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Cell membrane proteins
Structure and functions
Dr. GT Wijesinghe, MBBS
@ www.simplyphysiology.com
Key features
• 55% of total membrane constitutes are proteins 😮😮
• Transmembrane (intergral) or peripheral; two types
• Part of membrane structure
• Facilitate the diffusion of water and water soluble molecules
• Facilitate active transport
Integral protein
• Transmembrane protein
• Often carbohydrate molecule is bound and called glycoprotein
Integral protein cont.
• Act as channels; allow to diffuse water and water soluble molecules
• Act as carriers; carry special molecules in and out through the
membrane
Integral protein functions
• Part of cell membrane structure
• Allow substance transport across the membrane
• Act as enzymes
• Act as receptors for water soluble Chemicals
Carrier protein
• A type of integral protein
• Carry special molecules in or out of intracellular compartment
Ex: Glucose transporter, Urea transporter
• Sometimes carry molecules against the concentration gradient; Active
transport
Ex: Sodium-Pottasium ATPase pump
Peripheral proteins
• peripheral proteins are attached only to one surface of the membrane
and do not penetrate all the way through
• Often attached to integral proteins
• Almost all act as enzymes
• Act as controllers of transporters across cell membrane
Thank you
• Visit for more details
www.simplyphysiology.com

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Cell Membrane Proteins

  • 1. Cell membrane proteins Structure and functions Dr. GT Wijesinghe, MBBS @ www.simplyphysiology.com
  • 2. Key features • 55% of total membrane constitutes are proteins 😮😮 • Transmembrane (intergral) or peripheral; two types • Part of membrane structure • Facilitate the diffusion of water and water soluble molecules • Facilitate active transport
  • 3. Integral protein • Transmembrane protein • Often carbohydrate molecule is bound and called glycoprotein
  • 4. Integral protein cont. • Act as channels; allow to diffuse water and water soluble molecules • Act as carriers; carry special molecules in and out through the membrane
  • 5. Integral protein functions • Part of cell membrane structure • Allow substance transport across the membrane • Act as enzymes • Act as receptors for water soluble Chemicals
  • 6. Carrier protein • A type of integral protein • Carry special molecules in or out of intracellular compartment Ex: Glucose transporter, Urea transporter • Sometimes carry molecules against the concentration gradient; Active transport Ex: Sodium-Pottasium ATPase pump
  • 7. Peripheral proteins • peripheral proteins are attached only to one surface of the membrane and do not penetrate all the way through • Often attached to integral proteins • Almost all act as enzymes • Act as controllers of transporters across cell membrane
  • 8. Thank you • Visit for more details www.simplyphysiology.com