This document discusses cerebral palsy (CP), a nonprogressive neuromotor disorder of cerebral origin. CP can be caused by factors operating prenatally, during delivery, or postnatally. It is classified based on topographic distribution, neurological findings, and etiology, with the main types being spastic, hypotonic, extrapyramidal, and cerebellar CP. Evaluation of patients with CP includes assessing eyes, ears, speech, sensory function, seizures, intelligence, and other issues. The diagnosis is made based on signs of increased muscle tone, feeding difficulties, and developmental delays. Differential diagnoses need to be considered. Management aims to improve posture, reduce muscle tone, prevent contractures, and provide early
ATAXIA IN CHILDREN -CAUSES, MANAGEMENT, INVESTIGATIONS, TYPES, COMMONEST ATAXIA IN CHILDREN IN DETAIL, HOW WILL YOU FIND OUT THE CAUSE FOR ATAXIA IN CHILDREN FLOWCHART, DEFINITION, TREATMENT
ATAXIA IN CHILDREN -CAUSES, MANAGEMENT, INVESTIGATIONS, TYPES, COMMONEST ATAXIA IN CHILDREN IN DETAIL, HOW WILL YOU FIND OUT THE CAUSE FOR ATAXIA IN CHILDREN FLOWCHART, DEFINITION, TREATMENT
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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2. Cerebral palsy (CP) is defined as a nonprogressive
neuromotor disorder of cerebral origin.
3. Etiopathogenesis
Factors may operate prenatally, during delivery or in the
postnatal period. Cerebral malformations, perinatal
hypoxia, birth trauma, chorioamnionitis, prothrombotic
factors, acid base imbalance, indirect hyperbilirubinemia,
metabolic disturbances and intrauterine or acquired
infections may operate. Most infants have multiple risk
factors. Prematurity is an important risk factor for spastic
diplegia while term weight babies get quadriparesis or
hemiparesis.
4. CONT…
A variety of pathological lesions such as cerebral
atrophy, porencephaly, periventricular, leukomalacia,
basal ganglia thalamic and cerebellar lesions may be
observed.
5. Types of Cerebral Palsy
classified on basis of topographic
distribution, neurologic findings and etiology.
Spastic Cerebral Palsy This is the commonest form (65%) and
is topographically
classified into spastic quadriparesis, diplegia or hemiparesis.
Early diagnostic features of neural damage
include abnormally persistent neonatal reflexes, feeding
difficulties, persistent cortical thumb after 3 months age
and a firm grasp. They have variable
degrees of mental and visual handicaps, seizures and
behavioral problems.
6. Spastic quadriparesis is more common in term babies and
exhibits signs including opisthotonic posture, pseudobulbar
palsy, feeding difficulties, restricted voluntary
movements and motor deficits.
Spastic diplegia is commoner in preterm babies and is
associated with periventricular leukomalacia. The lower
limbs are more severely affected with extension and
adduction posturing, brisk tendon jerks and contractures
7. Spastic hemiplegia is usually recognized after 4-6 months
age. Early hand preference, abnormal persistent fisting,
abnormal posture or gait disturbance may be the
presenting
complaint
8. Hypotonic (Atonic) Cerebral PalsyDespite pyramidal
involvement, these patients are atonic
or hypotonic. Tendon reflexes are normal or brisk and
Babinski response is positive. They are often severely
mentally retarded. In cerebellar involvement, hypotonia
is not associated with exaggerated reflexes. Muscles may
show fiber disproportion and delayed CNS maturation is
common.
9. Extrapyramldal CP
This form accounts for 30% of cases. The clinical
manifestations
include athetosis, choreiform movements, dystonia,
tremors and rigidity. Arms, leg, neck and trunk may be
involved. Mental retardation and hearing deficits may be
present.
Cerebellar Involvement
This form is seen in less than 5% of the patients. There is
hypotonia and hyporeflexia. Ataxia and intention tremors
appear by the age of 2 yr. Nystagmus is unusual; mental
status may be near normal in some of these patients
10. Evaluation
Eyes. Nearly half of the patients have strabismus,
paralysis
of gaze, cataracts, coloboma, retrolental fibroplasia,
perceptual and refractive errors.
Ears. Partial or complete loss of hearing is usual in
kernicterus. Brain damage due to rubella may be
followed
by receptive auditory aphasia.
Speech. Aphasia, dysarthria and dyslalia are common
among dyskinetic individuals.
11. Sensory defects. Astereognosis and spatial disorientation
are seen in one-third of the patients.
Seizures. Spastic patients usually have generalized or
focal
tonic seizures. Seizures are more common in disorders
acquired postnatally. These patients respond poorly to
antiepileptic agents. Electroencephalograms show gross
abnormalities.
12. Intelligence. About a quarter of the children may have
borderline intelligence (IQ 80-100); and about half of
them
are severely mentally retarded.
Miscellaneous. Inadequate thermoregulation and
problems
of social and emotional adjustment are present in many
cases. These children may have associated dental defects
and are more susceptible to infections
13. Diagnosis
The diagnosis of cerebral palsy should be suspected in a
child with low birthweight and perinatal insult;
clinically
has an increased tone, feeding difficulties and global
development delay. Abnormalities of tone posture,
involuntary movements and neurological deficits should
be recorded. Evaluation includes perinatal history,
detailed neurological and developmental examination
and
assessment of language and learning disabilities
14. Dlfferentlal Diagnosis
Neurodegenerative disorders.
Hydrocephalus and subdural effusion.
Brain tumors or space occupying lesions
Muscle disorders
Ataxia-telangiectasia
15. Prevention
Prevention of maternal infection, fetal or perinatal
insults,
good maternal and neonatal care reduces prevalence.
Early diagnosis, prompt adequate management plans
can
reduce the residual neurological and psychosocial
emotional handicaps for the child and his family.
16. Management
The management plan should be holistic, involve the
family and be directed to severity, type of neurological
deficits and associated problems. Stress on improving
posture, reducing tone, preventing contractures and
early
stimulation is necessary
17. Tranquilizers are administered for behavior
disturbances and muscle relaxants may be used for
improving
muscle function. Baclofen and tizanidine help to reduce
spasticity. Diazepam may ameliorate spasticity and
athetosis. Dantrolene sodium helps in relaxation of
skeletal
muscles. Dynamic contractures can be managed with
botulinum toxin injection or alternatively nerve block
with
phenol.
18. Occupational therapy. The beginning is made with simple
movements of self-help in feeding and dressing with
progressive development of more intricate activities like
typing.
Orthopedic support. Tendon, muscle and bony surgeries
may be required. Light weight splints may be required
for tight tendo-Achilles and cortical thumb.