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DIPHTHERIA
DISCRIPTION
 Diphtheria is an upper respiratory tract disease
characterized by mild fever, sore throat and the
formation of a pseudomembrane on the tonsil (s),
pharynx, and/or nose.
 A local lesion develops in the upper respiratory tract
and involves necrotic injury to epithelial cells.
 As a result of this injury, blood plasma leaks into the
area and a fibrin network forms which is interlaced
with rapidly-growing C. diphtheriae cells.
CAUSATIVE ORGANISM
 The disease is caused by
the exotoxin produced by
Corynebacterium
diphtheriae.
 It is Gram-positive, rod
shaped aerobic bacterium
which grows mainly on
throat, larynx and other
portion of URTI.
MODE OF SPREAD
 It is spread by droplet infection and through carriers
whether sick or healthy.
 Handling of fomites recently contaminated by nasal
or throat secretions also transmit the disease.
 The droplets containing the bacilli are expelled from
the mouth and nose by coughing, sneezing, spitting,
speaking and kissing.
INCUBATION PERIOD
 Incubation period varies from 2 to 5 days.
SIGNS AND SYMPTEMS
 The sick persons experience fatigue, fever, a
mild sore throat and problems in swallowing.
Infected children have symptoms that include
chills, nausea, vomiting and a high fever.
 There is difficulty in swallowing and patches
of grayish and yellow membrane appear over
tonsils and throat.
Thick Membrane
Pseudo membrane
‘Bull Neck’
Skin Lesions
DIAGNOSIS
 The diagnosis of diphtheria is based on both clinical
symptoms and laboratory findings.
 Clinical criteria include upper respiratory tract
illness with sore throat, mild fever, and an adherent
membrane of the tonsil(s), pharynx, and/or nose.
 Laboratory criteria include isolation of
Corynebacterium diphtheriae from a clinical
specimen, or histopathologic diagnosis of diphtheria.
TREATMENT
 Advice complete bed rest to the patient to prevent
cardiac and other complications.
 Erythromycin (orally or by injection) for 14 days or
Procaine penicillin G given intramuscularly for 14
days. Patients with allergies to penicillin G or
erythromycin can use rifampin or clindamycin.
PREVENTIONAND CONTROL
 An effective DPT (Diphtheria-Tetanus-Pertussis) in
the form of a combination vaccine is available.
 DPT vaccine is given to all children. Boosters of the
vaccine are recommended for adults because the
benefits of the vaccine decrease with age;
 They are particularly recommended for those
travelling to areas where the disease has not been
eradicated yet.

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Diphtheria

  • 2. DISCRIPTION  Diphtheria is an upper respiratory tract disease characterized by mild fever, sore throat and the formation of a pseudomembrane on the tonsil (s), pharynx, and/or nose.  A local lesion develops in the upper respiratory tract and involves necrotic injury to epithelial cells.  As a result of this injury, blood plasma leaks into the area and a fibrin network forms which is interlaced with rapidly-growing C. diphtheriae cells.
  • 3. CAUSATIVE ORGANISM  The disease is caused by the exotoxin produced by Corynebacterium diphtheriae.  It is Gram-positive, rod shaped aerobic bacterium which grows mainly on throat, larynx and other portion of URTI.
  • 4. MODE OF SPREAD  It is spread by droplet infection and through carriers whether sick or healthy.  Handling of fomites recently contaminated by nasal or throat secretions also transmit the disease.  The droplets containing the bacilli are expelled from the mouth and nose by coughing, sneezing, spitting, speaking and kissing.
  • 5. INCUBATION PERIOD  Incubation period varies from 2 to 5 days.
  • 6. SIGNS AND SYMPTEMS  The sick persons experience fatigue, fever, a mild sore throat and problems in swallowing. Infected children have symptoms that include chills, nausea, vomiting and a high fever.  There is difficulty in swallowing and patches of grayish and yellow membrane appear over tonsils and throat.
  • 11. DIAGNOSIS  The diagnosis of diphtheria is based on both clinical symptoms and laboratory findings.  Clinical criteria include upper respiratory tract illness with sore throat, mild fever, and an adherent membrane of the tonsil(s), pharynx, and/or nose.  Laboratory criteria include isolation of Corynebacterium diphtheriae from a clinical specimen, or histopathologic diagnosis of diphtheria.
  • 12. TREATMENT  Advice complete bed rest to the patient to prevent cardiac and other complications.  Erythromycin (orally or by injection) for 14 days or Procaine penicillin G given intramuscularly for 14 days. Patients with allergies to penicillin G or erythromycin can use rifampin or clindamycin.
  • 13. PREVENTIONAND CONTROL  An effective DPT (Diphtheria-Tetanus-Pertussis) in the form of a combination vaccine is available.  DPT vaccine is given to all children. Boosters of the vaccine are recommended for adults because the benefits of the vaccine decrease with age;  They are particularly recommended for those travelling to areas where the disease has not been eradicated yet.