- In the 1600s, Robert Hooke observed "cells" under a microscope when examining cork and coined the term. Anton van Leeuwenhoek then described living cells from pond water in the 1670s.
- Scientists originally believed in the theory of spontaneous generation, that life could arise from non-living things like dust or decaying meat, until experiments by Francesco Redi and Louis Pasteur disproved this.
- Pasteur's experiments with swan neck flasks in the 1800s demonstrated that life only arises from other living cells, providing support for the cell theory that all living things are made of cells, cells come only from other cells, and cells perform functions necessary to sustain life