History of Epidemics & Pandemics of World & India- A case study-peterpdPeter Prasanta Debbarma
Here one will know the cases of Epidemic and Pandemic and their nature from the World and India as well as their history and nature of spread and also safety lessons learnt
History of Epidemics & Pandemics of World & India- A case study-peterpdPeter Prasanta Debbarma
Here one will know the cases of Epidemic and Pandemic and their nature from the World and India as well as their history and nature of spread and also safety lessons learnt
This resource pack supports the Spanish Flu simulator at http://resources.modelling4all.org/spanish-flu/teacher-guide-to-spanish-flu-simulation.
More people died from the 1918-1920 Spanish Influenza pandemic than there were casulties as a result of the First World War. This world-wide epidemic caused by influenza viruses led to between 50 and 100 million deaths in 1918 and 1919 (as much as 1 of every 18 people).
Many researchers have suggested that the conditions of the war significantly aided the spread of the disease. And others have argued that the course of the war (and subsequent peace treaty) was influenced by the pandemic.
This article aims to present the real causes of pandemics based on expert opinion and show how to prevent them in the future. The dominant opinion of these experts is that humanity will have to make profound changes in its relationship with nature to prevent new pandemics from happening that threaten its very existence.
Presentation from the European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE), published by the European Centre for Disease Prevention and Control (ECDC)
Eric Luellen's presentation at Harvard University virology class on December 3, 2015 about veepox, the weaponization of smallpox via recombination with Venezuelan equine encephalomyelitis (VEEV); Dark Winter, a model for extrapolating the impact of weaponized smallpox; and, Dark Winter 2.0, one example of applying veepox to that model.
Coronavirus effects heighten fears of recession in the world economy. Stock exchanges have had a difficult week around the world and, in Europe, the recession seems inevitable. The paralysis in China weighs on domestic growth because the supply chains of multinationals need components made in Chinese factories to guarantee their production. Consumption in western countries will be strongly affected. Tourism, air transport, leisure are already suffering the consequences.
After months of deliberation, the World Health Organization has
declared COVID-19 a pandemic. As it seemed clear for quite some time, the virus will likely spread to most (if not all) countries on the globe. However, actions can still limit its impact.
3 best reasons that describe Will There Be a Next Pandemic? | The Lifescience...The Lifesciences Magazine
Here are 3 best reasons that describe Will There Be a Next Pandemic? ;
1. What role does climate change play in the next pandemic?
2. How do we monitor for the next outbreak?
3. How do we prepare for the next pandemic?
This resource pack supports the Spanish Flu simulator at http://resources.modelling4all.org/spanish-flu/teacher-guide-to-spanish-flu-simulation.
More people died from the 1918-1920 Spanish Influenza pandemic than there were casulties as a result of the First World War. This world-wide epidemic caused by influenza viruses led to between 50 and 100 million deaths in 1918 and 1919 (as much as 1 of every 18 people).
Many researchers have suggested that the conditions of the war significantly aided the spread of the disease. And others have argued that the course of the war (and subsequent peace treaty) was influenced by the pandemic.
This article aims to present the real causes of pandemics based on expert opinion and show how to prevent them in the future. The dominant opinion of these experts is that humanity will have to make profound changes in its relationship with nature to prevent new pandemics from happening that threaten its very existence.
Presentation from the European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE), published by the European Centre for Disease Prevention and Control (ECDC)
Eric Luellen's presentation at Harvard University virology class on December 3, 2015 about veepox, the weaponization of smallpox via recombination with Venezuelan equine encephalomyelitis (VEEV); Dark Winter, a model for extrapolating the impact of weaponized smallpox; and, Dark Winter 2.0, one example of applying veepox to that model.
Coronavirus effects heighten fears of recession in the world economy. Stock exchanges have had a difficult week around the world and, in Europe, the recession seems inevitable. The paralysis in China weighs on domestic growth because the supply chains of multinationals need components made in Chinese factories to guarantee their production. Consumption in western countries will be strongly affected. Tourism, air transport, leisure are already suffering the consequences.
After months of deliberation, the World Health Organization has
declared COVID-19 a pandemic. As it seemed clear for quite some time, the virus will likely spread to most (if not all) countries on the globe. However, actions can still limit its impact.
3 best reasons that describe Will There Be a Next Pandemic? | The Lifescience...The Lifesciences Magazine
Here are 3 best reasons that describe Will There Be a Next Pandemic? ;
1. What role does climate change play in the next pandemic?
2. How do we monitor for the next outbreak?
3. How do we prepare for the next pandemic?
Coronavirus Unmasked - Biosecurity and Medical FascismAndrew Johnson
In this presentation, we will go through the evidence relating to the history and planning of the alleged COVID-19 Pandemic and how it fits in with a wider, more longstanding globalist agenda. We will look at how the UK Govt. has lied and committed crimes in relation to the measures it has implemented.
Slide 004 - Andrew’s Activities re COVID-19
https://cvpandemicinvestigation.com/
https://cvpandemicinvestigation.com/covid-19-investigation-report-challenging-the-narrative-pandemic/
https://cvpandemicinvestigation.com/2020/09/covid-19-evidence-of-fraud-medical-malpractice-acts-of-domestic-terrorism-and-breaches-of-human-rights/
Slide 006 - Swine Flu (2009) – Looking at Evidence
https://vimeo.com/25624580
Slide 018 - WHO Advisory Checklist - 1
https://www.who.int/csr/resources/publications/influenza/WHO_CDS_CSR_GIP_2005_4/en/
Slide 020 - Swine Flu – Retrospective Review
https://www.telegraph.co.uk/news/health/swine-flu/7865796/Swine-flu-killed-457-people-and-cost-1.24-billion-official-figures-show.html
Slide 021 - Swine Flu Vaccine?
https://www.bmj.com/content/362/bmj.k3948
Slide 024 - WHO Dunnit…
https://www.detroitnews.com/story/news/world/2020/03/11/declares-virus-crisis-now-pandemic/111415246/
https://www.bbc.co.uk/news/world-africa-51720184
https://www.opride.com/2017/05/11/case-director-general-candidate-tedros-adhanom/
https://www.theburningplatform.com/2020/04/04/the-crimes-of-tedros-adhanom/
Slide 025 - Who Planned it…??
https://hub.jhu.edu/2019/11/06/event-201-health-security/
https://www.youtube.com/watch?v=AoLw-Q8X174
http://www.centerforhealthsecurity.org/event201/about
https://www.bloomberg.com/features/2020-china-wuhan-pollution/
Slide 026 - Someone is worried about Dissent…
https://ec.europa.eu/info/live-work-travel-eu/health/coronavirus-response/fighting-disinformation/identifying-conspiracy-theories_en
Slide 028 - Dr Neil Ferguson’s “Scare” Model
https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-Europe-estimates-and-NPI-impact-30-03-2020.pdf
https://www.ecdc.europa.eu/en/covid-19/data-collection
https://www.washingtonexaminer.com/news/imperial-college-scientist-who-predicted-500k-coronavirus-deaths-in-uk-revises-to-20k-or-less
https://lockdownsceptics.org/code-review-of-fergusons-model/
https://twitter.com/neil_ferguson/status/1241835454707699713
https://www.vaccineimpact.org/resources/VIMC_orgchart_2017.pdf
https://www.mirror.co.uk/news/politics/professor-behind-coronavirus-lockdown-plan-21979710
Slide 030 - UK – COVID-19 is NOT an HCID…
https://cvpandemicinvestigation.com/wp-content/uploads/2020/08/Letter-JVT-March13th_Open_Government_Status-.pdf
Slide 031 - UK Government Posts Statement
https://www.gov.uk/guidance/high-consequence-infectious-diseases-hcid
Sorry - no more space!
Impacts of Covid 19 on Human Existence in the Contemporary Worldijtsrd
The COVID 19pandemictook the 2020 world by storm and shook it to the foundations. It hit the world without premonitions, spread faster than wild fire and struck with malignant ferociousness. What started as a puzzle in late 2019 became a full pandemic in 2020, throwing the entire world into a frenzy of panic and confusion. Nation after nation went into lockdown. The entire world raced for remedy. Hundreds of thousands became ill within weeks. Existence of humans became threatened worldwide. People’s mode of living forcefully changed. Death became imminent. Uncertainty hovered over human existence. The meaning of existence came under question as the world grappled with the malignant virus. This work probes the impacts of the COVID 19 pandemic on human existence. Ebo Socrates | Ikimi Charles German "Impacts of Covid-19 on Human Existence in the Contemporary World" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-3 , April 2022, URL: https://www.ijtsrd.com/papers/ijtsrd49834.pdf Paper URL: https://www.ijtsrd.com/chemistry/biochemistry/49834/impacts-of-covid19-on-human-existence-in-the-contemporary-world/ebo-socrates
Mundo Offshore - Coronavirus update - Luigi Wewege article (English)Luigi Wewege
The world is already facing financial, social and personal security issues on an ever increasing scale. The Coronavirus is yet another challenge in this plethora of attacks on personal and financial freedom, so the experts of Mundo Offshore have decided to prepare a report. This report is intended to give advice so you can prepare yourself for the upcoming challenges that you will have to face both in a financial and a personal sense.
Emergency management 11
Emergency Management
Abstract:
In the month of December, 2019 there was outbreak of pneumonia with unknown reason in Wuhan, China. Wuhan is the center of attention because of the respiratory disorder cause by a virus called Corona and also known as Novel COVID – 19. Validate the existence of this virus was also diagnosed in Wuhan. Then it start spreading all over the world due to the social gatherings. It ultimately take thousands of people towards death. Then after its huge destruction a final step of lockdown is taken up by the government of each country. The animal-to-human transmission was presumed as the main mechanism. It was concluded that the virus could also be transmitted from human-to-human, and symptomatic people are the most frequent source of COVID-19 spread. The virus-host interaction and the evolution of the epidemic, with specific reference to the times when the epidemic will reach its peak.
Introduction:
There is scanty knowledge on the actual pandemic potential of this new SARS-like virus. It might be speculated that SARS-CoV-2 epidemic is grossly underdiagnosed and that the infection is silently spreading across the globe. There are no comparable analogies to corona virus. This virus is not like any of the other epidemiological threats that have emerged in recent decades; it is less fatal but much more contagious.
Distribution of cases by the following:
· Time: The outbreak of 2019 novel coronavirus disease (COVID-19) was first reported on December 31, 2019.
· Place: the epidemiology of 2019 novel coronavirus disease (COVID-19) in a remote region of China, far from Wuhan, we analyzed the epidemiology of COVID-19 in Gansu Province
Explanation of the research topic (corona virus):
As the outbreak of coronavirus disease 2019 (COVID-19) is rapidly expanding in China and beyond, with the potential to become a world-wide pandemic, real-time analyses of epidemiological data are needed to increase situational awareness and inform interventions. The current most likely hypothesis is that an intermediary host animal has played a role in the transmission. Identifying the animal source of the 2019-nCoV would help to ensure that there will be no further future similar outbreaks with the same virus and will also help understanding the initial spread of the disease.
Numerator (cases of corona virus):
Deaths divided the total of deaths plus recoveries. In early days because of the exponential increase new cases significantly outpace recoveries. You’re dividing by new cases but the numerator hasn’t had a chance to catch up to the death toll yet to be associated with those cases. If you look at COVID 19 on Feb 17, you get the 2% number only if dividing by total cases. If you look vs recovered cases, it’s 13%.
The WHO’s fatality percentage, announced March 17, 2020, is based simply on the number of deaths g.
Migrating Diseases
Our second ‘World in 2030’ foresight focuses on the growing threat from migrating diseases that are being enabled by the escalating implications of global warming.
The fast-developing view is that with 2oC of global warming probable and 4oC possible, health systems will struggle to address the growing impact of climate change. The increased spread of vector-borne diseases is joining poor air quality as a major public health threat.
More anticipate an extension of the reach and duration of tropical disease alongside the re-emergence of old infections. Certainly, warmer conditions and changes in precipitation are facilitating the expansion of disease-carrying vectors, such as mosquitoes and ticks. Dengue fever has joined malaria and Lyme’s on the list of fast-spreading diseases that are, most significantly, entering countries with little or no prior experience of them. To stem the tide, improved surveillance, enhanced HCP education and better public understanding are all being called for.
This foresight is one of 50 looking at the key issues for the next decade that are being shared throughout 2020.
https://www.futureagenda.org/foresights/migratingdiseases/
this ppt is made by shrikrishna kesharwani , student of urban planning,4th year, Manit , Bhopal,
in this ppt, I have discussed how to do pandemic or epidemic management in detail.,
The presentation covers known Variants Covid -19 of medical importance and the second wave Covid - 19 that hit in India. The factors that led to the abrupt raised number of cases in a short time.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
THE REAL HISTORY OF COVID-19
1. The history of COVID-19
Make sure to check this link: https://www.digistore24.com/redir/299134/Lizaah/
The epic human Covid infection COVID-19 has become the fifth reported pandemic since the
1918 influenza pandemic. Coronavirus was first detailed in Wuhan, China, and accordingly
spread around the world. The Covid was authoritatively named serious intense respiratory
disorder Covid 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses
dependent on phylogenetic investigation.The epic Covid pandemic, known as Coronavirus,
couldn't have been more unsurprising. From my own detailing, I knew this directly. In October
2019, I went to a reenactment including an anecdotal pandemic, brought about by a novel Covid,
which killed 65 million individuals.
In 2019, US President Donald Trump's Division of Wellbeing and Human Administrations did a
pandemic exercise named "Blood red Virus", which envisioned an influenza pandemic beginning
in China and spreading all throughout the planet. The recreation anticipated that 586,000
individuals would pass on in the US alone. In the event that the most skeptical gauges about
Coronavirus work out as expected, the obviously better named "Ruby Disease" will appear to be
a day in the recreation center.
As of 26 March, there were in excess of 470,000 affirmed instances of Coronavirus all
throughout the planet and in excess of 20,000 passing are, contacting each landmass save
Antarctica. This was a pandemic, as a general rule, a long time before the World Wellbeing
Association at last pronounced it one on 11 Walk. Furthermore, we ought to have seen it coming.
Coronavirus marks the arrival of an old – and recognizable – adversary. Since the beginning,
nothing has slaughtered more people than the infections, microorganisms and parasites that cause
illness. Not catastrophic events like tremors or volcanoes. Not conflict – way off the mark.
Nearly 50 to 100 million individuals passed on in the 1918 flu pandemic – numbers that
outperform the loss of life of The Second Great War, which was being battled simultaneously.
The 1918 seasonal infection tainted one in each three individuals in the world. (Peruse more
about how the 1918 influenza changed the world). HIV, a pandemic that is still with us and still
comes up short on immunization, has killed an expected 32 million individuals and tainted 75
million, with more added each day.
In the event that these numbers stun, this is on the grounds that today pandemics are infrequently
talked about in history classes, while not long ago, they were just a horrendous unavoidable
truth. There are not many dedications to the survivors of infection. The student of history Alfred
Crosby was the writer of America's Failed to Remember Pandemic, one of the extraordinary
books on the 1918 influenza. In any case, Crosby was possibly incited to start investigating the
pandemic when he staggered on the failed to remember certainty that American future had out of
nowhere dropped from 51 years in 1917 to 39 years in 1918, preceding bouncing back the next
year. That plunge in 1918 was a direct result of an infection only 120 nanometers wide.
2. That is the uplifting news. The awful news, as Coronavirus reminds us, is that irresistible
infections haven't disappeared. Indeed, there are more new ones now than any other time: the
quantity of new irresistible illnesses like Sars, HIV and Coronavirus has expanded by almost
fourfold over the previous century. Since 1980 alone, the quantity of flare-ups each year has
dramatically multiplied.
There are a few purposes behind this uptick. For one, in the course of recent years, we've
dramatically increased the quantity of individuals in the world. This implies more individuals to
get contaminated and thus to taint others, particularly in thickly populated urban areas. We
likewise have more animals now than we did throughout the most recent 10,000 years of taming
up to 1960 joined, and infections can jump from those creatures to us.
As Covid-19 is agonizingly illustrating our interconnected worldwide economy the two aides
spread new irresistible sicknesses – and, with its long stock chains, is remarkably helpless
against the disturbance that they can cause. The capacity to get to almost any spot on the planet
in 20 hours or less, and pack an infection alongside our portable baggage, permits new illnesses
to arise and to develop when they may have ceased to exist before.
For every one of the advances we've made against irresistible sickness, our very development has
made us more helpless, not less, to microorganisms that advance 40 million times quicker than
people do.
The World Health Organization, which performed so well under the pressure of Sars, has
bungled later episodes so gravely that specialists have required the whole association to be
upgraded. Environmental change is extending the scope of illness conveying creatures and bugs
like the Aedes aegypti mosquitoes that send the Zika infection.
Indeed, even human brain research is to blame. The spread of immunization distrust has been
joined by the revival of since quite a while ago vanquished illnesses like measles, driving the
WHO in 2019 to name the anti vaccination development one of the world's main 10 general
wellbeing dangers.
Coronavirus is an infection existing apart from everything else, arising in a packed city in a
recently prosperous and associated China prior to spreading to the remainder of the world very
quickly. Be that as it may, our reaction to it has been both hyper-current – and for all intents and
purposes archaic. Researchers all throughout the planet are utilizing state of the art instruments
to quickly arrange the genome of the Covid, pass along data about its destructiveness, and team
up on potential countermeasures and antibodies, all far faster than might have been done
previously.
In any case, when the infection showed up among us, our lone powerful reaction was to close
down society and mood killer the sequential construction system of worldwide private enterprise.
Short of text-based notifications, videoconferencing and Netflix, what we were doing wasn't that
not the same as what our predecessors may have attempted to stop a flare-up of the plague. The
outcome has been chemotherapy for the worldwide economy.
Similarly as the inevitable development of something like Covid-19 was effectively unsurprising,
so too are the moves we ought to have made to shore ourselves against its coming.
3. We need to incorporate more leeway into our general wellbeing frameworks. Similarly as the US
military is planned — and financed — to battle a conflict on two fronts, so our medical care
frameworks ought to have the flood ability to meet the following pandemic.
One continuous test in pandemic readiness is the thing that specialists call stun and neglecting.
Time and again government officials make subsidizing guarantees in the quick repercussions of
an emergency like Sars or Ebola, just to allow those vows to slip by as the memory of the
episode blurs.
By one way or another, I expect that will not be the situation with Covid-19. We need to do
everything we can to endure this pandemic, yet to guarantee it stays a return from an earlier time,
not an indication of what might be on the horizon.
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