This document discusses directions, planes, and Miller indices in crystal structures. It begins by introducing lattice planes and how Miller indices are used to describe planes and directions within crystal structures. It then provides general rules and conventions for Miller indices, including how they are determined for both directions and planes. Specific examples are given to illustrate how to calculate Miller indices. Important directions and planes within crystal structures are also highlighted. The document emphasizes that Miller indices allow for the standardized description of orientations within crystalline materials.
The ideal, perfectly regular crystal structures in which atoms are arranged in a regular way does not exist in actual situations. In actual cases, the regular arrangements of atoms disrupted . These disruptions are known as Crystal imperfections or crystal defects
The ideal, perfectly regular crystal structures in which atoms are arranged in a regular way does not exist in actual situations. In actual cases, the regular arrangements of atoms disrupted . These disruptions are known as Crystal imperfections or crystal defects
NANO106 is UCSD Department of NanoEngineering's core course on crystallography of materials taught by Prof Shyue Ping Ong. For more information, visit the course wiki at http://nano106.wikispaces.com.
The study of crystal geometry helps to understand the behaviour of solids and their
mechanical,
electrical,
magnetic
optical and
Metallurgical properties
Crystal Material, Non-Crystalline Material, Crystal Structure, Space Lattice, Unit Cell, Crystal Systems, and Bravais Lattices, Simple Cubic Lattice, Body-Centered Cubic Structure, Face centered cubic structure, No of Atoms per Unit Cell, Atomic Radius, Atomic Packing Factor, Coordination Number, Crystal Defects, Point Defects, Line Defects, Planar Defects, Volume Defects.
The crystal structure notes gives the basic understanding about the different structures crystalline materials and their properties and physics of crystals. It also throw light on the basics of crystal diffraction
NANO106 is UCSD Department of NanoEngineering's core course on crystallography of materials taught by Prof Shyue Ping Ong. For more information, visit the course wiki at http://nano106.wikispaces.com.
The study of crystal geometry helps to understand the behaviour of solids and their
mechanical,
electrical,
magnetic
optical and
Metallurgical properties
Crystal Material, Non-Crystalline Material, Crystal Structure, Space Lattice, Unit Cell, Crystal Systems, and Bravais Lattices, Simple Cubic Lattice, Body-Centered Cubic Structure, Face centered cubic structure, No of Atoms per Unit Cell, Atomic Radius, Atomic Packing Factor, Coordination Number, Crystal Defects, Point Defects, Line Defects, Planar Defects, Volume Defects.
The crystal structure notes gives the basic understanding about the different structures crystalline materials and their properties and physics of crystals. It also throw light on the basics of crystal diffraction
Space lattice, Unit cell, Bravais lattices (3-D), Miller indices, Lattice planes, Hexagonal closed packing (hcp) structure, Characteristics of an hcp cell, Imperfections in crystal: Point defects (Concentration of Frenkel and Schottky defects).
X – ray diffraction : Bragg’s law and Bragg’s spectrometer, Powder method, Rotating crystal method.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
2. CONTENTS
• INTRODUCTION
• NEED OF DIRECTIONS AND PLANES
• GENERAL RULES AND CONVENTION
• MILLER INDICES FOR DIRECTIONS
• MILLER INDICES FOR PLANES
• IMPORTANT FEATURES OF MILLER INDICES
3. INTRODUCTION
The crystal lattice may be regarded as made
up of an infinite set of parallel equidistant
planes passing through the lattice points
which are known as lattice planes.
In simple terms, the planes passing through
lattice points are called ‘lattice planes’.
For a given lattice, the lattice planes can be
chosen in a different number of ways.
4. • The orientation of planes or faces in a crystal can
be described in terms of their intercepts on the
three axes.
• Miller introduced a system to designate a plane
in a crystal.
• He introduced a set of three numbers to specify
a plane in a crystal.
• This set of three numbers is known as ‘Miller
Indices’ of the concerned plane.
5. NEED OF DIRECTIONS AND PLANES
• Deformation under loading (slip) occurs on
certain
crystalline planes and in certain crystallographic
directions.
• Before we can predict how materials fail, we need
to know what modes of failure are more likely to
occur. Other properties of materials (electrical
conductivity, thermal conductivity, elastic
modulus) can vary in a crystal with orientation.
6.
7. GENERAL RULES FOR LATTICE
DIRECTIONS, PLANES AND MILLER
INDICES
• Miller indices used to express lattice planes and
directions
• x, y, z are the axes (on arbitrarily positioned
origin)
• a, b, c are lattice parameters (length of unit cell
along a side) h, k, l are the Miller indices for
planes and directions -
expressed as planes: (hkl) and directions: [hkl]
8. CONVENTION FOR NAMING
• There are NO COMMAS between numbers
• Negative values are expressed with a bar over
the number
Example: -5 is expressed 5
9. MILLER INDICES FOR DIRECTIONS
• Draw vector, and find the coordinates of the
head, h1,k1,l1 and the tail h2,k2,l2.
• subtract coordinates of tail from coordinates
of head
• Remove fractions by multiplying by smallest
possible factor
• Enclose in square brackets
10.
11. The direction can also be
determined by giving
the coordinates of the
first whole numbered
point (x,y) through
which each of the
direction passes.
In this figure direction of
OA is[110] and OB is
[520]
13. MILLER INDICES FOR PLANES
• If the plane passes through the origin, select
an equivalent plane or move the origin
• Determine the intersection of the plane with
the axes in terms of a,b, and c
• Take the reciprocal (1/∞ = 0)
• Convert to smallest integers
• Enclose by parentheses
14. EXAMPLE
• Here x,y and z
intercepts are 1,1,1.
• Therefore (111) is the
miller indices of the
plane
15. • DETERMINATION OF ‘MILLER
INDICES
• Step 1:The intercepts are 2,3 and
2 on the three axes.
• Step 2:The reciprocals are 1/2,
1/3 and 1/2.
• Step 3:The least common
denominator is ‘6’. Multiplying
each reciprocal by lcd, we get, 3,2
and 3.
• Step 4:Hence Miller indices for
the plane ABC is (3 2 3)
16. IMPORTANT FEATURES OF MILLER
INDICES
• A plane passing through the origin is defined in
terms of a parallel plane having non zero
intercepts.
• All equally spaced parallel planes have same
‘Miller indices’ i.e. The Miller indices do not only
define a particular plane but also a set of parallel
planes. Thus the planes whose intercepts are 1,
1,1; 2,2,2; -3,-3,-3 etc., are all represented by the
same set of Miller indices.
17. • It is only the ratio of the indices which is
important in this notation. The (6 2 2) planes
are the same as (3 1 1) planes.
• If a plane cuts an axis on the negative side of
the origin, corresponding index is negative. It
_
is represented by a bar, like (1 0 0). i.e. It
indicates that the plane has an intercept in
the –ve X –axis.
