improving public health
– Driving quality improvement, including medical treatments, interventions
or processes
• Alternatively, the content of the research could address the core
purpose of HEE:
– Delivering the right workforce with the right skills, values and
competencies
– Driving improvements in education & training that will have a real impact
on the quality of care delivered to patients and service users
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/310170/DH_HEE_Mandate.pdf
25. HEE/NIHR Integrated Clinical
Academic Programme
Internships
“A pre-masters clinical research taster”
An introduction to clinical academic research from trial design, data
management through to undertaking practical research in a clinical
environment.
Eligibility
• Belong to one of the ICA Eligible Professions
• No research qualification
More information
Administered and managed by HEE LETBs.
Queries and more information:
https://hee.nhs.uk/work-programmes/clinical-academic-careers/internships/
26. HEE/NIHR Integrated Clinical
Academic Programme
NIHR/HEE Masters in Clinical Research
“An Introduction to Clinical Research Theory and Practice”
Studentships cover:
•salary cost of the award holder
•course fees
Studentships can be undertaken full time over one year,
or part time over two years.
27. • Funded HEIs advertise
places (institutional
award)
• Places currently out for
retender
• Anticipated 100 places
per annum available over
next 3 years
Current HEIs running CAT Masters:
HEE/NIHR Integrated Clinical
Academic Programme
NIHR/HEE Masters in Clinical Research
28. HEE/NIHR Integrated Clinical
Academic Programme
“Obtain a PhD by research whilst still developing clinical skills”
Applicants:
•Graduates with some research experience.
•Based at an English Higher Education Institute (HEI), an NHS body or any
other organisation which provides health or social care services in England
and is in receipt of public funding.
•At least one year’s experience of professional, post graduation, clinical
practice at the point of application.
•Good academic and clinical supervisor
HEE/NIHR Clinical Doctoral Research Fellowship
29. HEE/NIHR Integrated Clinical
Academic Programme
HEE/NIHR Clinical Doctoral Research Fellowship
• Salary
• PhD tuition fees
• Research costs
• Training & development costs
(100% NHS, 80% HEI except training & development @100%)
• 3 years FT (4 or 5 years PT)
30. HEE/NIHR Integrated Clinical
Academic Programme
Applicants:
•Have obtained a PhD or have submitted their PhD at the time of application.
• 5 years WTE post-doctoral research experience˂
•Min 1 year experience of professional, post graduation, clinical practice at the
point of application
• Supported by a partnership of a HEI and an NHS trust, which must both
commit to support the applicant post award.
HEE/NIHR Clinical Lectureship
“Combine post-doctoral research in an academic position with
continued clinical practice”
31. HEE/NIHR Integrated Clinical
Academic Programme
• Clinical practice and academic research (50:50)
• 3 years full time (4 or 5 years part time)
• Up to 50% of salary plus research and training and development
costs
HEE/NIHR Clinical Lectureship
“Combine post-doctoral research in an academic position with
continued clinical practice”
32. HEE/NIHR Integrated Clinical
Academic Programme
Applicants:
•>5 years clinical experience and high research output
•Excellent or exceptionally promising track record as clinical academic
researcher (outputs & grants)
Award Structure:
•Senior (pre-Chair) 5 year award for clinical practice and academic
research (50:50)
•Requires support from a partnership of a HEI and an NHS trust, which
must both commit to support the applicant post award
•Up to 50% of salary plus research and training and development costs
HEE/NIHR Senior Clinical Lectureship
“Combine research and research leadership in a senior academic position with continued clinical practice”
33. HEE/NIHR Integrated Clinical
Academic Programme
ICA Personal Research Training Awards:
Clinical Doctoral Research Fellowships
Clinical Lectureships
Senior Clinical Lectureships
Competitions are now open:
Launched 4th
March 2015
Closes: 28th
May 2015
To apply : tcci.nihr.ac.uk
35. HEE/NIHR Integrated Clinical
Academic Programme
Mentorship and Outreach Programme
Open to doctoral and post-doctoral award holders of the new
ICA programme
Experience “one-to-one” academic mentorship to support the
development of an independent research career.
37. NIHR Personal Research
Training Awards
Benefits of an NIHR Personal Research Training Award
•Time out
•Training and development
(including overseas research visit)
•NIHR Faculty
•NIHR Trainees Meeting
38.
39. Assessment Criteria
Person
•Trajectory
•Career outputs
Project or programme of research
•Scientific quality
•Appropriate scale and scope
•Relevance of the Question
•Literature Review
•Impact of Findings
•Methods are Sound
•Fit with Remit and HEE mandate where relevant
40. Assessment Criteria
Training
– Meets needs of candidate and project
Host environment (institution, supervisor, mentor)
– RAE/REF rating
– Track record in relevant field
– Time and commitment
41. The Application
Preparation
•Consider all options
•Read the guidance
•Develop the proposal well ahead of submission
•Discuss the proposal with supporting departments as early
as possible.
42. The Application
Take Advice from:
–Supervisor
–Collaborators
–Mentor
–Methodologist (s)
–Finance Lead
–Previous applicants / award holders
45. The Interview
Practice
–Mock interviews are usually the worst
–Know your audience
Presentation
•Not too many slides
•Don’t go over time
Behaviour
•It is OK to be nervous
•Confident but not over confident
•Don’t get defensive
•Admit what you don’t know and be happy to take advice
•Relax and be yourself
46. The Interview
The project
–Know it inside and out
–Has anything altered since submission?
–Know the methods and identify the expertise
–Think through alternatives
Training and Development
•Identify your training needs
•How will the training support your project and future career
intentions
The future you
•Be clear where you want to be
•What is does this fellowship mean to your career
47. “We will….”
The project lacks theoretical grounding
The stated career aspirations are not supported by the programme
The training and development plan is generic and not tailored to needs
The required sample sizes are unjustified and/or too ambitious
Alternative approaches and analytical techniques have not been
considered
The supervisors have never supervised to completion before
(Doctorate)
Key individuals have not been approached for advice/mentorship
Common Mistakes /
Weaknesses in Applications