The document discusses types of dementia like Alzheimer's disease and provides details about its pathophysiology and diagnostic criteria. It notes the growing prevalence of dementia worldwide and defines the condition. It describes the amyloid cascade hypothesis of Alzheimer's and discusses current and potential future treatments like cholinesterase inhibitors and memantine.
Michelle Peck | Legal Nurse | Nurse Practitioner | Health Care | Geriatric | Consultant | Speaker | Educator | Researcher
During your journey through this slide deck of the geriatric populations 3 D’s, you will experience: the difference between geriatric dementia, geriatric delirium and geriatric depression; the global impact of dementia and the importance of a quality diagnosis; and the dementia assessment, management and treatment options.
The links in this slide deck lead you to expert geriatric teaching tools and videos that you will value and love.
According to the World Alzheimer Report if dementia care were a country, it would be the world’s 18th largest economy. The worldwide costs of dementia exceeded 1% of global GDP in 2010, at US$604 billion. If dementia were a company, it would be the world’s largest by annual revenue exceeding Wal-Mart (US$414 billion) and Exxon Mobil (US$311 billion). Geriatric populations are increasing and Alzheimer’s in the USA will ALMOST TRIPLE BY 2050. Let’s stay informed!
Learn it-Live it-Love it-Your path for a more informed life!
Michelle Peck | Legal Nurse | Nurse Practitioner | Health Care | Geriatric | Consultant | Speaker | Educator | Researcher
SO GUYS ONCE AGAIN HERE I PRESENT U THE OWN MADE PRESENTATION ON THE TOPIC DEMENTIA I HOPE U LIKE THAT IT IS BEEN USEFUL U WHILE MAKING PSYCHIATRIC PRESENTATION
The world’s population is ageing rapidly, and with it is coming to a significant increase in the number of
older people with dementia. This increase presents major challenges for the provision of healthcare
generally and for dementia care in particular, for as more people have dementia, there will be more
people exhibiting behavioural and psychological symptoms of dementia (BPSD).
BPSD exact a high price from both the patient and the caregiver in terms of the distress and disability
they cause if left untreated. BPSD is recognisable, understandable and treatable. The recognition and
appropriate management of BPSD are important factors in improving our care of dementia patients
and their caregivers,
Presentation delivered by Dr. Carol Manning at the live webinar hosted by AlzPossible at www.alzpossible.org on the 17th of March, 2014.
www.alzpossible.org
Presentation made March 17, 2017 and hosted by AlzPossible - www.alzpossible.org.
Review recording at http://alzpossible.org/webinars-2/the-basics-memory-loss-dementia-and-alzheimers-disease/
The word delirium means “out of one’s furrow” which refers to the dramatic behavior changes that the person may experience. Some have called delirium "brain failure” because it may represent a variety of caused such as heart failure does in cardiac health.
Delirium is an outcome of a general medical condition, head injury and drug intoxication or withdrawal.
Dementia consists of verity of symptoms that suggest chronic dysfunction. Global impairment of intellect is the essential feature, manifested as difficulty with memory, attention, thinking, and comprehension
Approximately 15% of people with dementia have reversible illness if treatment is initiated before irreversible damage takes place.
Dementia is a broad term which describes symptoms affecting memory, thinking ability that creates hindrance in performing daily activities. Two important brain functions are badly hit namely- memory and judgement.
Michelle Peck | Legal Nurse | Nurse Practitioner | Health Care | Geriatric | Consultant | Speaker | Educator | Researcher
During your journey through this slide deck of the geriatric populations 3 D’s, you will experience: the difference between geriatric dementia, geriatric delirium and geriatric depression; the global impact of dementia and the importance of a quality diagnosis; and the dementia assessment, management and treatment options.
The links in this slide deck lead you to expert geriatric teaching tools and videos that you will value and love.
According to the World Alzheimer Report if dementia care were a country, it would be the world’s 18th largest economy. The worldwide costs of dementia exceeded 1% of global GDP in 2010, at US$604 billion. If dementia were a company, it would be the world’s largest by annual revenue exceeding Wal-Mart (US$414 billion) and Exxon Mobil (US$311 billion). Geriatric populations are increasing and Alzheimer’s in the USA will ALMOST TRIPLE BY 2050. Let’s stay informed!
Learn it-Live it-Love it-Your path for a more informed life!
Michelle Peck | Legal Nurse | Nurse Practitioner | Health Care | Geriatric | Consultant | Speaker | Educator | Researcher
SO GUYS ONCE AGAIN HERE I PRESENT U THE OWN MADE PRESENTATION ON THE TOPIC DEMENTIA I HOPE U LIKE THAT IT IS BEEN USEFUL U WHILE MAKING PSYCHIATRIC PRESENTATION
The world’s population is ageing rapidly, and with it is coming to a significant increase in the number of
older people with dementia. This increase presents major challenges for the provision of healthcare
generally and for dementia care in particular, for as more people have dementia, there will be more
people exhibiting behavioural and psychological symptoms of dementia (BPSD).
BPSD exact a high price from both the patient and the caregiver in terms of the distress and disability
they cause if left untreated. BPSD is recognisable, understandable and treatable. The recognition and
appropriate management of BPSD are important factors in improving our care of dementia patients
and their caregivers,
Presentation delivered by Dr. Carol Manning at the live webinar hosted by AlzPossible at www.alzpossible.org on the 17th of March, 2014.
www.alzpossible.org
Presentation made March 17, 2017 and hosted by AlzPossible - www.alzpossible.org.
Review recording at http://alzpossible.org/webinars-2/the-basics-memory-loss-dementia-and-alzheimers-disease/
The word delirium means “out of one’s furrow” which refers to the dramatic behavior changes that the person may experience. Some have called delirium "brain failure” because it may represent a variety of caused such as heart failure does in cardiac health.
Delirium is an outcome of a general medical condition, head injury and drug intoxication or withdrawal.
Dementia consists of verity of symptoms that suggest chronic dysfunction. Global impairment of intellect is the essential feature, manifested as difficulty with memory, attention, thinking, and comprehension
Approximately 15% of people with dementia have reversible illness if treatment is initiated before irreversible damage takes place.
Dementia is a broad term which describes symptoms affecting memory, thinking ability that creates hindrance in performing daily activities. Two important brain functions are badly hit namely- memory and judgement.
This PPT contains all the important guidelines that are needed to manage a patient of Dementia. It involves diagnosis, psychosocial treatment, non-pharmacological management and pharmacological management. This PPT is prepared from NICE, APA and SIGN guidelines.
الطّباعة ثلاثيّة الأبعاد هي إحدى تقنيات التصنيع، حيث يتم تصنيع القطع عن طريق تقسيم التصاميم ثلاثية الأبعاد لها إلى طبقات صغيرة جدا باستخدام برامج الحاسوبية ومن ثم يتم تصنيعها باستخدام الطابعات ثلاثية الأبعاد عن طريق طباعة طبقة فوق الأخرى حتى يتكون الشكل النهائي.
تعريف الاقتصاد الرقمي
يعرف الاقتصاد الرقمي بأنه هو النشاط الناتج عن الاتصالات اليومية عبر الإنترنت، كما أن العمود الفقري له هو الارتباط التشعبي، ويعني تزايد الارتباط والترابط بين الأشخاص والمؤسسات والآلات، وتكنولوجيا الهاتف المحمول وإنترنت الأشياء. وهو عموما عبارة عن تصور لقطاع الأنشطة الاقتصادية ذات الصلة بالتقنية الرقمية. وتكون هذه الأنشطة مبنية على النماذج الاقتصادية الكلاسيكية أو الحديثة مثل نماذج الويب
التهديد المستمر المتقدم (Advanced persistent threat): هو مصطلح واسع يستخدم لوصف عملية هجوم يقوم فيها دخيل أو فريق من المتسللين بإنشاء وجود غير قانوني طويل الأمد على الشبكة من أجل استخراج البيانات شديدة الحساسية.
As we are getting further from the 20th century many historical facts become clearer and clearer. Looking at the past century in perspective helps us to figure out our way forward. Jung and Frankl urged humanity to assimilate the devastation of the two World Wars by taking personal responsibility, and become aware of our projections, such as nationalism. They insist that reason is not enough to prevent future tragedies. These post-World War issues were never dealt with by humanity, just swept under the rug, as in the second half of the 20th century psychiatry identified
with psychopharmacology. Moreover, psychology's self-imposed limitation to the cognitive domain alone, neglecting the study of emotion or introspection is setting the stage for the 21st century repetition of history. The idea is that the current trajectories of both psychiatry and psychology are unsustainable as they direct us towards polarization, thus opening the way for the terrible enantiodromia. The events world-wide such as geographical fragmentation and failure of the nation states are proofs that we, humans have not dealt with our dormant demons.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
1. Types of dementia, Pathphysiology of Alzheimer’s disease,
New diagnostic criteria and guidelines for Alzheimer’s
disease, Current and future psychopharmacological
interventions in Alzheimer’s disease.
2. Dementia – a growing epidemic
In 2012 -5.4 million Americans have dementia of all
causes.
In 2050- it is estimated that 15 million Americans will
live with dementia.
Every 68 seconds someone in America develops
dementia.
It is estimated that nearly 500,000 new cases will be
diagnosed this year alone.
Worldwide 36 million people are believed to live with
dementia. By 2050, if breakthroughs are not
discovered, the rates could exceed 115 million.
3. Definition
Dementia consists of:
memory impairment (amnesia),
deficits in either language (aphasia), or
motor function (apraxia),
recognition (agnosia), or
executive function, such as working memory and
problem solving.
personality changes can also be present (sometimes
even before the memory impairment)
4. Not Every Memory Disturbance Is
Dementia
Age-related memory-impairment (ARMI)
Self perceived memory loss
Over age 65 – prevalence around 40% = 16 million in US
About 1% of which eventually develop dementia
Minor Cognitive Impairment (MCI)
More severe memory loss, little/no functional impairment
Around 10% over 65 – does not necessarily develop to AD
Alzheimer’s Disease (AD)
Around 15% of those with MCI convert
6. Mixed Dementias
It is possible to have more than one dementia, and in fact many patients have
both Alzheimer’s disease and either dementia with Lewy bodies or vascular
dementia.
7. Pathology of Alzheimer’s Dementia
In order for a dementia to be called Alzhheimer’s disease
it has to present with both:
AMYLOID PATHOLOGY - Beta amyloid plaques
(extracellular)
TAU PROTEIN PATHOLOGY - Neurofibrillary tangles
(abnormal phosphorylation of tau proteins)
(intracellular)
14. AMYVID (Flobetapir)
Visualizing Amyloid
Indicated for PET imaging of the brain to estimate the
density of beta amyloid plaques in adult patients with
cognitive impairment who are being evaluated for
Alzheimer’s disease and other causes of cognitive
impairment.
25. Two kinds of AD: Familial and
Incidental
Autosomal dominant, early onset (5-10%)
(mutations in the APP or gamma secretase)
CHROMOSOME GENE
1 Presenilin 2
14 Presenilin 1
21 Amyloid PP
Incidental is non-genetic it does not run in
families.
26. Pre-symptomatic Entities
1. Pre clinical AD ( recommendations are intended for
research purposes).
2. MCI (Minor Cognitive Impairment).
28. Core clinical criteria
Neuropsychiatric symptoms that:
1. Interfere with the ability to function
2. Represent a decline from the previous level of functioning
3. Are not explained by delirium
4. Cognitive impairment is detected by history taking and objective cognitive
assessment
5. Impairment involves a minimum of two of the following domains:
Impaired ability to acquire and remember new information
Impaired reasoning and handling of complex tasks, poor judgment
Impaired visuospatial abilities
Impaired language functioning
Changes in personality or behavior
29. Diagnostic Overview
1. Possible AD dementia
2. Probable AD dementia
3. Probable or possible AD dementia with
evidence of the AD pathophysiological process.
30. Incorporation of Biomarkers into
AD Dementia Criteria
Biomarkers may be useful in three circumstances:
1. Investigational studies
2. Clinical trials
3. And as optional clinical tools for use where
available and when deemed appropriate by the
clinician.
31. CSF: Decreased Aβ42
Amyloid
Pathology
PET : Amyloid imaging with
Amyvid
Biomarkers CSF: Increased total or
phosphorylated tau
PET: hypoperfusion
Tau Pathology temporoparietal, precuneus
MRI: Medial temporal lobe
atrophy, Hippocampal atrophy,
39. Cholinesterase inhibitors offer
modest results
The usual response to cholinesterase inhibitor therapy
in Alzheimer’s disease is initial improvement that is
statistically detectable on cognitive testing and
perhaps noticeable to the caregiver but not necessarily
to the patient.
Such a response usually lasts about 6 months, at
which point cognitive functioning as measured on
cognitive testing is back to where it was before
beginning the drug.
40. Donepezil (Aricept)
Selective inhibitor of AChE, allowing more ACh to
accumulate
Once daily dosing
Severe AD
Benefits for all outcomes at 6 months
Some indication of positive changes on ADL and severe impairment battery
(SIB) scores
More selective for brain than periphery
GI side-effects usually moderate and transient - nausea, vomiting, diarrhea
No liver toxicity
Hallucinations twice as common as placebo .
41. Rivastigmine (Exelon)
Inhibits both AChE and the peripheral
butylcholinesterase (BuChE)
May be more selective for hippocampal AChE
May be more useful for late stage AD, when gliosis
increases BuChE
Might interfere with plaque formation
Increased incidence of GI side-effects, especially
during dose optimization/increase
42. Galantamine (Razadyne, previously
Reminyl)
Natural product isolated from daffodils and snowdrops
Inhibits AChE; allosteric modulator of nicotinic receptors;
synergistic at cholinergic synapses
Nicotinic action may boost attention and behaviors caused
by deficiencies of other neurotransmitters.
Studies:
16 or 24mg/day, 24 wks, benefits in cognitive and global function
Moderate AD gained more advantage than mild AD
BUT may be higher mortality than with the other AChEs
43. Memantine (“Artificial Magnesium”)
Voltage-dependent NMDA antagonist that targets
glutamatergic system
Mild side effect profile
Dizziness, confusion, headache, constipation
Dosing schedule:
Week 1 - 5 mg/day, Week 2 - 5 mg twice a day, Week 3 - 10 mg
twice a day, Week 4 - 15 mg twice a day
Administered with or without food
No PK/PD interactions with donepezil or other renally-
excreted drugs