The Great Compromise resolved disagreements between large and small states over representation in Congress. It created a bicameral legislature with two chambers - the Senate where every state gets two seats, and the House of Representatives where seats are allocated based on state population. This balanced the interests of both large and small states. The compromise also included the Three-Fifths Compromise, which counted slaves as three-fifths of a person for representation. These compromises helped ensure ratification of the new U.S. Constitution.