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DNA:
Structure and Function
Our understanding of DNA
2
1869
• Discovery of DNA
• F. Miescher
1883
• Chemical basis of
inherited traits
• A. Weismann & K.
Nageli
late 1920s
• "Transformation
Principle"
• F. Griffith
1944
• DNA is the
Genetic Material
• Avery, MacCleod,
McCarty
1950
• DNA really is the
Genetic Material
• Hershey and
Chase
1950
• In DNA samples,
equal quantities
of Adenine and
Thymine while
Guanine equal to
Cytosine
• E. Chargaff
1952
• Photo 51
• R. Franklin
1953
• Double Helix!
• J. Watson & F.
Crick
A=T
C=G
*The only names and dates you have to remember are Franklin, Crick, and
Watson and the year 1953.
Figure 7.2
Frederick Griffith
3
4
Figure 7.3
5
Race to discover the structure of DNA
6
X-ray diffraction
Maurice Wilkins and Rosalind Franklin
7
Chargaff’s Rule
Erwin Chargaff
8
A=T
C=G
James Watson and Francis Crick
9
10
Photo 51
By R. Franklin
1953 The Eagle
Pub, Cambridge
Double Helix!
11
Nobel Prize 1962
12
Wilkins Crick Watson
Figure 7.5
• Two strands
• Nucleotides
A. Phosphate
B. Deoxyribose sugar
C. Nitrogenous base
1. Adenine
2. Guanine
3. Thymine
4. Cytosine
• Antiparallel orientation
• Complementary Bases
• Purines pair with pyrimidines
• A-T and G-C
13
DNA Structure
14
Cell
Nucleus
Chromosome
DNA wrapped
around histone
protein
DNA Gene
DNA Structure within a Chromosome
15
Compare and Contrast:
DNA and RNA
16
The Central Dogma of Gene Expression
17
Proposed by Francis Crick 1958
18
19
20
21

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DNA structure and function blank sp 2020