Current trends in ACL surgery include a shift towards anatomical reconstruction techniques that more closely restore the native ACL footprint. While double bundle reconstruction aims to better restore knee rotation, high quality studies show no difference in outcomes compared to single bundle reconstruction. Autograft tissue like hamstring tendon is preferred over allograft for younger patients due to higher failure rates with allograft. Postoperative rehabilitation protocols emphasize early range of motion restoration and return to sport is recommended between 8 to 12 months following surgery accompanied by meeting specific strength and performance benchmarks.
Orthopedics is a Reconstructive Surgery. Mangled extremity is an injury to at least three out of four systems (soft tissue, bone, nerves, and vessels). A Decision have to be made Amputation + Prosthesis Vs. Limb salvage procedure which includes Irrigation & Debridement, External fixation, Antibiotic bead spacers, Soft tissue coverage and finally Restoring Skeletal Stability by Salvage of Bone Defect
Orthopedics is a Reconstructive Surgery. Mangled extremity is an injury to at least three out of four systems (soft tissue, bone, nerves, and vessels). A Decision have to be made Amputation + Prosthesis Vs. Limb salvage procedure which includes Irrigation & Debridement, External fixation, Antibiotic bead spacers, Soft tissue coverage and finally Restoring Skeletal Stability by Salvage of Bone Defect
Bobic Vladimir - ACL Injuries - Chester Uni MSc Sports Medicine 140324.pdfVladimir Bobic
Presentation for University of Chester MSc Sports Medicine Students. A review of knee ligament injuries, with emphasis on ACL injury, prevention, treatment and rehabilitation and inevitable PTOA in the long run.
PCL Posterior Cruciate Ligament Knee Injury: Is it Benign I Dr.RAJAT JANGIR JAIPUR
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#allinsideacl #internalbrace #drrajatjangir #bestaclsurgeon #aclexpert #bestkneesurgeon
To Know more about ACL Injury, Click the links below:
1. ACL surgery 7 different Techniques we do at our center - "Not single technique best for all"
https://youtu.be/oWkIr8IXvr8
2. Everything about ACL Injury tear surgery in Hindi I
https://youtu.be/bqpjkAkwZ14
3. Best Screw for ACL tear surgery in Hindi
https://youtu.be/1LGpU1NHiIs
4. ACL Injury Tear Surgery Recovery : All your questions & queries solved by Dr.Rajat Jangir
https://youtu.be/SIAPWiMbOqs
5. Partial ACL Tear Surgery or not ! ACL आधा टूटा हो तो क्या करें ?
https://youtu.be/NEJRPKskJTI
6. 5 Symptoms of ACL Injury tear इंजरी के पांच लक्षण ?
https://youtu.be/EXpgy19Jxzw
7. PRP injection therapy in Partial ACL TEARs
https://youtu.be/qyG1EYgS87E
Dr.RAJAT JANGIR(Asso Prof.)
Senior Consultant Arthroscopy and Joint Replacement
(Specialist in Shoulder Knee Hip Surgery)
Ligament and Joints Clinic
67/34 Mansarovar Jaipur
Whatsapp: shorturl.at/gnAEP
Appointment: +91 8104855900
Email: ligamentsurgeon@gmail.com
Google Page: https://g.page/KNEE-Shoulder-SURGERY?...
Facebook: https://www.facebook.com/Ligamentandj...
* Vast experience and specialisation in the field of Arthroscopy and sports surgery.
* M.S. orthopaedics from BJ Medical College, Civil hospital, Ahmedabad
* Fellowship in Arthroscopy and Sports injury with Prof Joon Ho Wang at Samsung Medical Center, South Korea
* Diploma in Sports Medicine from InternationaI Olympic Committee
* Invited as Athlete Medical Doctor at Rio Olympic 2016
* Done Rajasthan's first "All Inside Physeal Preserving ACL reconstruction" in 13 year old Athlete
Dr.Rajat is rated as one of the best orthopedic surgeon with with excellence in Knee Shoulder Arthroscopy surgeries as replacements'
Internal fixation of fractures of the capitellum and trochlea - Retrospective...Apollo Hospitals
Fractures of capitellum and trochlea account for 0.5-1% of elbow fractures and 6% of distal humerus fractures. These usually occur due to axial loading of the distal humerus by forces transmitted across the joint producing a coronal shear fracture of the capitellum or the trochlea. Internal fixation is the best modality to restore articular congruity in these fractures.
Structural Targets for Prevention of Post Traumatic OAOARSI
David Hunter MBBS, PhD, FRACP
Florance and Cope Chair of Rheumatology, Professor of Medicine
University of Sydney and Royal North Shore Hospital
Chair, Institute of Bone and Joint Research
Chair, Musculoskeletal, Sydney Medical Program
Consultant Rheumatologist, North Sydney Orthopedic and Sports Medicine
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
3. ACL INJURIES
ACL tears account for up to 64% of athletic knee injuries in cutting and
pivoting sports.
120,000–200,000 ACLRs performed annually in the United States.
Acute ACL injuries: joint effusion, altered knee kinematics and gait, muscle
weakness, and reduced functional performance
Long term sequelae: meniscal tears, chondral lesions, and posttraumatic
osteoarthritis.
3
6. ANATOMY
Tibial C-shape insertion runs from
along the medial tibial spine to the
anterior aspect of the anterior root of
LM
No ACL fibers inserted in the center of
the “C” nor posterolateral (which was
the place of the bony attachment of
the anterior root of the LM)
No PL bundle was found but
posteromedial (PM) fibers
6
Rainer Siebold. Tibial C-Shaped Insertion of the Anterior Cruciate Ligament Without Posterolateral Bundle.
ESSKA 2014.
8. TREATMENT OPTION
Non-operative management - poorly tolerated by both adults and
young patients
Leads to recurrent instability, chondral and meniscal injuries
People participating in sports or work related activities that
require a lot of pivoting, cutting, or jumping may decide to have
surgery
8
Stannard JP. AAOS Orthopaedic Knowledge Update 12. Ch. 36. 2017
Ajuied A. AJSM 2014
9. SURGICAL VERSUS CONSERVATIVE INTERVENTIONS FOR TREATING
ANTERIOR CRUCIATE LIGAMENT INJURIES
• No differences between surgical management (ACL reconstruction
followed by structured rehabilitation) and conservative treatment
(structured rehabilitation only) in patient-reported outcomes of
knee function at 2-5 years after injury.
• Many participants with an ACL rupture remained symptomatic following
rehabilitation and later opted for ACL reconstruction surgery
9
Cochrane Database of Systematic Reviews 2016, Issue 4. Art. No.: CD011166.
10. ACL RECONSTRUCTION – TIMING
ACL reconstructions performed beyond 3 weeks post-injury were at
significantly lower risk of developing arthrofibrosis
ACL reconstruction should preferably be performed within 6 months
from injury to avoid the risk of additional damage (LM in acute setting
and MM as time elapses)
10J Bone Joint Surg Am. 2010 Dec 1;92(17):2767-75
Shelbourne et al. AJSM 1991
11. ACL RECONSTRUCTION – TIMING
An increase in the number and grade of cartilage lesions with increasing time
from injury is a consistent finding especially MFC
Skeletally immature patients are at a similar risk of developing secondary
lesions and should be prioritized for ACL reconstruction with appropriate
physeal-sparing techniques
11
Knee Surg Sports Traumatol Arthrosc. 2004 Jul;12(4):262-70
Am J Sports Med. 2014 Nov;42(11):2560-6
13. NON-ANATOMIC ACLR
• Traditional ACLRs are placing the graft outside of the native insertion of the
ACL. (clockwise ref.)
• Vertically oriented grafts able to reconstitute stability in the sagittal plane
(anterior-posterior) but fail to provide adequate rotational stability.
• Non-anatomic tunnel placement can alter the forces experienced by the graft
and is one of the main reasons grafts fail (continued instability or re-rupture)
after ACLR.
13
Arch Bone Joint Surg 2016;4:291-7.
16. ANATOMIC ACLR
attempt to restore the native ACL footprint on both the tibial and
femoral sides of the knee to recreate the native functional
kinematics
Single bundle (SB) reconstruction is indicated for
tibial insertion sites less than 14 mm in length,
narrow notches (less than 12 mm in width)
concomitant ligamentous injuries
severe bone bruising
severe arthritic changes (KL3-4)
in the setting of open physis
16Arthroscopy 2010;26:258-68.
18. ANATOMIC ACLR
Double bundle (DB) reconstruction - considered in patients
with
a large tibial insertion site (anteroposterior length >14 mm)
large intercondylar notch (length and width >14 mm)
absence of concomitant ligament injuries
absence of advanced arthritic changes (KL <3)
absence of severe bone bruising
closed physis
18Arthroscopy 2010;26:258-68
21. SB vs DB ACLR
DB ACLR is to reconstruct both the AM and PL bundles, more closely
reproducing the native knee anatomy and kinematics
Biomechanical promise of DB fails to translate into clinical significance and
may predispose the graft to impingement and excessive tension through the PL
bundle during knee extension, resulting early graft rupture or attenuation
When patients are individually assigned based on the size of the ACL native
insertion site and the intercondylar notch width, prospective studies demonstrate
no difference in terms of anteroposterior and rotational laxity between single or
double-bundle reconstruction techniques
21
Arch Bone Joint Surg 2016
Am J Sports Med 2012;40:1781-8.
Paschos NK, Howell SM. EFORT Open Rev 2016
22. SB vs. DB ACLR
22
T. Järvelä and R. Siebold. in Anterior Cruciate Ligament Reconstruction
ESSKA 2014
23. TUNNEL DRILLING
Transtibial technique is falling more out of practice (decreased from
56.4% in 2007 to 17.6% in 2014) as a growing number of surgeons perform
an outside-in technique or use guides placed through the AM portal
(increased from 41.3% in 2007 to 65.1% in 2014)
Outcome data including fewer persistently positive Lachman and pivot shift
tests, lower KT-1000 scores, and higher Lysholm scores in the transportal
groups further support this paradigm shift.
23
J Bone Joint Surg Am 2016;98:1079-89.
24. Various types of interference screws used for ACLR (Titanium, Bio,
HA-coated: Right to left)
24
26. FIXATION TYPE
no clear consensus on superiority of aperture, suspensory
cortical, or button graft fixation or screw (metal/biologic) versus
button graft fixation.
Biologic screws can be associated with tunnel widening, a complication
infrequently observed in metallic screw fixation. However, biologic
screws allow for advanced imaging of the knee postoperatively without
metal artifact.
26
Bone Joint Surg Am 2016;98:1079-89
27. FIXATION TYPE
Decrease in use of first-generation bioabsorbable screws for graft
fixation and a shift toward biocomposite fixation
When securing soft tissue grafts, recent studies favor suspensory
fixation which fosters better junctional bone-tendon healing as
well as stronger zero time fixation
27
Stannard JP, Sherman SL, Cook JL. Soft tissues about the knee. In: Grauer JN, editor.
AAOS Orthopaedic Knowledge Update 12. Ch. 36. 1-13. 2017.
28. ACL remnant preserving
Intact remnants played an important role in mechanical strength in the
early postoperative period
Reservation of the blood supply aid in the healing process of the graft
Maintenance of proprioceptive innervation with evident benefits for the
subjective outcome and return to sports
Optimization of the accuracy of the procedure by improving the
arthroscopic orientation and bone tunnel placement at the insertion site
28
Knee Surg Sports Traumatol Arthrosc. 2012 Feb;20(2):245-51
30. Allograft vs. Autograft
Selection should be based on patient factors
(patient age, skeletal maturity, and activity level)
2.6x higher rate of failure when using allograft vs autograft in patients
<25 years
Allograft - acceptable outcome in middle-aged or recreational athlete
Allograft – need longer time for graft ligamentization
30
Stannard JP, Sherman SL, Cook JL. Soft tissues about the knee.
AAOS Orthopaedic Knowledge Update 12. 2017
31. PROS AND CONS OF VARIOUS GRAFTS USED FOR ACL
RECONSTRUCTION
31
32. GRAFT TYPES
HT - equivalent functional outcomes and less donor-site morbidity,
but increased risk of failure/revision, persistently positive pivot shift
test, diminished return to preinjury levels of activity, and higher
rates of infection
BPTB - strong stiff graft, secure fixation, bone-to-bone healing, and
low failure rates, but higher incidence of anterior knee pain and
kneeling pain
32
Am J Sports Med 2014.
33. GRAFT TYPES
QT - good strength, low donor-site morbidity, and reliable long term
outcomes
Quadriceps is an ACL antagonist, slightly impaired function of this
muscle may protect the ACL graft against the quadriceps anteriorly
directed force
Biomechanical studies demonstrate that the residual strength of the
QT after graft harvest is higher than that of the intact PT.
33
Knee Surg Sports Traumatol Arthrosc 2017 Mar 21. 26 (2), 418-425.
Arthroscopy. 2009 Feb;25(2):137-44
35. REHABILITATION
Pre-op rehabilitation – preserve Q strength and knee ROM
Post-op rehabilitation
Acute phase - restore ROM ,maintain Q strength, reduce
inflammation (0-3 wks.)
Recovery phase - improve lower limb muscle strength and
functional stability (3-6 wks.)
Functional phase - return to previous level of activity and reduce
risk of re-injury (6+ wks.)
35
36. REHABILITATION
Little consensus regarding rehab protocol
Early return to play – increased risk of graft failure and injury to
contralateral native ACL
Return to play when:
Time from surgery 8-12 months
Absence of pain and effusion
ROM comparable to contralateral knee
Negative Lachman / Pivot shift test
One leg hop test >85-90% of contralateral
Drop vertical jump without dynamic valgus
36
Ellman MB et al. JAAOS 2015
37. RETURN TO SPORTS AFTER ACLR
In the first 2 years after ACL reconstruction, 30 % of people who
returned to level I sports sustained a reinjury compared to 8 % of
those who participated in lower level sports.
For every month that return to sport was delayed, until 9 months after
ACL reconstruction, the rate of knee reinjury was reduced by 51%.
More symmetrical quadriceps strength prior to return to sport
significantly reduced the knee reinjury rate.
Only 5.6 % of patients who passed RTS criteria before returning to
level I sports suffered reinjuries compared to 37.5 % of those who
didn’t pass
37
Br J Sports Med 2016;50:804-808.
38. SUMMARY
ACL reconstruction surgery has evolved considerably over the past few decades.
Early reconstruction should be followed by accelerated rehabilitation, and delayed
reconstruction is associated with poor outcome.
Autograft yielded better results than allograft.
BPTB-R was associated with better postoperative knee stability but with a higher rate of
morbidity.
However, in terms of functional outcome, both BPTB and hamstring graft were similar in the
long-term
.Most of modern fixation devices have enough strength to fix the graft in ACL reconstruction
regardless of graft materials.
All fixation devices have their distinct advantages and disadvantages. Therefore, the choice of a
fixation device should be based on the type of graft or quality of bone. Since there is a variety of
options available today, selection of an optimum combination of the graft as well as fixation
devices should be individualized to the patient’s condition and the experience of the surgeon.
The double-bundle ACL reconstruction technique showed better outcomes in rotational laxity,
although functional recovery was similar between single-bundle and double-bundle.
Further advances in surgical techniques should continue to be developed so as to restore near-
normal knee kinematics and anatomy.
38