The document discusses cyber security threats to critical infrastructure and the need for proactive cyber defense. It notes that cyber attacks are becoming more sophisticated and professional. Zero-day vulnerabilities pose one of the biggest threats since there are no existing defenses. It also discusses how security of industrial control systems is changing as these systems become more interconnected and integrated with other networks. Fuzz testing and maturity models for fuzz testing are introduced as important methods for detecting unknown vulnerabilities. Maintaining security will require managing both known and unknown vulnerabilities through approaches like fuzz testing.