1) The document provides an overview of disorders of the eye and ear, including anatomy, common conditions like glaucoma and tinnitus, and types of hearing loss.
2) It describes the anatomy of the eye and ear in detail. For the eye, it outlines the three layers and optical components. For the ear, it outlines the external, middle, and inner ear.
3) It discusses two main types of glaucoma - open angle and closed angle glaucoma. It provides details on symptoms, risk factors, pathophysiology, and differences between the two types.
This document discusses the treatment of cough. It begins by classifying cough based on duration as acute (less than 3 weeks), subacute (3-8 weeks), or chronic (more than 3 weeks). For acute cough, the most common causes are viral infections, sinusitis, pertussis, COPD exacerbations, and allergies. Post-infectious cough can last 1-2 weeks. Chronic cough is often caused by postnasal drip, asthma, gastroesophageal reflux, or smoking-related chronic bronchitis. The document provides guidance on evaluating and treating cough based on duration and suspected etiology. Emphasis is placed on treating the underlying cause rather than just suppressing cough symptoms.
Bronchial asthma is a chronic inflammatory disorder of the airways characterized by recurrent episodes of wheezing, breathlessness, chest tightness and coughing due to bronchospasm and airway obstruction. The symptoms are usually triggered by allergens, exercise, cold air or other stimuli and are at least partially reversible with treatment. It is caused by an inflammatory response in the airways mediated by TH2 cells and mast cells leading to increased mucus secretion, smooth muscle hypertrophy and bronchospasm. Common types include atopic asthma triggered by environmental allergens and non-atopic asthma triggered by respiratory infections.
This document provides information on the treatment of bronchial asthma. It discusses the major classes of drugs used including bronchodilators like beta agonists, anticholinergics, and methylxanthines. It also covers corticosteroids, mast cell stabilizers, and leukotriene modulators. For each class the mechanism of action, administration route, indications, and potential adverse effects are outlined. Treatment of an acute asthma attack and contraindicated drugs are also summarized.
Emphysema is a type of chronic obstructive pulmonary disease. This presentation quickly throws light on its subtypes, etiology, pathophysiology, clinical manifestations, diagnostic procedures, treatment, and complications.
The document describes and classifies various skin lesions. It defines 26 different lesions including macules, papules, plaques, vesicles, bullae, pustules, cysts, nodules and wheals as primary skin lesions. Secondary skin lesions include scales, crusts, fissures, erosions, ulcers, lichenification and atrophy. Special skin lesions include telangiectasia, phlebectasia, burrows and comedones. Vasculopathies like petechiae, purpura and ecchymosis are also defined. Iris-like lesions are used to describe erythema multiforme. Each lesion is concisely defined and an example is provided.
The nose has several functions including smelling, breathing, filtering air, and draining secretions. It is divided into the external nose and nasal cavity. The nasal cavity contains convoluted bones and cartilages that warm and humidify air before it reaches the lungs. It is lined with mucosa and divided by the nasal septum into left and right sides. The nasal cavity is further divided by projections called conchae into passages and recesses where various sinuses open. Infections can spread from the nasal cavity to nearby areas like the sinuses, ears, or eyes.
This document discusses the treatment of cough. It begins by classifying cough based on duration as acute (less than 3 weeks), subacute (3-8 weeks), or chronic (more than 3 weeks). For acute cough, the most common causes are viral infections, sinusitis, pertussis, COPD exacerbations, and allergies. Post-infectious cough can last 1-2 weeks. Chronic cough is often caused by postnasal drip, asthma, gastroesophageal reflux, or smoking-related chronic bronchitis. The document provides guidance on evaluating and treating cough based on duration and suspected etiology. Emphasis is placed on treating the underlying cause rather than just suppressing cough symptoms.
Bronchial asthma is a chronic inflammatory disorder of the airways characterized by recurrent episodes of wheezing, breathlessness, chest tightness and coughing due to bronchospasm and airway obstruction. The symptoms are usually triggered by allergens, exercise, cold air or other stimuli and are at least partially reversible with treatment. It is caused by an inflammatory response in the airways mediated by TH2 cells and mast cells leading to increased mucus secretion, smooth muscle hypertrophy and bronchospasm. Common types include atopic asthma triggered by environmental allergens and non-atopic asthma triggered by respiratory infections.
This document provides information on the treatment of bronchial asthma. It discusses the major classes of drugs used including bronchodilators like beta agonists, anticholinergics, and methylxanthines. It also covers corticosteroids, mast cell stabilizers, and leukotriene modulators. For each class the mechanism of action, administration route, indications, and potential adverse effects are outlined. Treatment of an acute asthma attack and contraindicated drugs are also summarized.
Emphysema is a type of chronic obstructive pulmonary disease. This presentation quickly throws light on its subtypes, etiology, pathophysiology, clinical manifestations, diagnostic procedures, treatment, and complications.
The document describes and classifies various skin lesions. It defines 26 different lesions including macules, papules, plaques, vesicles, bullae, pustules, cysts, nodules and wheals as primary skin lesions. Secondary skin lesions include scales, crusts, fissures, erosions, ulcers, lichenification and atrophy. Special skin lesions include telangiectasia, phlebectasia, burrows and comedones. Vasculopathies like petechiae, purpura and ecchymosis are also defined. Iris-like lesions are used to describe erythema multiforme. Each lesion is concisely defined and an example is provided.
The nose has several functions including smelling, breathing, filtering air, and draining secretions. It is divided into the external nose and nasal cavity. The nasal cavity contains convoluted bones and cartilages that warm and humidify air before it reaches the lungs. It is lined with mucosa and divided by the nasal septum into left and right sides. The nasal cavity is further divided by projections called conchae into passages and recesses where various sinuses open. Infections can spread from the nasal cavity to nearby areas like the sinuses, ears, or eyes.
This document defines and describes different types of apnea, including central apnea which is due to cessation of brain stem motor stimuli, obstructive apnea which involves absence of airflow with chest wall motion, and mixed apnea which is the most common type. It lists various causes of apnea such as hypoxia, sepsis, metabolic disorders, CNS disorders, and issues like hypotension. The diagnosis of apnea requires investigating these potential underlying causes. Treatments mentioned include apnea monitors, stimulation, bag-mask ventilation, CPAP, theophylline, and caffeine citrate. Apnea of prematurity is also discussed as relating to immaturity of respiratory centers and chemoreceptors in premature babies.
This document discusses the pharmacotherapy of acute bronchitis. It begins by defining acute bronchitis as a cough lasting less than 3 weeks, which is usually viral in origin. The goals of therapy are to rule out serious illness, minimize symptoms, and limit unnecessary antibiotic use. Treatment is primarily supportive and includes analgesics, antitussives, and bronchodilators only for those with wheezing. Antibiotics are not routinely recommended as they do not impact illness duration or severity. Education of patients about the typical self-limiting course of acute bronchitis is important.
Asthma is a condition in which your airways narrow and swell and produce extra mucus. This can make breathing difficult and trigger coughing, wheezing and shortness of breath. For some people, asthma is a minor nuisance.
Bronchiectasis is a chronic lung condition defined by the permanent dilation of the bronchi. It has both congenital and acquired causes such as infections from tuberculosis, pneumonia, or cystic fibrosis. Symptoms include chronic cough, production of large amounts of purulent sputum, and recurrent lung infections. Diagnosis involves imaging like CT scans and pulmonary function tests. Treatment focuses on airway clearance techniques, antibiotics for infections, and surgery in severe cases. Nursing care aims to improve lung function and prevent infections through techniques like postural drainage and breathing exercises.
The document provides information on asthma, including its pathophysiology, epidemiology, risk factors, clinical manifestations, diagnosis, and treatment. Asthma is a chronic inflammatory disease of the airways characterized by airway hyperresponsiveness and reversible airflow obstruction. It commonly presents with wheezing, cough, chest tightness, and shortness of breath. Diagnosis involves assessing symptoms and lung function tests. Treatment focuses on reducing inflammation and managing acute exacerbations.
This document summarizes a presentation on acute and chronic bronchitis. It begins by defining acute bronchitis as inflammation of the large bronchi caused by bacterial or viral infection. It then compares acute and chronic bronchitis, noting their differences in pathogens, onset, duration, age groups affected, and clinical presentation. The document discusses the epidemiology and risk factors of acute bronchitis. It covers the infectious and non-infectious causes, pathophysiology, clinical presentation, diagnosis, treatment including pharmacological and non-pharmacological approaches, patient education, and prognosis. The presentation aims to provide an overview of acute and chronic bronchitis for healthcare professionals.
Cyanosis
Cyanosis refers to a bluish color of the skin and mucous membranes resulting from an increased quantity of reduced hemoglobin/deoxyhemoglobin or abnormal hemoglobin derivatives, in the small blood vessels of those areas.
This document provides information on asthma, including its definition, epidemiology, etiology, pathogenesis, classification, symptoms, exacerbations, and atypical forms. Asthma is defined as a chronic inflammatory disease of the airways associated with bronchial hyperresponsiveness and reversible obstruction. It commonly involves eosinophilic inflammation and affects over 300 million people worldwide. Triggers include allergens, infections, pollution, and emotions. Pathogenesis typically involves a type I hypersensitivity reaction. Classification systems consider severity, control, and clinical course. Symptoms include wheezing, coughing, chest tightness, and shortness of breath. Exacerbations can be life-threatening without treatment.
Simplification of Dermatology signs.pdfDrArulSelvan
Symptoms are subjective part from the patient whereas Signs are objective ones by the physician.
Here's to a collective set of Signs one can observe in a patient to rule out symptoms and helps interpret differential diagnosis.
Infectious dermatoses are skin lesions caused by infections that can be classified into five main types: impetigo, verrucae (warts), molluscum contagiosum, viral exanthematas, and superficial mycoses. Impetigo is a common superficial bacterial infection caused by Staphylococci and Streptococci that presents as vesicles and pustules that rupture leaving yellowish crusts. Warts are common viral skin lesions caused by human papillomavirus that appear as circumscribed, firm, elevated papules on the hands and fingers. Molluscum contagiosum presents as multiple, discrete, waxy papules on the face and trunk caused
This document summarizes several common bacterial and fungal skin infections. It describes the etiology, signs and symptoms, and management of conditions like impetigo, folliculitis, furuncles, carbuncles, hidradenitis suppurativa, acne, cellulitis, erysipelas, lymphadenitis, and gas gangrene. It also covers fungal infections caused by dermatophytes, including tinea capitis, corporis, unguium, and cruris. Effective treatment involves identifying the causative organism and using appropriate topical or systemic antifungal/antibacterial medications along with wound cleaning and drainage when necessary.
Bronchitis is an inflammation of the airways in the lungs called the bronchi. It can be acute (short-term) or chronic (long-lasting). Acute bronchitis is often caused by viruses and leads to coughing and excess mucus production. Chronic bronchitis is usually caused by cigarette smoking and long-term damage to the lungs. Symptoms include coughing, mucus production, wheezing, and shortness of breath. Preventive measures include avoiding tobacco smoke, getting flu shots, and reducing mucus-producing foods.
Within the document are discussions of chronic obstructive pulmonary disease (COPD) and pneumonia. It summarizes the pathogenesis of COPD as being caused by long-term smoke and irritant inhalation leading to airway and lung tissue damage, inflammation, and impaired lung function over time. Emphysema specifically involves destruction of alveoli walls, while chronic bronchitis involves inflammation of the airways. Complications discussed include respiratory infections, lung cancer, and cor pulmonale. Pneumonia is also briefly discussed through a clinical vignette of an alcoholic man presenting with fever, cough, and signs of consolidation on exam.
This document defines asthma and describes its types, symptoms, causes, risk factors, diagnosis, treatment and pathophysiology. Asthma is a chronic inflammatory lung disease characterized by airway hyperresponsiveness and reversible airflow obstruction. It is usually caused by allergic triggers like pollen or dust but can also be triggered by non-allergic factors like viruses or pollution. Diagnosis involves patient history, exams, lung function tests and allergy testing. Treatment includes bronchodilators, corticosteroids, leukotriene modifiers and immunotherapy. The pathophysiology involves type 2 inflammation, IgE production and eosinophil recruitment leading to bronchoconstriction.
This document discusses pruritus (itching) by defining it, listing common causes such as dry skin, skin conditions, systemic diseases, nerve disorders, allergic reactions, drugs, and psychological factors. It describes the pathophysiology of the itch-scratch cycle and classification of pruritus. Diagnosis involves history, physical exam, and potential lab tests. Management includes topical corticosteroids, oral antihistamines, antidepressants, treating underlying causes, phototherapy, and nursing interventions like moisturizing and distraction techniques. Complications can be skin injury, infection, and scarring if scratching is not prevented.
This document summarizes various tests and measurements used to investigate asthma, including:
- Spirometry tests such as FEV1 and PEFR to measure lung function and detect bronchodilation.
- Challenge tests that expose patients to substances like histamine to provoke asthma symptoms if present.
- Skin prick and blood tests to measure allergic status.
- CXR and sputum tests to examine lung inflammation and rule out other conditions.
- ABG tests to evaluate severity during asthma attacks by measuring oxygen and carbon dioxide levels.
This case involves a 25-year-old woman who presented to the emergency department with shortness of breath and an expanding rash. She has a history of asthma and allergies to aspirin and shellfish. On exam, she was tachypnic, hypertensive, and had periorbital edema and scattered wheals. Her symptoms and history are concerning for anaphylaxis.
The common cold is a viral infection of the upper respiratory tract that affects children. Children typically present with cough, runny nose, sneezing, and nasal congestion. Rhinoviruses cause over 50% of colds in children. Treatment focuses on symptom relief through medications. Prevention emphasizes handwashing, limiting self-inoculation, and annual influenza vaccination.
Swollen lymph nodes usually occur as a result of infection from bacteria or viruses. Rarely, swollen lymph nodes are caused by cancer. Your lymph nodes, also called lymph glands, play a vital role in your body's ability to fight off infections. They function as filters, trapping viruses, bacteria and other causes of illnesses before they can infect other parts of your body. Common areas where you might notice swollen lymph nodes include your neck, under your chin, in your armpits and in your groin.
In some cases, the passage of time .Hard, swollen or tender lymph nodes
Itchy skin, Lump, or mass that can be felt beneath the skin, Rash
Redness, warmth or selling immune system disorders
Lupus — a chronic inflammatory disease that targets your joints, skin, kidneys, blood cells, heart and lungs
Rheumatoid arthritis — a chronic inflammatory disease targeting the tissue that lines your joints (synovium)
Cancers
Lymphoma — cancer that originates in your lymphatic system
Leukemia — cancer of your body's blood-forming tissue, including your bone marrow and lymphatic system
Other cancers that have spread (metastasized) to lymph nodes
Otosclerosis is a hereditary disorder of the bony labyrinth characterized by abnormal bone remodeling. It most commonly causes conductive hearing loss due to fixation of the stapes footplate. Diagnosis is made based on audiometric findings and imaging showing areas of abnormal bone density near the oval and round windows. Treatment involves stapedotomy or stapedectomy to replace the fixed stapes with a prosthesis and restore hearing conduction. While surgery effectively treats conductive losses, there are risks of sensorineural hearing loss, vertigo, and facial nerve injury that must be considered.
This document defines and describes different types of apnea, including central apnea which is due to cessation of brain stem motor stimuli, obstructive apnea which involves absence of airflow with chest wall motion, and mixed apnea which is the most common type. It lists various causes of apnea such as hypoxia, sepsis, metabolic disorders, CNS disorders, and issues like hypotension. The diagnosis of apnea requires investigating these potential underlying causes. Treatments mentioned include apnea monitors, stimulation, bag-mask ventilation, CPAP, theophylline, and caffeine citrate. Apnea of prematurity is also discussed as relating to immaturity of respiratory centers and chemoreceptors in premature babies.
This document discusses the pharmacotherapy of acute bronchitis. It begins by defining acute bronchitis as a cough lasting less than 3 weeks, which is usually viral in origin. The goals of therapy are to rule out serious illness, minimize symptoms, and limit unnecessary antibiotic use. Treatment is primarily supportive and includes analgesics, antitussives, and bronchodilators only for those with wheezing. Antibiotics are not routinely recommended as they do not impact illness duration or severity. Education of patients about the typical self-limiting course of acute bronchitis is important.
Asthma is a condition in which your airways narrow and swell and produce extra mucus. This can make breathing difficult and trigger coughing, wheezing and shortness of breath. For some people, asthma is a minor nuisance.
Bronchiectasis is a chronic lung condition defined by the permanent dilation of the bronchi. It has both congenital and acquired causes such as infections from tuberculosis, pneumonia, or cystic fibrosis. Symptoms include chronic cough, production of large amounts of purulent sputum, and recurrent lung infections. Diagnosis involves imaging like CT scans and pulmonary function tests. Treatment focuses on airway clearance techniques, antibiotics for infections, and surgery in severe cases. Nursing care aims to improve lung function and prevent infections through techniques like postural drainage and breathing exercises.
The document provides information on asthma, including its pathophysiology, epidemiology, risk factors, clinical manifestations, diagnosis, and treatment. Asthma is a chronic inflammatory disease of the airways characterized by airway hyperresponsiveness and reversible airflow obstruction. It commonly presents with wheezing, cough, chest tightness, and shortness of breath. Diagnosis involves assessing symptoms and lung function tests. Treatment focuses on reducing inflammation and managing acute exacerbations.
This document summarizes a presentation on acute and chronic bronchitis. It begins by defining acute bronchitis as inflammation of the large bronchi caused by bacterial or viral infection. It then compares acute and chronic bronchitis, noting their differences in pathogens, onset, duration, age groups affected, and clinical presentation. The document discusses the epidemiology and risk factors of acute bronchitis. It covers the infectious and non-infectious causes, pathophysiology, clinical presentation, diagnosis, treatment including pharmacological and non-pharmacological approaches, patient education, and prognosis. The presentation aims to provide an overview of acute and chronic bronchitis for healthcare professionals.
Cyanosis
Cyanosis refers to a bluish color of the skin and mucous membranes resulting from an increased quantity of reduced hemoglobin/deoxyhemoglobin or abnormal hemoglobin derivatives, in the small blood vessels of those areas.
This document provides information on asthma, including its definition, epidemiology, etiology, pathogenesis, classification, symptoms, exacerbations, and atypical forms. Asthma is defined as a chronic inflammatory disease of the airways associated with bronchial hyperresponsiveness and reversible obstruction. It commonly involves eosinophilic inflammation and affects over 300 million people worldwide. Triggers include allergens, infections, pollution, and emotions. Pathogenesis typically involves a type I hypersensitivity reaction. Classification systems consider severity, control, and clinical course. Symptoms include wheezing, coughing, chest tightness, and shortness of breath. Exacerbations can be life-threatening without treatment.
Simplification of Dermatology signs.pdfDrArulSelvan
Symptoms are subjective part from the patient whereas Signs are objective ones by the physician.
Here's to a collective set of Signs one can observe in a patient to rule out symptoms and helps interpret differential diagnosis.
Infectious dermatoses are skin lesions caused by infections that can be classified into five main types: impetigo, verrucae (warts), molluscum contagiosum, viral exanthematas, and superficial mycoses. Impetigo is a common superficial bacterial infection caused by Staphylococci and Streptococci that presents as vesicles and pustules that rupture leaving yellowish crusts. Warts are common viral skin lesions caused by human papillomavirus that appear as circumscribed, firm, elevated papules on the hands and fingers. Molluscum contagiosum presents as multiple, discrete, waxy papules on the face and trunk caused
This document summarizes several common bacterial and fungal skin infections. It describes the etiology, signs and symptoms, and management of conditions like impetigo, folliculitis, furuncles, carbuncles, hidradenitis suppurativa, acne, cellulitis, erysipelas, lymphadenitis, and gas gangrene. It also covers fungal infections caused by dermatophytes, including tinea capitis, corporis, unguium, and cruris. Effective treatment involves identifying the causative organism and using appropriate topical or systemic antifungal/antibacterial medications along with wound cleaning and drainage when necessary.
Bronchitis is an inflammation of the airways in the lungs called the bronchi. It can be acute (short-term) or chronic (long-lasting). Acute bronchitis is often caused by viruses and leads to coughing and excess mucus production. Chronic bronchitis is usually caused by cigarette smoking and long-term damage to the lungs. Symptoms include coughing, mucus production, wheezing, and shortness of breath. Preventive measures include avoiding tobacco smoke, getting flu shots, and reducing mucus-producing foods.
Within the document are discussions of chronic obstructive pulmonary disease (COPD) and pneumonia. It summarizes the pathogenesis of COPD as being caused by long-term smoke and irritant inhalation leading to airway and lung tissue damage, inflammation, and impaired lung function over time. Emphysema specifically involves destruction of alveoli walls, while chronic bronchitis involves inflammation of the airways. Complications discussed include respiratory infections, lung cancer, and cor pulmonale. Pneumonia is also briefly discussed through a clinical vignette of an alcoholic man presenting with fever, cough, and signs of consolidation on exam.
This document defines asthma and describes its types, symptoms, causes, risk factors, diagnosis, treatment and pathophysiology. Asthma is a chronic inflammatory lung disease characterized by airway hyperresponsiveness and reversible airflow obstruction. It is usually caused by allergic triggers like pollen or dust but can also be triggered by non-allergic factors like viruses or pollution. Diagnosis involves patient history, exams, lung function tests and allergy testing. Treatment includes bronchodilators, corticosteroids, leukotriene modifiers and immunotherapy. The pathophysiology involves type 2 inflammation, IgE production and eosinophil recruitment leading to bronchoconstriction.
This document discusses pruritus (itching) by defining it, listing common causes such as dry skin, skin conditions, systemic diseases, nerve disorders, allergic reactions, drugs, and psychological factors. It describes the pathophysiology of the itch-scratch cycle and classification of pruritus. Diagnosis involves history, physical exam, and potential lab tests. Management includes topical corticosteroids, oral antihistamines, antidepressants, treating underlying causes, phototherapy, and nursing interventions like moisturizing and distraction techniques. Complications can be skin injury, infection, and scarring if scratching is not prevented.
This document summarizes various tests and measurements used to investigate asthma, including:
- Spirometry tests such as FEV1 and PEFR to measure lung function and detect bronchodilation.
- Challenge tests that expose patients to substances like histamine to provoke asthma symptoms if present.
- Skin prick and blood tests to measure allergic status.
- CXR and sputum tests to examine lung inflammation and rule out other conditions.
- ABG tests to evaluate severity during asthma attacks by measuring oxygen and carbon dioxide levels.
This case involves a 25-year-old woman who presented to the emergency department with shortness of breath and an expanding rash. She has a history of asthma and allergies to aspirin and shellfish. On exam, she was tachypnic, hypertensive, and had periorbital edema and scattered wheals. Her symptoms and history are concerning for anaphylaxis.
The common cold is a viral infection of the upper respiratory tract that affects children. Children typically present with cough, runny nose, sneezing, and nasal congestion. Rhinoviruses cause over 50% of colds in children. Treatment focuses on symptom relief through medications. Prevention emphasizes handwashing, limiting self-inoculation, and annual influenza vaccination.
Swollen lymph nodes usually occur as a result of infection from bacteria or viruses. Rarely, swollen lymph nodes are caused by cancer. Your lymph nodes, also called lymph glands, play a vital role in your body's ability to fight off infections. They function as filters, trapping viruses, bacteria and other causes of illnesses before they can infect other parts of your body. Common areas where you might notice swollen lymph nodes include your neck, under your chin, in your armpits and in your groin.
In some cases, the passage of time .Hard, swollen or tender lymph nodes
Itchy skin, Lump, or mass that can be felt beneath the skin, Rash
Redness, warmth or selling immune system disorders
Lupus — a chronic inflammatory disease that targets your joints, skin, kidneys, blood cells, heart and lungs
Rheumatoid arthritis — a chronic inflammatory disease targeting the tissue that lines your joints (synovium)
Cancers
Lymphoma — cancer that originates in your lymphatic system
Leukemia — cancer of your body's blood-forming tissue, including your bone marrow and lymphatic system
Other cancers that have spread (metastasized) to lymph nodes
Otosclerosis is a hereditary disorder of the bony labyrinth characterized by abnormal bone remodeling. It most commonly causes conductive hearing loss due to fixation of the stapes footplate. Diagnosis is made based on audiometric findings and imaging showing areas of abnormal bone density near the oval and round windows. Treatment involves stapedotomy or stapedectomy to replace the fixed stapes with a prosthesis and restore hearing conduction. While surgery effectively treats conductive losses, there are risks of sensorineural hearing loss, vertigo, and facial nerve injury that must be considered.
This document summarizes genetic ophthalmic disorders including color blindness and glaucoma. It describes the normal eye structure and defines color blindness as a color vision deficiency making it difficult to perceive color differences. It discusses the types of color blindness including red-green, blue cone monochromacy, and blue-yellow deficiencies. Glaucoma is defined as abnormally high fluid pressure in the eye, most commonly caused by blockage of the drainage channel or pressure from the iris on the lens. The two main types are open-angle and angle-closure glaucoma. Causes, signs, diagnosis, and treatments are described for both conditions.
The document summarizes key anatomy and pathologies of the temporal bone that can be evaluated on CT and MRI imaging. It describes the complex anatomy of the temporal bone and petrous apex in detail. It then outlines various normal anatomical variants, congenital anomalies, inflammatory conditions like otitis media, and neoplasms like cholesteatoma that can be seen on temporal bone imaging. Key imaging findings that help characterize and diagnose these conditions are also provided.
This document provides information on ocular disease and proptosis (forward displacement of the eyeball). It discusses various types and causes of proptosis including unilateral, bilateral, acute, and pulsating proptosis. Common causes listed include congenital defects, trauma, infections, circulatory issues, cysts, and tumors. The anatomy of the eyelids is also overviewed, describing structures like the palpebral fissure, canthi, eyelid margin, eyelashes, and lacrimal apparatus.
This document provides information on ocular disease and proptosis (forward displacement of the eyeball). It discusses various types and causes of proptosis including unilateral (affecting one eye), bilateral (affecting both eyes), acute, intermittent, and pulsating proptosis. Common causes listed include congenital defects, trauma, infections, circulatory issues, cysts, tumors, and sinus mucoceles. The anatomy of the eyelids is also reviewed including the positions, structures, lashes, and glands. Key diseases of the conjunctiva are defined like conjunctivitis, pinguecula, and pterygium along with their symptoms and causes. Opthalmia neonatorum as a type
The document discusses ring enhancing lesions seen on neuroimaging. These lesions appear as hypodense masses that enhance with contrast. Common causes include metastatic lesions, primary brain tumors, pyogenic brain abscesses, tuberculomas, cysticercus granuloma, demyelinating disorders, and opportunistic infections in HIV patients such as toxoplasmosis and primary CNS lymphoma. Differential diagnosis depends on location, size, enhancement pattern and associated findings on imaging and other tests.
This document discusses pupil size and reaction as it relates to attraction and interest between individuals. It notes that pupil size increases when looking at someone we find attractive due to an involuntary physiological response. It also states that observing whether a person's pupils expand, contract, or do nothing can provide clues as to whether they are attracted to or actively dislike the observer. The document then provides further information on pupil anatomy and control, as well as abnormal pupil responses and conditions that cause them.
This document discusses pupil size and reaction as it relates to attraction and interest between individuals. It notes that pupil size increases when looking at someone we find attractive due to an involuntary physiological response. It also states that observing whether a person's pupils expand, contract, or do nothing can provide clues as to whether they are attracted to or actively dislike the observer. The document then provides details on pupil anatomy, size, shape, location, and neural pathways controlling pupil size.
This document provides information about performing an ophthalmoscopic examination, including descriptions of different types of ophthalmoscopes, examination techniques, and common findings. It discusses examining the optic disc, blood vessels, and fundus, as well as conditions that can be identified such as papilledema, retinal artery occlusion, and diabetic retinopathy. Precautions for using mydriatic drops are also outlined.
Ménière’s disease is a disorder of the inner ear that causes episodes of vertigo, hearing loss, tinnitus, and aural fullness. It is caused by endolymphatic hydrops, or a distension of the endolymphatic duct. Key features include recurrent vertigo attacks lasting minutes to hours accompanied by nystagmus, nausea, and vomiting. Hearing loss is also present and often fluctuates, initially affecting low frequencies but becoming permanent over time. Diagnostic tests include electrocochleography and caloric testing. Management involves lifestyle modifications, medical treatment with vestibular sedatives and vasodilators during attacks, and potentially surgery for refractory cases.
A concise presentation about BPPV and Ménière's disease and other causes of vertigo, the difference between central and peripheral vertigo, symptoms and etiology and approach to physical examination and treatment.
This document provides information on physiotherapy treatment for Bell's palsy. It begins with an overview of Bell's palsy, including its causes, symptoms, and grading scales. It then discusses specific assessments, including cranial nerve and facial muscle testing. Treatment approaches covered include corticosteroids, antiviral medications, eye care, facial exercises, electrical stimulation, massage, and rarely, surgery. Outcome measures used to evaluate recovery are also outlined.
Meniere's disease is a disorder of the inner ear that causes spontaneous episodes of vertigo accompanied by fluctuating hearing loss, tinnitus, and a feeling of fullness in the ear. The exact cause is unknown but may involve viral infection, hereditary factors, or autoimmune issues. Pathologically, it involves endolymphatic hydrops or a buildup of fluid in the inner ear. Diagnosis is based on recurrent vertigo spells lasting 20 minutes to 24 hours along with hearing loss, tinnitus, and fullness. Treatment aims to reduce vertigo and includes dietary sodium restriction, diuretics, vestibular sedatives for acute attacks, intratympanic injections of gentamicin
The document discusses several diseases and disorders of the nervous system including:
1. Meningitis which is an inflammation of the meninges that can be caused by bacterial or viral infections. Common symptoms include fever, headache, neck stiffness.
2. Encephalitis which is inflammation of the brain.
3. Alzheimer's disease which is the most common form of dementia and involves nerve cell tangles and amyloid plaques in the brain leading to memory loss and cognitive decline.
4. Brain tumors which can be benign or malignant and occur in different areas of the brain such as glioblastomas in the cerebral hemispheres or medulloblastomas in the cerebellum in children.
5. Stroke which is
Meniere's disease is an inner ear disorder characterized by recurrent episodes of vertigo, fluctuating hearing loss, tinnitus, and aural fullness. It is caused by endolymphatic hydrops, which is an excess of fluid in the inner ear. A typical attack involves an initial irritative phase with vertigo and nystagmus beating towards the affected ear, followed by a paretic phase with nystagmus beating away from the ear, and a recovery phase with nystagmus returning towards the ear. The exact cause is unknown but may involve increased endolymph production or decreased absorption.
Types of hearing loss include conductive, sensorineural, and mixed. Common causes are otitis media, noise exposure, presbycusis, genetic factors, and certain drugs. Evaluation involves testing such as audiograms, tympanograms, and brainstem response audiometry. Management options depend on the type and severity of hearing loss and may include surgery, hearing aids, cochlear implants, or assistive devices.
Similar to Disorders of Special Senses (Eye & Ear.pptx (20)
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
1. Disorders of Special Senses
(Eye & Ear)
Unit-IV
Pathophysiology-II
By
Murad Ali
RN, GBSN, PGD Clinical Psychology, MSN Scholar
2. Objectives
At the completion of this unit learners will be able to:
• Review A & P of eye & ear
• Discuss some common visual & auditory
dysfunction
• Glaucoma
• Tinnitus & hearing Loss
4. Anatomy of the Eyeball
The adult eyeball measures about 2.5 cm (1 in.) in
diameter.
The eyeball consists of three layers:
1. Tunica fibrosa or Fibrous tunic (Sclera)
2. Tunica vasculosa or Vascular tunic (Choroid)
3. Tunica interna (Retina)
5. • Tunica Fibrosa
– It is tough outermost eyeball layer, divided into two
regions: the sclera and cornea
– Sclera—(scler=hard)—white of the eye; Covers
most of the eye surface, composed of collagen &
elastic fibers; optic nerve exits from sclera at the
back of eye.
– Cornea – is the anterior transparent region of
modified sclera that admits light into the eye.
– At the junction of sclera and cornea is an opening
called scleral venous sinus or canal of schlemm. A
fluid called aqueous humor drains into this sinus.
6. • The Optical Components
• The optical components of the eye are transparent
elements that admit light rays, refract (bend) them,
and focus images on the retina. They include the
cornea, aqueous humor, lens, and vitreous body.
• The aqueous humor is a serous fluid secreted by
the ciliary body into the posterior chamber, a space
between the lens and iris. It flows through the
pupil into the anterior chamber between the iris
and cornea. From here it is reabsorbed by a ring
like blood vessel called the scleral venous sinus or
canal of schlemm.
9. Glaucoma
• Glaucoma is a state of elevated intra-ocular
pressure which is resulted by the accumulation
of aqueous humor when it is not reabsorbed as
fast as it is secreted.
• Glaucoma describes a group of diseases that kill
retinal ganglion cells.
• IOP is measured with tonometer.
• Tonometry provides an early detection.
• Normal range of IOP is 10-22 mm Hg
10. Classification of Glaucoma
I. Primary:
A. Congenital
B. Adult (common types)
1. Narrow angle
2. Open angle
II. Secondary
1. Inflammatory
2. Traumatic
11. Closed / Narrow Angle Glaucoma
• The anterior chamber is narrowed and outflow
becomes impaired when the iris thickens as a result
of pupillary dilation.
• The thickened iris restricts the aqueous flow from
posterior to anterior chamber and thus reduces or
eliminates the access to the iridocorneal angle to
allow its passage via the trabecular meshwork of
the canal of Schlemm.
• Closed angle glaucoma usually occurs as a result of
inherited anatomic defect that causes the anterior
chamber shallow.
• About 5% to 10% are closed angle glaucoma.
12. Narrow Angle Glaucoma
Symptoms
Severe eye/headache
pain
Blurred vision
Nausea and vomiting
Halos around lights
Intermittent eye ache
at night
Signs
Red, teary eye
Corneal edema
Closed angle
Mid-dilated, fixed
pupil
13. Open Angle Glaucoma
• Primary open angle glaucoma is the most common form of
glaucoma.
• It tends to manifest after the age of 35 years.
• IOP occurs in the absence of obstruction at iridocorneal angle.
So the angle is open and It is therefore called open angle
glaucoma.
• It usually occurs because of an abnormality of the trabecular
meshwork that controls the aqueous flow in the canal of
Schlemm.
14. Risk Factors of Open Angle Glaucoma
• 40 years age and above
• Family history ( if positive)
• DM
• CVD
• Topical corticosteroid moderate use
• Myopia
• IOP
• Gender
16. What is the difference between open and closed-angle
glaucoma?
In open-angle glaucoma, the increase in pressure is often
small and slow. In closed-angle glaucoma, the increase
is often high and sudden
17. Pathophysiology
• The accumulation of aqueous humor elevates pressure in
the anterior chamber which compresses the canal of
Schlemm and causing a further reduction in aqueous
outflow.
• The elevated pressure in the anterior chamber drives lens
back and puts pressure on the vitreous body.
• The vitreous body presses the retina against the choroid
and compresses the blood vessels that nourish the retina.
• Impaired blood supply results in the death of retinal cells
and atrophy of optic nerve and thus ultimately in
blindness.
• Glaucoma leads to blindness if left untreated
18. Symptoms
• Symptoms often go unnoticed until the damage is
irreversible.
• In late stages, they include dimness of vision,
reduced visual field, and colored halo around
artificial lights.
20. Anatomy of the Ear
The ear has three regions:
• External ear
• Middle ear
• Inner ear
• The first two are concerned only with transmitting the sound
to the inner ear.
21. Internal Ear
• The internal ear is also called labyrinth because of its
series of canals.
• It consists of two main divisions.
Bony labyrinth.
Membranous labyrinth
• The bony labyrinth, a series of cavities and tubes in
the temporal bone, divides into three parts:
1) The semicircular canals,
2) the vestibule, both of them contain receptors for
equilibrium, and
3) the choclea (=snail), which contains receptors for
hearing.
22. Tinnitus
• Tinnitus is defined as sensations of hearing in the
absence of external sounds.
• Referred to as “ringing in the ears”.
• It may also be described as roaring, buzzing or
humming sound.
• May be unilateral or bilateral.
• Can be perceived inside or outside the ear.
• May be constant or intermittent.
• It is a symptom
23. • 1/3 of the population have had tinnitus at some stage in their
lives
• Up to 20% of the population currently experience tinnitus.
• Prevalence increases with age
• 80% of people don’t seek help
• 6-8% of those affected are severe
24. Division of Tinnitus
• Although it is subjective, yet it is divided into
objective and subjective for clinical purpose.
• Objective: It is a rare case in which the sound is
detected by another observer.
• Subjective: It refers to noise perception when
there is no noise stimulation of cochlea.
25. Pathophysiology
• Objective tinnitus is caused by vascular abnormalities
or neuromuscular disorders.
• In vascular disorders sounds are generated by
turbulent blood flow (like arterial bruits or venous
hums) which are conducted to the auditory system
producing a pulsatile type of tinnitus.
• The underlying physiologic mechanism of subjective
tinnitus is unclear. It seems likely that there are several
mechanisms including abnormal firing of auditory
receptors, abnormal cochlear neurotransmission
function or ionic imbalance, and alterations in central
processing of the signals.
26. Possible Causes
• Blow to the head
• Noise exposure
• Hypertension
• Stress
• Tumors
• Impacted cerumen
• Medication
• Infection
• Older age
• Meniere’s Disease (triad---- vertigo, tinnitus, hearing loss)
• Outer/Middle ear disease
27. Why is it worse at night?
• Distractions during the day make tinnitus less obvious.
• At night, when surroundings are quiet, tinnitus is more
obvious.
• Fatigue can also make tinnitus worse.
28. Hearing Disorders
The most common hearing disorders are those that
affect hearing sensitivity. When a sound is
presented to a listener with a hearing sensitivity
disorder, one of two things may occur:
1. The listener with a hearing sensitivity disorder
may be unable to detect the sound.
2. The sound will not be as loud to that listener as
it would be to a listener with normal hearing.
29. Hearing Loss
• Hearing is measured in decibels (db).
• Hard of hearing is defined as hearing loss greater
than 20 to 25 db in adults and greater than 15 db in
children.
• Hearing loss is qualified as mild, moderate, and
severe.
• Profound deafness is when hearing loss is greater
than 100 db or 75 db in children.
• Sounds over 80 decibels are considered hazardous
with prolonged exposure.
30. Types of Hearing Loss
• 1. Conductive Hearing Loss
• It occurs when auditory stimuli are not
adequately transmitted to via the auditory
canal, tympanic membrane, middle ear or
ossicle chain to the inner ear.
• Causes:
• External Ear conditions like:
• Impacted cerumen
• Otitis externa
32. Hearing Loss
• 2. Sensorineural or Perceptive Hearing Loss
• It occurs with disorders that affect the inner ear,
auditory nerve, or auditory pathways of the brain.
• Tinnitus often accompanies cochlear nerve irritation.
• Causes
• Trauma----Head injury, Noise
• CNS infection-----meningitis
• Atherosclerosis
• Ototoxic drugs-----aminoglycosides, salicyclates, loop
diuretics, chloroquine, cisplatin
• Tumor
• Meniere’s disease
33. Hearing Loss
• 3. Mixed Hearing Loss
• It is the combination of both conductive and sensorineural hearing
loss.
• Causes
Colds, Earaches, Sinus problems, Allergies, Noise Exposures
Childhood Diseases, Medications, Head Trauma, Age
34. General info…
The intensity of sound is
measured in units called
decibels .
Any sounds over 80 decibels
are considered hazardous with
prolonged exposure.
35. Some ways to reduce it….
Turn down the volume
on your stereo, TV,
headset on your
Walkman or CD player
Wear earplugs if you’re
going to a loud concert
and while working
around loud noise such
as power tools,
jackhammers, and etc.
Get your hearing tested on a regular
basis
36. Physical Characteristics….
Some people that are hearing impaired may wear a
hearing aid in or on the back of their ear
Some people might have a deformed ear
Some people might say some words differently
37. Mental Characteristics…
They may feel that people who they talk to lose
patience with them because they have to repeat
themselves
Hearing loss can create feelings of emotional
isolation
A person may feel that the focus of attention is
placed on their disability and that they are not
recognized as anything other than a hearing impaired
person