The document discusses integrative approaches for treating inflammation and arthritis. It describes how the immune system can become activated and lead to inflammation through cytokines in response to infections or environmental triggers. Chronic conditions like heart disease and dementia are also linked to inflammation. Exercise and dietary changes are highlighted as important ways to control chronic inflammation by lowering inflammatory markers. Specific anti-inflammatory foods, supplements, and herbs that may help treat rheumatoid arthritis are also outlined.
IroNext 200 ml (Ferrous Ascorbate with Methylcobalamin, Vitamins & minerals). IroNext Syrup 200 ml is an iron supplement to prevent anemia and also give nutrition to the body. Vitamin C improves iron absorption through the stomach. Powerful haematinic. Categories: Gynecology Care, Non-Chronic Medicines, Pharmaceutical, Vitamins and Minerals.
IroNext 200 ml (Ferrous Ascorbate with Methylcobalamin, Vitamins & minerals). IroNext Syrup 200 ml is an iron supplement to prevent anemia and also give nutrition to the body. Vitamin C improves iron absorption through the stomach. Powerful haematinic. Categories: Gynecology Care, Non-Chronic Medicines, Pharmaceutical, Vitamins and Minerals.
IroNext 200 ml (Ferrous Ascorbate with Methylcobalamin, Vitamins & minerals). IroNext Syrup 200 ml is an iron supplement to prevent anemia and also give nutrition to the body. Vitamin C improves iron absorption through the stomach. Powerful haematinic. Categories: Gynecology Care, Non-Chronic Medicines, Pharmaceutical, Vitamins and Minerals.
IroNext 200 ml (Ferrous Ascorbate with Methylcobalamin, Vitamins & minerals). IroNext Syrup 200 ml is an iron supplement to prevent anemia and also give nutrition to the body. Vitamin C improves iron absorption through the stomach. Powerful haematinic. Categories: Gynecology Care, Non-Chronic Medicines, Pharmaceutical, Vitamins and Minerals.
PowerPoint presentation describing various aspects of Pulmonary Hypertension. Please mail me your feedback on this presentation to following Email ID: tinkujoseph2010@gmail.com.
Rheumatoid arthritis is a chronic inflammatory and systemic auto immune disease affecting people for the most part
between the ages of 20-25 yrs with accidental course. About 1% of the worlds population is afflicted by rheumatoid
arthritis and is 2-3 times more common in women than men. The rheumatoid arthritis due to the presence of pro
inflammatory markers, cytokines and leukotrines. The primary inflammatory markers are IL-1, TNF-α, IL-6, IL-15,
IL-16, IL-17, IL-18, IFN-γ, and the granulocyte macrophage colony stimulating factor, chemokines such as IL-8,
macrophage inflammatory protein-1 and monocyte chemo attractant protein-1. IL-1, TNF-α, IL-6, B cells therapy all
these blockade are therapeutic target for its treatment. estimate the anti arthritic activity of the plants are used in
different animal models to induced arthritis. Medicinal plants have been used as major sources of pure of human
diseases since time immemorial. Now a days most of the people depends on traditional medicines of the plants. The
medicinal plants derived medicines for the first time of primary health care because of least or no side effects.
Health tips for reducing inflammation and risk of chronic degenerative disease using lifestyle and dietary changes. Phytonutrients can help our Circadian cycle and microbiome, and improve immune function and provide mitochondrial and receptor function support.
Overview of the Health Benefits of Vitamin C by Prof Margreet VissersKiwifruit Symposium
Prof Margreet Vissers, Research Professor at University of Otago, New Zealand: http://www.kiwifruitsymposium.org/presentations/overview-of-the-many-health-benefits-of-vitamin-c/
Presented at 1st International Symposium on Kiwifruit and Health.
Vitamin C is essential for life, and humans obtain this nutrient exclusively through the diet. It functions inside the cells in our bodies, where it plays an important role in supporting many essential processes. One kiwifruit a day gives the daily requirement of vitamin C.
Review by Louis B. Cady, MD (Cady Wellness Institute) of need for vitamin and mineral supplements, current evidence for loss of minerals and nutrients in soils. Reasonable strategies for identifying supplement needs. Understand how declining nutrients, inadequate intake of recommended servings of fruits and vegetables all contribute to chronic health conditions.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
In this presentation, Dr. Cady builds on previous lectures dealing with anti-oxidants and vitamin, mineral, and soil depletion to add discussions of vinpocetine and Bacopa monieri, as well as a discussion of the Medhya Rasayana approach from centuries old Aryuvedic practice in India. There is an emphasis on obtaining solid multivitamin, multi-mineral, and antioxidant support. References for two supplements lines (Physiologics and Metagenics) are given.
Smoking is the strongest environmental exposure, triggers citrullination of proteins in the lung. Citrullination: Amino acids catalyzed to citrulline which is attacked by the immune system
In Early-stage RA smoking may accelerates joint damage.
There is role of microbiome in RA development.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
1. Integrative Approach
for Inflammation and Arthritis
Immune system is our defense system and protects us from day to
day threats such as infections and fights against serious cancers.
Unfortunately, in some cases our body is exposed to unwanted
environmental triggers and infections which can activate our
immune system. This activation process can become
uncontrolled if the person has prolonged active infection or has
persistent exposure to culprit agents.
This activated immune
response leads to changes in
our defense cells and the
start producing chemicals
called cytokines, which are
part of the
p a t h o l o g i c i m m u n e
response. These cytokines
lead to unwanted
inflammation and damage
in our body tissues. These
markers of inflammation can
be testes in blood of patients
with autoimmune disorders
such as rheumatoid arthritis, lupus, and scleroderma. CRP and
ESR are common tests done to identify inflammation in the body.
Over the last decade, extensive research has concluded that
many chronic conditions such as asthma, heart disease and
dementia also have inflammation in the background as
contributor factor for the origin and high activity of these diseases.
Over the last few years it has also become evident that
environmental and nutritional factor play a major role
inflammation and its effects on our genes. Studies have also found
out that there are natural solutions available to slow the
inflammatory process occurring in our body.
Rheumatoid arthritis
Rheumatoid arthritis is the most common autoimmune arthritis
affecting 1% population. Rheumatoid factor and anti CCP are
antibodies help in confirming diagnosis. Integrative therapy has
very promising role in controlling inflammation seen in
rheumatoid arthritis and similar autoimmune conditions such as
psoriatic arthritis, ankylosing spondylitis and systemic lupus
erythematosis.
Integrative approaches can help us become stronger and keep
inflammation at minimum. Introducing anti-inflammatory
nutrition and healthy lifestyle is the cornerstone for stopping
inflammation. Incorporating nutritional supplements can also help
reduce inflammation and stabilize immune system through
regulation of immune system.
Exercise and dietary changes are now considered the most
important game changers to control chronic inflammation. A study
in England revealed that middle aged men and women who
increased their exercise were able to lower their levels
inflammatory markers, CRP and IL-6. Another study looked at 10
year follow up of more than 4000 men and those with at least 2.5
hours a week of moderate to vigorous exercise routine had
siginificantly lower levels of both CRP and IL-6.
Coffee and smoking: High consumption of coffee is linked to
rheumatoid arthritis. Cessation of tobacco use is been found
helpful in reducing RA disease activity.
The following nutritional agents are found helpful in rheumatoid
arthritis.
Omega 3 FA: There is been an increasing amount of scientific data
supporting use of omega-3 fatty acids obtained from cold-water
fish such as salmon and also sardines. Tree nuts such as walnuts
and almonds are also rich in omega 3 FA, plant source of omega 3
included flaxseeds. Dose is up to 2-3 g a day or GLA 1.5-3 g/day,
Conjugated linoleic acid does 2-3 g daily
Antioxidants: Vitamin E 100 units as mixed tocopherols, Vitamin C
250 mg twice daily, Selenium 400 mcg daily
Botanicals and Herbs: Green tea
extract (EGCG), curcumin (turmeric), quercetin, ginger, white
willow bark, boswellia. Most commonly Ginger dose is 1 g 2-3
times a day, Turmeric 500 mg to 1000 mg 2-3 times daily.
Mineral and Vitamins: Calcium 1000-1200 mg daily, Magnesium
400-750 mg daily, Vitamin D 2000 international units daily.
For a personlized advice for arthritis and inflammation related
conditions contact us at Dr Farhan Tahir MD,FACR ; Rheumatology
Care Consultants 267-685-6070 See Display Ad on page 16.
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The DEADLINE for our JULY/AUGUST Summer Issue is JUNE15th 45
