1. Different types of mediastinal masses have characteristic locations and relationships to surrounding structures on imaging. 2. Anterior mediastinal masses may efface the heart border or margin of the ascending aorta. Middle mediastinal masses may splay the carina. Posterior mediastinal masses displace the paravertebral lines laterally. 3. Thymic cysts can occur within the thymus gland or following radiation therapy. On imaging they appear as large, inhomogeneous solid masses in the antero-left mediastinum without calcium or fat.