Measures do not prevent deaths, transmission is not by contact, masks provide no benefit, vaccines are inherently dangerous: Review update of recent science relevant to COVID-19 policy.
For decades, it has been acknowledged by the world’s premier health authorities that amid a pandemic, the functioning of society should be maintained, and human rights upheld. Governments and health organisations have at their disposal country-specific pandemic preparedness plans, as well as the World Health Organisation pandemic guidelines, which provide a roadmap outlining how to keep society functioning, while also mitigating the impact of a disease or virus.
In 2020, SARS-CoV-2 brought an almost–instantaneous rewriting of disease management principles as countries, with few exceptions, disregarded existing pandemic plans and replaced them with policies of ‘lockdown’.
There is no evidence that lockdowns have reduced mortality from Covid-19 and research is now revealing the devastation that lockdowns are causing, particularly in the developing world. In these draconian lockdown policies, we have also seen the biggest infringement on civil liberties in democratic countries during peacetime.
PANDA believes that, at this juncture, the science is quite clear on what key policy responses should be—or should have been. The cure should not be worse than the disease. It is critically important that societies are reopened, whilst protecting those who may be vulnerable to serious illness from SARS-CoV-2. Human agency must be upheld, and individuals should be empowered to make their own choices.
PANDA’s Protocol for Reopening Society builds upon existing pandemic frameworks and incorporates current scientific understanding of Covid-19, to provide a roadmap out of the damaging cycle of lockdowns.
Pneumonia and diarrhoea: tackling the deadliest diseases for the world’s poor...UNICEF Publications
Pneumonia and diarrhoea are leading killers of the world’s youngest children, accounting for 29 per cent of deaths among children under age 5 worldwide – or more than 2 million lives lost each year. This report makes a remarkable and compelling argument for tackling pneumonia and diarrhoea, two of the leading killers of children under age five. The data in this report highlight a critically important point – children living in the poorest households are less likely than the children living in the richest households to benefit from preventive measures and, when they do become ill, to receive lifesaving treatments.
For decades, it has been acknowledged by the world’s premier health authorities that amid a pandemic, the functioning of society should be maintained, and human rights upheld. Governments and health organisations have at their disposal country-specific pandemic preparedness plans, as well as the World Health Organisation pandemic guidelines, which provide a roadmap outlining how to keep society functioning, while also mitigating the impact of a disease or virus.
In 2020, SARS-CoV-2 brought an almost–instantaneous rewriting of disease management principles as countries, with few exceptions, disregarded existing pandemic plans and replaced them with policies of ‘lockdown’.
There is no evidence that lockdowns have reduced mortality from Covid-19 and research is now revealing the devastation that lockdowns are causing, particularly in the developing world. In these draconian lockdown policies, we have also seen the biggest infringement on civil liberties in democratic countries during peacetime.
PANDA believes that, at this juncture, the science is quite clear on what key policy responses should be—or should have been. The cure should not be worse than the disease. It is critically important that societies are reopened, whilst protecting those who may be vulnerable to serious illness from SARS-CoV-2. Human agency must be upheld, and individuals should be empowered to make their own choices.
PANDA’s Protocol for Reopening Society builds upon existing pandemic frameworks and incorporates current scientific understanding of Covid-19, to provide a roadmap out of the damaging cycle of lockdowns.
Pneumonia and diarrhoea: tackling the deadliest diseases for the world’s poor...UNICEF Publications
Pneumonia and diarrhoea are leading killers of the world’s youngest children, accounting for 29 per cent of deaths among children under age 5 worldwide – or more than 2 million lives lost each year. This report makes a remarkable and compelling argument for tackling pneumonia and diarrhoea, two of the leading killers of children under age five. The data in this report highlight a critically important point – children living in the poorest households are less likely than the children living in the richest households to benefit from preventive measures and, when they do become ill, to receive lifesaving treatments.
The research of Warwick McKibbin (Australian National University, The Brookings Institution, Centre of Excellence in Population Ageing Research) and Roshen Fernando (Australian National University, Centre of Excellence in Population Ageing Research (CEPAR))
Containing the COVID 19 Pandemic in Nigeria A Reflection on Government Action...ijtsrd
The outbreak of the COVID 19 pandemic led to the lockdown of the global economy in the early part of the year 2020. In line with the measures recommended by the World Health Organization WHO , countries also introduced further mechanisms based on their respective unique environment to contain the virus. This paper reflected on the citizens’ reactions to government measures in containing the COVID 19 pandemic in Nigeria. Specifically, it reviewed the government’s actions towards containing the virus and how they influenced the citizens’ response. The study was qualitative and focused between March and September 2020. Relying on secondary data that were analyzed through content analysis, we triangulated the Persuasive Communication Theory and Resistance Theory to interrogate the governments actions and the citizens’ reactions. We argued that the governments approach towards containing the virus contributed to i the doubt on the existence of the virus in the country held by some of the citizens, ii the lack of strict observation of precautionary measures and safety regulations, iii the seeming non co operation between the government and the citizens in containing the virus. The implications of this relationship pose challenges for future epidemics, pandemics, and development in the country and could serve as a premise for further research. Vincent Chukwukadibia Onwughalu "Containing the COVID-19 Pandemic in Nigeria: A Reflection on Government Actions and Citizens Reactions" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, URL: https://www.ijtsrd.com/papers/ijtsrd35701.pdf Paper Url: https://www.ijtsrd.com/management/other/35701/containing-the-covid19-pandemic-in-nigeria-a-reflection-on-government-actions-and-citizens-reactions/vincent-chukwukadibia-onwughalu
While the world has focused on the traditional causes of premature death in Africa – communicable diseases such as HIV, malaria and tuberculosis, malnutrition, road and other accidents and political conflicts – a column of other types of killers has been gaining ground.
These are the chronic, noncommunicable diseases (NCDs) such as cancer, heart disease, diabetes, sickle-cell disease and kidney disease, whose collective toll is rising rapidly. How aware are patients of the causes of and cures for their diseases, and how well are they served by the healthcare providers in their countries?
Nepal's readiness and response to pandemic covid 19Ndrc Nepal
Nepal's Readiness and Response to COVID-19:
Key Initiatives, Emerging Challenges and the Way Forward
By Dhruba Gautam, PhD*
This occasional paper highlights the key initiatives on COVID 19 response in Nepal and readiness.
National Disaster Risk reduction Centre Nepal is supporting the agencies through Knowledge Management on COVID 19 in Nepal.
It's up to People and Governments, to reduce pandemic mortality by 50-60%! We have kea against pandemic and its Knowledge, that Oxidative Stress is in charge of more than half deaths! Please, show this file to your Health Minister and Premier Minister. You can start fight against pandemic with NEW, cheap and affordable weapon.
The defence of teaching philosophy as the noble discipline to the teachersAkashSharma618775
As students of philosophy there has always been a wonder about what the work of philosophers is and
what do they teach their students. The wonder of this nature becomes manifest when one has to become one of the
philosophers himself. Having heard it as a saying that “to err is human”, it then becomes inevitable to wonder
humans are really what they perceive themselves as or something else. One of the crucial things to note is that if
humans get deceived in the perception of themselves then all what they engage in will not be authentically of
service to humanity. This speaks to the issue of the way in which human interactions are guided by their will or, if
true, something in a form of a supernatural being outside themselves. Exploring such mindboggling issues around
human existence might guide a philosopher of education to understand what really makes a person be, and at what
point do philosophical teachings make guided students. In most cases students want to receive fair and just
education. But without teachings of critical thinking that philosophers of education emphasize, teachers will
always delve into matters of morality and forget the thought aspect that forms the basis of teaching itself. Although
morality in any form of education is paramount, but it is most important to at least know the fundamental
underpinnings of that morality. When teachers do not study philosophy their understanding of the applied
curriculum remains shallow and proper application of it might be hindered. Without saying that morality
education and curriculum knowledge is non-profiting, the argument here is that it is always most beneficial to
know the foundations of those things from their philosophical beginnings. It is in that backdrop that usage of
analytic theoretical framework will be employed in this paper to explore errors and other accurate uncertainties
that make life and its experiences almost certain
INFLUENCE OF BAKIGA CULTURAL BELIEFS AND PRACTICES ON MANAGEMENT OF CORONA VI...AkashSharma618775
The focus of this discourse is to construct an understanding of cultural beliefs and practices on the
influence and spread of corona virus as viewed from lenses of medical sociology. This review starts from the
premise that we need a sociology of health agenda to manage the corona virus epidemic. The study points to the
fact that cultural beliefs are an unsung aspect in our understanding of the sociology of health particularly in the
management of corona virus despite the role of describing social behavior in other disciplines, including utilization
of medicine itself. Some cultural fanatics among the Bakiga hold several casual beliefs that Corona Virus is a
disease of the West (most developed countries) and therefore, Africans are an exception. Another competing belief
is that most Africans have endured harsh conditions which made them develop immunity against the virus.
Another argument is that Africans have been infected by flu and common cold and therefore, their body has
requisite immunity to fight COVID 19.Culture in health interventions seems to have three domains of health
beliefs and behavior that should be taken into account: (1) Cultural Identity, (2) Relationships and Expectations,
and (3) Cultural Empowerment. It is essential to maximize the wealth of experience that emerges both from
anthropological and sociological analysis of epidemic responses in different contexts for similar airborne diseases,
including historical analyses. Although the socio-cultural practices of the Bakiga highlighted in this work have
been shown to contribute to the spread of COVID 19, any future efforts to eradicate and/or contain these
outbreaks should also include the medical sociologist on the African continent as the dearth of them was the main
structural contributor to the course of the pandemic.
The research of Warwick McKibbin (Australian National University, The Brookings Institution, Centre of Excellence in Population Ageing Research) and Roshen Fernando (Australian National University, Centre of Excellence in Population Ageing Research (CEPAR))
Containing the COVID 19 Pandemic in Nigeria A Reflection on Government Action...ijtsrd
The outbreak of the COVID 19 pandemic led to the lockdown of the global economy in the early part of the year 2020. In line with the measures recommended by the World Health Organization WHO , countries also introduced further mechanisms based on their respective unique environment to contain the virus. This paper reflected on the citizens’ reactions to government measures in containing the COVID 19 pandemic in Nigeria. Specifically, it reviewed the government’s actions towards containing the virus and how they influenced the citizens’ response. The study was qualitative and focused between March and September 2020. Relying on secondary data that were analyzed through content analysis, we triangulated the Persuasive Communication Theory and Resistance Theory to interrogate the governments actions and the citizens’ reactions. We argued that the governments approach towards containing the virus contributed to i the doubt on the existence of the virus in the country held by some of the citizens, ii the lack of strict observation of precautionary measures and safety regulations, iii the seeming non co operation between the government and the citizens in containing the virus. The implications of this relationship pose challenges for future epidemics, pandemics, and development in the country and could serve as a premise for further research. Vincent Chukwukadibia Onwughalu "Containing the COVID-19 Pandemic in Nigeria: A Reflection on Government Actions and Citizens Reactions" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, URL: https://www.ijtsrd.com/papers/ijtsrd35701.pdf Paper Url: https://www.ijtsrd.com/management/other/35701/containing-the-covid19-pandemic-in-nigeria-a-reflection-on-government-actions-and-citizens-reactions/vincent-chukwukadibia-onwughalu
While the world has focused on the traditional causes of premature death in Africa – communicable diseases such as HIV, malaria and tuberculosis, malnutrition, road and other accidents and political conflicts – a column of other types of killers has been gaining ground.
These are the chronic, noncommunicable diseases (NCDs) such as cancer, heart disease, diabetes, sickle-cell disease and kidney disease, whose collective toll is rising rapidly. How aware are patients of the causes of and cures for their diseases, and how well are they served by the healthcare providers in their countries?
Nepal's readiness and response to pandemic covid 19Ndrc Nepal
Nepal's Readiness and Response to COVID-19:
Key Initiatives, Emerging Challenges and the Way Forward
By Dhruba Gautam, PhD*
This occasional paper highlights the key initiatives on COVID 19 response in Nepal and readiness.
National Disaster Risk reduction Centre Nepal is supporting the agencies through Knowledge Management on COVID 19 in Nepal.
It's up to People and Governments, to reduce pandemic mortality by 50-60%! We have kea against pandemic and its Knowledge, that Oxidative Stress is in charge of more than half deaths! Please, show this file to your Health Minister and Premier Minister. You can start fight against pandemic with NEW, cheap and affordable weapon.
The defence of teaching philosophy as the noble discipline to the teachersAkashSharma618775
As students of philosophy there has always been a wonder about what the work of philosophers is and
what do they teach their students. The wonder of this nature becomes manifest when one has to become one of the
philosophers himself. Having heard it as a saying that “to err is human”, it then becomes inevitable to wonder
humans are really what they perceive themselves as or something else. One of the crucial things to note is that if
humans get deceived in the perception of themselves then all what they engage in will not be authentically of
service to humanity. This speaks to the issue of the way in which human interactions are guided by their will or, if
true, something in a form of a supernatural being outside themselves. Exploring such mindboggling issues around
human existence might guide a philosopher of education to understand what really makes a person be, and at what
point do philosophical teachings make guided students. In most cases students want to receive fair and just
education. But without teachings of critical thinking that philosophers of education emphasize, teachers will
always delve into matters of morality and forget the thought aspect that forms the basis of teaching itself. Although
morality in any form of education is paramount, but it is most important to at least know the fundamental
underpinnings of that morality. When teachers do not study philosophy their understanding of the applied
curriculum remains shallow and proper application of it might be hindered. Without saying that morality
education and curriculum knowledge is non-profiting, the argument here is that it is always most beneficial to
know the foundations of those things from their philosophical beginnings. It is in that backdrop that usage of
analytic theoretical framework will be employed in this paper to explore errors and other accurate uncertainties
that make life and its experiences almost certain
INFLUENCE OF BAKIGA CULTURAL BELIEFS AND PRACTICES ON MANAGEMENT OF CORONA VI...AkashSharma618775
The focus of this discourse is to construct an understanding of cultural beliefs and practices on the
influence and spread of corona virus as viewed from lenses of medical sociology. This review starts from the
premise that we need a sociology of health agenda to manage the corona virus epidemic. The study points to the
fact that cultural beliefs are an unsung aspect in our understanding of the sociology of health particularly in the
management of corona virus despite the role of describing social behavior in other disciplines, including utilization
of medicine itself. Some cultural fanatics among the Bakiga hold several casual beliefs that Corona Virus is a
disease of the West (most developed countries) and therefore, Africans are an exception. Another competing belief
is that most Africans have endured harsh conditions which made them develop immunity against the virus.
Another argument is that Africans have been infected by flu and common cold and therefore, their body has
requisite immunity to fight COVID 19.Culture in health interventions seems to have three domains of health
beliefs and behavior that should be taken into account: (1) Cultural Identity, (2) Relationships and Expectations,
and (3) Cultural Empowerment. It is essential to maximize the wealth of experience that emerges both from
anthropological and sociological analysis of epidemic responses in different contexts for similar airborne diseases,
including historical analyses. Although the socio-cultural practices of the Bakiga highlighted in this work have
been shown to contribute to the spread of COVID 19, any future efforts to eradicate and/or contain these
outbreaks should also include the medical sociologist on the African continent as the dearth of them was the main
structural contributor to the course of the pandemic.
COVID-19 amenaza con convertirse en una de las pruebas más difíciles que enfrenta la humanidad en la historia moderna. Como
la pandemia se ha extendido se ha cobrado vidas, ha provocado ansiedad y drama político, ha abrumado la salud
sistemas, y provocó un cambio geopolítico potencialmente duradero. El Fondo Monetario Internacional dice que
La economía mundial se enfrenta ahora a su peor recesión desde la Gran Depresión, y Oxfam Internacional ha
advirtió que 500 millones de personas podrían caer en la pobreza como resultado de la crisis en curso. Alrededor
En el mundo, se están realizando esfuerzos desesperados para contener lo que se ha convertido en un brote profundamente perturbador.
This presentatin examines the impact of Covid-19 on infectious diseases such as HIV and TB. The writer explores the impact of Covid-19 on the global landscape, the global public health system and how social and physical distancing rules at the workplace are making it impossible for optimal production capacity.
Alternative mental health therapies in prolonged lockdowns: narratives from C...Petar Radanliev
This article identifies and reviews alternative (home-based) therapies for prolonged lockdowns. Interdisciplinary study using multi-method approach – case study, action research, grounded theory. Only secondary data has been used in this study. Epistemological framework based on a set of digital humanities tools. The set of tools are based on publicly available, open access techno- logical solutions, enabling generalisability of the findings. Alternative therapies can be integrated in healthcare systems as home-based solutions operating on low-cost technologies.
Tourism Industry amid Pandemics Comparative Assessment of Past Outbreaks and ...ijtsrd
Covid 19 has reportedly shattered all previous records of outbreaks. Never a one expected the outbreak, which began in late December 2019, to spread quickly all across the globe, be devastating, and turn the global business upside down. SARS, Ebola Virus Disease EVD , MERS CoV, and other diseases brought about modest casualities in a smaller geographic area, therefore, Covid 19 was predicted to behave similarly at first. But this was not the case. Humans continuously lost their lives and faced financial hardships. Undoubtedly, tourism is amongst the most troubled industries. This research is a review of the literature. On the basis of facts and figures and prior studies, a comparison of the effects of prior outbreaks vis a vis Covid 19 on the tourism business has been attempted in this paper. Covid 19 and previous epidemics are so dissimilar, based on the facts and statistics gathered, that they cant be compared. Covid 19 has been the most hazardous viruses to live with owing to its instant spread, geographic distribution, several individuals who have died as a result of it, and the negative implications it has had across the region. Rajeev Ranjan Mishra | Pallavi Tandon "Tourism Industry amid Pandemics: Comparative Assessment of Past Outbreaks and Covid-19" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46434.pdf Paper URL : https://www.ijtsrd.com/humanities-and-the-arts/tourism/46434/tourism-industry-amid-pandemics-comparative-assessment-of-past-outbreaks-and-covid19/rajeev-ranjan-mishra
Impact of health facilities and low death rate of COVID-19-in Germany compare...SubmissionResearchpa
This research investigates the Impact of Health Facilities and low death rate of COVID-19-in Germany compare to other European Countries. Data were collected from various secondary sources COVID-19 data base. According to results German health system with its up to 4 fold higher number regional public hospitals and topic of many political discussions might have been one factor to keep mortality rate -according to the given database- low. However German doctors, without out any medicine like colleges all over the world were as helpless as everywhere.One essential fact according the statements of reputed virologists might be an early discovery of Corona infection by sincere attention, focussed testing and early start of treatment. In Germany with its the easy access to health service in combination with the large number of hospitals might be the reason for the „lower“ death rate. Not to forget the tremendous engagement of highly qualified doctors and nurses who were willing and able to work beyond imagination of a routine work. by Dr. Faiz Muhammad Shaikh 2020. Impact of health facilities and low death rate of COVID-19-in Germany compare to other European countries . International Journal on Integrated Education. 3, 6 (Jun. 2020), 68-71. DOI:https://doi.org/10.31149/ijie.v3i6.413. https://journals.researchparks.org/index.php/IJIE/article/view/413/389 https://journals.researchparks.org/index.php/IJIE/article/view/413
The first three months of the COVID-19 epidemic:
Epidemiological evidence for two separate strains of SARSCoV-2 viruses spreading and implications for prevention
strategies
Similar to Review of Recent COVID-19 Science ~ Denis G. Rancourt, PhD (20)
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Review of Recent COVID-19 Science ~ Denis G. Rancourt, PhD
1. Measures do not prevent deaths,
transmission is not by contact,
masks provide no benefit,
vaccines are inherently dangerous:
Review update of recent science
relevant to COVID-19 policy
Denis G. Rancourt, PhD
28 DECEMBER 2020
2. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 2
Working report (not submitted for
journal publication), published at
ResearchGate
Summary
The unprecedented measures of
universal lockdowns, tight institutional
lockdowns of care homes, universal
masking of the general population,
obsession with surfaces and hands, and
the accelerated vaccine deployment are
contrary to known science, and contrary
to recent leading studies. There has been
government recklessness by action and
negligence by omission. Institutional
measures have been needed for a long
time to stem corruption in both
medicine and public health policy.
The article is organized into the following
sections:
• Introduction – Iatrogenic
pandemic of panic
• Stringency of measures has no
effect on total deaths assigned to
COVID-19
• Corruption of science is being
exposed - Masks and PCR
• Transmission is not by contact
• Masking of the general
population provides no
detectable benefit
• Vaccines are inherently
dangerous
• Endnotes / References
3. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 3
Introduction - Iatrogenic
pandemic of panic
The health-politics context is one in
which, until 2019, the reviewed science
and policy consensus was that global
measures such as the measures that
were generally and universally applied in
2020 were [1][2]:
➔ not recommended without
being justified by sufficient
quantitative evidence of the local
(jurisdictional) epidemiological
circumstances (transmissibility,
seriousness of disease, impact),
and without balancing against
local resulting economic, public-
health and social harm
➔ for many of the measures
(Contact tracing, Quarantine of
exposed individuals, Entry and
exit screening, Border closure),
“Not recommended in any
circumstances”, irrespective of
the severity of the pandemic viral
respiratory disease (Moderate,
High, or Extraordinary)
The health-politics context is also one in
which there is a documented recent
history of “repeated pandemic health
scares” in which “Disease experts wish
to capture public attention and sway
resource allocation decisions in favour
of the disease of their interest.” [3].
Bonneux and Van Damme, in 2011, put it
this way [3]:
The repeated pandemic health
scares caused by an avian H5N1
and a new A(H1N1) human
influenza virus are part of the
culture of fear.[refs]. Worst-case
thinking replaced balanced risk
assessment. Worst-case thinking
is motivated by the belief that
the danger we face is so
overwhelmingly catastrophic
that we must act immediately.
Rather than wait for information,
we need a pre-emptive strike.
But if resources buy lives, wasting
resources wastes lives. The
precautionary stocking of largely
useless antivirals and the
irrational vaccination policies
against an unusually benign H1N1
virus wasted many billions of
euros and eroded the trust of the
public in health officials.[refs] The
pandemic policy was never
informed by evidence, but by
fear of worst-case scenarios.
Furthermore, a major conflict of interest
scandal regarding WHO flu pandemic
recommendations was exposed in detail
in 2010, where investigators Cohen and
Carter concluded: “Key scientists
advising the World Health Organization
on planning for an influenza pandemic
had done paid work for pharmaceutical
firms that stood to gain from the
guidance they wrote. These conflicts of
interest have never been publicly
disclosed by WHO.” [4]
In 2020, none of this mattered. We
entered a propaganda-driven world, with
captured institutions. The precautionary
principle (government must prove likely
absence of harm prior to imposing
dangerous policies) was turned on its
head, and the burden of proof was
imposed on science for a posteriori
justification of unprecedented measures,
swiftly imposed in an absence of and
contrary to science. Unfortunately, much,
or most of the science establishment
complied with the new program.
Recently, there have been both dramatic
events (vaccine roll out) and significant
science communications, since I
published my first two reviews of science
relevant to COVID-19 policy, on 11 April
2020 [5] and on 3 August 2020 [6], and
articles about the deadly harms of
government responses, inferred from
time and jurisdiction-dependent all-
cause mortality data [7][8]. My first two
reviews were focused on the science and
politics of masks [5][6]. The present
review update of recent developments is
again about masks, and additionally
includes key points about lockdown
measures and vaccines.
4. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 4
Stringency of measures has
no effect on total deaths
assigned to COVID-19
There have been two major recent
studies of global significance.
In their 21 July 2020 article “A country
level analysis measuring the impact of
government actions, country
preparedness and socioeconomic
factors on COVID-19 mortality and
related health outcomes” (50 countries),
Chaudhry et al. found [9]:
Rapid border closures, full
lockdowns, and wide-spread
testing were not associated with
COVID-19 mortality per million
people. (Abstract / Findings)
When COVID-19 mortality was
assessed, variables significantly
associated with an increased
death rate per million were
population prevalence of obesity
and per capita GDP. In contrast,
variables that was negatively
associated with increased
COVID-19 mortality were
reduced income dispersion
within the nation, smoking
prevalence, and the number of
nurses per million population.
Indeed, more nurses within a
given health care system was
associated with reduced
mortality. Mortality rates were
also higher in those counties
with an older population […].
Lastly, government actions such
as border closures, full
lockdowns, and a high rate of
COVID-19 testing were not
associated with statistically
significant reductions in the
number of critical cases or
overall mortality. (Section 3.4)
In their 19 November 2020 article
“COVID-19 Mortality: A Matter of
Vulnerability Among Nations Facing
Limited Margins of Adaptation” (160
countries), De Larochelambert et al.
found [10]:
Results: Higher COVID death
rates are observed in the [25/65°]
latitude and in the [−35/−125°]
longitude ranges. The national
criteria most associated with
death rate are life expectancy
and its slowdown, public health
context (metabolic and non-
communicable diseases (NCD)
burden vs. infectious diseases
prevalence), economy (growth
national product, financial
support), and environment
(temperature, ultra-violet index).
Stringency of the measures
settled to fight pandemia,
including lockdown, did not
appear to be linked with death
rate.
Conclusion: Countries that
already experienced a stagnation
or regression of life expectancy,
with high income and NCD rates,
had the highest price to pay. This
burden was not alleviated by
more stringent public decisions.
Inherent factors have
predetermined the COVID-19
mortality: understanding them
may improve prevention
strategies by increasing
population resilience through
better physical fitness and
immunity. (Abstract)
The American Institute for Economic
Research (AIER Staff) reviewed these
studies and 22 further studies that make
similar conclusions, in their 19 December
2020 report entitled “Lockdowns Do Not
Control the Coronavirus: The Evidence”
[11].
Therefore, overall, the numbers of total
critical cases and total deaths were
associated with the pre-existing health
and societal status of the population, and
this was not ameliorated by the
government measures intended to slow
transmission.
Importantly, in addition to studies of
total-death associations, time-
dependence and granularity
(jurisdictional-dependence) of all-cause
mortality show that the 11 March 2020
WHO declaration of a pandemic and
universal recommendation to “prepare
your hospitals” were followed by large
numbers of deaths, probably induced by
the infections and stringent lockdowns
5. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 5
of unventilated care homes for sick and
elderly persons.[7][8]
The mass psychology and sociology of
the 2020 COVID-19 iatrogenic pandemic
of propaganda are beginning to be
studied by quantitative methods.[12]
Corruption of science is being
exposed - Masks and PCR
A positive feature of what can be termed
the current “pandemic of propaganda” is
that widespread systemic corruption of
establishment science is being exposed,
not only via high-profile retractions of
papers published in leading journals, but
also through critical editorials. For
example, on 13 November 2020, exective
editor Kamran Abbasi put it in no
uncertain terms, in the pages of the
preeminent BMJ [13]:
Science is being suppressed for
political and financial gain.
COVID-19 has unleashed state
corruption on a grand scale, and
it is harmful to public health.[ref]
Politicians and industry are
responsible for this opportunistic
embezzlement. So too are
scientists and health experts. The
pandemic has revealed how the
medical-political complex can
be manipulated in an
emergency—a time when it is
even more important to
safeguard science.
I offer three illustrative examples.
First, systemic bias is palpable in a recent
mini-saga about masks, printed in the
pages of the New England Journal of
Medicine [14][15][16].
Gandhi and Rutherford authored a
“Perspective” article published on 29
October 2020 [14]. The authors advanced
the extraordinary notion that masking
lowers disease severity in those infected.
They open with the propagandistic
assertion that universal facial masking is
“one of the pillars of COVID-19 pandemic
control”. They go on to argue the
fantastic: That masks can reduce the viral
inoculum and thus provide
asymptomatic infections in which the
subject develops immunity. This
alarmed respondents because the
proposed mechanism is what could be
termed “mask-aided naturally acquired
6. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 6
immunity”. Admitting any type of natural
immunity, which is a hard fact of
evolutionary biology, has become
sacrilegious.
Two groups of researchers published
rebuttals against Gandhi and Rutherford,
in the same journal.
Rasmussen et al. wrote [15]:
There is insufficient evidence to
support the claim that masks
reduce the infectious dose of
SARS-CoV-2 and the severity of
COVID-19, much less that their
use can induce protective
immunity. […] The suggestion
that masks offer an alternative to
vaccination without evidence
that the benefits outweigh the
great risks implicitly encourages
reckless behavior.
Brosseau et al., for their part,
diplomatically reset the views
expounded by Gandhi and Rutherford by
bringing readers back to established
science and reality [16]:
Viral replication is related to
dose, but disease severity is not.
The epidemiology indicates that
the occurrence of severe COVID-
19 is associated with preexisting
conditions and other risk factors,
such as age, sex, and pregnancy
status.[ref]
Though not yet shown in
experimental models, the
infectious dose of SARS-CoV-2 is
probably similar to that of SARS-
CoV — approximately 300
virions.[ref] Regardless of disease
severity, people have high viral
titers and infectious virus for at
least 8 days after symptom
onset. Normal talking can
generate up to 3000 1-micron
particles per minute in exhaled
breath,[ref] and each particle
could contain more than 250
virions, which means that a
single minute of speaking
potentially generates more than
750,000 virions. Cloth face
coverings have highly variable
efficacy depending on both
filtering capacity and fit. Wearing
a cloth face covering while being
near an infected person for
several minutes may not prevent
the receipt of an infectious dose,
which, as noted above, does not
correlate with milder disease.
The authors of the original article were
not deterred and replied: “more evidence
is accruing to support the idea” and
“there is increasing evidence both from
physical sciences and from
epidemiologic investigations that cloth
masks (if worn properly) reduce both
transmission and acquisition.”[17]
Examination of their sources shows that
the authors have a generous view of
what can constitute supporting
“evidence”. See also [6], regarding the
spin of “accruing evidence” in the policy
context of face masks.
Second, a stunning example, again about
masks, is provided in the pages of Nature
Medicine. Here, the “IHME COVID-19
Forecasting Team”, on 23 October 2020
(“IHME study”), declared an amazing
benefit if universal masking were
followed in the USA [18]:
Universal mask use could save an
additional 129,574 (85,284–
170,867) lives from September
22, 2020 through the end of
February 2021, or an additional
95,814 (60,731–133,077) lives
assuming a lesser adoption of
mask wearing (85%), when
compared to the reference
scenario. (Abstract)
If masks provide such a large benefit, it is
impossible to understand how none of
the many large randomized controlled
trials (RCT) with verified outcomes have
detected this benefit. It is impossible to
obtain the oft-repeated negative results
found in the policy-grade RCT studies, if
the premises and conclusions of the
IHME study are correct. The IHME study
was disproved prior even to its
publication.
The IHME study is fatally flawed on at
least two points: (1) The meta-regression
used to estimate (“suggested”, in their
words) that universal masking provides a
7. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 7
40% and more reduction in transmission
is worthless, and palpably the fruit of
constructive bias; (2) They used incorrect
data to evaluate USA population
masking compliance for the relevant
time period.
The latter fatal flaw was exposed by
Magness, in his report published in the
Wall Street Journal, entitled “Case for
Mask Mandate Rests on Bad Data” [19]:
Unfortunately, the IHME
modelers’ findings contained an
error that even minimal scrutiny
should have caught. The
projected number of lives saved,
and the implied case for a mask
mandate, are based on a faulty
statistic. Using a months-old
survey, IHME modelers assumed
erroneously that the U.S. mask-
adoption rate stood at only 49%
as of late September, and
therefore had plenty of room to
increase to “universal adoption,”
defined as 95%, or to a more
plausible 85%. According to
more recent survey findings,
however, America’s mask-
adoption rate has hovered
around 80% since the summer.
Magness makes no mention of the IHME
study’s fictitious premise that universal
masking reduces transmission by 40%
and more.
Third, in one of the largest scandals in the
COVID-19 episode, a reverse transcription
polymerase chain reaction (RT-PCR) test
was hastily developed, under dubious
circumstances, which is neither
diagnostic of the presence of infectious
viruses, nor specific to SARS-CoV-2, and
deployed by States for confirmation of
infection in symptomatic individuals, and
for mass testing of the general
asymptomatic population.
The said RT-PCR test was presented by
Corman et al.[20], and their own article
has:
We aimed to develop and deploy
robust diagnostic methodology
for use in public health
laboratory settings without
having virus material available.
[…]
In all of these situations [all past
applications of RT-PCR to “detect
causative viruses from respiratory
secretions”], virus isolates were
available as the primary
substrate for establishing and
controlling assays and assay
performance.
In the present case of 2019-nCoV,
virus isolates or samples from
infected patients have so far not
become available to the
international public health
community. We report here on
the establishment and validation
of a diagnostic workflow for
2019-nCoV screening and
specific confirmation, designed
in absence of available virus
isolates or original patient
specimens. Design and
validation were enabled by the
close genetic relatedness to the
2003 SARS-CoV, and aided by
the use of synthetic nucleic acid
technology. […]
The present report describes the
establishment of a diagnostic
workflow for detection of an
emerging virus in the absence of
physical sources of viral genomic
nucleic acid. Effective assay
design was enabled by the
willingness of scientists from
China to share genome
information before formal
publication […] The speed and
effectiveness of the present
deployment and evaluation
effort were enabled by national
and European research networks
established in response to
international health crises in
recent years, demonstrating the
enormous response capacity that
can be released through
coordinated action of academic
and public laboratories [refs].
This laboratory capacity not only
supports immediate public
health interventions but enables
sites to enrol patients during
rapid clinical research responses.
The paper by Corman et al. is argued to
be fatally flawed on technological and
methodological grounds by an
international consortium of scientists in
the life sciences: See the report by Borger
et al. [21]. Borger et al., among several
criticisms, conclude [21]:
8. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 8
• These are severe design errors,
since the test cannot
discriminate between the whole
virus and viral fragments. The test
cannot be used as a diagnostic
for SARS-viruses.
• Furthermore, the absence of the
HE gene in both SARS-CoV1 and
SARS-CoV-2 makes this gene the
ideal negative control to exclude
other coronaviruses. The
Corman-Drosten paper does not
contain this negative control, nor
does it contain any other
negative controls. The PCR test in
the Corman-Drosten paper
therefore contains neither a
unique positive control nor a
negative control to exclude the
presence of other coronaviruses.
This is another major design flaw
which classifies the test as
unsuitable for diagnosis.
• We find severe conflicts of
interest for at least four authors,
in addition to the fact that two of
the authors of the Corman-
Drosten paper (Christian Drosten
and Chantal Reusken) are
members of the editorial board
of Eurosurveillance. A conflict of
interest was added on July 29
2020 (Olfert Landt is CEO of TIB-
Molbiol; Marco Kaiser is senior
researcher at GenExpress and
serves as scientific advisor for
TIB-Molbiol), that was not
declared in the original version
(and still is missing in the
PubMed version); TIB-Molbiol is
the company which was “the
first” to produce PCR kits (Light
Mix) based on the protocol
published in the Corman-
Drosten manuscript, and
according to their own words,
they distributed these PCR-test
kits before the publication was
even submitted [ref]; further,
Victor Corman & Christian
Drosten failed to mention their
second affiliation: the
commercial test laboratory
“Labor Berlin”. Both are
responsible for the virus
diagnostics there [ref] and the
company operates in the realm
of real time PCR-testing.
• In light of our re-examination of
the test protocol to identify
SARS-CoV-2 described in the
Corman-Drosten paper we have
identified concerning errors and
inherent fallacies which render
the SARS-CoV-2 PCR test useless.
Many of the criticisms of Borger et al. [21]
were already proven in detailed
laboratory verifications, such as the
remarkable paper by Singanayagam et
al. [22], using RT-PCR with the target
gene RdRp, which shows (especially their
figure 3 A):
➔ The importance of the number
of PCR cycles (Ct), in both clinical
reporting, and clinical
interpretation
➔ That except for extreme
hospitalization cases (which
were not studied), all the RT-PCR
positives detected more than 10
days after onset of symptoms or
exposure corresponded to non-
infectious viruses (dead virus
fragments) (no virus could be
cultured in optimal cell cultures)
➔ That no time limit for detection
of such non-infectious viruses
(dead virus fragments) was
observed, as these were
obtained, with Ct=28-39, up to
60 days after onset of symptoms
or exposure.
➔ That, at less than 10 days, with
Ct=18-40, almost half of the
“positives” were of non-infectious
viruses (dead virus fragments)
➔ An operational cut-off of Ct=30,
above which “positives” have less
than 40% probability (<8% at
Ct>35) of corresponding to viable
virus, irrespective of the time
relative to onset of symptoms or
exposure (their Figure 2)
Such results regarding false detection of
presumed viable viruses were also
obtained in the more recent large study
of Jaafar et al. [23] who used RT-PCR
amplification of the believed to be
somewhat less SARS-CoV-2-specific E
gene.
Clearly, the RT-PCR test used around the
world, on its own, is in effect garbage. It
produces large amounts of “positives”
that do not correspond to any viable
9. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 9
infectious virus, SARS-CoV-2 or other. This
is only partly remedied if laboratories
limit themselves to Ct<30, not to
mention the large potential for other bad
laboratory practices in the field.
Add to this the public health dishonesty
of fabricating a new definition of what
constitutes a “case”. A “case” is defined in
medicine as an active, symptomatic and
diagnosed infection. Not any more: Any
“positive” in the faulty RT-PCR “test” is
now counted as a “case”. The mass RT-
PCR testing campaign of the general
asymptomatic population, which has no
clinical or epidemiological utility, thereby
feeds media propaganda of fear, and
disastrous consequences: Garbage-RT-
PCR → meaningless-“cases” → propaganda
→ arbitrary-measures/great-harm →
popularity of leaders[12]
Transmission is not by
contact
On 17 September 2020, an extensive
review was published by Meyerowitz et
al. [24] in one of the leading medical
journals in the world, the Annals of
Internal Medicine, which concluded
what should have been obvious from the
start, even to the WHO: Contact
transmission of viral respiratory diseases,
including SARS-CoV-2, is not a thing.
In the words of Meyerowitz et al. [24]:
Strong evidence from case and
cluster reports indicates that
respiratory transmission is
dominant, with proximity and
ventilation being key
determinants of transmission
risk. In the few cases where
direct contact or fomite
transmission is presumed,
respiratory transmission has not
been completely excluded.
Infectiousness peaks around a
day before symptom onset and
declines within a week of
symptom onset, and no late
linked transmissions (after a
patient has had symptoms for
about a week) have been
documented. The virus has
heterogeneous transmission
dynamics: Most persons do not
transmit virus, whereas some
cause many secondary cases in
transmission clusters called
“superspreading events.”
(Abstract)
[…] There is currently no
conclusive evidence for fomite or
direct contact transmission of
SARS-CoV-2 in humans.
This conclusion has far reaching
implications:
➔ It means that “contact tracing” is
an absurdity for viral respiratory
diseases. No wonder the WHO in
2019 recommended that contact
tracing is “Not recommended in
any circumstances” (see above).
Why did the WHO negate aerosol
transmission for COVID-19? This is
anti-science and arbitrary. [6]
10. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 10
➔ It means that compulsive hand
washing and surface cleaning is
epidemiological nonsense, with
clear negative consequences,
such as massive recalls of toxic
hand sanitizers [25].
➔ It means that governments and
the WHO have been negligent
for more than a decade in not
studying, recommending and
implementing transmission-
focussed ventilation policies for
the built environment. In fact,
the WHO buried its own 2009
expert-panel report on the
subject, under “water sanitation
health” on its website [26], and
an extensive public-domain
review article was published in
2007 [27].
➔ It means that closed door and
window lockdowns of care
homes for elderly persons
constitute the worst possible
scenario to prevent care-home
epidemics.[7][8]
The reviewers Li et al. [27] concluded
(their review has been cited >600 times):
Ten of 40 studies reviewed were
considered to be conclusive with
regard to the association
between building ventilation and
the transmission of airborne
infection. There is strong and
sufficient evidence to
demonstrate the association
between ventilation, air
movements in buildings and the
transmission/spread of infectious
diseases such as measles,
tuberculosis, chickenpox,
influenza, smallpox and SARS.
(Abstract)
I have argued that it is precisely because
the main transmission route is fine
aerosol particles that masks cannot work
to reduce transmission [5][6].
In the face of incontrovertible policy-
grade evidence that masks do not
reduce the wearer’s risk of being infected
[5][6], the WHO and the public health
complex have invented the “magical one
way mask”, which prevents transmission
from the wearer, while not protecting the
wearer. The media has been overjoyed to
propagate this fantasy, which is contrary
to physics, regarding flow of aerosol-
bearing air via the lowest impedance
routes through and around face masks.
The fantasy is the so-called “source
control”, which many trained scientists
have also repeated.
In fact, even a strict military grade
quarantine of young healthy adults
cannot prevent transmission [28].
Nurses know this. In Ontario, there have
been two major administrative tribunal
decisions, in 2015 and in 2018, with
lengthy hearings of experts on all sides,
which both concluded that nurses in
several large hospitals could not be
forced to wear masks, irrespective of
whether they were vaccinated, because
this would not protect patients [29]:
“I think there is now a consensus
developing in the arbitral
community that there is no
question that these policies
really do not protect patients.
The arbitrator was quite robust in
describing the evidence led by
the hospital as ‘insufficient,
inadequate and completely
unpersuasive,’” she [Sharan
Basran, a lawyer for the nurses]
says.
11. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 11
Masking in the general-
population provides no
detectable benefit
Since 11 April 2020, I have argued in some
detail that masks don’t work, and I have
dissected and exposed the disingenuous
spin to the contrary.[5][6] At that time,
there had not yet been a policy-grade
study of masking in a general population.
On 18 November 2020, Bundgaard et al.
[30] published their large randomized
controlled trial (RCT) of participants
selected from the general Danish
population. In their words [30]:
A total of 3030 participants were
randomly assigned to the
recommendation to wear masks,
and 2994 were assigned to
control; 4862 completed the
study. Infection with SARS-CoV-2
occurred in 42 participants
recommended masks (1.8%) and
53 control participants (2.1%). The
between-group difference was
−0.3 percentage point (95% CI,
−1.2 to 0.4 percentage point; P =
0.38) (odds ratio, 0.82 [CI, 0.54 to
1.23]; P = 0.33). Multiple
imputation accounting for loss to
follow-up yielded similar results.
Although the difference
observed was not statistically
significant, the 95% CIs are
compatible with a 46%
reduction to a 23% increase in
infection. (Abstract / Results)
[…] a recommendation to wear a
surgical mask when outside the
home among others did not
reduce, at conventional levels of
statistical significance, incident
SARS-CoV-2 infection compared
with no mask recommendation.
[…] The face masks provided to
participants were high-quality
surgical masks with a filtration
rate of 98% ref]. (Discussion)
To be clear, “95% CIs are compatible with
a 46% reduction to a 23% increase in
infection” means that, within the bounds
of uncertainty, wearing a mask could
have increased the likelihood of being
infected by 23%. Such is the nature of
relative risk evaluation, when the
comparative impact on absolute risk is
too miniscule to be detected.
The authors appear to have been forced
by the “peer review” process to stress that
their study was not designed to test the
hypothesis that I referred to above as the
magical one way mask: “… and no
assessment of whether masks could
decrease disease transmission from mask
wearers to others.”
At this stage, some fifteen (15) policy-
grade RCTs later, with verified outcomes,
one has to wonder what it would take for
the public health complex to abandon its
new-found enthusiasm for forced
general-population masking, or at least
to fund research on the distributed
harms and societal costs of this
draconian policy.
Studies on the quantifiable and potential
harms of universal masking are
beginning to be published, both in
regular and alternative medical journals.
If the “precautionary principle” was more
than spin, then such studies would have
been required prior to general-
population masking laws and
impositions.
On 6 July 2020, for example, Fikenzer et
al. [31] published a rigorous study on the
physiological effect of masks on 12
healthy males (age 38 ± 6 years). They
concluded [31]:
Medical face masks have a
marked negative impact on
cardiopulmonary capacity that
significantly impairs strenuous
physical and occupational
activities. In addition, medical
masks significantly impair the
quality of life of their wearer.
These effects have to be
considered versus the potential
protective effects of face masks
on viral transmissions. The
quantitative data of this study
may, therefore, inform medical
recommendations and policy
makers.
12. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 12
In November 2020, Borovoy et al. [32]
published an extensive review of
biological and medical knowledge that
allows them to infer a large potential for
significant harms from masking. They
rightly stress the known yet underplayed
role of bacteria in viral pandemics, and
also review respiratory diseases arising
from oral bacteria.
Vaccines are inherently
dangerous
On 13 July 2020, an important reality
check was published by Arvin et al. [33]
in the pages of the leading scientific
journal Nature, in the form of an
extensive “Perspective” (review). The
paper, on careful reading, is a detailed
exposé about human ignorance
regarding artificial interference with the
human immune system. Any student of
science should conclude that “we mostly
don’t know anything”. The authors state
this in embellished form as [33]:
Antibody-dependent
enhancement (ADE) of disease is
a general concern for the
development of vaccines and
antibody therapies because the
mechanisms that underlie
antibody protection against any
virus have a theoretical potential
to amplify the infection or trigger
harmful immunopathology. This
possibility requires careful
consideration at this critical
point in the pandemic of
coronavirus disease 2019 (COVID-
19), which is caused by severe
acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). Here
we review observations relevant
to the risks of ADE of disease,
and their potential implications
for SARS-CoV-2 infection. At
present, there are no known
clinical findings, immunological
assays or biomarkers that can
differentiate any severe viral
infection from immune-
enhanced disease, whether by
measuring antibodies, T cells or
intrinsic host responses. In vitro
systems and animal models do
not predict the risk of ADE of
disease, in part because
protective and potentially
detrimental antibody-mediated
mechanisms are the same and
designing animal models
depends on understanding how
antiviral host responses may
become harmful in humans. The
implications of our lack of
knowledge are twofold. First,
comprehensive studies are
urgently needed to define
clinical correlates of protective
immunity against SARS-CoV-2.
13. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 13
Second, because ADE of disease
cannot be reliably predicted
after either vaccination or
treatment with antibodies—
regardless of what virus is the
causative agent—it will be
essential to depend on careful
analysis of safety in humans as
immune interventions for
COVID-19 move forward.
(Abstract)
Given the roll out that followed, this
means that we have blindly embarked
on a large-scale experiment on human
subjects, without animal trials, without
scientific transparency, without the
possibility of informed consent, driven by
pharmaceutical corporations that only
want the good of humanity.
On 1 October 2020, Wehenkel [34]
published a paper in which he studied 39
countries and found a large association
between national influenza vaccination
rate (IVR) of people 65 years and older
and reported COVID-19 deaths per
million inhabitants. The results are
preliminary but may be a documented
example of “antibody-dependent
enhancement (ADE) of disease” involving
COVID-19. All the highest COVID-19 death
rates occurred in countries with IVR >
50% (see his figures 1 and 3). I sense a
research funding opportunity to undo
this finding.
14. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 14
Endnotes / References
[1] 2019--WHO : “Non-pharmaceutical
public health measures for mitigating
the risk and impact of epidemic and
pandemic influenza”, with Annex, World
Health Organization, October 2019 :
https://www.who.int/influenza/publicatio
ns/public_health_measures/publication/
en/ . Report, ISBN: 978-92-4-151683-9, pp
91,
https://apps.who.int/iris/bitstream/handle
/10665/329438/9789241516839-eng.pdf /
“Annex: Report of systematic literature
reviews”, WHO/WHE/IHM/GIP/2019.1, pp
125,
https://apps.who.int/iris/bitstream/handle
/10665/329439/WHO-WHE-IHM-GIP-
2019.1-eng.pdf
[2] 2017--WHO : “PANDEMIC INFLUENZA
SEVERITY ASSESSMENT (PISA): A WHO
guide to assess the severity of influenza
in seasonal epidemics & pandemics”,
World Health Organization, May 2017,
WHO/WHE/IHM/GIP/2017.2,
https://apps.who.int/iris/bitstream/handle
/10665/259392/WHO-WHE-IHM-GIP-
2017.2-eng.pdf
[3] 2011--Bonneux : Luc Bonneux & Wim
Van Damme. “Health is more than
influenza”. Bulletin of the World Health
Organization 2011;89:539-540.
DOI:10.2471/BLT.11.089086.
https://www.who.int/bulletin/volumes/89
/7/11-089086/en/
[4] 2010--Cohen : Cohen, D. and Carter, P.
“WHO and the pandemic flu
“conspiracies””. British Medical Journal
2010; 340:c2912.
DOI:https://doi.org/10.1136/bmj.c2912
(Published 04 June 2010).
https://www.bmj.com/content/bmj/340/7
759/Feature.full.pdf
[5] 2020--Rancourt : “Masks Don’t Work:
a Review of Science Relevant to COVID-
19 Social Policy”. Rancourt, DG (11 April
2020) ResearchGate, obtained 400 K
reads, then was deplatformed, as per this
report: https://archive.org/details/COVID-
censorship-at-research-gate-2/ . Now at:
https://vixra.org/abs/2006.0044 , and at:
https://www.rcreader.com/commentary/
masks-dont-work-COVID-a-review-of-
science-relevant-to-COVIDe-19-social-
policy . And see the Digi-Debates about
criticism of the article: “Digi-Debates.
The Face Mask Debate”, Digi Debates
YouTube Channel, 25 July 2020,
https://youtu.be/AQyLFdoeUNk, and at:
https://www.digi-debates.com/ .
[6] 2020--Rancourt : “Face masks, lies,
damn lies, and public health officials: "A
growing body of evidence"”.
ResearchGate (3 August 2020).
DOI:10.13140/RG.2.2.25042.58569 -
https://www.researchgate.net/publicatio
n/343399832_Face_masks_lies_damn_lie
s_and_public_health_officials_A_growin
g_body_of_evidence
[7] 2020--Rancourt : “All-cause mortality
during COVID-19: No plague and a likely
signature of mass homicide by
government response”, by Rancourt, DG
(2 June 2020) ResearchGate.
DOI:10.13140/RG.2.2.24350.77125
https://www.researchgate.net/publicatio
n/341832637_All-
cause_mortality_during_COVID-
19_No_plague_and_a_likely_signature_of
_mass_homicide_by_government_respo
nse
[8] 2020--Rancourt : D. G. Rancourt,
Marine Baudin, Jérémie Mercier.
“Evaluation of the virulence of SARS-
CoV-2 in France, from all-cause
mortality 1946-2020”. ResearchGate (20
August 2020).
DOI:10.13140/RG.2.2.16836.65920/1 -
https://www.researchgate.net/publicatio
n/343775235_Evaluation_of_the_virulenc
e_of_SARS-CoV-2_in_France_from_all-
cause_mortality_1946-2020
15. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 15
[9] 2020--Chaudhry : Chaudhry, Rabail et
al. (2020) “A country level analysis
measuring the impact of government
actions, country preparedness and
socioeconomic factors on COVID-19
mortality and related health outcomes”.
EClinicalMedicine, Volume 25, 100464 (21
July 2020) -
https://www.thelancet.com/journals/eclin
m/article/PIIS2589-5370(20)30208-
X/fulltext
[10] 2020--De Larochelambert : De
Larochelambert Q, Marc A, Antero J, Le
Bourg E and Toussaint J-F (2020).
“COVID-19 Mortality: A Matter of
Vulnerability Among Nations Facing
Limited Margins of Adaptation”.
Frontiers in Public Health 8:604339.
DOI:10.3389/fpubh.2020.604339 (19
November 2020). -
https://www.frontiersin.org/articles/10.338
9/fpubh.2020.604339/full
[11] 2020--AIER : “Lockdowns Do Not
Control the Coronavirus: The Evidence”.
AIER Staff. American Institute for
Economic Research. December 19, 2020.
- https://www.aier.org/article/lockdowns-
do-not-control-the-coronavirus-the-
evidence/
[12] 2020--Yam : Kai Chi Yam, Joshua
Conrad Jackson, Christopher M. Barnes,
Jenson Lau, Xin Qin, Hin Yeung Lee. “The
rise of COVID-19 cases is associated with
support for world leaders”. Proceedings
of the National Academy of Sciences.
Oct 2020, 117 (41) 25429-25433;
DOI:10.1073/pnas.2009252117 -
https://www.pnas.org/content/117/41/2542
9.full
[13] 2020--Abbasi : Abbasi, Kamran
(executive editor). “COVID-19:
politicisation, “corruption,” and
suppression of science”. British Medical
Journal. BMJ 2020; 371 :m4425. -
https://www.bmj.com/content/371/bmj.m
4425
[14] 2020--Gandhi : Monica Gandhi and
George W. Rutherford. “Facial Masking
for COVID-19 — Potential for
“Variolation” as We Await a Vaccine”.
October 29, 2020. The New England
Journal of Medicine 2020; 383:e101.
DOI:10.1056/NEJMp2026913 -
https://www.nejm.org/doi/full/10.1056/NE
JMp2026913
[15] 2020--Rasmussen : Angela L.
Rasmussen et al. “Facial Masking for
COVID-19”. The New England Journal of
Medicine, nejm.org, 19 November 2020.
(criticism of Gandhi et al.)
[16] 2020--Brosseau : Lisa M. Brosseau et
al. “Facial Masking for COVID-19”. The
New England Journal of Medicine,
nejm.org, 19 November 2020. (criticism of
Gandhi et al.)
[17] 2020--Gandhi : Monica Gandhi and
George W. Rutherford. “Facial Masking
for COVID-19”. The New England Journal
of Medicine, nejm.org, 19 November
2020. (reply of Gandhi et al.)
[18] 2020--IHME : IHME COVID-19
Forecasting Team., Reiner, R.C., Barber,
R.M. et al. “Modeling COVID-19 scenarios
for the United States”. Nature Medicine
(2020). https://doi.org/10.1038/s41591-
020-1132-9 -
https://www.nature.com/articles/s41591-
020-1132-9
[19] 2020--Magness : Phillip W. Magness.
“Case for mask mandate rests on bad
data”. Wall Street Journal (11 November
2020). -
https://www.wsj.com/articles/case-for-
mask-mandate-rests-on-bad-data-
11605113310
[20] 2020--Corman : Corman Victor M,
Landt Olfert, Kaiser Marco, Molenkamp
Richard, Meijer Adam, Chu Daniel KW,
Bleicker Tobias, Brünink Sebastian,
Schneider Julia, Schmidt Marie Luisa,
Mulders Daphne GJC, Haagmans Bart L,
16. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 16
van der Veer Bas, van den Brink Sharon,
Wijsman Lisa, Goderski Gabriel, Romette
Jean-Louis, Ellis Joanna, Zambon Maria,
Peiris Malik, Goossens Herman, Reusken
Chantal, Koopmans Marion PG, Drosten
Christian. “Detection of 2019 novel
coronavirus (2019-nCoV) by real-time
RT-PCR”. Euro Surveillance.
2020;25(3):pii=2000045.
https://doi.org/10.2807/1560-
7917.ES.2020.25.3.2000045
[21] 2020--Borger : Borger, Pieter et al.
"Review report Corman-Drosten et al.
Eurosurveillance 2020 - External peer
review of the RTPCR test to detect
SARS-CoV-2 reveals 10 major scientific
flaws at the molecular and
methodological level: consequences for
false positive results". International
Consortium of Scientists in Life Sciences
(ICSLS). 27 November 2020.
https://cormandrostenreview.com/report/
[22] 2020--Singanayagam :
Singanayagam Anika, Patel Monika,
Charlett Andre, Lopez Bernal Jamie,
Saliba Vanessa, Ellis Joanna, Ladhani
Shamez, Zambon Maria, Gopal Robin.
“Duration of infectiousness and
correlation with RT-PCR cycle threshold
values in cases of COVID-19, England,
January to May 2020”. Euro Surveillance.
2020;25(32):pii=2001483.
https://doi.org/10.2807/1560-
7917.ES.2020.25.32.2001483
[23] 2020--Jaafar : Jaafar R, Aherfi S,
Wurtz N, Grimaldier C, Hoang VT, Colson
P, Raoult D, La Scola B. “Correlation
between 3790 qPCR positives samples
and positive cell cultures including 1941
SARS-CoV-2 isolates”. Clinical Infectious
Diseases. 2020 Sep 28:ciaa1491.
DOI:10.1093/cid/ciaa1491. Epub ahead of
print. PMID: 32986798; PMCID:
PMC7543373. -
https://academic.oup.com/cid/advance-
article/doi/10.1093/cid/ciaa1491/5912603
[24] 2020--Meyerowitz : Eric A.
Meyerowitz, Aaron Richterman, Rajesh T.
Gandhi, et al. “Transmission of SARS-
CoV-2: A Review of Viral, Host, and
Environmental Factors”. Annals of
Internal Medicine. [Epub ahead of print
17 September 2020]. doi:10.7326/M20-
5008 -
https://www.acpjournals.org/doi/full/10.73
26/M20-5008
[25] 2020--CBC--The Canadian Press :
“Health Canada recalls more than 50
hand sanitizers in evolving list”. (5
August 2020). -
https://www.cbc.ca/news/health/sanitizer
-recall-expands-canada-1.5675182
[26] 2009--WHO: “Natural ventilation
for infection control in health-care
settings - WHO guidelines 2009”.
Editors: James Atkinson, Yves Chartier,
Carmen Lúcia Pessoa-Silva, Paul Jensen,
Yuguo Li and Wing-Hong Seto, pp 106,
2009, ISBN: 978 92 4 154785 7 -
https://www.who.int/water_sanitation_he
alth/publications/natural_ventilation/en/
[27] 2007--Li : Li Y, Leung GM, Tang JW,
Yang X, Chao CY, Lin JZ, Lu JW, Nielsen
PV, Niu J, Qian H, Sleigh AC, Su HJ,
Sundell J, Wong TW, Yuen PL. “Role of
ventilation in airborne transmission of
infectious agents in the built
environment - a multidisciplinary
systematic review”. Indoor Air. 2007
Feb;17(1):2-18. DOI:10.1111/j.1600-
0668.2006.00445.x. PMID: 17257148.
[28] 2020--Letizia : Letizia AG, Ramos I,
Obla A, Goforth C, Weir DL, Ge Y,
Bamman MM, Dutta J, Ellis E, Estrella L,
George MC, Gonzalez-Reiche AS, Graham
WD, van de Guchte A, Gutierrez R, Jones
F, Kalomoiri A, Lizewski R, Lizewski S,
Marayag J, Marjanovic N, Millar EV, Nair
VD, Nudelman G, Nunez E, Pike BL, Porter
C, Regeimbal J, Rirak S, Santa Ana E,
Sealfon RSG, Sebra R, Simons MP, Soares-
Schanoski A, Sugiharto V, Termini M,
Vangeti S, Williams C, Troyanskaya OG,
17. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 17
van Bakel H, Sealfon SC. “SARS-CoV-2
Transmission among Marine Recruits
during Quarantine”. The New England
Journal of Medicine. 2020 Dec
17;383(25):2407-2416.
DOI:10.1056/NEJMoa2029717. Epub 2020
Nov 11. PMID: 33176093; PMCID:
PMC7675690. (11 November 2020) -
https://www.nejm.org/doi/full/10.1056/NE
JMoa2029717
[29] 2018--Brown : “ONA wins second
arbitration against hospitals on
‘vaccinate or mask’ policy” (13
September 2018), Canadian Lawyer
Magazine.
https://www.canadianlawyermag.com/pr
actice-areas/privacy-and-data/ona-wins-
second-arbitration-against-hospitals-on-
vaccinate-or-mask-policy/275455
[30] 2020--Bundgaard : Bundgaard H,
Bundgaard JS, Raaschou-Pedersen DET,
von Buchwald C, Todsen T, Norsk JB,
Pries-Heje MM, Vissing CR, Nielsen PB,
Winsløw UC, Fogh K, Hasselbalch R,
Kristensen JH, Ringgaard A, Porsborg
Andersen M, Goecke NB, Trebbien R,
Skovgaard K, Benfield T, Ullum H, Torp-
Pedersen C, Iversen K. “Effectiveness of
Adding a Mask Recommendation to
Other Public Health Measures to
Prevent SARS-CoV-2 Infection in Danish
Mask Wearers : A Randomized
Controlled Trial”. Annals of Internal
Medicine. 2020 Nov 18:M20-6817.
DOI:10.7326/M20-6817. Epub ahead of
print. PMID: 33205991; PMCID:
PMC7707213. -
https://www.acpjournals.org/doi/10.7326/
M20-6817
[31] 2020--Fikenzer : Fikenzer S, Uhe T,
Lavall D, Rudolph U, Falz R, Busse M,
Hepp P, Laufs U. “Effects of surgical and
FFP2/N95 face masks on
cardiopulmonary exercise capacity”.
Clinical Research in Cardiology. 2020
Dec;109(12):1522-1530.
DOI:10.1007/s00392-020-01704-y. Epub
2020 Jul 6. PMID: 32632523; PMCID:
PMC7338098. -
https://link.springer.com/article/10.1007/s
00392-020-01704-y
[32] 2020--Borovoy : Boris Borovoy,
Colleen Huber, Maria Crisler. “Masks,
false safety and real dangers, Part 2:
Microbial challenges from masks”.
Primary Doctor Medical Journal.
November 2020. - https://pdmj.org/
[33] 2020--Arvin : Arvin AM, Fink K,
Schmid MA, Cathcart A, Spreafico R,
Havenar-Daughton C, Lanzavecchia A,
Corti D, Virgin HW. “A perspective on
potential antibody-dependent
enhancement of SARS-CoV-2”. Nature.
2020 Aug;584(7821):353-363.
DOI:10.1038/s41586-020-2538-8. Epub
2020 Jul 13. PMID: 32659783. -
https://www.nature.com/articles/s41586-
020-2538-8
[34] 2020--Wehenkel : Wehenkel C.
2020. “Positive association between
COVID-19 deaths and influenza
vaccination rates in elderly people
worldwide”. PeerJ 8:e10112
https://doi.org/10.7717/peerj.10112
18. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 18
My competence to review
science about COVID-19
Denis G. Rancourt, PhD
Researcher, Ontario Civil Liberties
Association (ocla.ca)
Member scientist, PANDA
I am retired and a former tenured Full
Professor of Physics, University of Ottawa.
Full Professor is the highest academic
rank. During my 23-year career as a
university professor, I developed new
courses and taught over 2000 university
students, at all levels, and in three
different faculties (Science, Engineering,
Arts). I supervised more than 80 junior
research terms or degrees at all levels
from post-doctoral fellow to graduate
students to NSERC undergraduate
researchers. I headed an internationally
recognized interdisciplinary research
laboratory, and attracted significant
research funding for two decades.
I have been an invited plenary, keynote,
or special session speaker at major
scientific conferences some 40 times. I
have published over 100 research papers
in leading peer-reviewed scientific
journals, in the areas of physics,
chemistry, geology, bio-geochemistry,
measurement science, soil science, and
environmental science.
My scientific h-index impact factor is 40,
and my articles have been cited more
than 5,000 times in peer-reviewed
scientific journals (profile at Google
Scholar:
https://scholar.google.ca/citations?user=1
ChsRsQAAAAJ).
My personal knowledge and ability to
evaluate the facts in this article are
grounded in my education, research,
training and experience, as follows:
i. Regarding environmental
nanoparticles. Viral respiratory
diseases are transmitted by the
smallest size-fraction of virion-laden
aerosol particles, which are reactive
environmental nanoparticles.
Therefore, the chemical and physical
stabilities and transport properties of
these aerosol particles are the
foundation of the dominant
contagion mechanism through air.
My extensive work on reactive
environmental nanoparticles is
internationally recognized, and
includes: precipitation and growth,
surface reactivity, agglomeration,
surface charging, phase
transformation, settling and
sedimentation, and reactive
dissolution. In addition, I have taught
the relevant fluid dynamics (air is a
compressible fluid), and gravitational
settling at the university level, and I
have done industrial-application
research on the technology of
filtration (face masks are filters).
ii. Regarding molecular science,
molecular dynamics, and surface
complexation. I am an expert in
molecular structures, reactions, and
dynamics, including molecular
complexation to biotic and abiotic
surfaces. These processes are the basis
of viral attachment, antigen
attachment, molecular replication,
attachment to mask fibers, particle
charging, loss and growth in aerosol
particles, and all such phenomena
involved in viral transmission and
infection, and in protection measures.
I taught quantum mechanics at the
advanced university level for many
years, which is the fundamental
theory of atoms, molecules and
substances; and in my published
19. PANDA REPORTS - PANDATA.ORG | REVIEW OF RECENT SCIENCE RELEVANT TO COVID POLICY | 19
research I developed X-ray diffraction
theory and methodology for
characterizing small material
particles.
iii. Regarding statistical analysis
methods. Statistical analysis of
scientific studies, including robust
error propagation analysis and robust
estimates of bias, sets the limit of
what reliably can be inferred from any
observational study, including
randomized controlled trials in
medicine, and including field
measurements during epidemics. I
am an expert in error analysis and
statistical analysis of complex data, at
the research level in many areas of
science. Statistical analysis methods
are the basis of medical research.
iv. Regarding mathematical modelling.
Much of epidemiology is based on
mathematical models of disease
transmission and evolution in the
population. I have research-level
knowledge and experience with
predictive and exploratory
mathematical models and simulation
methods. I have expert knowledge
related to parameter uncertainties
and parameter dependencies in such
models. I have made extensive
simulations of epidemiological
dynamics, using standard
compartmental models (SIR, MSIR)
and new models.
v. Regarding measurement methods.
In science there are five main
categories of measurement methods:
(1) spectroscopy (including nuclear,
electronic and vibrational
spectroscopies), (2) imaging
(including optical and electron
microscopies, and resonance
imaging), (3) diffraction (including X-
ray and neutron diffractions, used to
elaborate molecular, defect and
magnetic structures), (4) transport
measurements (including reaction
rates, energy transfers, and
conductivities), and (5) physical
property measurements (including
specific density, thermal capacities,
stress response, material fatigue…). I
have taught these measurement
methods in an interdisciplinary
graduate course that I developed and
gave to graduate (M.Sc. and Ph.D.)
students of physics, biology,
chemistry, geology, and engineering
for many years. I have made
fundamental discoveries and
advances in areas of spectroscopy,
diffraction, magnetometry, and
microscopy, which have been
published in leading scientific
journals and presented at
international conferences. I know
measurement science, the basis of all
sciences, at the highest level.