Ameloblastoma is an aggressive odontogenic tumor that typically appears radiographically as an expansile lucency. This case report describes a large plexiform ameloblastoma found in a 29-year-old man through the use of cone beam computed tomography (CBCT) imaging. CBCT revealed thinning and perforation of the mandibular cortices, displacement and resorption of teeth roots, and incomplete septae within the lesion. Histological examination confirmed the diagnosis of plexiform ameloblastoma. Advanced three-dimensional CBCT imaging allowed visualization of the full extent and effects of the large lesion.