This document discusses the principles of damage control orthopedics (DCO) for treatment of polytrauma patients. DCO involves a staged approach, with initial temporary stabilization of fractures using external fixation, followed by resuscitation and optimization of the patient. Definitive stabilization is then performed after 4 days once the acute inflammatory response has subsided to minimize additional surgical stress. Femur fractures stabilized with external fixation can be converted to intramedullary nailing within 2-3 weeks once the risk of infection is low. Pelvic and acetabular fractures may also be definitively treated 7-10 days after injury. The goal of DCO is to balance life-saving care of injuries with avoiding lethal complications through additional