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CEREBRAL PALSY 
Dr Sachin Soni 
DNB Pediatrics Resident 
Indraprastha Apollo Hospital 
New Delhi 
www.dnbpediatrics.com
 Topic 
 Definition 
 Etiology and Classification 
 Classification 
 Clinical manifestation 
 Diagnosis and D/D 
 Management 
www.dnbpediatrics.com
Definition 
 A group of non-progressive but changing motor 
impairment syndromes characterized by abnormalities of 
movement, posture and tone 
 Its not a specific disease, but a symptom complex 
www.dnbpediatrics.com
Etiology 
PRENATAL(MATERNAL/FETA 
L/PLACENTAL) 
PERINATAL POST NATAL 
• Iodine deficiency, iron 
deficiency and poor 
nutrition 
• Intrauterine infections, 
high fever,UTI 
• Chorioamnionitis 
• Maternal disease- 
Diabetes, hypertension, 
Hyperthyroidism 
• Teratogens-drugs, 
Radiation,smoking, 
alcohal,intrauterine 
environmental toxins 
• Fertility problems- 
Advanced age at 
conception, history of 
infertility, recurrent fetal 
wastage 
• Prematurity/VLBW 
• Birth asphyxia 
• IUGR 
• Hyperbilirubinemia 
• intravenricular and 
intra cerebral bleed 
• Hypoglycemia, 
Dyselectrolytemias 
• Sepsis, peumonia and 
meningitis 
• Poor Antenatal care 
• poor socioeconomic 
status 
• Premature separation of 
placenta 
• CNS infections such as 
viral encephalitis, 
tubercular meningitis and 
pyogenic meningitis 
• Head injuries 
• Seizure 
• Hypoxic damage 
• Hyperpyrexic damage 
• Twins/abnormal fetal 
presentation 
• Fetal thrombotic 
vasculopathy 
• Genetic causes 
• Functional polymorphism 
in interleukin-6 gene has 
recently been associated 
with term infants. 
www.dnbpediatrics.com
Clinicopathological correlation of cerebral palsy 
www.dnbpediatrics.com
Suspected Cerebral palsy 
- Child with motor dysfunction-Abnormal muscle tone, abnormal 
posture and movement. 
- Clinical expression of the case depends on the extent and area of 
brain damage, growth of the child, coexisting problems 
- Include- Mental retardation 
- - Seizure 
- - Behavioral problem 
- - Speech, Hearing and Language disorders 
- Ocular- Strabismus, refractory error, field defect 
- Extra pyramidal abnormalities, sensory impairment/integrative 
- dysfunction 
- Feeding difficulties 
www.dnbpediatrics.com
Spastic 
 Most common type 
 Increased muscle tone 
 Develop deformities, contractures 
 Associated problems-Squint, oral motor dysfunction, perceptual and 
learning disorder 
Quadriplegic CP- 
 All limbs are affected, Arms> legs 
 Absent bladder bowel control 
 Difficulty in speech and feeding 
 Intelligence deceased 
 Epilepsy is common 
www.dnbpediatrics.com
 Hemiplegic CP: 
- Term baby 
- Rt hemiplegia twice as common as left hemiplegia, arm> legs 
- Persistent fisting and cortical thumb on affected side 
- Absent pincer grasp ,hemiplegic gait, loss of cortical sensation 
 Diplegic CP: 
- In Preterm baby wih IVH and PVL 
- Lower limb> Upper limb 
- Increased Abductor tone – later Ambulatory problem 
- Seizure is uncommon 
www.dnbpediatrics.com
Dyskinetic 
 Uncontrolled and purposeless movements 
 Dystonic: 
- Infants are hypotonic with poor head control 
- Dystonia evolve gradually, truncal twisting, facial grimacing, 
extremity rigidity 
 Choreo athetoid : Characteristically seen in babies with 
hyperbilirubinemia 
- Associated problem- high tone hearing loss, upward gaze 
palsies 
- Seizures are uncommon 
- Speech difficulty but intelligence is normal 
www.dnbpediatrics.com
 Hypotonic: 
- Marked motor delay, deceased tone, mental retardation 
- Preserved or brisk DTR differentiate it from LMN 
 Ataxic: 
- Uncommon form, defective postural function, disturbed 
equilibrium, in coordinated movement for all major task 
- Tremor on use of hand are common 
- Associated problem- spasticity, athetosis, dysarthria and 
Nystagmus 
www.dnbpediatrics.com
www.dnbpediatrics.com
Diagnosis 
 Early diagnosis of CP: - 
Warning symptoms: 
- Lack of alertness, deceased spontaneus motility 
- Inceased abnormal movements,seizure 
- Feeding problem, drooling 
- Poor quality of sleep 
- Fisting after 2 months of age 
www.dnbpediatrics.com
Family counseling 
 Its not a mental illness 
 Cause need to be identified 
 Holistic evaluation and care needed 
 Not inherited 
 Not curable 
Management aims at minimizing the disability to improve quality of life 
www.dnbpediatrics.com
Abnormal signs:- 
- Reduced head circumferance or fall in its growth 
- Delayed social smile 
- Poor head control at 3 months of age 
- Delayed appearance of postural reflexes and developmental 
milestones 
- Persistence of primitive reflexes 
- Increased tone , scissoring or assumption of equinus position of 
feet 
- Visual problem: roving of eyes, no visual following, poor hand 
regard after 6 month , persistant squint 
- Lack of auditory response 
www.dnbpediatrics.com
Conditions which mimic CP 
 Paraplegia,Quadriplegia due to trauma 
 Neural tube defects 
 Mental retardation, speech disorder 
 Slowly progressive degenerative brain disorders:- Metabolic disease, 
Mitochondrial disorder 
 Neuromuscular disorder 
www.dnbpediatrics.com
Assement of muscle tone and neonatal reflexes 
 Popliteal angle 
 Scarf sign 
 Abductor angle 
Modified Ashworth scale- Abnormal developmental reflexes 
- Absence of parachute response and landau reflex and persistence 
of other infantile automatism beyond the ages mentioned 
Reflexes Persistance beyond 
Rooting 3 month 
Moro 5-6 months 
Palmar grasp 6 month 
Tonic neck 5-6 months 
www.dnbpediatrics.com
Role of Investigations 
 Brain imaging- Useful in evaluating etiology of CP and suggesting 
prognosis 
 USG- To detect IVH And Periventricular Leucomalasia 
 CT and MRI- To detect other disease that may confused with CP 
 Visual and hearing assessment 
 Tests to detect inherited thrombophilic disorders - Patients in which 
an in utero or neonatal stroke 
is suspected as the cause of CP. 
www.dnbpediatrics.com
Management 
 Multidisciplinary approach: 
 A recent study indicates that prenatal treatment of mothers with 
magnesium lowers the prevalence of CP in their children at 
corrected age of 2 yr. 
www.dnbpediatrics.com
 Rehabilitation therapy: 
Two major goal 
1- To decease complication of 
CP 
2- To enhance or improve 
acquisition of new skills 
(A) Physical therapy 
(B) Occupation therapy 
(c) Speech and language 
Therapy 
 Physiotherapy and motor 
atraining 
 Prevention of contractures 
 Management of feeding 
difficulties 
 Educational problem 
 Drug treatment: 
- Diazepam 
- Baclofen 
- Dantrolane 
- Tizanidine 
 Visual problem 
 Communication problem 
 Epilepsy 
www.dnbpediatrics.com
 Alcohal and Phenol blocks 
 Botulism toxinType – A 
 Plaster casting and orthdoses 
 Adaptive equipment/Assistive 
devices 
 Orthopedic procedure: 
- Selective posterior 
rhizotomy 
 Rehablitation 
www.dnbpediatrics.com
Thank You 
www.dnbpediatrics.com 
www.dnbpediatrics.com

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Cp

  • 1. CEREBRAL PALSY Dr Sachin Soni DNB Pediatrics Resident Indraprastha Apollo Hospital New Delhi www.dnbpediatrics.com
  • 2.  Topic  Definition  Etiology and Classification  Classification  Clinical manifestation  Diagnosis and D/D  Management www.dnbpediatrics.com
  • 3. Definition  A group of non-progressive but changing motor impairment syndromes characterized by abnormalities of movement, posture and tone  Its not a specific disease, but a symptom complex www.dnbpediatrics.com
  • 4. Etiology PRENATAL(MATERNAL/FETA L/PLACENTAL) PERINATAL POST NATAL • Iodine deficiency, iron deficiency and poor nutrition • Intrauterine infections, high fever,UTI • Chorioamnionitis • Maternal disease- Diabetes, hypertension, Hyperthyroidism • Teratogens-drugs, Radiation,smoking, alcohal,intrauterine environmental toxins • Fertility problems- Advanced age at conception, history of infertility, recurrent fetal wastage • Prematurity/VLBW • Birth asphyxia • IUGR • Hyperbilirubinemia • intravenricular and intra cerebral bleed • Hypoglycemia, Dyselectrolytemias • Sepsis, peumonia and meningitis • Poor Antenatal care • poor socioeconomic status • Premature separation of placenta • CNS infections such as viral encephalitis, tubercular meningitis and pyogenic meningitis • Head injuries • Seizure • Hypoxic damage • Hyperpyrexic damage • Twins/abnormal fetal presentation • Fetal thrombotic vasculopathy • Genetic causes • Functional polymorphism in interleukin-6 gene has recently been associated with term infants. www.dnbpediatrics.com
  • 5. Clinicopathological correlation of cerebral palsy www.dnbpediatrics.com
  • 6. Suspected Cerebral palsy - Child with motor dysfunction-Abnormal muscle tone, abnormal posture and movement. - Clinical expression of the case depends on the extent and area of brain damage, growth of the child, coexisting problems - Include- Mental retardation - - Seizure - - Behavioral problem - - Speech, Hearing and Language disorders - Ocular- Strabismus, refractory error, field defect - Extra pyramidal abnormalities, sensory impairment/integrative - dysfunction - Feeding difficulties www.dnbpediatrics.com
  • 7. Spastic  Most common type  Increased muscle tone  Develop deformities, contractures  Associated problems-Squint, oral motor dysfunction, perceptual and learning disorder Quadriplegic CP-  All limbs are affected, Arms> legs  Absent bladder bowel control  Difficulty in speech and feeding  Intelligence deceased  Epilepsy is common www.dnbpediatrics.com
  • 8.  Hemiplegic CP: - Term baby - Rt hemiplegia twice as common as left hemiplegia, arm> legs - Persistent fisting and cortical thumb on affected side - Absent pincer grasp ,hemiplegic gait, loss of cortical sensation  Diplegic CP: - In Preterm baby wih IVH and PVL - Lower limb> Upper limb - Increased Abductor tone – later Ambulatory problem - Seizure is uncommon www.dnbpediatrics.com
  • 9. Dyskinetic  Uncontrolled and purposeless movements  Dystonic: - Infants are hypotonic with poor head control - Dystonia evolve gradually, truncal twisting, facial grimacing, extremity rigidity  Choreo athetoid : Characteristically seen in babies with hyperbilirubinemia - Associated problem- high tone hearing loss, upward gaze palsies - Seizures are uncommon - Speech difficulty but intelligence is normal www.dnbpediatrics.com
  • 10.  Hypotonic: - Marked motor delay, deceased tone, mental retardation - Preserved or brisk DTR differentiate it from LMN  Ataxic: - Uncommon form, defective postural function, disturbed equilibrium, in coordinated movement for all major task - Tremor on use of hand are common - Associated problem- spasticity, athetosis, dysarthria and Nystagmus www.dnbpediatrics.com
  • 12. Diagnosis  Early diagnosis of CP: - Warning symptoms: - Lack of alertness, deceased spontaneus motility - Inceased abnormal movements,seizure - Feeding problem, drooling - Poor quality of sleep - Fisting after 2 months of age www.dnbpediatrics.com
  • 13. Family counseling  Its not a mental illness  Cause need to be identified  Holistic evaluation and care needed  Not inherited  Not curable Management aims at minimizing the disability to improve quality of life www.dnbpediatrics.com
  • 14. Abnormal signs:- - Reduced head circumferance or fall in its growth - Delayed social smile - Poor head control at 3 months of age - Delayed appearance of postural reflexes and developmental milestones - Persistence of primitive reflexes - Increased tone , scissoring or assumption of equinus position of feet - Visual problem: roving of eyes, no visual following, poor hand regard after 6 month , persistant squint - Lack of auditory response www.dnbpediatrics.com
  • 15. Conditions which mimic CP  Paraplegia,Quadriplegia due to trauma  Neural tube defects  Mental retardation, speech disorder  Slowly progressive degenerative brain disorders:- Metabolic disease, Mitochondrial disorder  Neuromuscular disorder www.dnbpediatrics.com
  • 16. Assement of muscle tone and neonatal reflexes  Popliteal angle  Scarf sign  Abductor angle Modified Ashworth scale- Abnormal developmental reflexes - Absence of parachute response and landau reflex and persistence of other infantile automatism beyond the ages mentioned Reflexes Persistance beyond Rooting 3 month Moro 5-6 months Palmar grasp 6 month Tonic neck 5-6 months www.dnbpediatrics.com
  • 17. Role of Investigations  Brain imaging- Useful in evaluating etiology of CP and suggesting prognosis  USG- To detect IVH And Periventricular Leucomalasia  CT and MRI- To detect other disease that may confused with CP  Visual and hearing assessment  Tests to detect inherited thrombophilic disorders - Patients in which an in utero or neonatal stroke is suspected as the cause of CP. www.dnbpediatrics.com
  • 18. Management  Multidisciplinary approach:  A recent study indicates that prenatal treatment of mothers with magnesium lowers the prevalence of CP in their children at corrected age of 2 yr. www.dnbpediatrics.com
  • 19.  Rehabilitation therapy: Two major goal 1- To decease complication of CP 2- To enhance or improve acquisition of new skills (A) Physical therapy (B) Occupation therapy (c) Speech and language Therapy  Physiotherapy and motor atraining  Prevention of contractures  Management of feeding difficulties  Educational problem  Drug treatment: - Diazepam - Baclofen - Dantrolane - Tizanidine  Visual problem  Communication problem  Epilepsy www.dnbpediatrics.com
  • 20.  Alcohal and Phenol blocks  Botulism toxinType – A  Plaster casting and orthdoses  Adaptive equipment/Assistive devices  Orthopedic procedure: - Selective posterior rhizotomy  Rehablitation www.dnbpediatrics.com
  • 21. Thank You www.dnbpediatrics.com www.dnbpediatrics.com