The document defines immunology as the study of the immune system and how the body defends itself from pathogens. It discusses key terms like antigens, antibodies, inflammation, and immune response. The history of immunology is explored from early pioneers like Edward Jenner and Louis Pasteur to more modern developments. Milestones in the field are highlighted. The importance of immunology in areas like disease treatment, vaccination, and organ transplants is examined. Factors that influence antigen immunogenicity such as size, chemical properties, and genetic factors are also summarized.
The document discusses tumors and cancer. It defines tumors as abnormal tissue growth resulting from mutations in DNA that alter cell growth regulation. There are two types: benign tumors, which are non-cancerous and have defined boundaries; and malignant tumors (cancers), which invade other tissues and spread via the bloodstream and lymphatic system. Cancers arise from mutations in oncogenes and tumor suppressor genes, which normally regulate cell division. Environmental factors like radiation, viruses, hormones, and chemicals can also increase cancer risk by further mutating these genes. The body has some defense mechanisms to prevent cancer development, like shedding mutated cells, but cancers can still form when too many mutations accumulate.
The term Autoimmunity is coined by Paul Enrlich.
Autoimmunity is defined as humoral or cell mediated immune response against self antigens
Autoimmune diseases are a group of disorders caused by immune response to self antigens.
The document provides an overview of immune response properties and mechanisms. It discusses:
1) Innate immunity, which is non-specific and provides immediate defense mechanisms like anatomical barriers and phagocytosis.
2) Adaptive immunity, which is acquired and provides long-lasting, targeted defenses through humoral immunity using antibodies and cell-mediated immunity using T cells.
3) Key properties of adaptive immunity include specificity, diversity, and memory, allowing a tailored response to a wide range of pathogens.
Antibodies are Y-shaped proteins produced by B cells that recognize and bind to foreign substances like viruses and bacteria. There are two main types: polyclonal antibodies which recognize multiple epitopes on an antigen and are produced through serum, and monoclonal antibodies which are derived from a single clone and recognize a single epitope. Monoclonal antibodies are important for research, diagnostics, and therapeutics. Antibody engineering techniques allow modifying antibodies to make them more effective, such as humanizing mouse antibodies to reduce immunogenicity.
Dr. Ashish Warghane is a professor in the Department of Life Sciences at Mandsaur University in India. The document discusses immunological memory, which allows the immune system to mount a stronger and faster response when encountering an antigen for the second or subsequent times. Immunological memory is responsible for adaptive immunity and is created after an initial exposure to an antigen. It involves memory B and T cells that remain in the body in a resting state and can respond quickly when the same antigen is detected again. Immunological memory forms the basis of vaccination.
SYNTHETIC PEPTIDE VACCINES AND RECOMBINANT ANTIGEN VACCINED.R. Chandravanshi
This document discusses synthetic peptide vaccines and recombinant antigen vaccines. It begins with definitions of vaccines and how they work to induce an immune response. It then describes two types of modern vaccines: synthetic peptide vaccines and recombinant antigen vaccines. Synthetic peptide vaccines use short fragments of viral or bacterial proteins that contain epitopes to induce an immune response, while recombinant antigen vaccines produce antigens through DNA technology by inserting viral or bacterial DNA into cells that then express the antigen protein. Both types of modern vaccines offer advantages over traditional vaccines like easier production and stability without refrigeration.
- Monoclonal antibodies are identical antibodies produced by a single clone of B cells or hybridoma. They are produced by fusing B cells from an immunized animal with myeloma cells.
- The hybridoma technique involves immunizing an animal, isolating spleen B cells, fusing them with myeloma cells using polyethylene glycol, and screening clones to identify those that produce the desired antibody.
- Hybridomas are immortal cell lines that can produce large quantities of identical monoclonal antibodies directed against a specific antigen or epitope. This technique allows mass production of antibodies for research, diagnostic, and therapeutic uses.
Genetic engineering involves manipulating the structure of genes to create desired characteristics in an organism. It can involve adding genetic material from another species to create a transgenic organism, or removing genetic material to create a knockout organism. Some key events in the history of genetic engineering include the coining of the term in 1941, the discovery of DNA's double helix structure in 1953, and the first genetically engineered plants in 1986. The process involves taking a gene of interest from one cell and inserting it into the DNA of a host cell to create recombinant DNA that can be multiplied. Genetic engineering provides benefits like creating medicines, improving agriculture, and DNA profiling. Examples include using it to create disease-resistant plants, make insulin, and clone Dolly
The document discusses tumors and cancer. It defines tumors as abnormal tissue growth resulting from mutations in DNA that alter cell growth regulation. There are two types: benign tumors, which are non-cancerous and have defined boundaries; and malignant tumors (cancers), which invade other tissues and spread via the bloodstream and lymphatic system. Cancers arise from mutations in oncogenes and tumor suppressor genes, which normally regulate cell division. Environmental factors like radiation, viruses, hormones, and chemicals can also increase cancer risk by further mutating these genes. The body has some defense mechanisms to prevent cancer development, like shedding mutated cells, but cancers can still form when too many mutations accumulate.
The term Autoimmunity is coined by Paul Enrlich.
Autoimmunity is defined as humoral or cell mediated immune response against self antigens
Autoimmune diseases are a group of disorders caused by immune response to self antigens.
The document provides an overview of immune response properties and mechanisms. It discusses:
1) Innate immunity, which is non-specific and provides immediate defense mechanisms like anatomical barriers and phagocytosis.
2) Adaptive immunity, which is acquired and provides long-lasting, targeted defenses through humoral immunity using antibodies and cell-mediated immunity using T cells.
3) Key properties of adaptive immunity include specificity, diversity, and memory, allowing a tailored response to a wide range of pathogens.
Antibodies are Y-shaped proteins produced by B cells that recognize and bind to foreign substances like viruses and bacteria. There are two main types: polyclonal antibodies which recognize multiple epitopes on an antigen and are produced through serum, and monoclonal antibodies which are derived from a single clone and recognize a single epitope. Monoclonal antibodies are important for research, diagnostics, and therapeutics. Antibody engineering techniques allow modifying antibodies to make them more effective, such as humanizing mouse antibodies to reduce immunogenicity.
Dr. Ashish Warghane is a professor in the Department of Life Sciences at Mandsaur University in India. The document discusses immunological memory, which allows the immune system to mount a stronger and faster response when encountering an antigen for the second or subsequent times. Immunological memory is responsible for adaptive immunity and is created after an initial exposure to an antigen. It involves memory B and T cells that remain in the body in a resting state and can respond quickly when the same antigen is detected again. Immunological memory forms the basis of vaccination.
SYNTHETIC PEPTIDE VACCINES AND RECOMBINANT ANTIGEN VACCINED.R. Chandravanshi
This document discusses synthetic peptide vaccines and recombinant antigen vaccines. It begins with definitions of vaccines and how they work to induce an immune response. It then describes two types of modern vaccines: synthetic peptide vaccines and recombinant antigen vaccines. Synthetic peptide vaccines use short fragments of viral or bacterial proteins that contain epitopes to induce an immune response, while recombinant antigen vaccines produce antigens through DNA technology by inserting viral or bacterial DNA into cells that then express the antigen protein. Both types of modern vaccines offer advantages over traditional vaccines like easier production and stability without refrigeration.
- Monoclonal antibodies are identical antibodies produced by a single clone of B cells or hybridoma. They are produced by fusing B cells from an immunized animal with myeloma cells.
- The hybridoma technique involves immunizing an animal, isolating spleen B cells, fusing them with myeloma cells using polyethylene glycol, and screening clones to identify those that produce the desired antibody.
- Hybridomas are immortal cell lines that can produce large quantities of identical monoclonal antibodies directed against a specific antigen or epitope. This technique allows mass production of antibodies for research, diagnostic, and therapeutic uses.
Genetic engineering involves manipulating the structure of genes to create desired characteristics in an organism. It can involve adding genetic material from another species to create a transgenic organism, or removing genetic material to create a knockout organism. Some key events in the history of genetic engineering include the coining of the term in 1941, the discovery of DNA's double helix structure in 1953, and the first genetically engineered plants in 1986. The process involves taking a gene of interest from one cell and inserting it into the DNA of a host cell to create recombinant DNA that can be multiplied. Genetic engineering provides benefits like creating medicines, improving agriculture, and DNA profiling. Examples include using it to create disease-resistant plants, make insulin, and clone Dolly
This document summarizes innate and adaptive immunity. It explains that innate immunity is the first line of defense and is non-specific. It acts through physical, biochemical, and genetic factors like skin, mucous membranes, tears, and species immunity. Adaptive immunity is antigen-specific and develops immunological memory. It includes natural adaptive immunity gained from infection or passive transfer of antibodies from mother to child, and artificial adaptive immunity from vaccination or monoclonal antibody therapy.
this helps to understand the normal techniques related to biotechnology in a simple manner and provides you broad idea about the subject. A brief knowledge about the topic is presented in this presentation.
Application of Biotechnology In Medicine By Anila Rani Pullaguraanilarani
Biotechnology is a very huge field and its applications are used in a variety of fields of science such as agriculture and medicine. Medicine is by means of biotechnology techniques so much in diagnosing and treating dissimilar diseases. It also gives opportunity for the populace to defend themselves from hazardous diseases.
Vector vaccines use weakened live viruses or bacteria to transport antigen genes from pathogenic organisms and stimulate an immune response. They are derived from attenuated pathogens that are too weak to cause disease but strong enough to produce an immune response. Common vector vaccines include those using vaccinia virus, Salmonella bacteria, and adenoviruses to deliver antigens from pathogens like malaria, cholera, and HIV. While vector vaccines aim to induce mucosal immunity and have advantages over other vaccines, their development faces challenges in safety, production costs, and inducing effective immunity against diseases.
This document discusses different types of vaccines. There are three main types: whole organism vaccines, purified vaccines, and DNA vaccines. Whole organism vaccines use weakened or killed pathogens and can be attenuated (like measles and polio vaccines) or inactivated. Purified vaccines use isolated components of pathogens like capsular polysaccharides or toxins. DNA vaccines introduce DNA sequences that cause the body to produce antigens and activate an immune response. The document provides examples and details on each type of vaccine.
The document discusses the history and future of vaccines. It begins by explaining how vaccines work by tricking the immune system to produce antibodies to fight a harmless form of the virus. Next, it discusses how while hypodermic injection is most common, scientists are searching for alternative delivery methods. The document then discusses how Edward Jenner conducted the first vaccination against smallpox in the late 1700s and how Louis Pasteur developed the first vaccine against rabies in 1885. Finally, it notes that as more vaccines were developed, large groups like soldiers began being vaccinated against diseases during World Wars I and II.
This document provides an overview of immunology, including a brief history, definitions of innate and adaptive immunity, and descriptions of the components and mechanisms of each. It discusses the functions of epithelial layers, types of immune responses, phagocytosis, and the roles and mechanisms of natural killer cells. Key topics covered include physical and chemical barriers, phagocytic cells, inflammation, acute phase proteins, cellular and humoral immune responses, and how pathogens can overcome phagocytosis.
The presentation outlines aspects of immunity against cancer, evasion strategies by cells, immunotherapy in cancer, cancer vaccines etc. Download and view the slideshow for better experience.
Prepared in Sept 2014
This document provides an overview of immunotherapy for cancer. It discusses how immunotherapy works by boosting the body's natural immune response against cancer cells. The main types of immunotherapy discussed are monoclonal antibodies, cancer vaccines, and non-specific immunotherapies like cytokines and interferons. Monoclonal antibodies are engineered antibodies that target specific antigens on cancer cells, while cancer vaccines are designed to trigger an immune response against tumor antigens. Together, these immunotherapies help the immune system better recognize and destroy cancer cells.
This document discusses tumor immunology and immunotherapy. It provides evidence that the immune system can recognize and react against tumors. It describes tumor-associated antigens that can be recognized by the immune system. However, tumors also have mechanisms for escaping immune surveillance, such as not expressing immunogenic antigens or secreting immunosuppressive molecules. The document discusses various tumor-associated antigens and oncofetal antigens. It also outlines approaches for tumor immunotherapy, including using cytokines and immunopotentiating agents to enhance anti-tumor immunity.
The document discusses immuno-oncology and the relationship between cancer and the immune system. It provides an overview of topics that will be covered in an upcoming webinar, including advances in immuno-oncology for different cancer types and combination immunotherapy approaches. The document then reviews key topics in more depth, including how immuno-oncology focuses on improving the body's immune response against cancer and recent immunotherapy approvals. It also discusses how cancer can evade the immune system and strategies for cancer immunotherapy, such as manipulating co-stimulatory signals, enhancing antigen presenting cells, and using cytokines, monoclonal antibodies, and cancer vaccines.
This document discusses different types of immunity, including innate immunity, acquired immunity, and the differences between active and passive immunity. It provides details on natural and artificial active immunity, as well as natural and artificial passive immunity. Various methods of conferring immunity are described, such as vaccination, administration of antibodies, and herd immunity. Measurement of immunity through antibody detection and cell-mediated immunity tests are also summarized.
The document discusses the major histocompatibility complex (MHC), which plays a key role in immune response and organ transplantation. It describes the structure of MHC class I and II molecules, which present peptide fragments to T cells. MHC molecules are highly polymorphic and this variability allows recognition of diverse pathogens. The T cell receptor engages peptide-MHC complexes and accessory molecules provide costimulatory signals for T cell activation. Certain MHC alleles are associated with increased risk of various autoimmune diseases.
This document discusses transgenic plants that can be used to produce vaccines. It defines vaccines and describes how they can be prophylactic or therapeutic. An ideal vaccine should be non-toxic, cause few side effects, not contaminate the environment, and be simple and cheap to administer. Transgenic plants are genetically engineered to express vaccine antigens from bacterial and viral pathogens. Producing vaccines in plants can be less costly than other methods. When expressed in edible parts of plants, vaccines may not require purification and can be orally administered. The document describes the mechanism of mucosal and systemic immune response stimulation from oral vaccination using plant-produced vaccines. It also discusses methods for developing edible vaccines and transforming DNA into plants.
Vaccines work by activating the immune system through active immunization with live attenuated or killed pathogens. They provide long term immunity through memory B and T cells. Common types include killed/inactivated, attenuated, toxoid, recombinant, and DNA vaccines. Vaccines are manufactured through in vivo, in vitro, or chemical synthesis methods. Potential risks include vaccine strain infection, superantigen effects, and allergic reactions.
Vaccines, types of vaccines, Classification of vaccines, subunit vaccines, attenuated vaccines, live vaccines, inactivated vaccines, recombinant vaccines, DNA vaccines, development of vaccines, future of vaccines, advantages of vaccines, limitation of vaccines, benefits of vaccines.
In recent years, antibodies have become increasingly accepted as therapeutics for human diseases, particularly for cancer, viral infection and autoimmune disorders.
Monoclonal antibodies (Mabs) have been used as diagnostic and analytical reagents since hybridoma technology was invented in 1975.
“man-made antibodies.” was named by Cesar Milstein, who was one of the inventors of monoclonal antibody technology.
Until the late 1980’s, antibody technology relied primarily on animal immunization and the expression of engineered antibodies.
Introduction of Biotechnology presentationMahedyHassan3
This document provides an introduction and overview of biotechnology. It defines biotechnology as the controlled use of biological agents such as microorganisms and cellular components for beneficial use. The history of biotechnology is discussed, including early discoveries in alcohol production and antibiotics. Key developments include recombinant DNA technology and cloning. Old biotechnology includes processes like fermentation, while new biotechnology uses techniques like recombinant DNA and PCR. Achievements include genome mapping, gene cloning, gene banks, and applications in agriculture, health care, industry, and the environment.
This study investigated the relationship between absorbed gamma radiation dose and cellular senescence in lymphocytes. Lymphocytes were isolated from human blood samples and exposed to varying doses of gamma radiation from 0 to 4 Gy. The samples were then analyzed using flow cytometry and p16 biomarker staining to determine the percentage of senescent cells at each radiation level. The results showed a positive quadratic correlation between radiation dose and senescence. This research establishes a foundation for using cellular senescence analysis to determine an individual's original radiation exposure level.
Immunology is the study of the immune system and its functions, including distinguishing self from non-self and protecting the body from foreign substances. The immune system has evolved over time to include both innate immunity, which acts quickly but non-specifically, and adaptive immunity, which has specificity and memory. Key events in the development of immunology include the discovery of phagocytosis, humoral immunity, and the development of vaccination against smallpox. Modern immunology utilizes many techniques to study immune cells and molecules at the genetic and protein level to further understand immunity and its applications to disease treatment.
This document provides a history and overview of immunology. It discusses how immunology stems from concepts of protection from disease. The immune system involves both nonspecific innate immunity and specific adaptive immunity. Key developments included Jenner's smallpox vaccine in 1796, Pasteur's vaccines for rabies and other diseases in the late 1800s, the discoveries of phagocytic cells, antibodies, and T and B cells. Major figures who advanced the field included Jenner, Pasteur, von Behring, Ehrlich, Metchnikoff, Milstein, Köhler, Tonegawa, and Doherty and Zinkernagel. The document also outlines the cells of the immune system originating from bone
This document summarizes innate and adaptive immunity. It explains that innate immunity is the first line of defense and is non-specific. It acts through physical, biochemical, and genetic factors like skin, mucous membranes, tears, and species immunity. Adaptive immunity is antigen-specific and develops immunological memory. It includes natural adaptive immunity gained from infection or passive transfer of antibodies from mother to child, and artificial adaptive immunity from vaccination or monoclonal antibody therapy.
this helps to understand the normal techniques related to biotechnology in a simple manner and provides you broad idea about the subject. A brief knowledge about the topic is presented in this presentation.
Application of Biotechnology In Medicine By Anila Rani Pullaguraanilarani
Biotechnology is a very huge field and its applications are used in a variety of fields of science such as agriculture and medicine. Medicine is by means of biotechnology techniques so much in diagnosing and treating dissimilar diseases. It also gives opportunity for the populace to defend themselves from hazardous diseases.
Vector vaccines use weakened live viruses or bacteria to transport antigen genes from pathogenic organisms and stimulate an immune response. They are derived from attenuated pathogens that are too weak to cause disease but strong enough to produce an immune response. Common vector vaccines include those using vaccinia virus, Salmonella bacteria, and adenoviruses to deliver antigens from pathogens like malaria, cholera, and HIV. While vector vaccines aim to induce mucosal immunity and have advantages over other vaccines, their development faces challenges in safety, production costs, and inducing effective immunity against diseases.
This document discusses different types of vaccines. There are three main types: whole organism vaccines, purified vaccines, and DNA vaccines. Whole organism vaccines use weakened or killed pathogens and can be attenuated (like measles and polio vaccines) or inactivated. Purified vaccines use isolated components of pathogens like capsular polysaccharides or toxins. DNA vaccines introduce DNA sequences that cause the body to produce antigens and activate an immune response. The document provides examples and details on each type of vaccine.
The document discusses the history and future of vaccines. It begins by explaining how vaccines work by tricking the immune system to produce antibodies to fight a harmless form of the virus. Next, it discusses how while hypodermic injection is most common, scientists are searching for alternative delivery methods. The document then discusses how Edward Jenner conducted the first vaccination against smallpox in the late 1700s and how Louis Pasteur developed the first vaccine against rabies in 1885. Finally, it notes that as more vaccines were developed, large groups like soldiers began being vaccinated against diseases during World Wars I and II.
This document provides an overview of immunology, including a brief history, definitions of innate and adaptive immunity, and descriptions of the components and mechanisms of each. It discusses the functions of epithelial layers, types of immune responses, phagocytosis, and the roles and mechanisms of natural killer cells. Key topics covered include physical and chemical barriers, phagocytic cells, inflammation, acute phase proteins, cellular and humoral immune responses, and how pathogens can overcome phagocytosis.
The presentation outlines aspects of immunity against cancer, evasion strategies by cells, immunotherapy in cancer, cancer vaccines etc. Download and view the slideshow for better experience.
Prepared in Sept 2014
This document provides an overview of immunotherapy for cancer. It discusses how immunotherapy works by boosting the body's natural immune response against cancer cells. The main types of immunotherapy discussed are monoclonal antibodies, cancer vaccines, and non-specific immunotherapies like cytokines and interferons. Monoclonal antibodies are engineered antibodies that target specific antigens on cancer cells, while cancer vaccines are designed to trigger an immune response against tumor antigens. Together, these immunotherapies help the immune system better recognize and destroy cancer cells.
This document discusses tumor immunology and immunotherapy. It provides evidence that the immune system can recognize and react against tumors. It describes tumor-associated antigens that can be recognized by the immune system. However, tumors also have mechanisms for escaping immune surveillance, such as not expressing immunogenic antigens or secreting immunosuppressive molecules. The document discusses various tumor-associated antigens and oncofetal antigens. It also outlines approaches for tumor immunotherapy, including using cytokines and immunopotentiating agents to enhance anti-tumor immunity.
The document discusses immuno-oncology and the relationship between cancer and the immune system. It provides an overview of topics that will be covered in an upcoming webinar, including advances in immuno-oncology for different cancer types and combination immunotherapy approaches. The document then reviews key topics in more depth, including how immuno-oncology focuses on improving the body's immune response against cancer and recent immunotherapy approvals. It also discusses how cancer can evade the immune system and strategies for cancer immunotherapy, such as manipulating co-stimulatory signals, enhancing antigen presenting cells, and using cytokines, monoclonal antibodies, and cancer vaccines.
This document discusses different types of immunity, including innate immunity, acquired immunity, and the differences between active and passive immunity. It provides details on natural and artificial active immunity, as well as natural and artificial passive immunity. Various methods of conferring immunity are described, such as vaccination, administration of antibodies, and herd immunity. Measurement of immunity through antibody detection and cell-mediated immunity tests are also summarized.
The document discusses the major histocompatibility complex (MHC), which plays a key role in immune response and organ transplantation. It describes the structure of MHC class I and II molecules, which present peptide fragments to T cells. MHC molecules are highly polymorphic and this variability allows recognition of diverse pathogens. The T cell receptor engages peptide-MHC complexes and accessory molecules provide costimulatory signals for T cell activation. Certain MHC alleles are associated with increased risk of various autoimmune diseases.
This document discusses transgenic plants that can be used to produce vaccines. It defines vaccines and describes how they can be prophylactic or therapeutic. An ideal vaccine should be non-toxic, cause few side effects, not contaminate the environment, and be simple and cheap to administer. Transgenic plants are genetically engineered to express vaccine antigens from bacterial and viral pathogens. Producing vaccines in plants can be less costly than other methods. When expressed in edible parts of plants, vaccines may not require purification and can be orally administered. The document describes the mechanism of mucosal and systemic immune response stimulation from oral vaccination using plant-produced vaccines. It also discusses methods for developing edible vaccines and transforming DNA into plants.
Vaccines work by activating the immune system through active immunization with live attenuated or killed pathogens. They provide long term immunity through memory B and T cells. Common types include killed/inactivated, attenuated, toxoid, recombinant, and DNA vaccines. Vaccines are manufactured through in vivo, in vitro, or chemical synthesis methods. Potential risks include vaccine strain infection, superantigen effects, and allergic reactions.
Vaccines, types of vaccines, Classification of vaccines, subunit vaccines, attenuated vaccines, live vaccines, inactivated vaccines, recombinant vaccines, DNA vaccines, development of vaccines, future of vaccines, advantages of vaccines, limitation of vaccines, benefits of vaccines.
In recent years, antibodies have become increasingly accepted as therapeutics for human diseases, particularly for cancer, viral infection and autoimmune disorders.
Monoclonal antibodies (Mabs) have been used as diagnostic and analytical reagents since hybridoma technology was invented in 1975.
“man-made antibodies.” was named by Cesar Milstein, who was one of the inventors of monoclonal antibody technology.
Until the late 1980’s, antibody technology relied primarily on animal immunization and the expression of engineered antibodies.
Introduction of Biotechnology presentationMahedyHassan3
This document provides an introduction and overview of biotechnology. It defines biotechnology as the controlled use of biological agents such as microorganisms and cellular components for beneficial use. The history of biotechnology is discussed, including early discoveries in alcohol production and antibiotics. Key developments include recombinant DNA technology and cloning. Old biotechnology includes processes like fermentation, while new biotechnology uses techniques like recombinant DNA and PCR. Achievements include genome mapping, gene cloning, gene banks, and applications in agriculture, health care, industry, and the environment.
This study investigated the relationship between absorbed gamma radiation dose and cellular senescence in lymphocytes. Lymphocytes were isolated from human blood samples and exposed to varying doses of gamma radiation from 0 to 4 Gy. The samples were then analyzed using flow cytometry and p16 biomarker staining to determine the percentage of senescent cells at each radiation level. The results showed a positive quadratic correlation between radiation dose and senescence. This research establishes a foundation for using cellular senescence analysis to determine an individual's original radiation exposure level.
Immunology is the study of the immune system and its functions, including distinguishing self from non-self and protecting the body from foreign substances. The immune system has evolved over time to include both innate immunity, which acts quickly but non-specifically, and adaptive immunity, which has specificity and memory. Key events in the development of immunology include the discovery of phagocytosis, humoral immunity, and the development of vaccination against smallpox. Modern immunology utilizes many techniques to study immune cells and molecules at the genetic and protein level to further understand immunity and its applications to disease treatment.
This document provides a history and overview of immunology. It discusses how immunology stems from concepts of protection from disease. The immune system involves both nonspecific innate immunity and specific adaptive immunity. Key developments included Jenner's smallpox vaccine in 1796, Pasteur's vaccines for rabies and other diseases in the late 1800s, the discoveries of phagocytic cells, antibodies, and T and B cells. Major figures who advanced the field included Jenner, Pasteur, von Behring, Ehrlich, Metchnikoff, Milstein, Köhler, Tonegawa, and Doherty and Zinkernagel. The document also outlines the cells of the immune system originating from bone
This document provides an overview of basic immunology concepts. It begins with definitions of key immunology terms like immunity, immunology, antigen, and discusses the historical figures Edward Jenner and Louis Pasteur who were pioneers in vaccination. It then discusses the components of the immune system including organs like the bone marrow, thymus, lymph nodes, and spleen. It provides information on cells of the immune system like antigen presenting cells, T and B lymphocytes, and effector cells. It also discusses molecular components of antigen recognition including antibodies, T cell receptors, B cell receptors, and the major histocompatibility complex.
The study in immunology provides the fundamental understanding of how the human body defend itself against foreign organisms, materials or particles that have the ability to cause harm to host tissues.
This document discusses different types of vaccines. It begins with an introduction to vaccines and their purpose. Then it discusses the history of vaccines, focusing on Edward Jenner's development of the smallpox vaccine. The main body outlines 7 different types of vaccines: live attenuated, inactivated, subunit, toxoid, conjugate, DNA, and recombinant vector. Recent research on vaccines for HIV, dengue, and diabetes is also mentioned. It concludes that vaccines are effective public health tools that induce both humoral and cell-mediated immunity to improve health.
The document provides an introduction to immunology, covering the following key points:
- Immunology is the study of the body's protection from foreign substances and invading organisms. The immune system protects against pathogens and eliminates damaged or malignant cells.
- Key events in the history of immunology include Jenner's development of the smallpox vaccine in 1798 and Pasteur's application of vaccines for anthrax and rabies in the late 1800s.
- The immune system consists of innate (non-specific) immunity and acquired (adaptive/specific) immunity. Innate immunity provides immediate defense while adaptive immunity provides long-term, pathogen-specific memory and protection.
This document provides an overview of vaccines, including their history, types, and uses. It discusses how Edward Jenner developed the smallpox vaccine in 1796 and how Louis Pasteur later developed vaccines for chicken cholera and anthrax in the 1880s. The document outlines seven main types of vaccines: live attenuated, inactivated, subunit, toxoid, conjugate, DNA, and recombinant vector vaccines. It also discusses saponins' potential as vaccine adjuvants and research efforts to develop vaccines for diseases like HIV.
This document provides an overview of vaccines, including their history, types, and uses. It discusses how Edward Jenner developed the smallpox vaccine in 1796 and how Louis Pasteur later developed vaccines for chicken cholera and anthrax in the 1880s. The document outlines seven main types of vaccines: live attenuated, inactivated, subunit, toxoid, conjugate, DNA, and recombinant vector vaccines. It also discusses saponins' potential as vaccine adjuvants and research efforts to develop vaccines, such as for HIV.
This document provides an overview of vaccines, including their history, types, and uses. It discusses how Edward Jenner developed the smallpox vaccine in 1796 and how Louis Pasteur later developed vaccines for chicken cholera and anthrax in the 1880s. The document outlines seven main types of vaccines: live attenuated, inactivated, subunit, toxoid, conjugate, DNA, and recombinant vector vaccines. It also discusses saponins' potential as vaccine adjuvants and research efforts by organizations like WHO and NIAID to develop new vaccines.
This document provides an overview of vaccines, including their history, types, and uses. It discusses how Edward Jenner developed the smallpox vaccine in 1796 and how Louis Pasteur later developed vaccines for chicken cholera and anthrax in the 1880s. The document outlines seven main types of vaccines: live attenuated, inactivated, subunit, toxoid, conjugate, DNA, and recombinant vector vaccines. It also discusses saponins' potential as vaccine adjuvants and research efforts to develop vaccines, such as for HIV.
This document provides an overview of vaccines, including their history, types, and uses. It discusses how Edward Jenner developed the smallpox vaccine in 1796 and how Louis Pasteur later developed vaccines for chicken cholera and anthrax in the 1880s. The document outlines seven main types of vaccines: live attenuated, inactivated, subunit, toxoid, conjugate, DNA, and recombinant vector vaccines. It also discusses saponins' potential as vaccine adjuvants and research efforts to develop vaccines, such as for HIV.
microbiology and immunology basic immunologymulkiabdiadan
This document provides an overview of basic immunology. It begins with introductions and definitions of key immunology concepts. It then discusses the history of immunology, types of immunity including innate and acquired immunity. It describes the tissues, cells and basic aspects involved in the immune system such as antigens, antibodies and complement system. It also covers major histocompatibility complex, cytokines and disorders of the immune system. The document is intended as a basic introduction and reference for immunology.
The document provides an overview of the immune system. It discusses that the immune system consists of innate and adaptive immunity. The innate immune system provides non-specific defenses like skin, mucus, cilia and phagocytes. The adaptive immune system has antigen-specific responses mediated by B cells, T cells and antibodies that provide long-lasting immunity. Major cells involved are macrophages, neutrophils, NK cells, T helper cells, cytotoxic T cells, B cells and plasma cells. The adaptive immune response involves processes like clonal selection, antibody production and immunological memory.
1. The document discusses different types of vaccines including live attenuated, inactivated, subunit, toxoid, conjugate, DNA, and recombinant vector vaccines.
2. It describes how saponins can be used as vaccine adjuvants to increase the immune response, with examples like Quil A that stimulate both Th1 response and cytotoxic T-cells.
3. Research into new vaccines is conducted by organizations like WHO and NIAID to develop vaccines for diseases like HIV/AIDS.
Introduction to immune system and inflammatory responseSRQSRQ
The document provides a history of immunology and an overview of the immune system and its components. It discusses the innate and adaptive immune responses, the types of white blood cells and lymphocytes, immune organs and their functions, and B lymphocytes. The immune system is made up of complex interactions between physical barriers, cells, tissues and cell products that work together to defend the body against pathogens and foreign substances.
1. Edward Jenner is considered the founder of immunology, having performed the first smallpox vaccination in 1796 by inoculating a boy with cowpox to protect him from smallpox.
2. Louis Pasteur made several important contributions to immunology in the late 19th century, including developing the first vaccines for rabies and anthrax and proving the germ theory of disease.
3. Immunology is the study of the immune system, which protects the body from foreign substances called antigens. Both innate immunity, which provides immediate protection, and acquired active and passive immunity work together to recognize and destroy pathogens.
This document provides an overview of immunology and the immune system. It defines key terms like immunity, immune system, and immunology. It describes the basic functions of the immune system, which are to protect the body from microbes, tumors, and remove dead or abnormal cells. The immune system contains both innate immunity, which provides immediate non-specific defense, and acquired adaptive immunity which has antigen-specific responses and immunological memory. The document outlines the basic subjects and concepts in immunology including cell-mediated defenses, antibodies, hypersensitivities, immunodeficiencies and transplantation.
The humoral response involves B cells interacting with antigens and differentiating into antibody-secreting cells. The cell-mediated response involves various T lymphocyte subpopulations that can kill infected cells or secrete signals to direct other immune cells. Memory is a hallmark of adaptive immunity, allowing faster responses upon reexposure. Innate immunity provides initial defenses while adaptive immunity develops antigen-specific responses over days. Together they provide protective immunity, but can also cause issues if misdirected.
This document provides an overview of basic immunology. It begins with an introduction to immunity, the immune system, and immunology. It then discusses the history of immunology, types of immunity including innate and acquired immunity. It describes the tissues and cells involved in immunity. It covers basic aspects like antigens, antibodies, antigen-antibody reactions, and the complement system. It also discusses major histocompatibility complex, cytokines, immune disorders, and immune responses in periodontal pathogenesis.
Vaccines work by exposing the immune system to antigens from a pathogen. This stimulates the body to develop antibodies that recognize and fight the pathogen if exposed in the future. There are several types of vaccines including live attenuated, inactivated, subunit, toxoid, conjugate, DNA, and recombinant vector vaccines. DNA vaccines and recombinant vector vaccines are experimental and involve introducing microbial DNA into cells to produce antigens and stimulate an immune response. Saponins from the bark of the Quillaja saponaria tree have shown promise as vaccine adjuvants by enhancing immune responses. Further research aims to develop safe and effective vaccines such as an HIV vaccine.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
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2. DEFINATION
Immunology is the study of the ways in which the body defends itself
from infectious agents and other foreign substances in its environment.
The immune system protect us from pathogens.
• It has the ability to discriminate (differentiate)between the
individual`s own cells and harmful invading organisms.
• The study of structure and function of the immune system
• The branch of medicine and biology concerned with immunity.
3. Definition of terms
ANTIGEN-foreign substance when introduced into the body
• Will provoke or stimulate immune response
• React with antibodies they stimulate
Characteristics of immunogens
• They are proteins or carbohydrates in nature e.g. micro-organisms, toxins and
cellular cells
• They are usually large in size or macro-molecules of 10,000daltons
• Haptens-small molecules less than 10,000daltons (low molecular weight) with
only one characteristic of antigen this is they react with antibodies i.e. specificity
• Haptens are important in the purification and production of monoclonal
antibodies.
4. Definition of terms
• Antibodies molecules produced by the body in response to a foreign
substance and antagonistic. Also called immunoglobulins when not
referring to their specificity
• Inflammation is the overall reaction of the body to injury or invasion.
Involves cellular and Humoral responses e.g. loss of function, pain,
swelling, heat, redness
• Immune system: Cells tissues and molecules that mediate resistance to
infection
• Immunity: Resistance of host to pathogens and their toxic effects/ability of
the body to stimulate antibodies against foreign substances
• Immune response; the collective and co-ordinated response to the
introduction of foreign substances in an individual mediated by the cells
and molecules of the immune system
5. HISTORY OF IMMUNOLOGY
• 1798-Edward Jenner discovered the cowpox vaccine after discovering
the cowpox virus where he discovered infection with milder form of
virus provided protection against the disease.
• The small pox vaccine, introduced by Edward Jenner in 1796 was the
first successful vaccine to be developed.
• He observed that milkmaids who previously had caught cowpox did
not catch smallpox and showed that inoculated vaccinia protected
against inoculated Variola virus
• Neil Key Verne discovered natural selection theory of form in 1955
6. HISTORY OF IMMUNOLOGY
• Louis Pasteur in 1885 developed the rabies vaccine making an impact on
human disease.
• Then antitoxins and vaccines against diphtheria, tetanus, anthrax, cholera,
plague, typhoid, tuberculosis, and more were developed through the 1930s
• Cesar Milstein and Georges Kohler in 1975 discovered monoclonal antibody
and together with Niels Kaj Jerne won the Nobel prize in physiology in 1984
for work on the immune system and production of monoclonal antibodies.
• Milstein and Kohler’s technique for producing monoclonal antibodies laid
the foundation for the exploitation of antibodies for diagnostics,
therapeutics and many other scientific applications
7. HISTORY OF IMMUNOLOGY
• Emil von Behring was a German physiologist who received the 1901
Nobel prize in physiology or medicine for discovery of a diphtheria
antitoxin.
• He was widely known as a “saviour of children” as diphtheria used to
be a major cause child death.
• In 1897 Edmond Nocard demonstrated the protective effect of
passively transferred antitoxin and passive immunization in humans
was used for treatment and prophylaxis during World War I.
• A method for inactivating tetanus toxin with formaldehyde was
developed in the early 1920s
8. HISTORY OF IMMUNOLOGY
• 1900-1901 Landsteiner discovered blood group antigens and their
corresponding antibodies which led to transfusing blood without
provoking reactions
• Late 18th Century Robert Koch made important discoveries in
identifying many bacteria such as anthrax, tuberculosis, and cholera
and establishing their relation to diseases.
• Together with Friedrich Loeffler they developed landmark set of rules
for linking a disease to the pathogen that causes it.
9. HISTORY OF IMMUNOLOGY
• The presence of foreign particles within cells was first described by Kranid
Slavjansky a pathologist, and in the 1880s Russian born zoologist and
microbiologist Elie Metchnikoff introduced the term phagocyte reference to
immune cells that engulf and destroy foreign bodies such as bacteria
• 1903- Ainswoth Wright proposed the theory of opsonisation which suggested
that antibody and phagocytes are important to immunity against disease
• 1940-Linces Pulling proposed the structure theory for the synthesis of antibody
molecules
• 1957- Burnette proposed clonal section theory for the immunoglobulin formation
• 1916-First Immunology journal publication was published. Since then the
progress of immunology has been rapid in various fields such as transplantation,
vaccine development etc
• 1908-Mechnikoff established the concept of “cell-mediated-immunity” and won
the Nobel prize in 1908
10. MILESTONES IN THE HISTORY OF
IMMUNOLOGY
• 1798-Edward Jenner initiates small pox vaccination
• 1877-Paul Erlich recognises mast cells
• 1879-Louis Pasteur develops an attenuated chicken cholera vaccine
• 1883-Elie Metchnikoff develops cellular theory of immunisation
• 1885-Louis Pasteur develops rabies vaccine
• 1891-Robert Koch explored delayed type hypersensitivity
11. MILESTONES IN THE HISTORY OF
IMMUNOLOGY
• 1900-Paul Erlich theorizes specific antibody formation
• 1906-Clemens von Pirquet coined the word allergy
• 1938-John Marrack formulates antigen-antibody binding hypothesis
• 1942-Jules Freud and Katherine McDermott research adjuvants
• 1949-Macfarlane Burnet and Frank Fenner formulate immunological tolerance
hypothesis
• 1959-Niels Jerne, David Talmage, Macfarlane Burnet develop clonal selection
theory
• 1957-Alick Isaacs and Jean Lindermann discover interferon (Cytokine)
• 1962-Rodney Porter and team discover structure of antibodies
• 1962-Jaques Miller and team discover thymus involvement in cellular immunity
12. MILESTONES IN THE HISTORY OF
IMMUNOLOGY
• 1962-Noel Warner and team distinguish between cellular and humoral
immune responses
• 1968-Anthony Davis and team discover T-cell and B-cell cooperation in
immune response
• 1974-Rolf Zinkerand Peter Doherty explore Major Histocompatibility
Complex restriction
• 1985-Susumu Tonegawa, Leroy Hood and team identify genes for the T cell
receptor
• 1987-Leroy Hood and team identify genes for the T cell receptor
• 1985-Scientists begin the rapid identification of genes for immune cells
that continues to the present time
13. IMPORTANCE OF IMMUNOLOGY
• Plays a role in combating disease
• Vaccination of immunizable diseases
• Cancer immunotherapy-immunotherapy combating cancer and infections
(cytokines, monoclonal antibody gene therapy)
• During treatment of emerging diseases like influenza, ebola, covid
• Immunology of type I diabetes and variety of cancer
• Application in discipline of medicine-organ transplants
• Helps understand pathogenesis allergens and treatment of hypersensitivity state
• Diagnosis of immune status Diabetes type I
• Diseases association with MHC
• Study of immunodeficiency diseases
• Provides immune diagnostic technique
• Understanding of graft rejection
14. Applications of immunology in human
medicine
• Organ transplant
• Immunotherapy/ oncology
• Virology
• Bacteriology
• Parasitology
• Microscopy
• Electrophoresis
• Immunoelectrofluorescence
15. Property of antigens/ Factors Influencing
Immunogenicity
Immunogenicity is determined by:
1. Foreignness
• An antigen must be a foreign substance to the animal to elicit an immune
response.
2. Molecular Size
• The most active immunogens tend to have a molecular mass of 14,000 to
600,000 Da.
• Examples: tetanus toxoid, egg albumin, thyroglobulin are highly antigenic.
• Insulin (5700 ) are either non-antigenic or weakly antigenic.
16. Immunogenicity is determined by:
3. Chemical Nature and Composition
• In general, the more complex the substance is chemically the more
immunogenic it will be.
• Antigens are mainly proteins and some are polysaccharides.
• It is presumed that presence of an aromatic radical is essential for rigidity and
antigenicity of a substance.
4. Physical Form
• In general particulate antigens are more immunogenic than soluble ones.
• Denatured antigens are more immunogenic than the native form.
17. Immunogenicity is determined by:
5. Antigen Specificity
• Antigen Specificity depends on the specific actives sites on the antigenic
molecules (Antigenic determinants).
• Antigenic determinants or epitopes are the regions of antigen which
specifically binds with the antibody molecule.
6. Species Specificity
• Tissues of all individuals in a particular species possess, species specific
antigen.
• Human Blood proteins can be differentiated from animal protein by specific
antigen-antibody reaction.
18. Immunogenicity is determined by:
7. Organ Specificity
• Organ specific antigens are confined to particular organ or tissue.
• Certain proteins of brain, kidney, thyroglobulin and lens protein of one
species share specificity with that of another species.
8. Auto-specificity
• The autologous or self-antigens are ordinarily not immunogenic, but under
certain circumstances lens protein, thyroglobulin and others may act
as autoantigens.
19. Immunogenicity is determined by:
9. Genetic Factors
• Some substances are immunogenic in one species but not in another.
Similarly, some substances are immunogenic in one individual but not in
others (i.e. responders and non-responders).
• The species or individuals may lack or have altered genes that code for the
receptors for antigen on B cells and T cells.
• They may not have the appropriate genes needed for the APC to present
antigen to the helper T cells.
20. Immunogenicity is determined by:
10. Age
• Age can also influence immunogenicity.
• Usually the very young and the very old have a diminished ability to
elicit and immune response in response to an immunogen.
21. Immunogenicity is determined by:
11. Degradability
• Antigens that are easily phagocytosed are generally more immunogenic.
• This is because for most antigens (T-dependant antigens) the development of
an immune response requires that the antigen be phagocytosed, processed
and presented to helper T cells by an antigen presenting cell (APC).
12. Dose of the antigen
• The dose of administration of an immunogen can influence its
immunogenicity.
• There is a dose of antigen above or below which the immune response will
not be optimal.
22. Immunogenicity is determined by:
13. Route of Administration
• Generally the subcutaneous route is better than the intravenous or
intragastric routes.
• The route of antigen administration can also alter the nature of the response.
• Antigen administered intravenously is carried first to the spleen, whereas
antigen administered subcutaneously moves first to local lymph nodes.
23. Immunogenicity is determined by:
14. Adjuvants
• Substances that can enhance the immune response to an immunogen are
called adjuvants.
• The use of adjuvants, however, is often hampered by undesirable side effects
such as fever and inflammation.
• Example: aluminum hydroxide.
24. QUIZ
• Who was the first person to discover response to foreign substance
• Describe the contribution of Landsteiner to the field of immunology
• Describe the Properties of antigens/ Factors influencing
Immunogenicity