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DEVELOPMENT OF CNS
• The wall of neural tube at 1st has single layer
of cells. The cells multiply & form 3 layers:
1)Ependymal 2)Mantle 3)Marginal.
• Mantle layer divides into ventral part- the
basal lamina & dorsal part- the alar lamina.
These are separated by sulcus limitans.
DEVELOMENT OF MEDULLA OBLONGATA
DEVELOMENT OF MEDULLA OBLONGATA
• Develops from myelencephalon.
• Early development similar to spinal cord.
Appearance of sulcus limitans divide lateral wall
into- Alar lamina & Basal lamina
Widening of thin roof plate
As a result, alar lamina comes to lie dorso
lateral to basal lamina
Both lamina are now in floor of developing
4th ventricle.
DEVELOMENT OF MEDULLA OBLONGATA
• Cells developing in lateral part of each alar lamina
migrate ventrally & reach marginal layer overlying
ventrolateral aspect of basal lamina.
• These cells constitute caudal part of BULBO
PONTINE EXTENSION & develop into olivary
nuclei.
• The remaining cells of alar lamina develop into
sensory nuclei of CNN.
• The motor nuclei of these nerves derived from
basal lamina.
DEVELOPMENT OF PONS
DEVELOPMENT OF PONS
• Arise from:-
Ventral part of metencephalon
&
Cranial part of bulbopontine extension
(Alar lamina of myelencephalon).
--- Cranial part of bulbopontine extension give rise to Pontine
nuclei.
---ALAR LAMINA: Lateral part becomes RHOMBIC Lip
(cerebellar rudiments) &
Ventral part gives origin to sensory CNN.
---BASAL LAMINA: gives motor CNN
DEVELOPMENT OF CEREBELLUM
DEVELOPMENT OF CEREBELLUM
• Develops from dorsolateral part of alar lamina
of metencephalon(cerebellar rudiments as
rhombic lip).
• Some cells of mantle layer of cerebellum
migrate into marginal layer to form cerebellar
cortex.
• The cells of mantle layer that do not migrate
into cortex develop into- dentate, emboliform,
globose & fastigal nuclei.
• SUPERIOR cerebellar peduncle- formed by
axons growing out of dentate nucleus.
• MIDDLE cerebellar peduncle- formed by axons
growing into cerebellum from cells of pontine
nuclei.
• INFERIOR cerebellar peduncle- formed by
fibres that grow into cerebellum from spinal
cord & medulla.
DEVELOPMENT OF MIDBRAIN
• Alar lamina of mesencephalon forms colliculi,
red nucleus & substantia nigra.
• Basal lamina: oculomotor nucleus, trochlear
nerve nucleus, edinger westphal nucleus.
Development of CNS 02

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Development of CNS 02

  • 2.
  • 3.
  • 4. • The wall of neural tube at 1st has single layer of cells. The cells multiply & form 3 layers: 1)Ependymal 2)Mantle 3)Marginal. • Mantle layer divides into ventral part- the basal lamina & dorsal part- the alar lamina. These are separated by sulcus limitans.
  • 5.
  • 7. DEVELOMENT OF MEDULLA OBLONGATA • Develops from myelencephalon. • Early development similar to spinal cord. Appearance of sulcus limitans divide lateral wall into- Alar lamina & Basal lamina Widening of thin roof plate As a result, alar lamina comes to lie dorso lateral to basal lamina Both lamina are now in floor of developing 4th ventricle.
  • 8. DEVELOMENT OF MEDULLA OBLONGATA • Cells developing in lateral part of each alar lamina migrate ventrally & reach marginal layer overlying ventrolateral aspect of basal lamina. • These cells constitute caudal part of BULBO PONTINE EXTENSION & develop into olivary nuclei. • The remaining cells of alar lamina develop into sensory nuclei of CNN. • The motor nuclei of these nerves derived from basal lamina.
  • 10. DEVELOPMENT OF PONS • Arise from:- Ventral part of metencephalon & Cranial part of bulbopontine extension (Alar lamina of myelencephalon). --- Cranial part of bulbopontine extension give rise to Pontine nuclei. ---ALAR LAMINA: Lateral part becomes RHOMBIC Lip (cerebellar rudiments) & Ventral part gives origin to sensory CNN. ---BASAL LAMINA: gives motor CNN
  • 12. DEVELOPMENT OF CEREBELLUM • Develops from dorsolateral part of alar lamina of metencephalon(cerebellar rudiments as rhombic lip). • Some cells of mantle layer of cerebellum migrate into marginal layer to form cerebellar cortex. • The cells of mantle layer that do not migrate into cortex develop into- dentate, emboliform, globose & fastigal nuclei.
  • 13. • SUPERIOR cerebellar peduncle- formed by axons growing out of dentate nucleus. • MIDDLE cerebellar peduncle- formed by axons growing into cerebellum from cells of pontine nuclei. • INFERIOR cerebellar peduncle- formed by fibres that grow into cerebellum from spinal cord & medulla.
  • 14.
  • 15. DEVELOPMENT OF MIDBRAIN • Alar lamina of mesencephalon forms colliculi, red nucleus & substantia nigra. • Basal lamina: oculomotor nucleus, trochlear nerve nucleus, edinger westphal nucleus.