Obesity and type 2 diabetes mellitus are the most important chronic diseases around the world. They are associated with huge medical expenditure and with increasing morbidity and mortality among related cardio-metabolic diseases in developing and developed countries [1,2].
Vinegar was first reported to have anti-glycemic effects since 1988 in animal and human studies [3]. Vinegar may be associated with improved insulin sensitivity and delayed gastric emptying that accompanied improved glycemic control and reduced body weight [4,5].
Potential role of uric acid in correlation with epidemics of hypertension and...Apollo Hospitals
Diabetic nephropathy (DN) is a microvascular complication of Type 2 diabetes mellitus. Uric acid (UA) is the end product of purine nucleotide metabolism and its primary mode of clearance is by renal excretion. Modifiable factors such as blood pressure, albuminuria, glycemic control, etc., play an important role in the progression of DN and none of them are curative. Hence, there is a pressing interest to identify other potentially modifiable factors such as UA in the progression of DN.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay
Study of serum magnesium and fasting blood glucose in hypertensioniosrjce
A study was carried out to determine the fasting blood glucose and serum magnesium levels in
patients with hypertension. A total of 80 hypertensive patients were evaluated, of which, 58 were males and 22
were females. The mean ages of male and female hypertensive subjects were 48.06±6.53 and 50.83±7.62
respectively. Hypomagnesemia was observed in 61.25% subjects and raised fasting blood glucose was identified
in 55.1% of individuals. Therefore occurrence of low serum magnesium and raised blood sugar level in patients
with hypertension was observed
To determine whether modestly severe obesity modifies
Glucose homeostasis, Levels of cardiometabolic markers, and HDL function in African Americans (AAs) and White Americans (WAs) with pre-diabetes.
A comparative analysis of biochemical and hematological parameters in diabeti...amsjournal
This study evaluated the biochemical and the hematological parameters in diabetic and non- diabetic patients. The measured biochemical parameters were fasting blood sugar, serum alanine aminotransferase (SGPT/ALT), total cholesterol, urea, creatinine and hematological parameters were hemoglobin, total white blood cell, neutrophil, lymphocyte,monocyte, eosinophil and ESR. There were 403 diabetic and 320 non-diabetic subjects included in this study and the study was carried out in BIRDEM (Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders) General Hospital). It was observed that the mean values of SGPT/ALT (p<0.001),><0.001)><0.001)><0.001),><0.004),><0.001) of hematological parameters were significantly higher in diabetic patients than in the non-diabetic patients. In univariate analysis, all biochemical parameters and only four hematological parameters were found significantly associated with fasting blood sugar after adjusted with age and sex. The fasting blood sugar correlates highly with the other biochemical parameters but less or none with the hematological parameters. Our findings demonstrated that control of increased biochemical parameters and abnormal hematological levels in the early stage of diabetes mellitus may help the patients to raise quality of life.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Potential role of uric acid in correlation with epidemics of hypertension and...Apollo Hospitals
Diabetic nephropathy (DN) is a microvascular complication of Type 2 diabetes mellitus. Uric acid (UA) is the end product of purine nucleotide metabolism and its primary mode of clearance is by renal excretion. Modifiable factors such as blood pressure, albuminuria, glycemic control, etc., play an important role in the progression of DN and none of them are curative. Hence, there is a pressing interest to identify other potentially modifiable factors such as UA in the progression of DN.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay
Study of serum magnesium and fasting blood glucose in hypertensioniosrjce
A study was carried out to determine the fasting blood glucose and serum magnesium levels in
patients with hypertension. A total of 80 hypertensive patients were evaluated, of which, 58 were males and 22
were females. The mean ages of male and female hypertensive subjects were 48.06±6.53 and 50.83±7.62
respectively. Hypomagnesemia was observed in 61.25% subjects and raised fasting blood glucose was identified
in 55.1% of individuals. Therefore occurrence of low serum magnesium and raised blood sugar level in patients
with hypertension was observed
To determine whether modestly severe obesity modifies
Glucose homeostasis, Levels of cardiometabolic markers, and HDL function in African Americans (AAs) and White Americans (WAs) with pre-diabetes.
A comparative analysis of biochemical and hematological parameters in diabeti...amsjournal
This study evaluated the biochemical and the hematological parameters in diabetic and non- diabetic patients. The measured biochemical parameters were fasting blood sugar, serum alanine aminotransferase (SGPT/ALT), total cholesterol, urea, creatinine and hematological parameters were hemoglobin, total white blood cell, neutrophil, lymphocyte,monocyte, eosinophil and ESR. There were 403 diabetic and 320 non-diabetic subjects included in this study and the study was carried out in BIRDEM (Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders) General Hospital). It was observed that the mean values of SGPT/ALT (p<0.001),><0.001)><0.001)><0.001),><0.004),><0.001) of hematological parameters were significantly higher in diabetic patients than in the non-diabetic patients. In univariate analysis, all biochemical parameters and only four hematological parameters were found significantly associated with fasting blood sugar after adjusted with age and sex. The fasting blood sugar correlates highly with the other biochemical parameters but less or none with the hematological parameters. Our findings demonstrated that control of increased biochemical parameters and abnormal hematological levels in the early stage of diabetes mellitus may help the patients to raise quality of life.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
ABSTRACT- Previous studies have suggested an association between vegetarian persons and non-vegetarian persons, although this relationship
positive correlation significant. The present study was designed to investigate comparative study of lipid profile levels in vegetarian and nonvegetarian
person. The lipid profile is used to determine the risk of obesity, heart disease in myocardial infarction, atherosclerosis and help in deciding
treatment has borderline or high risk. the present study was undertaken to compare case and control produce effect on individuals lipid profile, the
parameters of lipid metabolism i.e. cholesterol, tri-glyceride, high density lipoprotein, low density lipoprotein of the age of 20-85 years and early
aged 50 years and above males and females, divided categories i.e. vegetarian and non- vegetarian persons. the study was done on 20 cases in 10
control (non-vegetarians) and 10 cases (vegetarians) diet was significantly found to reduce the values of all the parameter lipid metabolism except
HDL-Cholesterol(45.02± 9.595; p<0.0001).when><0.0001 ) from this study, it can be concluded
that along with diet, sex and age factor also influence parameters of lipid metabolism.
Key words- Vegetarian persons, non-Vegetarian, Lipid profile
Investigation of the changes on muscular endurance in response to aerobic and...Sports Journal
The rationale of the study is to investigate the changes on muscular endurance in response to aerobic and
anaerobic training among type 2 diabetic patients. To achieve the purpose of the study 45 male type 2
diabetic patients from Ongole, in the southern state of Andhra Pradesh, India, were selected as subjects.
The subjects were selected in the age group of 45 to 50 years and they were randomly assigned into three
equal groups of 15 each. Experimental group-I performed aerobic training, experimental group-II
performed anaerobic training and group III acted as control. The muscular endurance was selected as
dependent variable. The data collected from the three groups prior to and post experimentation on
selected dependent variable was statistically analyzed to find out the significant difference if any, by
applying the analysis of covariance (ANCOVA). Whenever the obtained ‘F’ ratio value was found to be
significant for adjusted post-test means, the Scheffe’s test was applied as post hoc test. In all the cases the
level of confidence was fixed at 0.05 level for significance. The result of the study produced 20.48%
percentage of improvement due to aerobic training and 15.32% of improvement due to anaerobic training
in muscular endurance of the diabetic patients
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
Alicia Wong1
, Wan Chien Han1
, Elsie Low1
,
Chai Xiang Goh1
,
Siew Li Ng1
,
Lee Kuan Kwan1
Abstract: Diabetes-specific formulas have shown to be effective at improving glucose control with additional
nutritional benefits. Furthermore, diabetes-specific formulas are commonly used for diabetic patients with
insufficient oral intake. However, not much diabetes-specific formulas in the market shows the GI of these
formulas, which is clinically useful on glycemic control in patients with diabetes. The aim of this study was to
assess the GI of a newly developed diabetes-specific formula, Contro eazy NOW. The open labelled, single center
study involved 11 individuals from a pool of 18 healthy subjects. After an overnight fast, volunteers were given
Contro eazy NOW containing 50g of carbohydrate or the reference drink (glucolin) on different occasions in
random order. Postprandial blood glucose levels were measured in finger pricked capillary blood for two hours
after intake of the beverages and positive incremental area under the curve (AUC) was calculated for both Contro
eazy NOW and reference drink. The GI of Contro eazy NOW was determined by dividing AUC (Contro eazy
NOW) by the AUC (reference drink). The results show that the diabetes-specific formula has the GI of 38.4, which
is categorized as low GI. Therefore, Contro eazy NOW with low GI can be the preferred option for nutritional
management of diabetic patients in need of nutritional support.
Keywords: diabetes-specific formula, diabetes, low glycemic index, medical nutrition therapy.
ABSTRACT- Previous studies have suggested an association between vegetarian persons and non-vegetarian persons, although this relationship
positive correlation significant. The present study was designed to investigate comparative study of lipid profile levels in vegetarian and nonvegetarian
person. The lipid profile is used to determine the risk of obesity, heart disease in myocardial infarction, atherosclerosis and help in deciding
treatment has borderline or high risk. the present study was undertaken to compare case and control produce effect on individuals lipid profile, the
parameters of lipid metabolism i.e. cholesterol, tri-glyceride, high density lipoprotein, low density lipoprotein of the age of 20-85 years and early
aged 50 years and above males and females, divided categories i.e. vegetarian and non- vegetarian persons. the study was done on 20 cases in 10
control (non-vegetarians) and 10 cases (vegetarians) diet was significantly found to reduce the values of all the parameter lipid metabolism except
HDL-Cholesterol(45.02± 9.595; p<0.0001).when><0.0001 ) from this study, it can be concluded
that along with diet, sex and age factor also influence parameters of lipid metabolism.
Key words- Vegetarian persons, non-Vegetarian, Lipid profile
Investigation of the changes on muscular endurance in response to aerobic and...Sports Journal
The rationale of the study is to investigate the changes on muscular endurance in response to aerobic and
anaerobic training among type 2 diabetic patients. To achieve the purpose of the study 45 male type 2
diabetic patients from Ongole, in the southern state of Andhra Pradesh, India, were selected as subjects.
The subjects were selected in the age group of 45 to 50 years and they were randomly assigned into three
equal groups of 15 each. Experimental group-I performed aerobic training, experimental group-II
performed anaerobic training and group III acted as control. The muscular endurance was selected as
dependent variable. The data collected from the three groups prior to and post experimentation on
selected dependent variable was statistically analyzed to find out the significant difference if any, by
applying the analysis of covariance (ANCOVA). Whenever the obtained ‘F’ ratio value was found to be
significant for adjusted post-test means, the Scheffe’s test was applied as post hoc test. In all the cases the
level of confidence was fixed at 0.05 level for significance. The result of the study produced 20.48%
percentage of improvement due to aerobic training and 15.32% of improvement due to anaerobic training
in muscular endurance of the diabetic patients
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
Similar to Intake of Black Vinegar on Anthropometric Measures, Cardiometabolic Profiles, and Insulin Sensitivity among Impaired Glucose Tolerance Subjects
Alicia Wong1
, Wan Chien Han1
, Elsie Low1
,
Chai Xiang Goh1
,
Siew Li Ng1
,
Lee Kuan Kwan1
Abstract: Diabetes-specific formulas have shown to be effective at improving glucose control with additional
nutritional benefits. Furthermore, diabetes-specific formulas are commonly used for diabetic patients with
insufficient oral intake. However, not much diabetes-specific formulas in the market shows the GI of these
formulas, which is clinically useful on glycemic control in patients with diabetes. The aim of this study was to
assess the GI of a newly developed diabetes-specific formula, Contro eazy NOW. The open labelled, single center
study involved 11 individuals from a pool of 18 healthy subjects. After an overnight fast, volunteers were given
Contro eazy NOW containing 50g of carbohydrate or the reference drink (glucolin) on different occasions in
random order. Postprandial blood glucose levels were measured in finger pricked capillary blood for two hours
after intake of the beverages and positive incremental area under the curve (AUC) was calculated for both Contro
eazy NOW and reference drink. The GI of Contro eazy NOW was determined by dividing AUC (Contro eazy
NOW) by the AUC (reference drink). The results show that the diabetes-specific formula has the GI of 38.4, which
is categorized as low GI. Therefore, Contro eazy NOW with low GI can be the preferred option for nutritional
management of diabetic patients in need of nutritional support.
Keywords: diabetes-specific formula, diabetes, low glycemic index, medical nutrition therapy.
Alicia Wong1
, Wan Chien Han1
, Elsie Low1
,Chai Xiang Goh1
, Siew Li Ng1
,
Lee Kuan Kwan1
1Alpro Academy, Lot 45880, Jalan Techvalley 3/2, Sendayan Techvally, 71950 Bandar Sri Sendayan, Negeri Sembilan,
Malaysia.
Abstract: Glycemic index (GI) describes the blood glucose response after consumption of a carbohydrate
containing test food relative to a carbohydrate containing reference food, typically glucose or white bread. GI was
originally designed for people with diabetes as a guide to food selection, and advice being given to select foods with
a low GI. Nonetheless low GI food should not be limited to diabetes patients but healthy individuals too as more
recent recommendations on the potential of low GI diets to reduce the risk of chronic diseases and to treat other
metabolic syndromes. This study aims to evaluate the GI of 2 oral nutritional supplements, Metabolic Recovery
and Metabolic Relievve in healthy adults. Fasted subjects consumed one of the 2 oral nutritional supplements at
each visit, with a two day wash out period between visits. Every subject received both oral nutritional supplements
and blood glucose at 0, 15, 30, 45, 60, 90 and 120 mins were measured after the consumption of oral nutritional
supplements which all containing 50g carbohydrates per serving. The trapezium method was used to compute the
area under the curve for blood glucose and GI of both oral nutritional supplements were determined with
reference to glucolin. The results show that both oral nutritional supplements has low GI, with Metabolic Recovery
having the GI of 46.7 ± 16.4 and Metabolic Relievve with GI of 45.2 ± 16.4. Therefore, both Metabolic Recovery
and Metabolic Relievve can be the preferred option for nutritional management of diabetic patients and healthy
individuals in need of nutritional support.
Keywords: Oral nutritional supplements, glycemic index, blood sugar level, diabetes, meal replacement.
Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components
Turbo Metabolism
Weight loss has got to be the most frustrating experience for many people, young and old alike. Eating foods that are just horrible, denying yourself foods you truly love and enjoy. Exercising, even though you absolutely hate exercising, and end up stiff as a board with no results. Finally Learn amazing secrets that will increase your metabolism, allowing your body to turn into a fat burning furnace day after day!
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Journal of Schizophrenia Research is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts in all related aspects of a mental disorder often characterized by abnormal social behavior and failure to recognize what is real with common symptoms including false beliefs, auditory hallucinations, confused or unclear thinking, inactivity, and reduced social engagement and emotional expression. The journal focuses upon the latest research in finding causes, understanding mechanisms, diagnosis, prevention, management, prognosis, epidemiology, ancestral history and treatment of schizophrenia.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and medicine with intent to bridge the gap between academia and research access.
Journal of Schizophrenia Research accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all related aspects of schizophrenia including, finding causes, understanding mechanisms, diagnosis, prevention, management, prognosis, epidemiology, ancestral history and its treatment.
The article it is about is The Journal of Nutrition Nutrition and.docxfelicitytaft14745
The article it is about is:
The Journal of Nutrition Nutrition and Disease
Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women1–4
April J. Stull, Katherine C. Cash, William D. Johnson, Catherine M. Champagne, and William T. Cefalu*
Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808
Abstract
Dietary supplementation with whole blueberries in a preclinical study resulted in a reduction in glucose concentrations over time. We sought to evaluate the effect of daily dietary supplementation with bioactives from blueberries on whole-body insulin sensitivity in men and women. A double-blinded, randomized, and placebo-controlled clinical study design was used. After screening to resolve study eligibility, baseline (wk 0) insulin sensitivity was measured on 32 obese, nondiabetic, and insulin-resistant subjects using a high-dose hyperinsulinemic-euglycemic clamp (insulin infusion of 120 mU(861 pmol)×m22×min21). Serum inflammatory biomarkers and adiposity were measured at baseline. At the end of the study, insulin sensitivity, inflammatory biomarkers, and adiposity were reassessed. Participants were randomized to consume either a smoothie containing 22.5 g blueberry bioactives (blueberry group, n = 15) or a smoothie of equal nutritional value without added blueberry bioactives (placebo group, n = 17) twice daily for 6 wk. Both groups were instructed to maintain their body weight by reducing ad libitum intake by an amount equal to the energy intake of the smoothies. Participants’ body weights were evaluated weekly and 3-d food records were collected at baseline, the middle, and end of the study. The mean change in insulin sensitivity improved more in the blueberry group (1.7 6 0.5 mg×kg FFM21×min21) than in the placebo group (0.4 6 0.4 mg×kg FFM21×min21)(P = 0.04). Insulin sensitivity was enhanced in the blueberry group at the end of the study without significant changes in adiposity, energy intake, and inflammatory biomarkers. In conclusion, daily dietary supplementation with bioactives from whole blueberries improved insulin sensitivity in obese, nondiabetic, and insulin-resistant participants. J. Nutr. 140: 1764–1768, 2010.
Introduction
Increased consumption of berries has been shown to improve cognitive function, risk of cardiovascular disease, and cancer (1,2). Studies have also reported that specific berries, i.e., blueberries, have antidiabetic effects. Specifically, a study performed in mice (3) found that supplementation with
whole blueberries reduced the blood glucose area under the curve (AUC)5 in vivo and cell culture studies (4,5) demonstrated increased glucose uptake in vitro (6). In addition, inflammatory genes have been reduced in mice after consuming blueberry bioactives, which suggests an antiinflammatory response (3). The purported health benefits from blueberries have been attributed to their phenol.
Diabetes is a rapidly and serious health problem in Pakistan. This chronic condition is associated with serious long-term complications, including higher risk of heart disease and stroke. Aggressive treatment of hypertension and hyperlipideamia can result in a substantial reduction in cardiovascular events in patients with diabetes 1. Consequently pharmacist-led diabetes cardiovascular risk (DCVR) clinics have been established in both primary and secondary care sites in NHS Lothian during the past five years. An audit of the pharmaceutical care delivery at the clinics was conducted in order to evaluate practice and to standardize the pharmacists’ documentation of outcomes. Pharmaceutical care issues (PCI) and patient details were collected both prospectively and retrospectively from three DCVR clinics. The PCI`s were categorized according to a triangularised system consisting of multiple categories. These were ‘checks’, ‘changes’ (‘change in drug therapy process’ and ‘change in drug therapy’), ‘drug therapy problems’ and ‘quality assurance descriptors’ (‘timer perspective’ and ‘degree of change’). A verified medication assessment tool (MAT) for patients with chronic cardiovascular disease was applied to the patients from one of the clinics. The tool was used to quantify PCI`s and pharmacist actions that were centered on implementing or enforcing clinical guideline standards. A database was developed to be used as an assessment tool and to standardize the documentation of achievement of outcomes. Feedback on the audit of the pharmaceutical care delivery and the database was received from the DCVR clinic pharmacist at a focus group meeting.
A Review on Continuous Glucose Monitoring System A Competent Technique in Mon...ijtsrd
Continuous glucose monitoring system CGMS is an emerging and widely accepted technique for monitoring and management of blood glucose levels. Blood glucose level can be compared with a tennis ball, the way a tennis ball bounces blood sugar also behaves the same going from high to low rapidly. Without having an accurate measurement of the patient’s level of sugar, injecting insulin could pose more of a risk to the patient rather than a benefit by inducing hypoglycemia. Continuous glucose monitoring system measures blood glucose level every 5 15 minutes of intervals which helps in having a clear idea of blood glucose level and accordingly dose of insulin that can be administered. This review discusses the history of blood glucose monitoring in the past 100 years, and also gives detailed information on the continuous glucose monitoring system, its working, technology, its wide usage and its superiority over other glucose monitoring techniques and limitations that are to be addressed, and also giving a view on how the future will be of glucose monitoring based on the survey of the variety of literature available on the topic. This review will help readers to understand the continuous glucose monitoring system in the most precise manner and will help to adopt continuous glucose monitoring systems more efficiently in the management of diabetes. Rajratna Gaikwad | Dr. Vijaya Barge "A Review on Continuous Glucose Monitoring System: A Competent Technique in Monitoring and Management of Blood Glucose Levels" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-2 , April 2023, URL: https://www.ijtsrd.com.com/papers/ijtsrd55165.pdf Paper URL: https://www.ijtsrd.com.com/pharmacy/biomaterial-sciences/55165/a-review-on-continuous-glucose-monitoring-system-a-competent-technique-in-monitoring-and-management-of-blood-glucose-levels/rajratna-gaikwad
Alterations of Mitochondrial Functions and DNA in Diabetic Cardiomyopathy of ...CrimsonPublishersIOD
Alterations of Mitochondrial Functions and DNA in Diabetic Cardiomyopathy of CCK1 Receptors-Deficient Rats by Abdelbary Prince, Magdy A Ghoneim, Abdallah M El-Ebidi, Hala A Mousa and Jin Han in Interventions in Obesity & Diabetes
Similar to Intake of Black Vinegar on Anthropometric Measures, Cardiometabolic Profiles, and Insulin Sensitivity among Impaired Glucose Tolerance Subjects (20)
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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suggests that the effects of vinegar on weight loss, insulin sensitivity
and blood glucose or insulin levels have not been consistent and
further studies are needed in different metabolic status subjects.
The purpose of this study is to evaluate the effects of black vinegar
on anthropometric, cardiometabolic profiles, and insulin sensitivity
among impaired glucose tolerance subjects.
Materials and Methods
In total, 32 adults (14 males and 18 females) who have impaired
fasting glucose or glucose intolerance were recruited from the out-
patient clinic of the Tri-Service General Hospital at Taipei, Taiwan.
The criteria for inclusion into this trial were as follows: ages 25–65,
absence of infection within the previous three weeks, and no history
of malignant tumors. The exclusion criteria were pregnancy, current
or a history of cerebrovascular accident, myocardial infarction,
heart failure, renal failure, hepatic failure, autoimmune disorders,
endocrine diseases, or psychiatric conditions, including mood
disorders and alcohol abuse. The subjects allergic to vinegar are also
excluded.
All study participants consumed black vinegar 50 ml diluted to
500 ml with drinking water every day for eight weeks. All participants
provided written informed consent and agreed to take black vinegar
for eight weeks and have their blood samples taken for this study.
The institutional review board of our hospital approved this study
(Number: TSGHIRB-2-106-65-010).
Anthropometric measurements
Body Weight (BW) was measured to an accuracy of 0.1 kg using a
standard beam balance scale for participants in barefoot and wearing
light indoor clothing. Body height was recorded to the nearest 0.5 cm
using a stadiometer.
using a segmental body composition analyzer (TBF-410, Tanita
Corp., Tokyo, Japan).
Waist Circumference (WC) was measured to the nearest 0.1 cm
at the midpoint between the inferior margin of the last rib and the
iliac crest of ilium. Hip circumference (HIP) was measured to the
widest of the pelvic region. Body Mass Index (BMI) was calculated
using BW (kg) divided by the square of the height (m2
). Waist to Hip
Ratio (WHR) was also calculated using waist circumference (cm)
divided by hip circumference (cm) [10].
Blood pressure measurement
Blood pressures were measured after the subjects had rested for
five minutes with cuffs of appropriate sizes and under sitting position.
The subjects’ arms were placed at the same height as the heart. Two
measurements were recorded and the mean values of two pressures
were used for data analyses.
Specimen collection
After 10-12 hours of fasting overnight, a 10mL venous blood
specimen was collected using venous containers from participants
at baseline and after 8-weeks of ingestion of black vinegar while
maintaining their usual dietary pattern of the past three days.
Plasma and serum were separated from blood within one hour
and stored at −80o
C until measurement.
Measurements of lipid profiles
We measured serum total Cholesterol (Chol) using an esterase
oxidase method [11], triglyceride using an enzymatic procedure
[12] on a Hitachi 7150 auto-analyzer (Hitachi, Tokyo, Japan). High-
Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL)
cholesterol were measured using an enzymatic method [13] with
magnesium precipitation with the Synchron CX5 analyzer (Beckman
Instruments, Palo Alto, California, USA).
We also determined the ratio of total cholesterol to HDL
cholesterol (Chol/HDL) as atherogenic index for statistical purposes
[14].
Glucose tolerance test
The 75-gm oral glucose tolerance test was conducted after 10
hours of fasting at baseline and after eight weeks of black vinegar
intake. 15 ml venous blood specimens were obtained by tail bleeding,
before and 30, 60, 90 and 120 minutes after the glucose load to
measure glucose and insulin levels.
The plasma glucose concentrations were analyzed immediately
after blood sampling and other assays were performed within a
2-week period of the sampling. Plasma glucose concentrations were
determined using the glucose oxidase method on a Beckman Glucose
Analyzer II (Beckman Instruments, Fullerton, CA) [15]. Plasma
insulin concentrations were measured using a commercially available
immunoradiometric kit (BioSource Europe S.A., Nivelles, Belgium).
The intra-assay and inter-assay coefficients of variance for the insulin
measurements were 2.2% and 6.5%, respectively.
Areas under curve were calculated by the trapezoid rule from the
start of the meal to 120 min (AUC0–120) [16].
Statistical analysis
We used SPSS ver-22 to conduct all statistical analyses.
Continuous variables, anthropometric measures, cardiometabolic
profiles and insulin sensitivity were described by sample means and
SD. The Wilcoxon signed-rank test was used to compare the difference
between baseline and after eight weeks of black vinegar intake for each
subject. A two-tailed p value less than 0.05 is considered statistically
significant.
Results
Table 1 shows the general characteristics of the study subjects at
baseline and after eight weeks of vinegar intake. After eight weeks of
vinegar intake, the body weight and BMI decreased from 68.2±14.4
kg to 67.6±14.2 kg and 26.3±4.5 kg/m2
to 26.0±4.4 kg/m2
, respectively
(p<0.05). For lipid profiles, the triglyceride level also reduced from
152.5±134.7mg/dlto140.6±93.8mg/dlbutnotstatisticallysignificant.
Table 2 compares the difference of insulin sensitivity and
metabolic-related profiles between baseline and after eight weeks of
vinegar intake. The fasting glucose levels decreased from 106.9±14.7
mg/dl to 105.0±15.0 mg/dl but not statistically significant (p>0.05).
The under-curve area of glucose decreased from 448.8±76.6 to
440.1±81.7 (units) but not statistically significant (p>0.05). The AGE
level decreased from 7.6±3.9 to 7.1±5.0 but not statistically significant
(p>0.05).
Figure 1 shows the change of blood glucose and insulin levels
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during OGTT at baseline and after eight weeks of vinegar intake.
The blood glucose levels at 120 minutes of OGTT decreased from
178.8±57.0 mg/dl to 173.7±57.5 mg/dl and the insulin levels at 120
minutes of OGTT increased from 117.5±74.2 IU/L to 126.4±95.9
IU/L but not statistically significant (p>0.05). The AUC-glucose
decreased from 448.8 to 440.1 and AUC-insulin increased from 222.8
to 234.9 but not statistically significant (p>0.05).
Discussion
Vinegar is the product of acetic acid and is reported to have
anti-glycemic effects in either animal or human studies [4]. The
mechanisms of vinegar are based on improved insulin sensitivity
and delayed gastric emptying accompanied with improved glycemic
control and reduced body weight [5,17-19].
In this study, we found there is a slight decrease of body weight
and BMI, but no significantly change in blood pressure, lipid profiles
and insulin sensitivity after eight weeks of black vinegar intake among
impaired fasting glucose adults. It may be due to the short study
period or those subjects are in impaired glucose tolerance but not in
diabetic status.
A systemic review and meta-analysis study show that the
consumption of vinegar can decrease postprandial glucose and
insulin level [17]. Samad et al, reviewed the therapeutic effects of
vinegar and shown that daily consumption of vinegar is associated
with improvement of chronic disease status such as high blood
Baseline 8th
week Difference
mean ± SD mean ± SD mean(SD) p-value
BH (cm) 160.8 8.8
BW (kg) 68.2 14.4 67.6 14.2 -0.1(1.6) 0.033*
BMI 26.3 4.5 26.0 4.4 -0.2(0.6) 0.029*
Waist (cm) 87.5 9.9 87.6 9.0 0.0(2.1) 0.900
Hip (cm) 99.5 8.6 99.3 8.4 -0.2(1.5) 0.556
WHR 0.88 0.1 0.88 0.0 0.0(0.3) 0.631
SBP (mmHg) 131.3 14.0 133.8 12.7 2.4(11.6) 0.250
DBP (mmHg) 81.3 9.6 82.1 8.4 0.8(8.6) 0.611
HR (BPM) 72.9 9.1 74.0 7.8 1.1(8.1) 0.438
Chol (mg/dl) 175.8 30.0 181.7 32.9 5.8(17.0) 0.062
HDL (mg/dl) 49.3 9.5 50.9 10.1 1.6(5.6) 0.116
LDL (mg/dl) 88.6 22.7 90.6 22.1 2.0(15.0) 0.078
TG (mg/dl) 152.5 134.7 140.6 93.8 -11.9(60.5) 0.274
Chol/HDL 3.7 1.2 3.7 1.1 0.0(0.6) 0.865
Table 1: Anthropometric measures and cardiometabolic profiles at baseline and after eight weeks of vinegar intake (with difference), n=32.
Data are expressed as mean ± SD.
BH: Body Height; BW: Body Weight; BMI: Body Mass Index; Waist: Waist Circumference; Hip: Hip Circumference; WHR: Wait-to-Hip Ratio; SBP: Systolic Blood
Pressure; DBP: Diastolic Blood Pressure; HR: Heart Rate; Chol: Total Cholesterol; HDL: High-Density Lipoprotein Cholesterol; LDL: Low-Density Lipoprotein
Cholesterol; TG: Triglyceride.
*p< 0.05, using the Wilcoxon signed-rank test to compare the difference between baseline and after eight weeks of vinegar intake.
Figure 1: Mean blood glucose and insulin levels during oral glucose tolerance
test at baseline and after eight weeks of vinegar intake, n=32.
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Baseline 8th
week Difference
mean ± SD mean ± SD mean(SD) p-value
Glucose-0 (mg/dl) 106.9 14.7 105.0 15.0 -1.9(8.5) 0.217
Glucose-30 185.5 23.8 182.7 26.3 -2.7(22.6) 0.505
Glucose-60 214.1 35.4 216.0 41.2 1.9(24.0) 0.657
Glucose-90 207.8 46.2 201.5 47.5 -6.3(24.7) 0.164
Glucose-120 178.8 57.0 173.4 57.5 -5.4(32.1) 0.351
AUC-glucose
(mg/dl*h)
448.8 76.6 440.1 81.7 -8.7(34.9) 0.176
Insulin-0 (IU/L) 14.9 6.9 15.6 8.1 0.8(4.2) 0.305
Insulin-30 68.9 44.7 67.3 50.8 -1.6(36.1) 0.807
Insulin-60 118.0 101.1 134.6 110.1 16.6(56.4) 0.105
Insulin-90 135.9 96.9 144.4 112.6 8.5(87.0) 0.501
Insulin-120 117.5 74.2 126.4 95.9 8.9(73.7) 0.250
AUC-insulin
(IU/L*h)
222.8 135.3 234.9 163.3 12.1(81.3) 0.412
HbA1c (%) 6.3 0.5 6.2 0.5 -0.1(0.2) 0.140
Pro-insulin (pM) 3.4 2.0 3.3 1.9 -0.1(1.3) 0.769
AGEs (AU) 7.6 3.9 7.1 5.0 -0.5(3.2) 0.370
Table 2: Blood glucose, insulin and metabolic-related characteristics at baseline and after eight weeks of vinegar intake (with difference), n=32.
Data are expressed as mean ± SD.
AUC: Area Under the Curve of OGTT; AGEs: Advanced Glycation End-Products.
*p< 0.05, using the Wilcoxon signed-rank test to compare the difference between baseline and after eight weeks of vinegar intake.
pressure, hyperlipidemia and obesity. More interestingly, different
types of vinegar, such as persimmon or tomato vinegar, is associated
with anti-obesity and anti-diabetic effects [20].
In our study, the results of body weight and BMI reduction were
similar to that of the Halima et al study [5] and Seo et al, study [21],
which showed that apple cider intake could reduce body weight and
BMI significantly. However, there is no reduction of lipid profiles in
our results, which is not consistent with the Halima et al, and Seo et
al, study.
Johnston et al, [6] showed that fasting glucose level was reduced
after 750 mg acetic acid intake per day for 12 weeks, whereas our
results indicate that there is no change in fasting glucose and insulin
levels. This may be due to insufficient vinegar intake in our study.
Larger dosage of vinegar intake may be conducted in the future.
Ourresultsshowedthatthechangeofglucoseandinsulinresponse
and under area curve of OGTT before and after black vinegar intake
for eight weeks is not statistically significant. It is not consistent with
the results of the Johnston et al study [7], which indicated that vinegar
intake can improve insulin sensitivity for insulin resistant or type 2
diabetes subjects. These inconsistent results may be due to the short
duration of study period or the study population with minor cardio-
metabolic abnormalities. Further studies and larger sample size may
be needed to explore the possible mechanism of vinegar on insulin
and glucose metabolism.
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