The document summarizes a study that evaluated oxidative stress and antioxidant parameters in patients with spinal cord injuries (SCI) and their relationship to pain symptoms. The study found that SCI patients had significantly higher levels of lipid peroxides and protein carbonyl groups, indicating greater oxidative stress, compared to healthy controls. SCI patients also had lower levels of the antioxidant enzymes catalase, glutathione peroxidase, and glutathione reductase. Additionally, oxidative stress markers correlated more strongly with pain symptoms in SCI patients than in controls. The results suggest that increased oxidative stress may contribute to the pathogenesis and symptoms of SCI.
Investigation of the changes on muscular endurance in response to aerobic and...Sports Journal
The rationale of the study is to investigate the changes on muscular endurance in response to aerobic and
anaerobic training among type 2 diabetic patients. To achieve the purpose of the study 45 male type 2
diabetic patients from Ongole, in the southern state of Andhra Pradesh, India, were selected as subjects.
The subjects were selected in the age group of 45 to 50 years and they were randomly assigned into three
equal groups of 15 each. Experimental group-I performed aerobic training, experimental group-II
performed anaerobic training and group III acted as control. The muscular endurance was selected as
dependent variable. The data collected from the three groups prior to and post experimentation on
selected dependent variable was statistically analyzed to find out the significant difference if any, by
applying the analysis of covariance (ANCOVA). Whenever the obtained ‘F’ ratio value was found to be
significant for adjusted post-test means, the Scheffe’s test was applied as post hoc test. In all the cases the
level of confidence was fixed at 0.05 level for significance. The result of the study produced 20.48%
percentage of improvement due to aerobic training and 15.32% of improvement due to anaerobic training
in muscular endurance of the diabetic patients
Investigation of the changes on muscular endurance in response to aerobic and...Sports Journal
The rationale of the study is to investigate the changes on muscular endurance in response to aerobic and
anaerobic training among type 2 diabetic patients. To achieve the purpose of the study 45 male type 2
diabetic patients from Ongole, in the southern state of Andhra Pradesh, India, were selected as subjects.
The subjects were selected in the age group of 45 to 50 years and they were randomly assigned into three
equal groups of 15 each. Experimental group-I performed aerobic training, experimental group-II
performed anaerobic training and group III acted as control. The muscular endurance was selected as
dependent variable. The data collected from the three groups prior to and post experimentation on
selected dependent variable was statistically analyzed to find out the significant difference if any, by
applying the analysis of covariance (ANCOVA). Whenever the obtained ‘F’ ratio value was found to be
significant for adjusted post-test means, the Scheffe’s test was applied as post hoc test. In all the cases the
level of confidence was fixed at 0.05 level for significance. The result of the study produced 20.48%
percentage of improvement due to aerobic training and 15.32% of improvement due to anaerobic training
in muscular endurance of the diabetic patients
Post exercise cold water immersion attenuates acute anabolic signallingFernando Farias
these two studies offer new and
important insights into how cold water immersion during
recovery from strength exercise affects chronic training
adaptations and some of the molecular mechanisms that
underpin such adaptations. Cold water immersion delayed
or inhibited satellite cell activity and suppressed the
activation of p70S6K after acute strength exercise. These
effects may have been compounded over time to diminish
the expected increases in muscle mass and strength as a
result of training. The results of these studies challenge the
notion that cold water immersion improves recovery after
exercise. Individuals who use strength training to improve
athletic performance, recover from injury or maintain
their health should therefore reconsider whether to use
cold water immersion as an adjuvant to their training.
Data Collection & Analysis in Human Autonomic Research: How to Guide to Succe...InsideScientific
In this American Physiological Society (APS) webinar produced in partnership with ADInstruments, Jackie Limberg, PhD discusses the basics of human autonomic research as well as some tips and tricks for successful human testing. Implementing key experimental controls and understanding nuances in data collection and analysis during human autonomic testing have important implications for the accuracy and reliability of your findings.
Dr. Limberg introduces the gold standards for measuring both basal and reflex autonomic responses in humans, what equipment is required, and how to minimize variability in your data. The focus of the webinar is on data collection, including recommendations for study design as well as data analysis and interpretation.
Key Topics Include:
- Identify tests appropriate for measuring basal versus reflex autonomic control
- Describe the pros and cons of tests used in human autonomic research
- Create a research setting that is conducive to reliable and accurate human autonomic data
- Select equipment appropriate for the research questions being addressed
- Anticipate and avoid areas that may increase data variability and reduce your ability to interpret results
High intensity warm ups elicit superior performance Fernando Farias
The benefits of an active warm-up (WU) have been
attributed to increases in muscle temperature, nerve
conductivity, and the speeding of metabolic reactions.1 Non-
temperature-related benefifis include an increased blood-flflw
to working muscles, elevated baseline oxygen consumption,
and the induction of a post-activation potentiation (PAP)
effect.
Comparative study of sympathetic cardiovascular parameters in overweight, nor...IOSR Journals
This study was undertaken to investigate and compare the sympathetic cardio vascular parameters in age matched overweight, underweight and normal weight school going boys in southern Odisha. 75 Boys between age group of 12-16 were subjected to study out of which 25 were overweight (BMI>25), next 25 were underweight(BMI<18.5),rest 25 were control group having normal BMI. Cold pressure test and hand grip dynamometer test were performed and blood pressure was measured during and after the tests as measures of cardiovascular parameter. Baseline SBP and MAP were significantly higher in overweight boys & lower in underweight boys. Maximum rise of SBP, DBP & MAP during hand grip dynamometer test were significantly higher in overweight boys & lower in underweight boys. Increase in SBP & MAP from their basal value during cold pressure test were significantly lower in overweight boys & higher in underweight boys. Thus it is concluded that both overweight & underweight boys have derangement of sympathetic cardiovascular function. SBP- Systolic blood pressure, DBP- Diastolic blood pressure , MAP- Mean arterial pressure
Diabetic Peripheral Neuropathy- 6 Months Follow up Using Resisted Exercises a...inventionjournals
Introduction: An alarming global increase in type 2 diabetes, with second maximum known diabetic subjects in India, peripheral neuropathy which remain unfocussed with complications such as falls, ulcers, amputation, decreased mobility, dependence for ADL and disability associated along with. Aims and Objectives of This Research: To analyse obesity, glycemic control and neuropathy on a diabetic subject. Materials and Methodology: This original study was on a subject for 30 years with known type 2 diabetes and for 10 years with peripheral neuropathy, where the impact of resisted exercises and Proprioceptive training were analysed for 6 months period from October 2016 to March 2017. Results: A marginal reduction in obesity and improved glycemic control by 0.5% and slight lowering of Toronto clinical scoring system for diabetic neuropathy were recorded. Conclusion: The findings of this study could implicate benefits of larger population in the society as nearly 50% of diabetic develop neuropathy. Also this was an innovative and first research study among diabetic neuropathy subjects using RET and proprioceptive exercises. Key Words: HbA1C – Glycosylated Hemoglobin, IDF - International Diabetes Federation, TCSS - Toronto clinical scoring system, BMI – Body Mass Index, WC – Waist Circumference, UKPDS – United Kingdom Prospective Diabetes Study, NCV – Nerve Conduction Velocity, ACSM – American College of Sports Medicine, TENS – Transcutaneous Electrical Nerve Stimulation, VAS – Visual Analogue Scale, ADL – Activities of Daily Life
Post exercise cold water immersion attenuates acute anabolic signallingFernando Farias
these two studies offer new and
important insights into how cold water immersion during
recovery from strength exercise affects chronic training
adaptations and some of the molecular mechanisms that
underpin such adaptations. Cold water immersion delayed
or inhibited satellite cell activity and suppressed the
activation of p70S6K after acute strength exercise. These
effects may have been compounded over time to diminish
the expected increases in muscle mass and strength as a
result of training. The results of these studies challenge the
notion that cold water immersion improves recovery after
exercise. Individuals who use strength training to improve
athletic performance, recover from injury or maintain
their health should therefore reconsider whether to use
cold water immersion as an adjuvant to their training.
Data Collection & Analysis in Human Autonomic Research: How to Guide to Succe...InsideScientific
In this American Physiological Society (APS) webinar produced in partnership with ADInstruments, Jackie Limberg, PhD discusses the basics of human autonomic research as well as some tips and tricks for successful human testing. Implementing key experimental controls and understanding nuances in data collection and analysis during human autonomic testing have important implications for the accuracy and reliability of your findings.
Dr. Limberg introduces the gold standards for measuring both basal and reflex autonomic responses in humans, what equipment is required, and how to minimize variability in your data. The focus of the webinar is on data collection, including recommendations for study design as well as data analysis and interpretation.
Key Topics Include:
- Identify tests appropriate for measuring basal versus reflex autonomic control
- Describe the pros and cons of tests used in human autonomic research
- Create a research setting that is conducive to reliable and accurate human autonomic data
- Select equipment appropriate for the research questions being addressed
- Anticipate and avoid areas that may increase data variability and reduce your ability to interpret results
High intensity warm ups elicit superior performance Fernando Farias
The benefits of an active warm-up (WU) have been
attributed to increases in muscle temperature, nerve
conductivity, and the speeding of metabolic reactions.1 Non-
temperature-related benefifis include an increased blood-flflw
to working muscles, elevated baseline oxygen consumption,
and the induction of a post-activation potentiation (PAP)
effect.
Comparative study of sympathetic cardiovascular parameters in overweight, nor...IOSR Journals
This study was undertaken to investigate and compare the sympathetic cardio vascular parameters in age matched overweight, underweight and normal weight school going boys in southern Odisha. 75 Boys between age group of 12-16 were subjected to study out of which 25 were overweight (BMI>25), next 25 were underweight(BMI<18.5),rest 25 were control group having normal BMI. Cold pressure test and hand grip dynamometer test were performed and blood pressure was measured during and after the tests as measures of cardiovascular parameter. Baseline SBP and MAP were significantly higher in overweight boys & lower in underweight boys. Maximum rise of SBP, DBP & MAP during hand grip dynamometer test were significantly higher in overweight boys & lower in underweight boys. Increase in SBP & MAP from their basal value during cold pressure test were significantly lower in overweight boys & higher in underweight boys. Thus it is concluded that both overweight & underweight boys have derangement of sympathetic cardiovascular function. SBP- Systolic blood pressure, DBP- Diastolic blood pressure , MAP- Mean arterial pressure
Diabetic Peripheral Neuropathy- 6 Months Follow up Using Resisted Exercises a...inventionjournals
Introduction: An alarming global increase in type 2 diabetes, with second maximum known diabetic subjects in India, peripheral neuropathy which remain unfocussed with complications such as falls, ulcers, amputation, decreased mobility, dependence for ADL and disability associated along with. Aims and Objectives of This Research: To analyse obesity, glycemic control and neuropathy on a diabetic subject. Materials and Methodology: This original study was on a subject for 30 years with known type 2 diabetes and for 10 years with peripheral neuropathy, where the impact of resisted exercises and Proprioceptive training were analysed for 6 months period from October 2016 to March 2017. Results: A marginal reduction in obesity and improved glycemic control by 0.5% and slight lowering of Toronto clinical scoring system for diabetic neuropathy were recorded. Conclusion: The findings of this study could implicate benefits of larger population in the society as nearly 50% of diabetic develop neuropathy. Also this was an innovative and first research study among diabetic neuropathy subjects using RET and proprioceptive exercises. Key Words: HbA1C – Glycosylated Hemoglobin, IDF - International Diabetes Federation, TCSS - Toronto clinical scoring system, BMI – Body Mass Index, WC – Waist Circumference, UKPDS – United Kingdom Prospective Diabetes Study, NCV – Nerve Conduction Velocity, ACSM – American College of Sports Medicine, TENS – Transcutaneous Electrical Nerve Stimulation, VAS – Visual Analogue Scale, ADL – Activities of Daily Life
2020 OA Vision: Emerging Therapeutics on the OA landscapeOARSI
Philip Conaghan MBBS PhD FRACP FRCP
Director, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds
Deputy Director, NIHR Leeds Biomedical Research Centre
Intake of Black Vinegar on Anthropometric Measures, Cardiometabolic Profiles,...mahendrareddychirra
Obesity and type 2 diabetes mellitus are the most important chronic diseases around the world. They are associated with huge medical expenditure and with increasing morbidity and mortality among related cardio-metabolic diseases in developing and developed countries [1,2].
Vinegar was first reported to have anti-glycemic effects since 1988 in animal and human studies [3]. Vinegar may be associated with improved insulin sensitivity and delayed gastric emptying that accompanied improved glycemic control and reduced body weight [4,5].
Turbo Metabolism
Weight loss has got to be the most frustrating experience for many people, young and old alike. Eating foods that are just horrible, denying yourself foods you truly love and enjoy. Exercising, even though you absolutely hate exercising, and end up stiff as a board with no results. Finally Learn amazing secrets that will increase your metabolism, allowing your body to turn into a fat burning furnace day after day!
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ANS Testing Device University of Miami Study PresentationMaxiMedRx
Visit www.maximedrx.com
Sudopath Sudoscan testing device diabetic study by university of miami. Evaluating a New Approach to Detect Type 2 Diabetes Mellitus using the ES Complex-TSS
COMPARISON OF SERUM LEVELS OF ZINC AND LEPTIN IN FEMALE ENDURANCE AND SPRINTI...EDITOR IJCRCPS
Abstract in consideration of leptin effects such as reducing food intake and increasing energy consumption, many researchers
have sought to examine the relation between leptin and exercise. The presence of reports arguing that zinc can be a mediator in
leptin production indicates a possible relation between zinc and leptin. The purpose of this study was to compare plasma leptin,
plasma zinc, and their relationship in Elite female endurance and sprinting runner(n=15) with non-athletes(n=15).Blood samples
were obtained 24 h after training to measure plasma zinc and leptin levels. In the present study, we did not observe any significant
difference for plasma zinc and leptin levels between groups(p >0.05). There was not significant correlation between plasma leptin
and plasma zinc in the study groups.
Keywords: Leptin, Zinc, Athletes.
Efficiency of Use of Dietary Supplement Arteroprotect® In Prevention of Cardi...inventionjournals
Cardiovascular diseases are the leading cause of death in most developed countries and in many developing countries. The main cause of cardiovascular disease in 95% cases is supposed to be atherosclerosis, and the symptoms occur when the process is already at an advanced stage of disease. Present study was conducted to examine an efficiency of ARTEROprotect® (by Abela Pharm, Serbia) in prevention of cardiovascular diseases. The study was conducted by 76 doctors in primary health centers throughout the Republic of Serbia as a prospective clinical study of two groups of subjects. The study group included 4031 subjects (1785 males and 2246 females) who were taking ARTEROprotect® , while the control group consisted of 2564 subjects (1135 males and 1428 females) who were not taking it. Based on the results, dietary supplement ARTEROprotect® , used alone, could contribute to lowering levels of cholesterol, triglycerides, LDL-cholesterol; in combination with a statin it can achieve the target value of LDL- and HDL-cholesterol.
Association of cardio metabolic risk factors, serum nitric oxide metabolite a...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
1. To evaluate the level of oxidative and antioxidative
parameters and its relationship with pain symptoms
in patients with Spinal Cord Injuries
PROF. GHIZAL FATIMA
Department of RHEUMATOLOGY,
King George’s Medical University,
Lucknow, India.
2. Introduction: Why we did this study
• Spinal cord injuries (SCI) cause myelopathy or damage to nerve
roots or myelinated fiber tracts that carry signals to and from the
brain.
• The prevalence of spinal cord injury is not known in India and
many other countries.
• According to known data, about 450,000 people in the United
States live with spinal cord injury (one in 670), and there are
about 11,000 new spinal cord injuries every year (one in 30,000).
3. • The damage begins at the moment of injury when displaced
bone fragments, disc material, or ligaments bruise or tear into
spinal cord tissue.
• The pathophysiological disturbances of SCI are not well
known. Redox imbalance are associated with symptoms
suggestive of SCI.
• It is possible that oxidative stress, antioxidative enzymes is
involved in SCI.
Introduction: cont.
4. • Furthermore, oxidative and antioxidative parameters in India
has been investigated only since the last few years in SCI
patients and very few association studies have been performed
in these patients when compared to the global reports,
establishing oxidative, antioxidative association studies in
North Indian population is essential for understanding the
significance of inflammation in the development of SCI.
Introduction: cont.
5. • Oxidative stress means an alteration in the delicate balance
between free radicals and the scavenging capacity of
antioxidant enzymes in the body.
• There are several clinical conditions associated with increased
oxidative stress, but novel data suggest a relationship between
oxidative stress and SCI. Furthermore, there is little
information available in scientific literature about oxidative
stress in SCI patients.
• In the present study we examined the involvement of oxidative
and antioxidative parameters in patients with Spinal Cord
Injuries (SCI) and also evaluated its correlation with the
severity of its pain symptoms.
Introduction: cont.
6. Objectives
• Assessment of the Oxidative stress parameter like Lipid Peroxides (LPO)
and Protein carbonyl group in 14 SCI patients and 14 healthy controls
without SCI.
• Assessment of the Antioxidative stress parameters like catalase ,
Glutathione peroxidase (GPx) and Glutathione Reductase (GR) ) in 14 SCI
patients and 14 healthy controls without SCI.
• Assessment of Pain symptoms of SCI by Visual Analog Scale (VAS).
• To evaluate its relationship with pain symptoms and oxidative stress
parameters and Antioxidative stress parameters in SCI patients and healthy
controls without SCI.
• .
7. Materials and Method
• Oxidative stress was determined by measuring the levels of Lipid Peroxides (LPO)
(Ohkawa et al 1979) and Protein carbonyl group ((Levine and Williams, 1994) in plasma
in 14 SCI patients and 14 healthy controls without SCI.
• Antioxidative stress parameters was determined by measuring the levels of catalase ,
Glutathione peroxidase (GPx) and Glutathione Reductase (GR) ) in lysate in 14 SCI
patients and 14 healthy controls without SCI.
• Assessment of Pain symptoms of SCI was done by Visual Analog Scale (VAS).
• Clinical assessment was done by following questionnaires
1- General Assessment Questionnaire (self designed)
2- Pain symptoms of SCI was done by Visual Analog Scale (VAS).
8. Inclusion and exclusion criteria
Inclusion Exclusion
Patients who fulfilled the criteria
developed by the American Spinal
Injury Association (ASIA) were
included in the study.
Smokers and those using any oral
contraceptives were excluded from the
study as these factors can influence the
oxidative stress and antioxidative
parameters.
Informed consent for inclusion in
the study were taken from all the
subjects.
Moreover, subjects with known co-morbid
conditions like diabetes mellitus and other
endocrinal disorder (thyroid and Pituitary
dysfunction), psychiatric patients will be
excluded from the study. Subjects suffering
from Multiple Myeloma will also be
excluded from the study.
9. Diagnosis of patients: (SCI)
Traumatic spinal cord injury is classified into five categories on the ASIA
Impairment Scale. The criteria is-
• A indicates a "complete" spinal cord injury where no motor or sensory function is preserved in the
sacral segments S4-S5.
• B indicates an "incomplete" spinal cord injury where sensory but not motor function is preserved
below the neurological level and includes the sacral segments S4-S5. This is typically a transient
phase and if the person recovers any motor function below the neurological level, that person
essentially becomes a motor incomplete, i.e. ASIA C or D.
• C indicates an "incomplete" spinal cord injury where motor function is preserved below the
neurological level and more than half of key muscles below the neurological level have a muscle
grade of less than 3, which indicates active movement with full range of motion against gravity.
• D indicates an "incomplete" spinal cord injury where motor function is preserved below the
neurological level and at least half of the key muscles below the neurological level have a muscle
grade of 3 or more.
• E indicates "normal" where motor and sensory scores are normal. Note that it is possible to have
spinal cord injury and neurological deficits with completely normal motor and sensory scores.
10. • Statistical analysis was done using SPSS statistical software (16.0 versions).
• Quantitative variables of SCI patients and controls were presented as the
mean ± standard deviation, and are compared by independent t-test.
• Pearson correlation was done to find the pattern of associations between the
groups.
• A value of p<0.05 was considered statistically significant and p<0.01 is
considered highly significant.
• .
Statistical analysis
11. Clinical and Biochemical Characteristics among Study and Control groups
Parameters SCI=14
[mean ± SD]
Controls=14
[mean ± SD]
P-value
Age (years) 34.7±9.8 32.8±10.5 N.S
ESR 27.2±9.7 24.9±8.2 N.S
ALT 39.8±14.1 37.6±14.4 N.S
VAS 87.2±11.4 35.0±8.3 <0.05
12. Oxidative Parameters
Study (n=14)
(Mean ± SD)
Control (n=14)
(Mean ± SD)
P-Value
Lipid Peroxides (LPO)
3.31±0.57 2.24±0.35
p<0.01
Protein carbonyl group
1.90±0.45 1.32±0.26
p<0.01
Oxidative stress parameters among Study and Control groups
13. Comparison of Lipid Peroxide level in SCIpatients and Control Group
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
Patients (n=14) Control (n=14)
Lipid Peroxide
Lipid Peroxide
14. Comparison of Protein Carbonyl Group level in SCIpatients and Control
Group
0
0.5
1
1.5
2
2.5
Patients (n=14) Control (n=14)
Protein Carbonyl Group
Protein Carbonyl
Group
15. Antioxidative parameters among Study and Control groups
Antioxidative Parameters
Study (n=14)
(Mean ± SD)
Control (n=14)
(Mean ± SD)
P-Value
Catalase
41.0±5.1 57.3±8.6 <0.01
Glutathione peroxidase
(GPx)
28.2±3.7 38.7±5.1 <0.01
Glutathione Reductase
(GR)
24.4±4.2 28.1±6.2 <0.01
16. Comparison of Catalase in SCI patients and Control Group
0
10
20
30
40
50
60
70
Patients (n=14) Control (n=14)
Catalase
Catalase
17. Comparison of Glutathione peroxidase in SCI patients and Control Group
0
5
10
15
20
25
30
35
40
45
50
Patients (n=14) Control (n=14)
GPx
GPx
18. Comparison of Glutathione reductase in SCI patients and Control Group
0
5
10
15
20
25
30
35
40
Patients (n=14) Control (n=14)
GR
GR
19. Pearson correlation analysis in Lipid Peroxides (LPO), Protein carbonyl
group with age and VAS
Parameters Groups Age VAS
r r
Lipid Peroxides (LPO)
SCI patients 0.084 0.533*
Control 0.043 0.129
Protein carbonyl group
SCI patients 0.038
0.434*
Control -0.064
0.115
20. Pearson correlation analysis in Catalase, Glutathione peroxidase and
Glutathione reductase with age and VAS
Parameters Groups Age VAS
r r
Catalase
SCI patients -0.093 -0.182
Control .114 0.072
Glutathione
peroxidase (GPx)
SCI patients -0.138 0.081
Control -.133 0.125
Glutathione
Reductase (GR)
SCI patients 0.058 0.084
Control -.101 0.043
21. • In conclusion, the present study indicate that SCI patients are exposed to
oxidative stress and this increased oxidative stress may play a role in the
etiopathogenesis of SCI. Moreover, our results also show that increased
oxidative stress parameters are more strongly associated with Pain symptoms
in SCI patients. The limitations of the study is the sample size we need good
sample size to draw much better conclusion.
• Therefore, an intervention study is recommended to address the question of
whether improved oxidative stress parameters in SCI patients can lead to
decrease in its symptomatology.
Conclusion
22. Relevance of the Study
These findings resulted in better understanding of oxidative
stress parameters in SCI patients which is found elevated in
patients group as compared to the control group. Therefore,
increased oxidative stress levels may be responsible for the
worsening of SCI symptoms.
23.
24. • Lipid peroxidation (LPO) (Ohkawa et al 1979)
• Mix 0.2 ml of blood plasma with 0.5 ml of acetic acid subsequently 0.5 ml of 8% SDS will be added and
shake the above mixture, after this, add 1.5 ml of 0.8% TBA solution. The reaction mixture was incubated in a
boiling water bath for one hour. After cooling at room temperature, add 3 ml n-butanol and this reaction
mixture will be centrifuged at 10,000 rpm for 15 minute. A clear supernatant obtained after centrifugation will
be used for measuring the absorbance at 532 mm against reagent blank. We will also run an appropriate
standard Melondialdehyde (MDA) 10 n mol of (=10l) simultaneously.
• Protein carbonyl group (Levine and Williams, 1994): Procedure: The experiment will be carried out in two
setups. In one set (experimental), 5 ml DNPH and 1.5 ml blood plasma will be taken and in the second set
(reference) 1.5 ml blood plasma will be added in the 5 ml of 2.5 M HCl instead of DNPH. Tubes will be left
for 1 hour at room temperature (in dark). The samples vortexes for 15 min. then 5ml of 20% TCA will be
added in both sets to a final concentration of TCA by 10% itself. Tubes then are kept to ice water for 30 min to
get protein precipitated and centrifuged. The protein precipitate collected, washed with 4 ml of 10% TCA and
recovered by centrifugations. Protein pellet washed 3 times with 4 ml mixture of ethanol: ethyl acetate (1:1
v/v) to remove unreacted DNPH and lipid components. Finally precipitate of experimental and reference
dissolved in 2ml of 6M guanidine HCl and left for 10 min at 37◦ C with general vortex mixing and insoluble
material will be removed by additional centrifugation. A clear supernatant obtained. The absorbance of this
will be measured at 365nm (UV) against guanidine HCl on spectrophotometer. The results expressed as
nmol/mg protein.
25. • Catalase (Aebi 1974): (Done in lysate)
• Procedure: 2ml of phosphate buffer and 1 ml. of diluted (0.2M) H2O2 will be taken in a cuvette, in
this we will add 0.02 ml enzyme source and mix thoroughly. The decrease in absorbance at 240nm
will be recorded after every 30 seconds for 3 minutes against reagent blank. One catalase unit is
defined as the amount of enzyme required to cause a decrease in optical density by 0.100 of
substrate (H2O2). We will also determine Protein content in enzyme source. The results will be
expressed as unit/mg protein.
• Glutathione Reductase (Hazelton and Lang; 1995) (Done in lysate)
• Procedure: The reaction mixture consist of 0.1 ml NADPH, 0.2 ml GSSG, 0.1 ml EDTA, 2.5 ml
buffer and 0.1 ml of enzyme source to a total volume of 3.0 ml. The reaction will be initiated by the
addition of enzyme source. Oxidation of NADPH followed at 340 nm. Blank reaction will be run
simultaneously. The decrease in absorbance at 340 nm is followed at 30 second intervals. We will
also determine Protein content in the enzyme source. Enzyme unit will be defined as nmole of
NADPH oxidized per minute per mg protein. The results will be expressed as unit/min/mg protein.
• Glutathione Peroxidase (Pagila and Valentine; 1967) (Done in lysate)
• Procedure: An incubation mixture containing 0.4 ml buffer, 0.2 ml of GSH, 0.2 ml EDTA, 0.2 ml
Sodium azide and 0.2 ml hydrogen peroxide will be pre-incubated at 37o C for 10 min. 0.1 ml of
enzyme source will be added and incubated at 37oC for 10 min. The reaction will then be
terminated by the addition of the 0.1 ml of 10% TCA. Supernatant taken and 3 ml of phosphate
buffer and 1 ml of DTNB will be added. The color developed read immediately at 412 nm in a
spectrophotometer. We will also estimate Protein in enzyme source. GPx enzyme activity will be
expressed as µg GSH oxidized per mg protein and the results will be expressed as unit/mg protein.
26. Centrifuge at 3000 rpm
for 15 min
Supernatant= Plasma
TBARS (LPO) analysis Pellet (RBCs)
Washed twice with 1 ml
normal saline (0.9% Nacl)
and Centrifuge at 3000 rpm
for 10 min, discarded the
supernatant (normal saline)
Pellet + Chilled Distilled water
(Equal volume to plasma)
Centrifuge at 5000
rpm for 20 min
Supernatant =
Lysate
(Enzymatic
analysis)
Preparation of Lysate
Blood Sample
27. • Using the Snedecor and Cochran(1989) sample size calculation formula
• Sample size (n) = 1 + 2C (SD/D)2
• (α) =0.05,
• (1-β) =0.9, then C=10.5
• n= 1+2*10.5(2/4)2
• n=30