Celestial coordinates are used to define positions of objects in the sky and there are two main systems - equatorial and horizontal coordinates. The equatorial system uses right ascension and declination, where declination is measured in degrees north or south of the celestial equator. Right ascension is measured in hours, minutes, and seconds along the celestial equator. The horizontal coordinate system uses altitude and azimuth which depend on the observer's location and measure the angular distances above the horizon and east from north. Celestial coordinates can change slightly over time due to the phenomenon of precession as the equinoxes and poles very slowly change position.
A time zone is a region of the globe that observes a uniform standard time for legal, commercial, and social purposes.
The International Date Line (IDL) is an imaginary line of demarcation on the surface of the Earth that runs from the North Pole to the South Pole and demarcates the change of one calendar day to the next.
Lines of Latitude and Longitude – PowerPointYaryalitsa
PowerPoint on Lines of Latitude, Lines of Longitude, Climate Zones, Equinoxes, Solstices, The Three Norths, Prime Meridian, International Date Line, Greenwich Mean Time, Coordinated Universal Time.
Lines of Latitude and Longitude – Worksheet at:
http://www.slideshare.net/yaryalitsa/lines-of-latitude-and-longitude-worksheet
This slide contains some basic content about astronomical scales and some methods to find the astronomical distances. This slide tells about the concept of luminosity.
A time zone is a region of the globe that observes a uniform standard time for legal, commercial, and social purposes.
The International Date Line (IDL) is an imaginary line of demarcation on the surface of the Earth that runs from the North Pole to the South Pole and demarcates the change of one calendar day to the next.
Lines of Latitude and Longitude – PowerPointYaryalitsa
PowerPoint on Lines of Latitude, Lines of Longitude, Climate Zones, Equinoxes, Solstices, The Three Norths, Prime Meridian, International Date Line, Greenwich Mean Time, Coordinated Universal Time.
Lines of Latitude and Longitude – Worksheet at:
http://www.slideshare.net/yaryalitsa/lines-of-latitude-and-longitude-worksheet
This slide contains some basic content about astronomical scales and some methods to find the astronomical distances. This slide tells about the concept of luminosity.
Filed astronomy a part of surveying-II.
Astronomy usefully a new project planning and construction. These topic cover " Filed Astronomy define & common coordinate systems " according by tabular form.
The language of uranian astrology jacobson,1975 searchableAndrew Khabaza
The Language of Uranian Astrology, Roger A Jacobson (1975)
Searchable pdf file
A key text for students of Uranian astrology; a lot on 360 degree dial and Uranian houses; also mentions 90 degree dial.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. Definition
Celestial coordinates are a
reference system used to
define the positions of objects
on the celestial sphere. There
are two main coordinate
systems
Declination (green) is
measured in degrees north
and south of the celestial
equator. ... Anything south of
the equator has a negative
declination written with a
negative sign. For instance,
Vega's declination is +38° 47′
1″, while Alpha Centauri's is
–60° 50′
3. Horizontal Coordinate
System
Alternatively known as ‘Alt/Az
coordinates’, this system of celestial
coordinates is dependent on the
observer’s latitude and longitude.
Using the observer’s local horizon as a
reference plane, the position of an
object on the celestial sphere at a
particular time is given by its:
Altitude- the angular distance above the
horizon
Azimuth- the angular distance measured
east from north and parallel to the
horizon
4. Equatorial system
The Equatorial Coordinate System is generally the preferred
way astronomers use to keep track of the positions of objects in
the sky. Astronomers imagine that the Earth is surrounded by
a large sphere called the celestial sphere. The Earth's equator
and the plane of the Earth's orbit are projected onto this
sphere.
5. LATITUDE & LONGITUDE
Each city has a unique latitude and longitude.
Take Tuscaloosa, Alabama, for example, which
is located at latitude +33.2° north, longitude
87.6° west. Or Wonglepong, Australia, situated
along that continent's east coast at –27.0° south,
153.2° east.
A negative sign in front of the latitude indicates
south and a positive sign north. Every location,
whether it be a city, airport, or even your own
home or apartment building lies somewhere on
the worldwide coordinate grid (below), its
location fixed by two numbers.
6. How are celestial coordinates
measured?
The celestial equivalent of latitude is called declination
and is measured in degrees North (positive numbers) or
South (negative numbers) of the Celestial Equator. The
celestial equivalent of longitude is called right ascension.
7. Declination
Declination is measured in degrees north (+) or
south (-) of an imaginary line called the Celestial
Equator (CE). The Celestial Equator is the
projection of the Earth's Equator onto the
Celestial Sphere. The CE has a declination of 0
degrees, by definition. At dec = +90 degrees (90
degrees N) is the North Celestial Pole (NCP), the
projection of the Earth's North Pole onto the
Celestial Sphere. The South Celestial Pole (SCP)
is at dec = -90 degrees.
8. The zero point for celestial longitude (that is, for right
ascension) is the Vernal Equinox, which is that
intersection of the ecliptic and the celestial equator near
where the Sun is located in the Northern Hemisphere
Spring. The other intersection of the Celestial Equator
and the Ecliptic is termed the Autumnal Equinox. When
the Sun is at one of the equinoxes the lengths of day and
night are equivalent (equinox derives from a root
meaning "equal night"). The time of the Vernal Equinox
is typically about March 21 and of the Autumnal
Equinox about September 22.
Equinoxes and Solstices
9. Ecliptic coordinate system
The ecliptic coordinate system is a
celestial coordinate system commonly
used for representing the apparent
positions, orbits, and pole orientations of
Solar System objects. Because most
planets (except Mercury) and many
small Solar System bodies have orbits
with only slight inclinations to the
ecliptic, using it as the fundamental
plane is convenient. The system's origin
can be the center of either the Sun or
Earth, its primary direction is towards
the vernal (March) equinox, and it has a
right-hand convention. It may be
implemented in spherical or rectangular
coordinates.
10. Precession
The advantage of the equatorial coordinate
system is that it expresses the position of a
star or galaxy in a way that is independent
of the observer's position on Earth.
However, the right ascension and declination
of a given object change slowly over time,
mainly due to a phenomenon called
precession.
11.
12. Example
Celestial Coordinates
The distance around the
celestial equator is equal to
24 hours. ... The equator is
0° 0' 0". The position of an
object is stated with the
right ascension first, then
the declination. For
example, the bright star
Sirius' position is RA:
6h45m8.