Dr. Alex Morrow - Global Coordination of Animal Disease Research
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Global Coordination of Animal Disease Research - Dr. Alex Morrow, STAR‐IDAZ, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA. More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
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Dr. Alex Morrow - Global Coordination of Animal Disease Research
- 1. Global Coordination of Animal Disease Research PRRSV/CRWAD - Chicago Alex Morrow
- 2. Focus of Presentation Background to STAR-IDAZ IRC STAR-IDAZ International Research Consortium Objectives Governance structure Secretariat PRRSV CRWAD – PRRSV – Dec ‘16
- 3. Animal Health Challenges •Existing disease challenges/endemic diseases •Re-emerging diseases •Drug resistance •Threats from Epizootic Diseases •Extension of range of vector-borne diseases •New strains of organisms •“New” disease challenges We can’t all do everything CRWAD – PRRSV – Dec ‘16
- 4. Infectious disease emergence events CRWAD – PRRSV – Dec ‘16 West Nile, 1999 PPRV, 2007; PED, 2010 Nipah, 1998 ASFV, 2007 BTV, 1998 BTV-8, 2006 SBV, 2011 SARS, 2002 Hendra, 1994 MERS, 2012
- 5. CRWAD – PRRSV – Dec ‘16 International Research CoordinationSTAR-IDAZ (Global Strategic Alliances for the Coordination of Research on the Major Infectious Diseases of Animals and Zoonoses) A global initiative to address the coordination of research programmes at international level in the area of animal health and in particular infectious animal diseases including zoonoses.
- 6. STAR-IDAZ Outputs/Achievements • A database of research publications • A research programmes database (including capacity and activities) • Research needs at global, regional and industry sector levels established • Agendas on target priority diseases and issues developed • Instruments to enable cooperation, clustering and partnerships identified • Development of a long-term Strategic Research Agenda • An extensive network of research programme managers developed CRWAD – PRRSV – Dec ‘16
- 7. International Research Consortium(IRC) Higher level of commitment for coordinated research activities through the STAR-IDAZ International Research Consortium for Animal Health (IRC) •Agree minimum level of investment in research on priorities over a five year period (threshold $US 10 million; group funding commitment possible) •Agree delivery targets •Agree to coordinate/align funding to deliver these targets (members' own funding procedures, unless agreed otherwise; governance document & policy guidelines) •Agree to share research results (as much as necessary, without jeopardising IPR) •20 partners from 13 countries plus one international organisation and three from industry have signed Letter of Intent to participate •Total combined research budget of $US 2.5+ billion CRWAD – PRRSV – Dec ‘16
- 8. IRC Partners (to date) DTU/Denmark INRA/France ANSES/ France MoH/Italy Ministry of Economic Affairs /The Netherlands INIA/Spain Defra/UK BBSRC/UK Regional Consortium Belgium (Universiteit Ghent; Universite di Liege; Federal Public Service, Health Food Chain Safety and the Environment; CODA-CERVA) Kimron Veterinary Institute/Israel CRWAD – PRRSV – Dec ‘16
- 9. IRC Partners (to date) – continued ILRI Tanzania Veterinary Laboratory Agency NIAH/Japan USDA-ARS/US INTA/Argentina MINCYT/Argentina CFIA/Canada Zoetis HealthforAnimals EMVD CRWAD – PRRSV – Dec ‘16
- 10. G20 Ministry of Agriculture Chief Scientists (MACS) - Beijing, May 2016 We welcome the establishment of the STAR- IDAZ International Research Consortium on animal diseases and high priority vaccines. CRWAD – PRRSV – Dec ‘16
- 11. To coordinate research at international level to contribute to new and improved animal health strategies for at least 30 priority diseases/infections/issues The deliverables include: • Candidate vaccines • Diagnostics • Therapeutics • Other animal health products and procedures • Key scientific information/tools to support risk analysis and disease control Objective of STAR-IDAZ IRC CRWAD – PRRSV – Dec ‘16
- 12. IRC Governance Structure CRWAD – PRRSV – Dec ‘16 IRC Executive Committee (Representatives of Funders) IRC Executive Committee (Representatives of Funders) Secretariat Scientific Committee Coronaviruses Emerging Issues One HealthFMD Diagnostics ASF Influenza Innovative anti-infective approaches Vector-borne diseases Brucellosis Bovine Tuberculosis Working Groups Immunology/ Vaccinology Mastitis Animal genetics/ genomics Foresight Epidemiology Helminths Porcine Respiratory Disease Complex PRRSV ???? STAR-IDAZSTAR-IDAZ
- 13. Scientific Committee Don Knowles Dieter Schillinger Gary Entrican Martin Beer Edwin Claerebout Wim van der Poel Denis Kolbasov Stéphan Zientara CRWAD – PRRSV – Dec ‘16 Bruno Goddeeris Clara María Marín Alcalá Gustavo Zielinski Glen Gifford Jeremy Salt Anette Bøtner Irit Davidson Sergio Rosati
- 14. SIRCAH “Secretariat for the International Research Consortium on Animal Health” A €3 million EC- funded initiative. Partners DEFRA BBSRC OIE CABI IFAH-EUROPE CRWAD – PRRSV – Dec ‘16
- 15. SIRCAH Activities • Establish working groups for priority diseases and crosscutting issues - assisting with the organisation of meetings, including helping to pull together the gap analysis and mapping funding activities against identified research needs. • Produce and publish gap analysis and roadmap reports from working groups. • Advise the Scientific Committee (SC) and ExC on how research programmes could be aligned and make funding recommendations based on the gap analysis, roadmap reports and current funding activities. • Help mobilise resources - bringing together funding bodies and helping to identify funding opportunities • Facilitating knowledge transfer to bring innovation to the market CRWAD – PRRSV – Dec ‘16
- 16. CRWAD – PRRSV – Dec ‘16
- 17. PRRSV Research Gaps CRWAD – PRRSV – Dec ‘16
- 18. CRWAD – PRRSV – Dec ‘16 Avenues in the PRRSV Research Roadmap… PRRSV attenuated vaccine Identify protective antigens Identify protective pathways Identify correlates of protection Role of immune effector cells Genetic modification to remove stealth mechanisms and virulence Identify stealth mechanisms Identify virulence mechanisms Gene expression under different in vivo environments Identify suitable vector PRRSV Vector vaccine
- 19. For further information visit www.star-idaz.net. To enquire about joining the IRC or the working groups please contact the STAR-IDAZ IRC Project Office: Alex Morrow or Luke Dalton Defra, Area 5B, Nobel House, 17 Smith Square, London SW1P 3JR Alex.Morrow@Defra.gsi.gov.uk, Luke.Dalton@Defra.gsi.gov.uk Contact us
Editor's Notes
- STAR-IDAZ was an EU funded project with the aim to accelerate coordinated development of animal disease control methods through the sharing of information, reduction of duplication and more efficient use of resources. Network of research funders and programme managers including industry partners (Zoetis, Merial and IFAH) and the OIE. Regional networks and disease networks were established in addition to the network at the global level. Researchers are involved at the disease network level.
- Network now operating under an MoU signed, as of 27/4/2016, by 28 funding organisations from 21 countries A four-year EU-funded global initiative to address the coordination of research programmes at international level STAR-IDAZ had 25 partners from 18 countries. Regional networks were established for a) the Americas, b) Asia and Australasia, and d) Africa and the Middle East complementing the existing European network – so total outreach = > 50 countries Network now operating under an MoU signed, as of 27/4/2016, by 28 funding organisations from 21 countries
- In addition to funding bodies and Programme Owners OIE will also be a member of the Executive Committee Secretariat – European Commission called for proposals to establish a secretariat in their 2016 Work Programme. Scientific Committee – approx. 15 independent experts covering a range of fields. Working groups – involving the leading researchers in the field including those from projects supported by the IRC partners.