This document summarizes a presentation about the Patient Centered Outcomes Research Institute (PCORI) and its methods. It discusses how PCORI funds research to help patients make informed healthcare decisions by producing high-quality evidence. Key points include that PCORI research must be patient-centered, compare at least two alternatives, and use outcomes that matter to patients. It also outlines PCORI's research portfolio, methodology standards, and application review process.
Weitzman 2013 Relative patient benefits of a hospital-PCMH collaboration with...CHC Connecticut
Anuj K Dalal presents information on a PCORI research grant: Relative patient benefits of a hospital-PCMH collaboration within an ACO to improve care transitions.
Weitzman 2013 Relative patient benefits of a hospital-PCMH collaboration with...CHC Connecticut
Anuj K Dalal presents information on a PCORI research grant: Relative patient benefits of a hospital-PCMH collaboration within an ACO to improve care transitions.
Slide presentation for the June 4, 2014 joint PCORI/ National Institute on Aging (NIA) of the National Institutes of Health webinar. This webinar announced the selection of the research team that will carry out a major, five-year, $30 million patient-centered study of the effectiveness of individually tailored care plans to help older individuals avoid falls and related injuries.
Policy and Funding for CER: Making Sense of a Confusing Landscape CTSI at UCSF
UCSF researcher, Michael Steinman, MD, Director of CTSI's Comparative Effectiveness Research initiative presents. View more related presentations and resources at http://accelerate.ucsf.edu/research/cer
Un diaporama très très inspiré de Philippe Chavanne (sur le site histoire-géo de l'académie de Lyon) http://www2.ac-lyon.fr/enseigne/histoire/spip.php?article870
Slide presentation for the June 4, 2014 joint PCORI/ National Institute on Aging (NIA) of the National Institutes of Health webinar. This webinar announced the selection of the research team that will carry out a major, five-year, $30 million patient-centered study of the effectiveness of individually tailored care plans to help older individuals avoid falls and related injuries.
Policy and Funding for CER: Making Sense of a Confusing Landscape CTSI at UCSF
UCSF researcher, Michael Steinman, MD, Director of CTSI's Comparative Effectiveness Research initiative presents. View more related presentations and resources at http://accelerate.ucsf.edu/research/cer
Un diaporama très très inspiré de Philippe Chavanne (sur le site histoire-géo de l'académie de Lyon) http://www2.ac-lyon.fr/enseigne/histoire/spip.php?article870
Ce cours est composé à partir du cours de Philippe Chavanne http://www2.ac-lyon.fr/enseigne/histoire/spip.php?article870 et à destination de mes élèves de terminale
Romana Hasnain-Wynia: Incorporating the Patient’s Perspective in ResearchNIHACS2015
Romana Hasnain-Wynia, MS, PhD, is the Director of the Addressing Disparities Program at the Patient-Centered Outcomes Research Institute (PCORI). During the conference, she gave a presentation on incorporating the patient’s perspective in research.
Sills MR. Overview of the SAFTINet Program. Presented to the Emergency Department Research Committee, Department of Pediatrics, University of Colorado School of Medicine. 6 January 2015.
Stakeholder Engagement in a Patient-Reported Outcomes Implementation by a Pra...Marion Sills
Kwan BM, Sills MR, Graham D, Hamer MK, Fairclough DL, Hammermeister KE, Kaiser A, Diaz-Perez MJ, Schilling LM. Stakeholder Engagement in a Patient-Reported Outcomes Implementation by a Practice-Based Research Network. JABFM. In Press.
Module 5 (week 9) - InterventionAs you continue to work on your .docxroushhsiu
Module 5 (week 9) - Intervention
As you continue to work on your assignment, you will be pulling in some information from your work throughout this course. For one part of this presentation, you will be identifying the current problem (or opportunity for change). This was part of your discussion in the week 2 assignment PowerPoint.
You will also propose an evidence-based intervention to address this particular problem. This intervention should be derived from the literature you have found and presented in your critical appraisal template.
As you have seen, these assignments have provided you the ability to identify a problem, develop a PCIOT question, search for evidence related to this PICOT, critically appraise the evidence for a solution to the problem, and now you will identify the solution and disseminate the results.
You are well on your way to becoming evidence-based practitioners!
Week 9!
Nice work on last week’s discussion. As you have discovered, decision aids can be very helpful when providing information for patients and families.
This week, you will continue to work on your assignment for this module. This will be an 8-9 slide PowerPoint presentation in which you will recommend an evidence-based practice change. Review the 4 articles you critiqued to determine what practice change is supported by the literature.
Some of the content for this assignment will be taken from your previous work and some will be new. This PowerPoint is a total of 8-9 slides.
Please review the full assignment details located under the learning resources for module 5.
Please let me know if you have questions
David
Provider perspectives on the utility of a colorectal
cancer screening decision aid for facilitating shared
decision making
Paul C. Schroy III MD MPH,* Shamini Mylvaganam MPH� and Peter Davidson MD�
*Director of Clinical Research, Section of Gastroenterology, Boston Medical Center, Boston, MA, �Study Coordinator, Section of
Gastroenterology, Boston Medical Center, Boston, MA and �Clinical Director, Section of General Internal Medicine, Boston
Medical Center, Boston, MA, USA
Correspondence
Paul C. Schroy III, MD MPH
Boston Medical Center
85 E. Concord Street
Suite 7715
Boston
MA 02118
USA
E-mail: [email protected]
Accepted for publication
8 August 2011
Keywords: decision aids, informed
decision making, shared decision
making
Abstract
Background Decision aids for colorectal cancer (CRC) screening
have been shown to enable patients to identify a preferred screening
option, but the extent to which such tools facilitate shared decision
making (SDM) from the perspective of the provider is less well
established.
Objective Our goal was to elicit provider feedback regarding the
impact of a CRC screening decision aid on SDM in the primary care
setting.
Methods Cross-sectional survey.
Participants Primary care providers participating in a clinical trial
evaluating the impact of a novel CRC screening d ...
Overview of the Patient-Centered Outcomes Research Institute (PCORI), how PCORI views Patient-Centered Outcomes Research and how this is related to PCORI’s major funding mechanisms.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. Healthcare Decisions and Methods
that Matter:
The Link to Patient
Centered Outcomes Research
Methodological Standards
Robin Newhouse, PhD, RN, NEA-BC, FAAN
University of Arkansas for Medical Sciences
Translational Research Institute
April 7, 2014
2. Key Points
PCOR methods matter…they
1. affect design, methods
and outcomes.
2. produces evidence for practice
that can be used to make
decisions by patients, providers,
caregivers and policy makers.
3. use outcomes that people care
about.
2
4. The Patient Centered Outcomes
Research Institute
Robin Newhouse is Chair of the Methodology Committee of the Patient
Centered Outcomes Research Institute (PCORI).The views expressed in
this presentation are those of the authors and not necessarily those of
PCORI.
5. 5
• Research has not
answered many
questions patients face.
• People want to know
which treatment is right
for them.
• Patients need information
they can understand and
use.
Why PCORI?
6. “The purpose of the Institute is to assist
patients, clinicians, purchasers, and policy-
makers in making informed health
decisions by advancing the quality and
relevance of evidence concerning the manner
in which diseases, disorders, and other health
conditions can effectively and appropriately
be prevented, diagnosed, treated,
monitored, and managed through research
and evidence synthesis...and the
dissemination of research findings with
respect to the relative health outcomes, clinical
effectiveness, and appropriateness of the
medical treatments, services...”
PCORI Has a Broad and Complex Mandate
-- from Patient Protection and Affordable
Care Act
4
7. PCORI Is Accountable for Changing Practice
-- from Patient Protection and Affordable
Care Act
“(g) FINANCIAL AND GOVERNMENTAL
OVERSIGHT. …
(2) REVIEW AND ANNUAL REPORTS.
…
(iv) Not less frequently than every 5
years … the overall effectiveness of
activities conducted under this section …
such review shall include an analysis of the
extent to which research findings are
used by health care decision-makers,
the effect of the dissemination of such
findings on reducing practice variation
and disparities in health care…”
5
8. Mission
PCORI helps people make informed health care decisions, and improves health
care delivery and outcomes, by producing and promoting high integrity, evidence-
based information that comes from research guided by patients, caregivers and
the broader health care community.
6
9. Strategic Goals
Influence Research Funded by Others
Speed the Implementation and
Use of Evidence
Increase Quantity, Quality and
Timeliness of Research Information
7
11. National Priorities for Research
Assessment of Prevention,
Diagnosis, and Treatment
Options
Improving Healthcare
Systems
Communication &
Dissemination Research
Addressing Disparities
Accelerating PCOR and
Methodological Research
9
14. Key Features of PCORI Research
Our work answers patient’s questions.
“Given my personal characteristics, conditions and
preferences…
…what should I
expect will
happen to me?”
…what are my
options and
what are the
potential
benefits and
harms of those
options?”
.. what can I do
to improve the
outcomes that
are most
important to
me?”
…how can
clinicians and the
care delivery
systems they work
in help me make
the best decisions
about my health
and healthcare?”
11
15. Key Features of PCORI Research
Study the benefits and harms of
interventions and strategies
delivered in real-world settings
Compare at least two alternative
approaches
Research Should:
Special Topics of Interest:
Be based on health outcomes that
are meaningful to the patient
population
Be likely to improve current clinical
practices
Conditions that heavily burden
patients, families and/or the health
care system.
Chronic or multiple chronic
conditions
Rare and understudied conditions
Conditions for which outcomes
vary across subpopulations
12
16. 13
Formulating Research Questions
Patient-Centeredness
Data Integrity and Rigorous
Analyses
Preventing/Handling Missing Data
Heterogeneity of Treatment
Effects
Key Features of PCORI Research
Research should adhere to PCORI’s Methodology
Standards.
Data Networks
Data Registries
Adaptive and Bayesian Trial
Designs
Causal Inference
Studies of Diagnostic Tests
Systematic Reviews
Methodology Standards: 11 Broad Categories
17. Patient Engagement vs. Patient-Centeredness
Patient engagement is about having patients as partners in
research as opposed to merely subjects
Active engagement between scientists, patients, and
stakeholders
Community, patient, and caregiver involvement already in
existence or a well-thought out plan
Patient- Centeredness is a component of what PCOR is looking
for in research applications
Does the project aim to answer questions or examine outcomes
that matter to patients within the context of patient
preferences?
Research questions and outcomes should reflect what is
important to patients and caregivers
17
18. Engage Patients and Stakeholders
in the Research Process
Patients and Caregivers
Patient Organizations
Practice-Based Research Networks
Medical Groups
Health Plans
Integrated Delivery Systems
Disease Registries
Centers for Medicaid and Medicare
Services
State and Local Health Agencies
18
20. Examples of Promising Practices from First
150 Awards
Patients participate in:
Determining what needs
to be researched
The creation of the intervention to
be studied
Defining outcomes important to
patients
Leading the project as Co-PI,
consultant or advisory committee
member
Determining methods and
processes of research study
Recruiting and retaining
participants
Collecting data and, co creating
privacy and confidentiality policies
Creation of patient friendly
informed consent forms
Evaluating the patient engagement
throughout the life of the project
Disseminating research results to
advocacy organizations and
research participant community
20
21. Methodology Committee of the Patient Centered Outcomes Research Institute. (2013). Hickam, D., Totten, T., Berg, A., Rader, K.,
Goodman, S., Newhouse, R. (Eds). Section II, Prioritizing Research Questions and Development of the Translation Table, pages
11-20.
http://www.pcori.org/assets/2013/11/PCORI-Board-Meeting-Methodology-Report-for-Acceptance-1118131.pdf
PCORI Translation Table
23. Funded Projects to Date
Total number of research
projects awarded : 279
Total funds awarded:
$464.2 million
Number of states where we
are funding research:
38 states (plus the District of Columbia
and Quebec, Canada)
15
25. Assessment of Prevention, Diagnosis, and
Treatment Options
Seeks to fund investigator-
initiated research that:
• Compares the effectiveness of
two or more options that are
known to be effective but have not
been adequately compared in
previous studies.
• Among compared population
groups, investigates factors that
account for variation in treatment
outcomes that may influence
those outcomes in the context of
comparing at least two treatment
approaches.
Portfolio Snapshot
By primary health topic
• 65 Projects
• $117 Million Awarded
18
26. Selection of Peritoneal Dialysis or Hemodialysis for Kidney Failure:
Gaining Meaningful Information for Patients and Caregivers
Francesca Tentori, MD, MS,
Arbor Research Collaborative for Health
Engagement
• Interviews over 130 patients with
kidney disease to determine how to
address personal preferences in
choosing type of dialysis:
hemodialysis or peritoneal dialysis.
Potential Impact
• Over 100,000 patients start dialysis
in the United States each year.
• This research could provide
practical information regarding the
consequences (outcomes) of each
choice for patients with kidney
disease and their families.
Methods
• Research is completed through
qualitative methods.
Aims to identify factors that
matter to most to patients with
kidney disease and study how they are
impacted by different types of dialysis,
focusing on hemodialysis and
peritoneal dialysis. Today, patients
often choose a dialysis type without
fully understanding how it will impact
their lives
Assessment of Prevention, Diagnosis and Treatment Options,
awarded December 2012
19
27. Improving Healthcare Systems
Seeks to fund investigator-initiated
research on effects of system
changes on :
• Patients’ access to high quality,
support for self-care, and
coordination across healthcare
settings.
• Decision making based on patients’
values.
• Experiences that are important to
patients and their caregivers, such
as overall health, functional ability,
quality of life, stress, and survival.
• The efficiency of healthcare delivery,
as measured by the amount of
ineffective, duplicative, or wasteful
care provided to patients.
Portfolio Snapshot
By primary health topic
• 41 Projects
• $76.5 Million Awarded
20
28. Evaluating the Impact of Patient-Centered
Oncology Care
Sarah Scholle, MPH, DPH
National Committee for Quality Assurance
Engagement
• A broad multi-stakeholder advisory
group will help define the Patient-
Centered Oncology Care model.
Potential Impact
• Could change practice by
addressing current gaps in cancer
care and providing patients and
clinicians with important
information about what kind of
care is possible.
Methods
• Research is completed through
qualitative and quantitative
analysis.
Tests and evaluates using the
patient-centered medical home
(PCMH) model of care for treating
oncology patients. The goal is to
examine whether the model improves
patient experiences and quality of
care, reduces events such as ED visits
and hospital stays, and whether its
adoption varies across practices.
Improving Healthcare Systems,
awarded May 2013
21
29. Communication and Dissemination
Research
Portfolio Snapshot
• 25 Projects
• $43.2 Million Awarded
Seeks to fund investigator-
initiated research in:
• Clinician engagement with CER.
• Translating research, decision
support interventions, and risk
communication.
• For this funding
announcement, studies of
decision support aids are not
encouraged.
• Distribution of CER to patients,
caregivers, and providers.
By population; some projects address
multiple populations.
22
30. Patient-Identified Personal Strengths (PIPS) vs. Deficit-Focused
Models of Care
Kurt Stange, MD, PhD,
Case Western Reserve University
Engagement
• Engages patients, caregivers, and
primary care clinicians in identifying
mechanisms by which leveraging
focusing on patient-identified
strengths might affect processes
and patient-centered outcomes of
care.
Potential Impact
• Could change practice by
demonstrating a method for
motivating positive change and
engaging patients in ways that the
usual deficit-based model of
chronic care cannot.
Methods
• Uses a mixed methods approach.
Compares a model of chronic care
focused on patient-identified
personal strengths vs. deficit-focused
models of care to leverage strengths
that can help patients to live a fulfilling
life with multiple chronic illnesses.
Aims to build simulation models for
how focusing on patient-identified
strengths can change outcomes.
Communication and Dissemination,
awarded December 2012
23
31. Addressing Disparities
Portfolio Snapshot
• 31 Projects
• $53 Million Awarded
By primary health topic
Seeks to fund investigator-initiated
research that:
• Compares interventions to reduce
or eliminate disparities in patient-
centered outcomes.
• Identifies/compares promising
practices that address contextual
factors and their impact on
outcomes.
• Compares health care options
across different patient
populations.
• Compares and identifies best
practices within various patient
populations for information sharing
about outcomes and research.
24
32. Long-Term Outcomes of Community Engagement to
Address Depression Outcomes Disparities
Kenneth Brooks Wells, MD, MPH
University of California, Los Angeles
Engagement
• Community agencies collaborate to
tailor depression toolkits to needs
and strengths of community.
Potential Impact
• Could change practice by providing
information about how depressed
patients prioritize outcomes and
make decisions. Also, could impact
practice by showing how clinicians
respond to patients’ preferences.
Methods
• Research is completed both a
mixed methods approach and a
randomized controlled trial.
Project looks at whether a
community engagement
intervention or technical assistance
model will improve clients’ mental
health and physical functioning and
reduced risk factors for homelessness.
It will also identify patient preferences
and priorities and assess community
capacity to respond to these priorities.
Addressing Disparities Research Project,
awarded December 2012
25
33. Portfolio Snapshot
• 30 Projects
• $28.1 Million Awarded
Seeks to fund investigator-initiated
research that:
Improving Methods for Conducting Patient-
Centered Outcomes Research
• Addresses gaps in
methodological research relevant
to conducting patient-centered
outcomes research (PCOR).
Results of these projects will
inform future iterations of
PCORI’s Methodology Report.
• Focuses on Patient-Reported
Outcome Measurement
Information System (PROMIS)-
related research.
26
34. The National Patient-Centered Clinical
Research Network (PCORnet)
System-based networks, such as
hospital systems
Patient-Powered Research Networks
Coordinating Center
Provides technical and logistical
assistance under the direction of the
Steering Committee and PCORI Staff.
35
• 11 Networks
• $76.8 Million Awarded
• 18 Networks
• $16.8 Million Awarded
Patients with a single condition
form a research network
Clinical Data Research Networks
35. Pragmatic Clinical Studies and Large
Simple Trials
Opportunity Snapshot
Number of Anticipated
Awards: Six to Nine
Funds Available: $90 Million
Maximum Project Duration:
5 Years
Maximum Direct Costs Per
Project: $10 Million
Seeks to fund investigator-initiated
research that compares two or
more alternatives for:
• Addressing prevention, diagnosis,
treatment, or management of a disease
or symptom
• Improving health care system–level
approaches to managing care; or
• Eliminating health or healthcare
disparities.
• Research topics of particular
interest identified by stakeholders,
or questions included in IOM’s Top
100 Topics for CER or AHRQ’s
Future Research Needs.
36
36. Eugene Washington PCORI
Engagement Awards
Smaller awards, up to $250,000 total, to provide “wrap-around”
support and enhance impact of PCORI’s scientific research.
Objectives
Engage new groups who have not previously been involved with PCORI
Develop new mechanisms for disseminating research findings
Promote research done differently by supporting the engagement and
partnering
Three Types of Awards
Knowledge: Support knowledge of PCORI’s work, and inform about our
program efforts
Training and Development: Training and development of “non-usual
suspects” and non-traditional researchers
Dissemination and Implementation: Disseminate the results of our
research to promote implementation into practice
37
38. How to Submit an Application
Visit pcori.org/apply
Key Dates
Funding Announcements
Application Guidelines and Templates
Guidance on the PCORI
Methodology Standards
Sample Engagement Plans
Frequently Asked Questions
40
39. PCORI’s Merit Review Process
39
1. Impact of the condition on the
health of individuals and
populations
2. Potential for the study to
improve healthcare and
outcomes
3. Technical merit
4. Patient-centeredness
5. Patient and stakeholder
engagement
Applications are reviewed
against five criteria:
Applications are reviewed
by a committee of two
scientists, one patient,
and one other stakeholder
PCORI’s Board of
Governors makes funding
decisions based on merit
review and staff
recommendations
41
40. Have a Question?
General Inquiries
info@pcori.org | (202) 827-7200
Research/Programmatic Questions
sciencequestions@pcori.org | (202) 627-1884
Administrative/Financial/Technical Questions
pfa@pcori.org
43
41. Connect with PCORI
Bryan Luce, PhD, MBA
Chief Science Officer
bluce@pcori.org
Regina L. Yan, MA
Chief Operating Officer
ryan@pcori.org
Joe V. Selby, MD, MPH
Executive Director
jselby@pcori.org
44
44. Straus, S.E., Tetroe, J. & Grahm, I.D. (2009). Knowledge to action: What it is and what it isn’t. In
Knowledge Translation in Health Care: Moving from Evidence to Practice. Hoboken,
N.J.:Wiley-Blackwell, pp. 3-9.
Johantgen, M., Newhouse, R. P. (2013). Participating in a Multi-Hospital Study to Promote Adoption
of Heart Failure Guidelines: Lessons Learned for Nurse Leaders. Journal of Nursing
Administration, 43(12), 660-666.
44
45. 2 hospitals
HF patients (N=40, 20 each hospital)
Nurses who care for HF patients on study units
This study is funded by AHRQ as a subproject (Newhouse, PI) in PATient-centered
Involvement in Evaluating the effectiveNess of TreatmentS (PATIENTS)
Program.
( PATIENTS PI, Mullins, 1R24 HS22135-01)
45
46. 46
Expanding PCOR through Advancements in
Implementation & Dissemination Science
• Develop infrastructure for dissemination and implementation
of research products and findings to patients, patient
advocates, clinicians, and healthcare systems
• Build sustainable digital infrastructure for data mining, data set
integration, and virtual collaborations for training and research
• Provide mentorship for faculty research development
• Offer tools and methods for implementation and dissemination
PATient-centered Involvement in Evaluating the effectiveNess of TreatmentS
(PATIENTS) Program. AHRQ (PI, Mullins).
(1R24 HS22135-01)
47. 47
PCOR is a Win for Everyone
PATIENT RESEARCHER
Informed decision making
Meaningful
research
Not a “one-
size-fits-all”
result
Interaction
Continuous
Topics and research
questions
Translate/disseminate
results
Comparators and
outcomes
48. Implementation Science:
Best Practices
48
• Mixed methods
• Engagement of target audience and stakeholders
• Conceptual models and implementation frameworks (RE-AIM)
• Tailoring interventions to context
• Fidelity
• Measurement (context and outcomes)
• Evidence-based interventions
Required to build the science:
1) Core set of implementation concepts and metrics
2) Standards for implementation methods
3) Reporting standards for implementation studies
Newhouse, R.P., Bobay, K, Dykes, P.C., Stevens, K.R., Titler, M. (2013).
Methodology Issues in Implementation Science. Medical Care, 51,S32-S40.
doi: 101097/MLR.0b013e31827feeca
50. Committed to advance research to
improve health care…………
Robin Newhouse, PhD, RN, NEA-BC, FAAN
newhouse@son.umaryland.edu
Editor's Notes
Robin, to insert a video link to this slide:First, save video clip to your desktop or a folder on your computer. Next, there are three options to link to and run a video from a PPT. Note that video will only run in Slideshow mode.In PPT:A) Select “Insert” and then “Video” and then select file. Test video in Slideshow.B) Select picture of Harlan, select “Insert” and then “Action”, and then select “Hyperlink to” and link to file (this will allow you to click picture to start the video. Test video in Slideshow.or C)To run video off YouTube, copy and paste “Start Video” link to slide. Test video in Slideshow: Start Videohttps://www.youtube.com/watch?v=mOZ8W71weVI
For more background on the research PCORI supports, see: www.pcori.org/research-we-support
There are 47 standards grouped into 11 broad categories
Really stressed the global principles and put them as a category in the rubric
What the methodology committee established as standards recently have been confirmed and strengthened by the PEAP in helping identify and define parameters of “Meaningful Engagement in researchAs PCORI has been evolving in patient centeredness and seeking more input on WHAT is meaningful engagement in ResearchWorkshop last year with 150 participants to establish best practices in patient centered researchPILOT PROJECT – data coming out right now is also confirming as we sit back we realize how there is a nice triangulation of what “meaningful engagement in the conduct of research” looks like
Total number includes PFAs + Pilot Projects
Addressing Disparities
Addressing Disparities
Addressing Disparities
Addressing Disparities
Building a “network of networks” to conduct large-scale, efficient CER.
For details on PCORI’s funding opportunities, see: www.pcori.org/funding-opportunities
Purpose is really two fold. To respond to the needs identified by workshop participants as well as to address PCORI’s need to accelerate funding of quality proposals and to “produce” Define community Define non research partner to include patients, caregivers, advocacy organizations, community members, clinicians and other stakeholders who will use the information generated by PCORI