This document discusses factors for a dentist to consider when determining if a case is appropriate for endodontic treatment or if it should be referred. It identifies patient-related factors like age and medical conditions, tooth-related factors like abnormal canal configurations and cracks, and dentist-related factors like lack of experience or equipment. Contraindications are discussed for conditions that could make endodontic treatment difficult or risky. The document provides an extensive list of medical conditions and how they may impact anesthesia or healing from endodontic treatment.