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GOOD EVENING
DIPHTHERIA  PATHOGENESIS ,DIAGNOSIS  &TREATMANT Presented by- Subrata Das
Biological Features Corynebacteriumdiphtheriae ,[object Object],[object Object]
specially in children
spread by droplets
secretions
direct contact
Poor nutrition
Crowded or unsanitary living conditions
Low vaccine coverage among infants and children
Immunity gaps in adults
Incubation period -2 to 10,[object Object]
Pathogenesis of diphtheria Mechanism of action Diphtheria Toxin  ,[object Object],          - B (transmembrane  and  receptor binding domains)  ,[object Object]
Toxin diffuses throughout body via blood - Cardiac, neurologic complications - Heart/respiratory damage, paralysis ,[object Object]
May involve any mucous membrane

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