Dendrimers

1. DENDRIMERS
PRESENTED BY
MUHAMMAD ASHFAQ

2. DENDRIMERS
•Greek words
•Dendron means Tree
•Meros means Part
•Discovered by Donald Tomalia and co-workers in
1980
•Also called Arboroles or Cascades molecules
•Nanosized, highly branched, 3D molecules

3. STRUCTURE OF DENDRIMER
•An interior core
•Interior layers composed of repeating units
radically attached to core
•Exterior layers attached to interior generations

5. PROPERTIES OF DENDRIMERS
• Monodispersity
• Monoscale size and shape
• High aquous solubility
• Viscosity
• High solubility in non-polar solutions
• Non crystalline and low glass temperature
• Low compressibility

6. SYNTHESIS
Two methods
1.Divergent method
2.Convergent method

7. DIVERGENT METHOD
•Dendrite grows from core to periphery
•The core molecule reacts with monomer
molecule having two dormant and one reactive
group

8. CONVERGENT METHOD
•Dendrite grows starting from end groups and
progresses inward
•Small molecules come together and reaction
proceeds inward
•Eventually the molecules becomes attached to
the core
•Easier impurity removal

10. DRUG LOADING
•Simple encapsulation
•Electrostatic interaction
•Covalent conjugation

11. DRUG DELIVERY
•In-vivo degradation of drug dendrimer
•Drug release due to change in physical
environment
•Temperature change
•PH change

12. APPLICATIONS
•Solubility Enhancers
•Genes transfection
•Nano drug
•Dendrimers as nanoparticles
•Hydrogel for ocular drug delivery
•Transdermal drug delivery
•Targeted drug delivery

13. COMMON DENDRIMERS
•Polyamidoamine (PAMAM)
•Poly propylene imine (PPI)
•TECTO dendrimer
•PAMAMOS dendrimer

15. FOR DETAIL STUDY
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097927/