Furunculosis is a localized infection of a single hair follicle in the external ear canal caused mainly by Staphylococcus aureus bacteria. It presents as a painful, blocked ear with discharge and tender swelling around the pinna. Treatment involves antibiotics, incision and drainage of abscesses, and topical antiseptic ear drops. Without treatment, it can cause scarring and narrowing of the ear canal.
Perilymph Fistula can be difficult to diagnose as a standalone condition. Post-trauma symptoms such as dizziness, headache, etc. can be linked to other conditions like a traumatic brain injury with a concussion.
Perilymph Fistula can be difficult to diagnose as a standalone condition. Post-trauma symptoms such as dizziness, headache, etc. can be linked to other conditions like a traumatic brain injury with a concussion.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
1. Furunculosis
A boil (furuncle) is an
infection of a hair
follicle]
A carbuncle occurs
when a group of hair
follicles next to each
other become
infected
2. • Furunculosis is a localized form of otitis
externa resulting from infection of a
single hair follicle
• Bacterial invasion of a single hair
follicle
well-circumscribed deep skin
infection
Pustule
local abscess formation
• Associated cellulitis and oedema
• Bacteria attach initially to the cells of
the stratum corneum and proliferate
around the ostium of the hair follicle.
• There is deeper invasion of the hair
follicle between the inner and outer
root sheath
3. DIAGNOSIS
• Symptoms do not usually discriminate furunculosis from
severe diffuse otitis externa
• The affected ear is extremely painful, feels blocked and
exudes a scanty serosanguinous discharge
• The pinna and tragus are tender on palpation
4. AETIOLOGY AND EPIDEMIOLOGY
• Staphylococcus aureus (S. aureus) is the most
common organism
• leukocidal toxins commonly isolated from
pathogenic strains of S. aureus trigger lysis of
phagocytic cells and may have an important role
in cutaneous infection.
• Recurrent furunculosis---Several conditions
appear to be associated with recurrent
furunculosis including hypogammaglobulinaemia,
diabetes mellitus and dysphagocytosis.
5. • Repeated infection can cause permanent
scarring and fibrosis of the external canal with
subsequent meatal stenosis.
• Ultimately, this may also predispose to chronic
diffuse otitis externa.
6. Treatment choices include:
• Antibiotics
• Topical treatment (antibiotics, astringents, hygroscopic dehydrating
agents);
• Incision and drainage
• Oral antibiotic treatment is recommended in the early stages of the
disease.
• Severe spreading soft tissue infection should be treated with intravenous
antibiotic therapy
• Abscess formation is an indication for formal drainage. After the abscess
has discharged, surgically or spontaneously, topical treatment is
preferable.
• Topical antibiotics active against staphylococcus are usually prescribed
• Insertion of a wick into the ear canal facilitates treatment in the presence
of severe canal oedema and narrowing
7. • Glycerol and ichthammol solution has a
specific antistaphylococcal action6, 7 and is
hygroscopic, thus causing dehydration of the
canal tissue.
• Aluminium acetate solution is an astringent as
well as a hygroscopic agent.
8. For patients suffering generalized
recurrent furunculosis
• Eradication therapy with nasal mupirocin.
• Eradication therapy with oral flucloxacillin for 14 days.
• Bacterial interference therapy: deliberately
implanting a nonpathogenic strain of S. aureus
(strain 502A is the most popular) to recolonize the nares
and skin.
• It has been reported that correction of specific
biochemical abnormalities (e.g. hypoferraemia, low
serum zinc) may lead to a marked reduction in the
frequency of infections.
9. Bullous myringitis
• Bullous myringitis (myringitis bullosa
haemorrhagica) is the finding of vesicles in
the superficial layer of the tympanic
membrane
The vesicles occur
between the outer
epithelium and the
lamina propria of the
tympanic membran
11. SYMPTOMS
• Sudden onset of severe
• usually unilateral
• often throbbing pain in the ear is the most
common presentation
• The symptoms usually set in during or following
an upper respiratory tract infection
• A bloodstained discharge can be present for a
couple of hours
• A hearing impairment (conductive and/or
sensorineural) is common in the affected ear.
12. SIGNS
• Otoscopy—
blood-filled, serous or serosanginous
blisters involving the tympanic membrane
Serosanginous secretion can be seen if the blisters
rupture
The tympanic membrane is intact
• In young children with bullous myringitis, middle ear fluid
was present in the majority (97 percent) but is an
uncommon finding in other age groups.
• The site of the sensorineural hearing loss is the cochlea;
however, the pathogenic base is not understood.
13. DIAGNOSIS
• based on physical examination.
• Vesicles in the superficial layer of the TM.
• The main differential diagnoses
Acute otitis media,
Herpes zoster oticus or
Ramsay Hunt syndrom
14. Investigations
• Inspection of the ear using a microscope is essential for
diagnosis.
• Pneumatic otoscopy and tympanometry help determine
whether the middle ear contains fluid
• Clinical evaluation of the cranial nerves and, in particular,
the facial nerve must be carried out for to distinguish from
herpes zoster oticus or Ramsey Hunt syndrome
• Pure-tone audiogram
• Cultures from blisters are not necessary in the
management of uncomplicated cases
• A serologic sample for herpes zoster is of value in cases
with sensorineural hearing loss and may be of help in the
differential diagnosis
15. OUTCOMES
• In the vast majority of cases a complete
recovery is seen within days.
• a sensorineural hearing impariment of more
than 15 dB in two frequencies was reported in
65 percent of 18 patients referred to an ENT
clinic for bullous myringitis.
16. MANAGEMENT OPTIONS
• In cases without middle ear affection and without sensorineural
hearing loss
only analgesics are recommended.
• When the middle ear is affected
antibiotics can be used as in the treatment of acute otitis media.
• In children less than two years of age, acute bullous myringitis
should be treated as acute otitis media.
• in cases with sensorineural hearing impairment- Antibiotics have
also been recommended
17. Effect of management
• Spontaneous resolution of the blisters and
middle ear effusion, if present, is the norm.
• Complete recovery of the sensorineural
impairment within three months occurred in
between 60 and 100 percent of affected
patients treated with amoxicillin.
(this study was not controlled)
18. Granular
myringitis
Granular myringitis is a
specific form of external otitis.
It is characterized by
granulation tissue on the
lateral aspect
of the tympanic membrane
with possible involvement of
the external ear canal.
various names
Granulating myringitis,
Myringitis granulosa,
Otitis externa granulosa,
Otitis externa with granulations,
Granulomatous otitis externa,
Granulomatous myringitis,
Acute granulomatous myringitis,
Chronic myringitis
19.
20.
21.
22. PATHOLOGY
• Microscopic examination--oedematous
granulation tissue with capillaries and diffuse
infiltration of chronic inflammatory cells
• Large areas of the granulation tissue have no
covering epithelium
• It has been suggested that a nonspecific injury
involving the lamina propria of the tympanic
membrane suppresses epithelialization which
leads to the development of granulation tissue.
23. AETIOLOGY
• Not related to sex, age, systemic disease or season.
• High-ambient temperature, swimming, lack of hygiene,
local irritants and foreign bodies have all been
suggested as causative factors.
• Bacterial and sometimes fungal infection is present in
the affected ear in all reports.
• The incidence of granular myringitis has been
calculated to be a quarter of that of cholesteatoma
• Granular myringitis is also occasionally seen as a
postoperative complication of tympanic membrane
grafting.
24. SYMPTOMS
• Foul-smelling discharge from the affected ear.
• There is usually little or no pain.
• Some individuals have a sensation of fullness
or irritation in the ear.
• The hearing is either not at all or only slightly
impaired.
• Associated tinnitus is uncommon. Some
patients can be asymptomatic.
25. SIGNS
A moderate amount of purulent secretion is
seen in the affected ear .3 The tympanic
membrane is covered with secretions that
sometimes crust.
After aural toilet the granulation tissue is
revealed.
localized form of granular myringitis:
most common
Small areas of the drum are affected
one or more polyps are present
Most commonly, the granulations are
situated posterosuperior on the eardrum
and may affect the adjacent canal wall.
Diffuse form:
slightly raised carpet of granulations, which covers
the tympanic membrane
Perforation of the tympanic membrane is not
present
26. DIAGNOSIS
• Discharge from the ear is present.
• Inflammation and granulation tissue are seen on
the lateral aspect of the tympanic membrane
with possible involvement of the external ear
canal.
• Differential diagnoses:
chronic (suppurative) otitis media and diffuse
external otitis
• The lack of a conductive hearing impairment and
a normal computed tomography (CT) scan
excludesm chronic otitis media
27. Investigations
• Microscope
• Pneumatic otoscopy and tympanometry should be used to confirm
that the middle ear is normal and no perforation is present.
• Pure-tone audiometry should be performed to exclude a
conductive hearing impairment due to chronic otitis media.
• Culture:Gram-negative bacteria (Pseudomonas aeruginosa, Proteus
species and Staphylococcus aureus) and Candida albicans are most
commonly cultured.
The bacterial culture does not differ from specimens found in
external otitis and chronic otitis media.
• If there is doubt as to whether the middle ear and mastoid is
involved, a high resolution CT scan can help exclude chronic otitis
media
• If the granulations do not resolve with treatment, biopsy for
histological examination should be carried out to exclude carcinoma
28. OUTCOMES, NATURAL HISTORY AND
COMPLICATIONS
• Many patients are asymptomatic
• Granular myringitis has a chronic course and
granulations may continue to grow slowly for years
,however, healing may happen spontaneously.
• The inflammation in the epithelial layer and lamina
propria of the tympanic membrane sometimes leads to
replacement with proliferating granulation tissue,
fibrosis and an atresia forming from the medial part of
the ear canal.
• When the fibrosis and atresia has extended laterally,
the atresia ceases to grow.
30. • Topical treatment with ear drops containing steroids and antibiotic
and/or antifungal agents based on the results from the culture
should be given
• The treatment should be continued for a longer period than in otitis
externa.
• Various antiseptic agents have been employed, but none of them
have been evaluated in a controlled way.
• A solution of 0.5 percent formalin or trichloroacetic acid applied
once a week has been given, with good results
• Strong caustic agents may harm the fibrous middle layer of the
eardrum and should be avoided.
• Removal of granulations by physical methods should be considered
if conservative treatment fails.
• If a perforation does happen, immediate repair with the temporalis
fascia should be carried out.
32. Benign necrotizing otitis externa
Benign necrotizing otitis externa is the clinical
condition of idiopathic necrosis of a localized
area of bone of the tympanic ring, with
secondary inflammation of the
verlying soft tissue and skin
OTHER NAMES--
•Benign necrotizing otitis externa;
•Benign necrotizing osteitis of the external
auditory meatus canal;
•Benign osteonecrosis of the external auditory
meatus;
•Aseptic necrosis of the external auditory meatus;
•Idiopathic tympanic bone necrosis;
•Necrosis and sequestration of the tympanic bone;
•Necrosis and sequestration of the tympanic part
of the temporal bone;
•Focal or circumscribed osteonecrosis of the
external auditory meatus.
33.
34.
35. Malignant otitis externa
Malignant otitis externa is
an aggressive and
potentially life-threatening
infection of the soft tissues
of the external ear and
surrounding structures,
quickly spreading to involve
the periostium and bone of
the skull base.