Diabetic foot infections and ulcers are common complications of diabetes that occur due to peripheral neuropathy, peripheral artery disease, and immune dysfunction caused by hyperglycemia. Risk factors include prior ulcers or amputations, foot deformities, and peripheral artery disease. Evaluation involves assessing infection severity, underlying bone involvement, and vascular status. Management requires wound debridement and dressings, antimicrobial therapy, glycemic control, and possible surgery. Close follow up is needed to monitor treatment response and detect any need for treatment modifications.
The Diabetic Foot: What You Need to KnowOmar Haqqani
Authored by Dr. Jeffrey Stone, DPM. Presented at the First Annual Omar P. Haqqani MD Vascular Symposium, November 10, 2106, Midland Country Club, Midland, MI.
The Diabetic Foot: What You Need to KnowOmar Haqqani
Authored by Dr. Jeffrey Stone, DPM. Presented at the First Annual Omar P. Haqqani MD Vascular Symposium, November 10, 2106, Midland Country Club, Midland, MI.
Diabetic foot refers to a range of complications that can occur in individuals with diabetes, particularly those who have poor blood sugar control over an extended period of time. It is a serious condition that can lead to various foot problems, such as ulcers, infections, and even amputations if not properly managed.
The underlying cause of diabetic foot is neuropathy, which is nerve damage that occurs due to high blood sugar levels. Neuropathy can lead to loss of sensation in the feet, making it difficult for individuals to detect injuries or areas of pressure. Additionally, diabetes can impair blood circulation, which reduces the body's ability to heal wounds effectively.
Nephritis is a inflammation of kidney .
It is classified into various types like lupus nephritis ,interstitial nephritis , glomerulonephritis ,pyelonephritis.
Lupus nephritis is an inflammation of kidney due to autoimmune disorder named as lupus .
It is inflammation of lower urinary tract .
Vascular ulcers presented to the department of surgery, Niger Delta University Teaching Hospital, Okolobiri, Bayelsa State, Nigeria as resident postgraduate presentation
Vascular ulcers presented as part of surgery resident postgraduate seminar to the department of surgery, Niger Delta University Teaching Hospital, Okolobiri, Bayelsa State, Nigeria
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
3. Introduction: Diabetic Foot Ulcers
and Infections
• Most common problem in persons with
diabetes.
• Lifetime risk of a foot ulcer in Diabetes
patients: 25 %
• Account for approximately 25 percent of all
hospital stays for patients with diabetes
4. Risk factors
• Local trauma and/or pressure
• Prior ulcers or amputations
• Infection
• Effects of chronic ischemia, due to peripheral
artery disease
• Patients with diabetes also have an increased
risk for nonhealing related to mechanical and
cytogenic factors
5. Aetiopathogenesis
• Peripheral neuropathy and peripheral arterial
disease (PAD) (or both) play a central role
• Diabetic Foot Ulcers are classified as:
– Neuropathic
– Ischaemic
– Neuroischaemic
10. Peripheral Arterial Disease (PAD)
• People with diabetes are twice as likely to have PAD as
those without diabetes.
Macroangiopathy : atherosclerosis of arteries
Microangiopathy : increased and abnormal basement
membrane thickening and endothelial proliferation
Leads to capillary damage and release of ROS
Leading to decreased blood flow ---- poor antibiotic
penetration -- poor wound healing
11. Immune Dysfunction
Hyperglycemia impairs neutrophil function and
reduces host defenses.
• Persistently high pro-inflammatory cytokines
and proteases concentration
• Degrade growth factors, receptors and matrix
proteins
• Decreased PMNs migration and phagocytosis
• Decreased chemotaxis and intracellular killing
14. Microbiology
• Most diabetic foot infections are polymicrobial
• Superficial diabetic foot infections :likely due
to aerobic gram-positive cocci.
• Ulcers that are deep, chronically infected
and/or previously treated with antibiotics are
more likely to be polymicrobial.
15. • Wounds with extensive local inflammation,
necrosis, malodorous drainage, or gangrene
with signs of systemic toxicity should be
presumed to have anaerobic organisms in
addition to the above pathogens.
16. Risk of specific organism
• MRSA: Prior antibiotic use, previous hospitalization,
and residence in a long-term care facility.
• Pseudomonas aeruginosa :Macerated ulcers, foot
soaking, and other exposure to water or moist
environments.
• Resistant enteric gram-negative rods: patients with
prolonged hospital stays, prolonged catheterization,
prior antibiotic use, or residence in a long-term care
facility.
17. Ulcer classification
University of Texas system
Grade 0: Pre- or postulcerative
Grade 1:Full-thickness ulcer not involving tendon, capsule, or bone
Grade 2: Tendon or capsular involvement without bone palpable
Grade 3: Probes to bone
• STAGE:
●A: Noninfected
●B: Infected
●C: Ischemic
●D: Infected and ischemic
26. Clinical manifestation
Diabetic foot infections typically take one of
the following forms:
• Localized superficial skin involvement at the
site of a preexisting lesion
• Deep-skin and soft-tissue infections
• Acute osteomyelitis
• Chronic osteomyelitis
27. History
• Duration of diabetes
• Glycemic control
• Presence of micro- or macrovascular disease
• History of prior foot ulcers, lower limb
bypasses or amputation
• Presence of claudication
• History of cigarette smoking
28. Physical examination
Assessment for the presence of
• existing ulcers
• peripheral neuropathy
• loss of protective sensation
• peripheral artery disease, and
• foot deformities
– claw toes and
– Charcot arthropathy
29.
30. Examination of Ulcer
• Predominantly neuropathic, ischaemic or
neuroischaemic?
• Is there critical limb ischaemia?
• Any musculoskeletal deformities?
• Ulcer Characteristics:
size/depth/location/wound bed
• wound infection
• status of the wound edge
31. Screening tests for peripheral neuropathy
• Vibration sensation
• Pressure sensation
• Superficial pain (pinprick) or temperature
sensation
• Scoring Systems
32. The Tuning Fork Test
• 128Hz tuning Fork used
• Placed on the interphalangeal joint of the
right hallux and compared with dorsal wrist.
– Severe Deficit: no senation in hallux
– Mild/Moderate: vibration feels stronger at the
wrist
– Normal: vibration feels no different at the wrist.
34. • Procedure:
– Quiet Surrounding
– Eyes Closed for the test
– Supine position
– Testing in inner aspect of arm/hand
– Apply the monofilament perpendicular to the skin
surface with sufficient force to bend it
– Ask: whether they felt it?/Where they felt it?
– Duration: 2 secs
– 3 applications in each site with at least 1 mock
35. • Inference:
– Protective sensation is present at each site if the
patient correctly answers two out of three
applications
– Protective sensation is absent with two out of
three incorrect answers
36. Scoring Systems for Peripheral
Neuropathy
• The San Antonio Consensus
• The Mayo Clinic criteria
• The Toronto criteria
• United Kingdom screening test
• Michigan Neuropathy Screening Instrument
37. Feldman EL, Stevens MJ, Thomas PK, et al. A practical two-step quantitative clinical and
electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes
Care 1994; 17:1281.
38. Physical signs of peripheral artery disease
• diminished foot pulses,
• decrease in skin temperature,
• thin skin,
• lack of skin hair, and
• bluish skin color
39. Quantitative clinical tests:
• measurement of venous filling time
• Doppler examination of lower limb pulses
• leg blood pressure measurements (eg, ankle-
brachial pressure index [ABI])
40. Diagnosis of Diabetic Foot Infection
• Primarily based on suggestive clinical manifestations
• The presence of two or more features of inflammation
(erythema, warmth, tenderness, swelling, induration
and purulent secretions) can establish the diagnosis
• Presence of microbial growth from a wound culture in
the absence of supportive clinical findings is not
sufficient to make the diagnosis of infection
41. Diagnosis of underlying osteomyelitis
• Grossly visible bone or ability to probe to bone
• Ulcer size larger than 2 cm2
• Ulcer duration longer than one to two weeks
• Erythrocyte sedimentation rate (ESR) >70 mm/h
• A conventional radiograph with consistent
changes can be helpful in making the
diagnosis ((MRI), which is highly sensitive and
specific for osteomyelitis )
• Culture of bone biopsy specimens is also
important for identifying the causative organisms
43. Determination of severity
• Assessment of the severity of diabetic foot
infections is important for prognosis and to
assist with management decisions (eg, need
for hospitalization, surgical evaluation, or
parenteral versus oral antibiotic therapy)
44. Infectious Diseases Society of America and International Working Group on the Diabetic Foot
Classifications of Diabetic Foot Infection
45. Management
Management of diabetic foot infections
requires:
• Attentive wound management
• Good nutrition
• Appropriate antimicrobial therapy
• Glycemic control, and
• fluid and electrolyte balance.
46. Wound management
• Local wound care for diabetic foot infections typically
includes debridement of callus and necrotic tissue, wound
cleansing, and relief of pressure on the ulcer
DEBRIDMENT:
• Debridement is essential for ulcer
healing
• choice of debridement
– sharp,
– enzymatic,
– autolytic,
– mechanical, and
– biological)
Fig: Neuropathic ulcer
Top: Pre debridement
Bottom: Post debridement
47. DRESSINGS
• After debridement, ulcers should be kept clean
and moist but free of excess fluids
• Dressings should be selected based upon ulcer
characteristics, such as the extent of exudate,
desiccation, or necrotic tissue
Adjunctive local therapies :
• negative pressure wound therapy (NPWT)
• use of custom-fit semipermeable polymeric
membrane dressings
• cultured human dermal grafts
• application of growth factors
48. • Wound Management Dressing Guide
International Best Practice Guidelines: Wound Management in Diabetic Foot Ulcers.
50. Surgery
Required for cure of infections complicated by
• abscess,
• extensive bone or joint involvement,
• crepitus, necrosis, gangrene or necrotizing fasciitis
• And for source control in patients with severe sepsis
In addition to surgical debridement, revascularization (via
angioplasty or bypass grafting) and/or amputation may
be necessary.
51. Antimicrobial therapy
EMPERIC THERAPY:
Mild infection: Outpatient oral antimicrobial
therapy.
Should include activity against skin flora
including streptococci and S. aureus
Agents with activity against methicillin-resistant S.
aureus (MRSA) should be used in patients with
purulent infections and those at risk for MRSA
infection
52. • Moderate infection: Deep ulcers with extension to
fascia. Should include activity against
streptococci, S. aureus (and MRSA if risk factors
are present), aerobic gram-negative bacilli and
anaerobes
– can be administered orally
• Empiric coverage for P. aeruginosa may not
always be necessary unless the patient has
particular risk for involvement with this organism,
such as a macerated wound or one with
significant water exposure
53. Severe infection: Limb-threatening diabetic foot
infections and those that are associated with
systemic toxicity should be treated with
broad-spectrum parenteral antibiotic therapy
In most cases, surgical debridement is also
necessary.
54.
55. Duration of therapy
• Mild infection should receive oral antibiotic
therapy in conjunction with attentive wound
care until there is evidence that the infection
has resolved (usually about one to two weeks)
• Patients with infection also requiring surgical
debridement or amputation should receive
intravenous antibiotic therapy perioperatively
56. • In case of osteomyelitis:
• No data support the superiority of specific
antimicrobial agents for osteomyelitis
• Appropriate regimens for empiric therapy are
similar to that for moderate to severe diabetic
foot infections
• Therapy should be tailored to culture and
sensitivity results, ideally from bone biopsy.
• Patients who were initiated on parenteral
therapy, a switch to an oral regimen is
reasonable following clinical improvement
57. Extensive surgical debridement or resection is
preferable in the following clinical circumstances
• Persistent sepsis without an alternate source
• Inability to receive or tolerate appropriate
antibiotic therapy
• Progressive bone deterioration despite
appropriate antibiotic therapy
• Mechanics of the foot are compromised by
extensive bony destruction requiring correction
• Surgery is needed to achieve soft tissue wound or
primary closure
59. Follow-up
• Close follow-up is important to ensure
continued improvement and to evaluate the
need for modification of antimicrobial
therapy, further imaging, or additional surgical
intervention
60. Summary
• Hyperglycemia, sensory and autonomic
neuropathy, and peripheral arterial disease all
contribute to the pathogenesis of lower
extremity infections in diabetic patients
• Evaluation of a patient with a diabetic foot
infection involves determining the extent and
severity of infection through clinical and
radiographic assessment
61. • The presence of two or more features of inflammation
(erythema, warmth, tenderness, swelling, induration,
or purulent secretions) can establish the diagnosis of a
diabetic foot infection. The definitive diagnosis of
osteomyelitis is made through histologic and
microbiologic evaluation of a bone biopsy sample
• Management of diabetic foot infections requires
attentive wound management, good nutrition,
antimicrobial therapy, glycemic control, and fluid and
electrolyte balance
62. References::
• Lipsky BA, et al. 2012 Infectious Diseases Society of
America clinical practice guideline for the diagnosis and
treatment of diabetic foot infections. Clin Infect Dis
2012; 54:e132.
• International Best Practice Guidelines: Wound
Management in Diabetic Foot Ulcers. Wounds
International, 2013.
• Gulf Diabetic Foot Working Group. Identification and
management of infection in diabetic foot ulcers:
International consensus. Wounds International 2017.
• www.uptodate.com
• Internet
Pancreas:
Retroperitoneal organ; Posterior to stomach ant L1-2 level.
Blood Supply: Splenic Artery (pancreatic branches); Superior pancreaticoduodenal and inferior Pancreaticoduodenal arteries.
Portal Vein
Diabetes mellitus is a disorder that primarily affects the microvascular circulation. Impaired microvascular circulation hinders white blood cell migration into the area of infection and limits the ability of antibiotics to reach the site of infection in an effective concentration
1st point:(often in association with lack of sensation because of neuropathy)
foot deformities (such as hammer toes and claw foot)
International Best Practice Guidelines: Wound Management in Diabetic Foot Ulcers. Wounds International,2013.
Superficial:Gram Positive Cocci:
Staphylococcus aureus,
Streptococcus agalactiae,
Streptococcus pyogenes, and
coagulase-negative staphylococci.
Deep Chronically infected:
Gram +ve cocci and: Enterococci, Enterobacteriaceae, Pseudomonas aeruginosa, and anaerobes.
anaerobic streptococci, Bacteroides species, and Clostridium species
developed for use in both diabetic and non-diabetic patients, using a classification system of ‘the threatened lower limb’ and includes
infection as one of its elements.
validated and adopted by the Society for Vascular Surgery
Charcot arthropathy:::characterized by collapse of the arch of the midfoot and abnormal bony prominences )
Ulcer Characteristics:
size/depth/location of the wound?
colour/status of the wound bed?: Black (necrosis)/ Yellow/ red/ pink
any exposed bone?
any necrosis or gangrene?
Wound infection:
If so, are there systemic signs and symptoms of infection
any malodour?/ local pain?/
exudate? level of production (high, moderate, low, none), colour and consistency of exudate, and is it purulent?
What is the status of the wound edge
(callus, maceration, erythema, oedema, undermining)?
Vibration testing is typically conducted with a 128 Hz tuning fork applied to the bony prominence at the dorsum of the first toe, just proximal to the nail bed.
Pressure sensation The Semmes-Weinstein monofilament test
Tests Vibration sensation
Apply the monofilament along the perimeter of (not on) the ulcer site
Do not allow the monofilament to slide across the skin or make repetitive contact at the test site
The total duration of the approach (skin contact and removal of the monofilament) should be around 2 seconds
San Antonio Consensus statement:: in 1988, a group of diabetologists and neurologists proposed a comprehensive set of criteria, to diagnose and monitor diabetic neuropathy
Toronto Criteria:: consensus panel convened in Toronto in 2009 and advocated that, for controlled clinical trials and epidemiologic studies of diabetic neuropathy, nerve conduction studies are needed for accurate assessment, and are coupled with assessments of symptoms and signs
A score greater than 2 indicated neuropathy with both a high specificity (95 percent) and sensitivity (80 percent)
Foot Pulses: Dorsalis Pedis and Posterior Tibial
Infectious Diseases Society of America and International Working Group on the Diabetic Foot Classifications of Diabetic Foot Infection
Enzymatic debridement (topical application of proteolytic enzymes such as collagenase) may be more appropriate in certain settings (eg, extensive vascular disease not under team management
Autolytic debridement may be a good option in patients with painful ulcers, using a semiocclusive or occlusive dressing to cover the ulcer so that necrotic tissue is digested by enzymes normally present in wound tissue.
Empiric therapy should include activity against streptococci, MRSA, aerobic gram-negative bacilli, and anaerobes
Antibiotics need not be administered for the entire duration that the wound remains open
In the absence of osteomyelitis, (two to four weeks of therapy is usually sufficient).