Vascular ulcers presented as part of surgery resident postgraduate seminar to the department of surgery, Niger Delta University Teaching Hospital, Okolobiri, Bayelsa State, Nigeria
Lecture on haemorrhoids for medical students. Encompasses basic sciences, classifications, principles and tips of management of this very common yet potentially complicated disorder.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
3. Introduction
• is the loss of continuity of the skin or mucous
membrane1
An ulcer
• underlying vascular pathology
Vascular ulcers
Chronic or recurrent
• Location
• Appearance
• Bleeding and
• Associated pain and findings1
Distinct:
4. Epidemiology
• 500,000 to 600,000 and increases in age2
Prevalence US estimates
• estimates – 1%
• 80% thought to be venous
Ireland and Australia1
5. Epidemiology contd Chronic Leg Ulcer
Vascular Malignant Infective Trauma
56.7%
31.7%
Rahman GA et al2
3.3%
3.3%
7. Venous ulcers
A venous ulcer is an open skin lesion of the leg or foot
that occurs in an area affected by venous hypertension3
Most common cause of leg ulcers
• 60 – 80% of leg ulcers
Prevalence
• 0.18% and 1%
• 4% over age 65years4
8. Risk factors to developing Venous ulcers3,4
• Older age
• Female sex
• Obesity
• Trauma
• Pregnancy
• Estrogen
• Prolonged standing
• Congenital absence of veins
• Deep vein thrombosis (DVT), phlebitis,
• Varicose veins
Include
12. Arterial ulcer
• Ischemic ulcer is an open skin lesion of the leg or foot that
occurs in an area with underlying peripheral vascular disease
(PVD)
Ischemic ulcers
• 6% of vascular ulcers
Ischemic ulcers
• men older than 45 and
• women older than 55
PVD
• Atherosclerotic disease of medium and large sized arteries5
Most common cause
14. Risk factors6
• Age
• Family history of PAD
Non modifiable
• Smoking
• Diabetes
• Hyperlipidaemia
• Hypertension
• Obesity
• Sedentary lifestyle
Modifiable
16. Ankle brachial index7
• Non invasion diagnosis test
• Compares blood pressures in
upper and lower limb
• Determine presence of lower limb
PAD
Ankle brachial index
Value Interpretation
0 – 0.4 Severe PAD sufficient to cause resting pain or gangrene
0.41 – 0.9 PAD sufficient to cause claudication
0.91 –
1.30
Normal vessels
>1.30 Noncompressible, severely calcified vessel
17. Classification – Society for Vascular Surgery WIFI6
Wound
Grade Ulcer Gangrene
0 No ulcer No gangrene
1 Small, shallow ulcer on distal leg or foot; no exposed bone,
unless limited to distal phalax
No gangrene
2 Deeper ulcer with exposed bone, joint or tendon, generally not
involving the heel; shallow heel ulcer without calcaeneal
involvement
Gangrenous changes limited to digits
3 Extensive, deep ulcer involving forefoot and/or midfoot; deep
full thickness heel ulcer +- calcaneal involvement
Extensive gangrene involving the
forefoot/midfoot; full thickness heel
necrosis +- calcaneal involvement
Ischemia
Grade ABI Ankle systolic pressure
0 >= 0.8 >100mmHg
1 0.6 – 0.79 70 – 100mmHg
2 0.4 – 0.59 50 – 70mmHg
3 <= 0.39 <50mmHg
18. Infection
Grade Clinical manifestation of infection
0 No symptoms or signs of infection
1 Local infection involving only the skin and the subcutaneous tissue
2 Local infection with erythema >2 cm, or involving structures deeper than skin and
subcutaneous tissues, and no systemic inflammatory response signs
3 Local infection with the signs of SIRS, as manifested by two or more of the following:
• Temperature > 38 or < 36°C
• Heart rate > 90 beats/min
• Respiratory rate > 20 breaths/min or PaCO2 < 32 mm Hg
• White blood cell count > 12,000 or < 4,000 cu/mm or 10% immature bands
Interpretation (Risk of amputation at 1 year)
Total score
0 – 1 Very low
2 Low
3 Moderate
4+ High
20. History
Biodata Sex and Age
Complain Chronicity
Course Associations Pain
Cause (risk
factors)
Venous Vs Arterial
Care
Complications
Effect on work
Quality of life
21. • General examination
• Regional lymph nodes
• Assess for obesity
• Peripheral neuropathy
• Peripheral pulses
• Documentation of the size of the ulcer and
photographs
• Characterization of the ulcers
Physical Examination
22. Venous ulcers5
• 95% in the gaiter area of the leg, characteristically around the
malleoli
Location
• Irregular and gently sloping edges
Shape/edges
• Slough and granulation tissue
Ulcer bed
• Pitting edema, may predate the ulcer
Edema
Presence of exudation
Presence of varicose veins
v
33. Wound care9,5
Dressing
• use a dressing that will maintain a moist wound-healing
environment
• Has ability to absorb exudates and protect periwound skin
Debridement
• Thorough serial debridement and irrigation
Infection control
• Empirical antibiotics and tailor to narrow spectrum in line with
sensitivity
35. Advanced Wound Care
A large, growing array of therapies have been developed . . .
Bioengineered Alternative Tissues
Bio-Active Wound Adjuncts:
• Oasis
• Porcine intestinal submucosa
• Epifix
• Dried human amniotic membrane
Living Tissues / Growth Factors:
• Regranex (becaplermin)
• Platelet derived growth factor topical
• Apligraf
• Living human dermal fibroblasts and epidermal keratinocytes in bovine collagen matrix
36.
37. Arterial ulcer
Prior to revascularization, an anatomic road map should be obtained9
Options include:
Angiogram9
Duplex Angiography9,
• Femoropopliteal segment
• Sensitivity 99%, Specificity 94%
• Tibial segment
• Sensitivity 80% Specificity 91%
Magnetic Resonance Angiography9
Contrast Tomography Angiography9
38. Surgical options
• Reconstructive surgery (arterial bypass)5
Diffuse disease
• Angioplasty5
Local stenosis
• Non healing ulceration
• Gangrene
• Rest pain
• Progression of disabling claudication
Indication6
39. Wound care9,5
Dressing
• use a dressing that will maintain a moist wound-healing environment.
• Dry gangrene or eschar is best left dry until revascularization is successful
Debridement
• Debridement of nonviable and noninfected tissue is performed ONLY AFTER the
revascularization procedure.
• Prerevascularization debridement should be indicated only in a septic foot with
and without ischemic signs
• Should be minimal
Infection control
• Empirical antibiotics and tailor to narrow spectrum in line with sensitivity
40. Adjuvant treatment
Hyperbaric Oxygen therapy9
• In patients with nonreconstructable anatomy
• Non healing ulcer despite revascularization
Indications
• Increase tissue oxygen
• Increase angiogenesis in hypoxic or injured tissue
• Increase signal transduction between growth factors and
receptors
Benefits
41. Others
Control of DM, hyperlipidaemia, hypertension etc
Cessation of smoking
Patients may find benefits from sleeping in a bed raised at the head end
Opioid for pain
43. Guidelines for patients on protecting lower
limbs and feet5
• Examine the feet daily for broken skin, blisters, swelling, or redness
• Report worsening symptoms—for example, decreasing walking
distance, pain at rest, pain at night, changes in skin colour
• Never walk barefoot
• Ensure shoes are well fitting and free of friction and pressure points;
check them for foreign objects (such as stones) before wearing; and
avoid open toed sandals and pointed shoes
• Give up smoking
• Take regular exercise within limits of pain and tolerance
• Weight reduction
44.
45. Conclusion
Management of patients with vascular ulcers has to be multidisciplinary
Should include
• Detailed history
• Physical examination
• Appropriate investigations
• Basic and newer treatment modalities
While educating patients on issues of correct skin care and the
importance of seeking early medical advice
46. References
1. Allen Gabriel et al: Vascular Ulcers – Practical Essentials,
Epidemiology, Etiology. https://emedicine.Medscape.com. 17th
August 2021
2. G.A. Rahman et al: Epidemiology, Etiology and Treatment of Chronic
Leg Ulcers: Experience of 60 patients. Annals of African Medicine
Vol. 9, No. 1, 2010:1-4. DOI: 10:4103/1596-3519.62615
3. Deborah A Simon et al:Management of venous leg ulcers. BMJ
VOLUME 328 5 JUNE 2004 bmj.com
4. Biju Vasudevan: Venous leg ulcers: Pathophysiology and
Classification. Indian Dermatology Online Journal - July-September
2014 - Volume 5 - Issue 3. DOI: 10.4103/2229-5178.137819
5. Joseph E Grey, Stuart Enoch, Keith G Harding: ABC of wound healing
Venous and arterial leg ulcers. BMJ 2006;332:347–50 bmj.com
Considerable amount of morbidity among patients with peripheral vascular disease including work incapacity
The care of chronic vascular ulcers places a significant burden on the patient and the healthcare system
Prevalence US estimates – 500,000 to 600,000 and increases in age2
Ireland and Australia estimates – 1%
80% thought to be venous
Venous Disease: 72%
Arterial Disease: 6%
Mixed Arterial/Venous: 22%
Exact prevalence in Nigeria unknown but
Rahman GA et al – study of CLU in 60 patients over a 3 years period in University of Ilorin Teaching Hospital
They are the most common cause of leg ulcers, accounting for 60-80% of them.[2] The prevalence of VLUs is between 0.18% and 1%.[3] Over the age of 65, the prevalence increases to 4%.[4] On an average 33-60% of these ulcers persist for more than 6 weeks and are therefore referred to as chronic VLUs.
family history, female gender, pregnancy, estrogen,
prolonged standing, sitting postures, and obesity
The deep veins of the lower limbs are located in the deep compartment of the leg bound by the muscle fascia and accompany the main arteries of the leg and pelvis.
Superficial veins of the lower limbs are those located between the deep fascia covering the muscles of the limb and the skin and primarily included the saphenous system.
Perforating veins pass through the deep muscle fascia and connect the superficial to the deep venous system.
Communicating veins connect veins within the same system
CEAP classification
Peripheral vascular disease is most common in men older The most common cause is atherosclerotic disease of the medium and large sized arteries. Other causes include diabetes, thromboangiitis, vasculitis, pyoderma gangrenosum, thalassaemia, and sickle cell disease, some of which may predispose to the formation of atheromathan 45 and women older than 55
Modifiable
risk factors for peripheral vascular disease include smoking,
hyperlipidaemia, hypertension, diabetes, and obesity, with
associated decreased activity
Procedure:
Supine
Both brachial systolic – highest
Both Dorsalis and Posterior tibial systolic – Highest
ABI = ankle systolic/brachial systolic
Infection present, as defined by presence of at least 2 of the
Local swelling or induration
• Erythema 0.5–2 cm around the ulcer
• Local tenderness or pain
• Local warmth
• Purulent discharge (thick, opaque to white, or sanguineous secretion)
Pain – Claudication pain, pain at rest, night pain. Pain Relieved on hanging leg down the bed
Arterial: Smoking, Diabetes, Hyperlipidaemia, Hypertension, Obesity, Sedentary lifestyle, family hx of PVD, SCD
Venous: varicose veins, DVT (previous or present), Trauma, Pregnancy, Prolonged standing, phlebitis
Should be thorough bearing in the mind the possible causes/risk factors
Ninety five per cent of venous ulceration is in the gaiter area of the leg, characteristically around the malleoli. Ulceration may be discrete or circumferential. The ulcer bed is often covered with a fibrinous layer mixed with granulation tissue, surrounded by an irregular, gently sloping edge. Ulcers occurring above the mid-calf or on the foot are likely to have other origins. Pitting oedema is often present and may predate the ulcer. It is often worse towards the end of the day. Extravasation of erythrocytes into the skin occurs, resulting in the deposition of haemosiderin within macrophages, which stimulates melanin production, pigmenting the skin brown.
Extravasation of erythrocytes into the skin occurs, resulting in the deposition of haemosiderin within macrophages, which stimulates melanin production, pigmenting the skin brown
Characterised by dermal and subcutaneous induration and fibrosis, atrophic skin with surrounding hypo or hyperpigmentation
Severe lipodermatosclerosis
The toenails thicken and become opaque and may be lost.
Gangrene of the extremities may also occur
Manage exudate and protect periwound skin
Dressing should stay in place, minimize friction, not cause pain, atraumatic removal
Cost-effectiveness, ease of use, provider time
Dressings are used under compression