Dr. Swamy Venuturupalli talks about Rheumatoid Arthritis, Early Diagnosis and Treatment at the James R. Klinenberg symposium on Rheumatic diseases in Pasadena, CA.
Rheumatoid arthritis (RA) is a chronic, progressive inflammatory disorder of unknown etiology characterized by polyarticular symmetric joint involvement and systemic manifestations.
The incidence of lung cancer is the third highest in the United States, and it is the leading cause of cancer-related mortality globally. Rates of lung cancer and deaths from the disease have been falling in the United States over the last two decades, while five-year survival rates have been rising.
Dr. Swamy Venuturupalli talks about Rheumatoid Arthritis, Early Diagnosis and Treatment at the James R. Klinenberg symposium on Rheumatic diseases in Pasadena, CA.
Rheumatoid arthritis (RA) is a chronic, progressive inflammatory disorder of unknown etiology characterized by polyarticular symmetric joint involvement and systemic manifestations.
The incidence of lung cancer is the third highest in the United States, and it is the leading cause of cancer-related mortality globally. Rates of lung cancer and deaths from the disease have been falling in the United States over the last two decades, while five-year survival rates have been rising.
Lifestyle changes can prevent at least 60% of all Cancers - By Dr Sanjiv Hari...Sanjiv Haribhakti
5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle factors. Learn how can we prevent lifestyle related cancers. For more details visit at http://gisurgery.info
Two major factors and prevention methods for gastric cancer huatengDoriaFang
The largest genome-wide association study (GWAS) of gastric cancer in the Chinese population shows that genetic risk and lifestyle are the two major factors leading to the high incidence of gastric cancer in Chinese people.
Presentazione a cura del Dottor Gabriele Capurso - "HOT TOPICS IN GASTROENTEROLOGIA - I TUMORI DELL'APPARATO DIGERENTE: cosa è cambiato e cosa bisogna sapere" - Roma 10/11/2018
Awareness about Liver Cancer in Biotechnology Students_Crimson PublishersCrimsonpublishersCancer
Liver cancer is a major disease caused by sudden mutation occurred in the genes. To cure this disease gemcitabine seems to be affective. Gemcitabine is anticancer agent that has profile containing mild toxicity. It seems to be affective in solid tumors. To check its effectiveness, a questionnaire was developed and the awareness about liver cancer is checked in the post graduate students. All the students were fully aware of this disease.
Awareness regarding the systemic effects- PERIO SYSTEMIC RELATIONSHIPNagarajan Srini
For decades, physicians and dentists have paid close attention to their own respective fields, specializing in medicine pertaining to the body and the oral cavity, respectively. However, recent findings have strongly suggested that oral health may be indicative of systemic health. Currently, this gap between allopathic medicine and dental medicine is quickly closing, due to significant findings supporting the association between periodontal disease and systemic conditions such as cardiovascular disease, type 2 diabetes mellitus, adverse pregnancy outcomes, and osteoporosis. Significant effort has brought numerous advances in revealing the etiological and pathological links between this chronic inflammatory dental disease and these other conditions. Therefore, there is reason to hope that the strong evidence from these studies may guide researchers towards greatly improved treatment of periodontal infection that would also ameliorate these systemic illnesses. Hence, researchers must continue not only to uncover more information about the correlations between periodontal and systemic diseases but also to focus on positive associations that may result from treating periodontal disease as a means of ameliorating systemic diseases.
Rheumatoid arthirits (RA) is a chronic inflammatory disorder that affects many tissues and organs but mainly affects the joints,
producing a proliferative and inflammatory disease that progresses to damage the joint cartilage and ankylosis of the joints. About
1% of the world’s population is affected by RA. Women three to five times more often than men, it is more common in age group
of 40 to 70 years of age. The useful serological markers for RA are Rheumatoid factor (RF) and antibodies to citrullinated peptides.
This present study was done to find out the prevalence of serological marker in suspected arthritis case in tertiary care hospital.
This prospective study was carried out in serology section in central pathology lab in Government Medical College, Banda from
April 2015 to August 2018. Total 776 blood samples were received for RA factor analysis. Out of 776 samples, 111 samples were
positive for RA factor 14.3% prevalence. Total 88 cases were females and 23 were males. Most common age group involved was
21 - 60 years in females and 40 - 70 years in males. For evaluation of patients with suspected RA, it is recommended to perform
anti-cyclic citrullinated peptide antibody and RF analysis to increase specificity of the results.
Smoking is the strongest environmental exposure, triggers citrullination of proteins in the lung. Citrullination: Amino acids catalyzed to citrulline which is attacked by the immune system
In Early-stage RA smoking may accelerates joint damage.
There is role of microbiome in RA development.
Lifestyle changes can prevent at least 60% of all Cancers - By Dr Sanjiv Hari...Sanjiv Haribhakti
5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle factors. Learn how can we prevent lifestyle related cancers. For more details visit at http://gisurgery.info
Two major factors and prevention methods for gastric cancer huatengDoriaFang
The largest genome-wide association study (GWAS) of gastric cancer in the Chinese population shows that genetic risk and lifestyle are the two major factors leading to the high incidence of gastric cancer in Chinese people.
Presentazione a cura del Dottor Gabriele Capurso - "HOT TOPICS IN GASTROENTEROLOGIA - I TUMORI DELL'APPARATO DIGERENTE: cosa è cambiato e cosa bisogna sapere" - Roma 10/11/2018
Awareness about Liver Cancer in Biotechnology Students_Crimson PublishersCrimsonpublishersCancer
Liver cancer is a major disease caused by sudden mutation occurred in the genes. To cure this disease gemcitabine seems to be affective. Gemcitabine is anticancer agent that has profile containing mild toxicity. It seems to be affective in solid tumors. To check its effectiveness, a questionnaire was developed and the awareness about liver cancer is checked in the post graduate students. All the students were fully aware of this disease.
Awareness regarding the systemic effects- PERIO SYSTEMIC RELATIONSHIPNagarajan Srini
For decades, physicians and dentists have paid close attention to their own respective fields, specializing in medicine pertaining to the body and the oral cavity, respectively. However, recent findings have strongly suggested that oral health may be indicative of systemic health. Currently, this gap between allopathic medicine and dental medicine is quickly closing, due to significant findings supporting the association between periodontal disease and systemic conditions such as cardiovascular disease, type 2 diabetes mellitus, adverse pregnancy outcomes, and osteoporosis. Significant effort has brought numerous advances in revealing the etiological and pathological links between this chronic inflammatory dental disease and these other conditions. Therefore, there is reason to hope that the strong evidence from these studies may guide researchers towards greatly improved treatment of periodontal infection that would also ameliorate these systemic illnesses. Hence, researchers must continue not only to uncover more information about the correlations between periodontal and systemic diseases but also to focus on positive associations that may result from treating periodontal disease as a means of ameliorating systemic diseases.
Rheumatoid arthirits (RA) is a chronic inflammatory disorder that affects many tissues and organs but mainly affects the joints,
producing a proliferative and inflammatory disease that progresses to damage the joint cartilage and ankylosis of the joints. About
1% of the world’s population is affected by RA. Women three to five times more often than men, it is more common in age group
of 40 to 70 years of age. The useful serological markers for RA are Rheumatoid factor (RF) and antibodies to citrullinated peptides.
This present study was done to find out the prevalence of serological marker in suspected arthritis case in tertiary care hospital.
This prospective study was carried out in serology section in central pathology lab in Government Medical College, Banda from
April 2015 to August 2018. Total 776 blood samples were received for RA factor analysis. Out of 776 samples, 111 samples were
positive for RA factor 14.3% prevalence. Total 88 cases were females and 23 were males. Most common age group involved was
21 - 60 years in females and 40 - 70 years in males. For evaluation of patients with suspected RA, it is recommended to perform
anti-cyclic citrullinated peptide antibody and RF analysis to increase specificity of the results.
Smoking is the strongest environmental exposure, triggers citrullination of proteins in the lung. Citrullination: Amino acids catalyzed to citrulline which is attacked by the immune system
In Early-stage RA smoking may accelerates joint damage.
There is role of microbiome in RA development.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
1. Greatest adverse events associated
with RA is uncontrolled RA
Farhan Tahir MD, FACR
Interview with ReachMD
August 17, 2017
2. Rationale for paradigm shift in RA
Move from “first do no harm” to “I must control your
RA
Need to address early and effectively
Objective -1
3. The-earlier-the-better principle
synovitis is qualitatively different within the window
Best time to strike is before 15 to 20 weeks after
onset
Lower disease activity less progression and
reductions in joint damage
Early RA: Defining the Window of
Opportunity
https://www.medpagetoday.com/Rheumatology/Arthritis/50927
4. Inflammation future joint destruction
May not be obvious
83% - non swollen joints, + for erosions had subclinical
inflammation MRI
MRI inflammation baseline erosions 11% increased
risk of erosions
Erosions on presentation had 3.45 times
radiological damage
Early Erosions Future Damage
https://www.medpagetoday.com/rheumatology/arthritis/50985
5. RA independent risk factor for multi-vessel CAD
Inflammation and disease activity in first year boost
ACS risk
The incidence of acute coronary syndrome (ACS) early
in new-onset RA
@ markers of inflammation, high disease activity,
poorer perceived health and lower physical function
Early RA Control Prevents CV Events
https://www.medpagetoday.com/Rheumatology/Arthritis/52567
https://www.medpagetoday.com/rheumatology/arthritis/1282
6. Course of disease activity is milder in recent years,
perhaps because of more aggressive treatment
strategies
Systemic Burden: CVS death and Lymphoma remains
high in untreated RA
Severe and longstanding RA 70 times the risk
for developing lymphoma
Objective 2
RA course and Treatment Impact
https://www.medpagetoday.com/rheumatology/arthritis/1679
https://www.medpagetoday.com/rheumatology/arthritis/2749
7. Methotrexate, 25 mg/week, and prednisone started
at 60 mg/day
At 2 years, half of patients were in remission
49% with early RA or UA were in DAS remission
21% were off drugs
Taper and stop medication avoiding prolonged use
Early Remission Key in RA
IMPROVED study
https://www.medpagetoday.com/rheumatology/arthritis/55939
8. Upfront Combination Therapy Improves Early RA
Symptoms
Hitting RA early with a double whammy of DMARDs
76% of methotrexate plus steroid injections had low
disease activity as shown at 1 year
Equivalent to rates achieved with the addition of
adalimumab (Humira) in early rheumatoid arthritis
(RA)
Early treatment less drugs
Combo Therapy Wins
https://www.medpagetoday.com/PrimaryCare/PreventiveCare/2025
https://www.medpagetoday.com/Rheumatology/Arthritis/44591
10. Early Treatment Yields Better Long-Term Outcomes
U.K. study suggests 22 % reduction in mortality with
early RA Treatment
Treat Early to Live Longer
11. Biologic therapies do not increase cancer risks despite
concerns
Growing confidence of Rheumatologist’s in safety
Screening and immunizations protocols to be
adopted more for monitoring
Medication Concerns
https://www.medpagetoday.com/meetingcoverage/acr/11522
http://www.mdedge.com/rheumatologynews/article/141180/rheumatoid-arthritis/biologics-tnf-inhibitors-confer-no-excess
12. Systemic inflammation may underlie mortality risk in
men
Rapid and cumulative weight loss are the strongest
predictors of cardiovascular and cancer mortality in
men with rheumatoid arthritis (RA)
Untreated RA is dangerous than treated RA
Weight Loss CVS, Cancer Mortality
13. Obesity in Women Linked With Early RA
Overweight or obese, particularly those becoming so
by late adolescence
35% higher risk among those with body mass index
(BMI) values of 25 or higher at age 18
Risk among those women for developing seropositive
RA -- generally considered more severe -- increased by
almost 50%
Lifestyle and RA
https://www.medpagetoday.com/Rheumatology/Arthritis/47034
14. Women who are overweight or obese
Late adolescence have an elevated risk for developing
RA
Adipocytes produce inflammatory markers
Tumor necrosis factor, interleukin-6, and C-reactive
protein
Obesity in Women Linked With Early
RA
https://www.medpagetoday.com/Rheumatology/Arthritis/47034
15. Eating Fish May Ease Rheumatoid Arthritis
Eating fish 2x /week may help reduce joint pain and
inflammation in rheumatoid arthritis (RA)
tuna, salmon, sardines, trout, sole, halibut, poke, and
grouper
Eat More Fish
16. Strongly increase rheumatoid arthritis risk among
individuals with genetic susceptibility to the disease
Smoking in RA Genotype + Caucasians roughly
doubled their chances of developing the disease if
they smoked (relative risk 8.7 versus 4.8 for
nonsmokers)
Quit Smoking
https://www.medpagetoday.com/geriatrics/arthritis/14577
17. Occupations with exposure to noxious airborne
agents at risk. Similar to Smoking
Especially in Men; Seropositive RA
Production-related occupational groups
Electrical and electronics workers
Bricklayers and concrete workers and material
handling operators
Work Exposures Linked with RA
https://www.medpagetoday.com/rheumatology/arthritis/67187
18. Over 5 Years
Assessment and rehab could help prevent grip force
loss
Monitoring and exercises regimen by profesisonal
therapist
Early RA Patients Lose Grip
https://www.medpagetoday.com/Rheumatology/Arthritis/66815
19. Connectivity through digital media
Apps to track RA
https://arthritispower.creakyjoints.org/
Improved communications
