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OpioidAnalgesics2008

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Opioid Analgesics Opioid Analgesics
 
Constituents of Opium ,[object Object]
History of Morphine in the U.S . ,[object Object],[object Object],[object Object],[object Object]
History of Morphine Use in the U.S. ,[object Object],[object Object],[object Object],[object Object]
How Does Morphine Work? ,[object Object],[object Object],[object Object]
Side effects of morphine ,[object Object],[object Object],[object Object]
Structure of Morphine
‘Tinkering’ with the structure of morphine produced heroin
Heroin ,[object Object],[object Object],[object Object],[object Object]
Heroin is addictive because it crosses the BBB more quickly than morphine.
Heroin Addiction ,[object Object],[object Object],[object Object],[object Object]
How do these drugs work? ,[object Object]
Manufacture of codeine ,[object Object]
Codeine is demethylated back to morphine in the liver ,[object Object],[object Object]
Codeine ,[object Object],[object Object],[object Object]
The C3 hydroxyl group is necessary for activity. (The methyl ether is only 0.1% as active)
Codeine is a useful cough suppressant ,[object Object]
‘Tinkering’ with the morphine structure can produce useful painkillers

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