This document provides an overview of the corpus callosum and abnormalities that can occur. It begins with an introduction to the corpus callosum, including its location, parts, formation, functions, and blood supply. It then discusses abnormalities such as agenesis (complete or partial absence) of the corpus callosum. Causes of agenesis include genetic factors and prenatal infections or injuries. Signs and symptoms can include neurological, behavioral, learning and intellectual issues. Diagnosis is typically made via MRI or ultrasound. Treatment focuses on managing symptoms like seizures. The document concludes with a brief case study of complete agenesis.
Surgical approach to thalamus explained in details their surgical anatomy and lesion, Preop post op results with different surgical approach for thalamic lesions
introduction of neck and boundaries of neck , superficial fascia and structures present with in it, deep cervical fascia types and most importantly spaces with in it mainly about Retro-pharyngeal spaces and applied anatomy along with incision markings.
Surgical approach to thalamus explained in details their surgical anatomy and lesion, Preop post op results with different surgical approach for thalamic lesions
introduction of neck and boundaries of neck , superficial fascia and structures present with in it, deep cervical fascia types and most importantly spaces with in it mainly about Retro-pharyngeal spaces and applied anatomy along with incision markings.
It's about HYDROCEPHALUS
TO EXPLAIN ANATOMY OF HUMAN BRAIN
TO INTRODUCE HYDROCEPHALUS
TO DEFINE HYDROCEPHALUS
TO EXPLAIN INCIDENCE OF HYDROCEPHALUS
TO EXPLAIN ETIOLOGY OF HYDROCEPHALUS
TO EXPLAIN PATHOPHYSIOLOGY OF HYDROCEPHALUS
TO EXPLAIN CLINICAL MANIFESTATION OF HYDROCEPHALUS
TO ENLIST DIAGNOSIS & DIAGNOSTIC EVALUATION FOR HYDROCEPHALUS
TO DESCRIBE MANAGEMENT OF HYDROCEPHALUS
TO EXPLAIN COMPLICATION & PROGNOSIS OF HYDROCEPHALUS
here i am to explain the Anatomy and physiology of part of the Pyramidal tract, that is the corticospinal tract. I also added the clinical significance of corticospinal tract. The course of the corticospinal tract are well explained.
Similar to CORPUS CALLOSUM (Final Review Project) (20)
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Colonic and anorectal physiology with surgical implications
CORPUS CALLOSUM (Final Review Project)
1. CORPUS CALLOSUM & ITS
ABNORMALITIES
( FINAL REVIEW PROJECT )
AFFAF KHAN
2. LAYOUT
▪ CORPUS CALLSOUM :-
* INTRODUCTION
* LOCATION
* PARTS
* FORMATION
* FUNCTIONS
▪ ABNORMALITIES OF CORPUS CALLOSUM :
* AGENESIS
▪ CASE STUDY :
* COMPLETE AGENESIS
* PARTIAL AGENESIS
▪ ANALYSIS OF THE COURSE
3. CORPUS CALLOSUM
" a great interhemispheric commisure consisting of large white
matter tracts that connects the two halves of cerebrum "
▪ It is C shaped .
▪ It is formed in the brain 12 to 16 weeks after conception , and
continues to develop throughout the childhood .
▪ By the age of 12 years , its development is completed .
4. LOCATION OF CORPUS CALLOSUM
▪ Directionally, the corpus callosum is located underneath the
cerebrum at the midline of the brain. It resides within
the interhemispheric fissure, which is a deep furrow that separates
the brain hemispheres.
▪ The corpus callosum is near the center of the brain and is covered by
the cerebral hemispheres.
▪ It lies deep to the cingulate gyrus , superficial to the fornix , to which
it is connected anteriorly by the septum pellucidum.
6. Detail
▪ The rostrum is continuous with the lamina terminalis and connects
the orbital surfaces of the frontal lobes.
▪ The genu is the bend of the anterior corpus callosum and the forceps
minor is a tract that projects fibres from the genu to connect the
medial and lateral surfaces of the frontal lobes.
▪ The body forms the long central section and its fibres pass through
the corona radiata to reach the surface of the hemispheres.
▪ The splenium tapers awayat the posterior section, with the forceps
major projecting fibres from the splenium to connect the two
occipital lobes.
▪ A narrowed part between the trunk and the splenium is known as
the isthmus.
7. FORMATION OF CORPUS CALLOSUM
▪ There are approximately 200 million axons that form the corpus
callosum.
▪ At 12 to 13 weeks of gestation, nerve fibers begin to cross the
midline, giving rise to connections that later become the corpus
callosum. By 18 weeks, all components of the corpus callosum can be
visualized using a transvaginal sonogram,completed by age of 12.
▪ It begins with the genu and then continues posteriorly along the
body to the splenium.The rostrumis the last part to be formed.
8. RELATIONS OF CORPUS CALLOSUM
▪ On either side of the corpus callosum, the transverse fibers of corpus
callosum radiate in the white matter and pass to the various parts of
the cerebral cortex ;
▪ Those curving forward from the genu into the frontal
lobes constitute the forceps minor (also forceps anterior)
▪ Those curving backward from the splenium into the occipital lobes,
the forceps major (also forceps posterior).
▪ Between these two parts is the main body of the fibers which
constitute the tapetum and extend laterally on either side into
the temporal lobe .The tapetum and anterior commissure share the
function of connecting left and right temporal lobes.
9.
10. NEURONAL FIBERS OF CORPUS CALLOSUM
▪ Thinner, lightly myelinated fibers are slower conducting and they
connect the association and prefrontal areas.
▪ Thicker and fast-conducting fibers connect the visual and motor
areas.
▪ The tractogram pictured, shows the nerve tracts from six segments
of the corpus callosum, providing linking of the cortical regions
between the cerebral hemispheres.
▪ Those of the genu are shown in coral, of the premotor – green, of the
sensory-motor – purple, of the parietal – pink, of the temporal –
yellow, and of the splenium – blue.
11. • Thinner axons in the genu connect the prefrontal
cortex between the two halves of the brain; these fibers arise
from a fork-like bundle of fibers from the tapetum, the forceps
minor.
• Thicker axons in the trunk of the corpus callosum, interconnect
areas of the motor cortex, with proportionately more of the
corpus callosum dedicated to supplementary motor regions
including Broca's area.
• The splenium, communicates somatosensory information
between the two halves of the parietal lobe and the visual
cortex at the occipital lobe, these are the fibers of the forceps
major
12. FUNCTIONS OF CORPUS CALLOSUM
▪ The main function of the corpus callosum is the communication
between the two hemispheres ; transferring cognitive, sensory, and
motor information between them.
▪ The rostrum and genu connect the frontal lobes of the left and the
right hemisphere .
▪ The body and the splenium connect the temporal lobes of the
hemispheres as well as the occipital lobes.
13. • Involved in the transfer of visual, auditory, and somatosensory
information in posterior regions, and higher cognition is processing
anteriorly .
• There is evidence for the idea that the anterior callosal fibers transfer
motor information between the frontal lobes, and the posterior fibers
are involved in the processing of somatosensory (posterior midbody),
auditory (isthmus) and visual (splenium) cues by connecting the
parietal, temporal, and occipital lobes .
• As the brain matures and white matter develops, the corpus callosum
seems to play a crucial role in refining motor movements and
cognitive functions .
• Additional studies have shown that the corpus callosum has an
inhibitory effect that normally prevents alien-hand syndrome and
uncoordinated hand-motor behavior .
14.
15. BLOOD SUPPLY OF CORPUS CALLOSUM
▪ The internal carotid artery network provides arterial blood supply to
a majority of the corpus callosum, specifically via the pericallosal
artery (a branch of the anterior cerebral artery).
▪ The splenium is the exception as it receives vascular input from the
vertebrobasilar system.
▪ The terminal and choroidal branches of the posterior cerebral
artery supply the splenium with arterial blood.
▪ Venous drainage occurs via the callosal and callosal cingular veins
and finally , the internal cerebral veins.
16. OBSERVATION OF CORPUS CALLOSUM
Corpus callosum has been studied over the years through the use
of :
MRI , Ultrasound
Brains of deceased human individuals
Animals such as cats , monkeys ,rats
17. ABNORMALITIES OF CORPUS CALLOSUM
1. AGENESIS OF CORPUS CALLOSUM :
Complete agenesis :This is when the corpus
callosum does not form at all.The front, middle, and back parts are all
missing.
Partial agenesis : This is when part of the corpus
callosum is missing, usually just the back part. Sometimes it is the middle or
front part that is missing instead.
ADDITIONAL TYPES :-
2. HYPOPLASIA OF CORPUS CALLOSUM : This is when all parts of the
corpus callosum form, but the entire structure is very thin or very small.
3. CORPUS CALLOSUM ABNORMALITY DUE TO HYDROCEPHALUS :This
is when too much fluid in the brain causes the corpus callosum to not form
properly.
18. AGENESIS OF CORPUS CALLOSUM
" a rare disorder characterized by a partial or complete absence
(agenesis) of an area of the brain that connects the two cerebral
hemispheres "
▪ It is present at birth ( congential )
▪ can be inherited as either an autosomal recessive trait or an X-
linked dominant trait.
▪ heterogeneous condition ranging from severe intellectual disability
to normal cognitive function
19. CAUSES OF AGENESIS
▪ Disruption of brain cell migration during fetal development.
▪ Chromosomaldefects that affect fetal brain development
▪ Certain viral infections that a mother has while pregnant such
as rubella
▪ Abnormal brain development caused by cystsprenatal infections
▪ Tenetic abnormalities, such as Andermann or Aicardi syndromes
▪ Toxic metabolic conditions, such as fetal alcohol syndrome (heavy
drinking or alcoholism during pregnancy)
▪ Injury during the twelfth to the twenty-second week of pregnancy
(intrauterine) leading to developmental disturbance of the fetal
brain
20. OCCURRENCE OF AGENESIS
▪ between the 3rd and 12th week of gestational life
▪ Though rare,it is one of the more frequently occurring congenital
malformations, affecting three to seven people per 1000 births.
▪ Injuryduring surgery or accident during later years of life leading
to partial agenesis
▪ In persons with developmental disabilities: 2.2%‐ 2.4%
▪ In persons with FetalAlcohol Syndrome: 6.8%
▪ In the normalpopulation: 0.0005% ‐ 0.7%
▪ Incidence is increased in patients with Trisomy 18 andTrisomy 13
21. SIGNS & SYMPTOMS OF AGENESIS
▪ Neurological (brain and nerve) problems
▪ Seizures or Epilepsy ( within first 2 years )
▪ Trouble with tasks that require two hands
▪ Trouble with balance or depth perception (judging depth and
distance correctly)
▪ Behavioral and learning problems
▪ Challenges with self-control, making decisions, or problem solving
▪ Speech delays or language challenges
▪ Learning or intellectual disabilities
▪ Behavioral or mental health challenges
22. DIAGNOSIS OF AGENESIS
▪ Diagnosis is made by viewing the brain through
▪ MRI,
▪ CT scan
▪ Prenatal or post-natal ultrasound
Partial
agenesis
Complete
Agenesis
23. ADDITIONAL ABNORMALITIES CAUSED BY
AGENESIS
These include:
▪ fluid in the skull, known as hydrocephalus
▪ Arnold-Chiarimalformations
▪ failure of the forebrainto divide into lobes
▪ disordersof neural migration
SYNDROMES associatedwith agenesisinclude:
▪ Aicardi
▪ Andermann
▪ Acrocallosal
▪ Menkes
▪ Agenesisof the corpus callosumcan also happenin conjunctionwith spinabifida.
24. TREATMENT OF AGENESIS
▪ There is no standard course of treatment for ACC.
▪ Treatment usually involves management of symptoms and seizures if they
occurAnti-seizure medications.
▪ Early Intervention (EI) services to monitor for and treat developmental
delays
▪ Physical therapy to treat movement difficulties
▪ Occupational therapy to help build everyday skills
▪ Speech therapy to help with speech and language development
▪ Special education in your child’s school
▪ When hydrocephalus is present it may be treated with a surgical shunt to
drain the fluid from the brain cavity .
▪ Genetic counseling
25. CASE STUDY OF COMPLETE
AGENESIS
▪ A baby girl was born five (5) weeks prematurevia
C‐section because of nerve loss and blood clot in
mother & was kept in ICU overnight .At age of two
(2) months, contracted Respiratory SyncytialVirus
(RSV) with suspected seizure activity occurred ,
accompanied with slow oral‐motor stimulation,
feeding and movement.The baby was then
referred to a neurologist .
26. SIGNS & SYMPTOMS OBSERVED BY
NEUROLOGIST
▪ Cognitive skills within normal limits
▪ At age 18 months, testing revealed receptive
language skills had mild expressive delay .
Exhibited single word vocabulary (mostly nouns)
with beginning two word combinations
▪ Used gestures to assist in communication
▪ Imaginative play, turn‐taking , choice making,
answered questions, identified objects , followed
simple directions , speech better understood when
text was known .
27. CAUSES OF SIGNS & SYMPTOMS
▪ Respiratory SyncytialVirus (RVS) resulted in loss of
entire corpus callosum .
▪ As it occurred at a very young age , both the
cerbral hemispheres were able to co-ordinate with
each other rather than resulting in a split-brain
situation .
▪ Hence, cognitive skills are within normal limits .
▪ Language skills had mild expressive delay
because sensory signals are unable to pass through
corpus callosum to reach the speech areas in left
hemisphere .
28. DIAGNOSIS & TREATMENT
▪ The condition of the child was diagnosed to be " COMPLETE
AGENESIS " of corpus callosum
▪ Treatment :-
* Medications to control seizures.
* Speech therapy to help with speech and language
development.
* Physical therapy to improve muscle strength and
coordination.
* Section of corpus callosum has been attempted surgically
inorder to prevent spread of seizures from one hemisphere to another.
29. CASE STUDY OF PARTIAL
AGENESIS
▪ A baby boy was born weighing 7 lbs . Failure to
thrive was observed at 4th month and was given
services from public health nurse until 12 months
of age . Parents noticed delay in rolling over (6
months) , sitting (9 months) , crawling (12
months), walking independently ( 21 months ).
delay in frequencyof vocalization and babbling (12
months) was also observed .The parents were
then refered to a neurologist by a pediatrician by
the age of 3 .
30. SIGNS & SYMPTOMS OBSERVED BY
THE NEUROLOGIST
▪ Severe/profound delays in communication, motor,
cognitive, social‐emotional and adaptive domains
▪ Limited engagement with peers and activities
▪ Use of gestures and vocalizations to obtain
attention of teachers/clinicians
▪ Verbalizations repeated severaltimes before
attempted responses were made
31. CAUSES OF SIGNS & SYMPTOMS
▪ Profund delay in communication , motor , cognitive , social-
emotional & adaptive domain is due to delay/ less amount of sensory
signals reaching the right hemisphere , especially the comprehensive
& production areas analogous to Wernicke's & Broca's area to the
left & lack of fibres reaching frontal cortex which is also responsible
for communication difficulties and behavioural abnormalities .
▪ Limited attraction with peers & activities is due to inability to
understand the tone & emotional state of person speaking , enen
though meaning of words are understood .
▪ Use of gestures & vocalization was due to less amount of signals
reaching the Broca's area , causing difficulty in using of words & lack
of primary motor cortex to generate neuronalimpulses that control
the execution of movement.
▪ Verbalization is repeated several types because ability to
comprehend which is done through Broca's area is reduced .
32. DIAGNOSIS & TREATMENT
▪ The condition of the child was diagnosed to
be " PARTIAL AGENESIS " of corpus callosum .
▪ Treatment :-
* Medications to control seizures.
* Speech therapy to help with speech and
language development.
* Physical therapy to improve
muscle strength and coordination.
* Occupational therapy to help build self-
care and mobility skills such as eating, getting dressed,
and walking
33. ANALYSIS OF THE COURSE
▪ It has really helped me understand how difficult it is for people with
disabilities to survive , how they cope up with it and continue to
fight with their specific conditions in hopes of living a normal life .
▪ It has changed my perspective towards them .
▪ It has also helped me in observing the signs & symptoms of various
diseases in my surroundings and help those people out by asking
them to visit a doctor .
▪ It has also helped me observe how people suffering from a particular
disability have adapted to their new lives and given me a better
understanding of how the human brain works to assist normal body
functions during various disease conditions.
▪ It has shown me how much the scientific , biological field has
expanded and how people are able to functional normally even after
complex surgeries
34. • It has helped me observe how many older people suffer from hearing
problems and how the modern day technology has made hearing
easier for them .