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MANAGEMENT OF MEDICALLY
COMPROMISED PATIENTS
DR. NANDHINI, M.D.S.,
 Management of patients in whom dental treatment may need
modification according to their medical condition.
 Necessary steps should be taken before & during any dental treatment to
avoid any possible complications, which may occur due to patients
systemic conditions.
CARDIOVASCULAR DISEASE
Hypertension
Problem Precaution
• Stress & anxiety – increased
BP, angina, MI or CVA
• Antihypertensive drugs –
nauseated or hypotensive or
may develop postural
hypotension
• Excessive vasopressors –
increase BP
• Stress, anxiety, duration of procedure – minimized
• Short appointments & friendly atmosphere
• Preoperative reassurance & sedation with 5 mg
diazepam may be helpful
• If over stressed – terminate the treatment
• Low dose epinephrine
• Avoid gingival retraction cords with epinephrine
• Epinephrine + non-selective beta-blockers –
hypertension & cardiac complications
• Epinephrine + TCA – acute hypertensive changes
• Epinephrine + diuretics – dysrhythmias
Angina pectoris
Problem Precaution
• Stress & anxiety –
precipitate angina in
dental office
• If not managed properly –
MI may occur
• Sudden death
• Primary concern – prevent recurrence of ischemia or
infarction
• Reduce anxiety & determine vitals prior
• Effective anesthesia is a must
• Dental care – late morning or early noon
• Avoid epinephrine
• Increased HR, BP – terminate the procedure
• 0.3-0.6 mg sublingual nitroglycerin. If pain persists > 3
mins, additional dose up to 3 mg every 5 mins & sought
medical help
• 300 mg chewable Aspirin
• Morphine iv – relieves pain & anxiety
Myocardial infarction
Problem Precaution
• Recent history of MI can
precipitate
• Cardiac arrest
• Bleeding tendency
secondary to
anticoagulant
• No routine dental care in first 6 months
• Consult physician before starting dental
care to know the current status
• Avoid gingival retraction cords with
epinephrine
• Terminate appointment if – fatigue, short
of breath or change in pulse rate or
rhythm. Inform physician
Rheumatic heart disease/ valvular heart disease
Problem Precaution
• Risk of infective endocarditis from
dental treatment
• Bacteremia can be introduced by
dental treatment
• Antibiotic prophylaxis
When to & not to give antibiotic prophylaxis ???
Required Not required
• Extraction
• Periodontal surgery, sub-
gingival scaling & root planning
• Implant
• Tooth reimplantation
• Orthodontic bands
• Endodontic instrumentation
beyond apex
• Periapical surgery
• Intraligamentary injections
• Prophylactic scaling where
bleeding is anticipated
• Operative & prosthodontic procedures without
retraction cord
• LA (non-intraligamentary)
• Intracanal endodontic procedures including post &
core
• Removable prostho & ortho appliance
• Orthodontic appliance adjustments
• Impression taking
• Exfoliation of primary teeth
• Oral radiography
• Fluoride treatment
• Rubber dam placement
Antibiotic prophylaxis
Situation Drug Adults Children
• Can take
orally
• Amoxicillin • 2g, 1hr before procedure • 50 mg/ kg, 1 hr before
procedure
• Cannot
take orally
• Ampicillin • 2g, im/ iv, ½ hr before
procedure
• 50 mg/ kg, 1/2 hr before
procedure
• Cefazolin or
Ceftriaxone
• 1 g im/iv, 1/2 hr before
procedure
• 50 mg/ kg, 1/2 hr before
procedure
• Allergy to
penicillin
& can
take orally
• Cephalexin or
Cefadroxil
• 2 g, 1 hr before procedure • 50 mg/ kg, 1 hr before
procedure
• Clindamycin • 600 mg, 1 hr before
procedure
• 20 mg/ kg, 1 hr before
procedure
• Azithromycin
or
Clarithromyci
n
• 500 mg, 1 hr before
procedure
• 15 mg/ kg, 1 hr before
procedure
• Allergy to
penicillin
& cannot
• Cefazolin or
Ceftriaxone
• 1 g im/ iv 1/2 hr before
procedure
• 50 mg/ kg, 1/2 hr before
procedure
• Clindamycin • 600 mg im/ iv, 1 hr before • 20 mg/ kg, 1 hr before
RESPITATORY DISORDERS
Asthma
Problem Precaution
• Dental materials may exacerbate
– pit & fissure sealants, methyl
methacrylate, tooth paste
• Aggravation or worsening of
compromised respiratory
function
• Airway obstruction by dental
procedure
• Sometime it may be a life
threatening medical emergency
• Avoid anxiety
• Advised to bring their regular medication
• Elective dental care must be deferred in severe
cases until they are in a better phase
• Appointments – late morning or later
• Avoid inhalation anesthetics or NSAIDs
• Should not be treated during sickness
• Epinephrine, Clindamycin & Azithromycin –
contraindicated for patients on Theophylline
• Epinephrine + B2 agonist – increase BP &
arrhymias
• Steroid inhalers – oral & pharyngeal thrush
Chronic obstructive pulmonary disease
Problem Precaution
• Aggravation or worsening of
compromised respiratory function
• Airway obstruction by dental
procedure
• Avoid long treatment sessions
• Avoid partial airway obstructing
devices – rubber dam
• Avoid Diazepam, Midazolam –
respiratory depression
• Avoid GA
Tuberculosis
Problem Precaution
• Infected patients pose risk to
dentist & dental office employees
a) Before treatment:
• Medical evaluation before elective
dental procedures
• Physician consult – if history or
treatment details are unclear
b) During treatment:
• Do dental emergencies only under
controlled environment
GIT/ LIVER DISEASES
Peptic, duodenal, gastric ulcers
Problem Precaution
• Stress – increased acid stimulation
& epigastric pain
• Chances of peptic ulcer if NSAIDs
is given
• Avoid drugs that exacerbate
ulceration & cause GI distress
• If patient reacts in a stressful way
sedate before the procedure
• Avoid lengthy procedures
Jaundice
Problem Precaution
• Clotting factor deficiency might
lead to prolonged bleeding
• Physicians consent
• Advise BT, CT, INR, LFT
Hepatitis
• Clotting factor deficiency might
lead to prolonged bleeding
• Physicians consent
• Advise BT, CT, INR, LFT, etc
Problem Precaution
• Clotting factor deficiency might
lead to prolonged bleeding
• High chances of cross
contamination to dentist through
blood or saliva
• Advise BT, CT, INR, LFT
• Control cross contamination &
follow proper sterilization
QUESTIONS ???
RENAL DISEASE
Renal failure/ Dialysis
Problem Precaution
• Heparin on dialysis day –
prolonged bleeding if procedure
done on the same day
• High prevalence of arterial
hypertension
• Aspirin, Ibuprofen, Erythromycin
not removed by malfunctioned
kidney
• Renal osteodystrophy –
pathological fractures &
complicate extraction
• Elective dental procedures done during
non-dialysis day & early in dialysis cycle
• Monitor BP pre & post op
• BP cuff not on the dialysis vascular
access arm
• Hemostatic investigations is a must
• Allow to stand/ walk intermittently
• Drugs excreted by kidney – modify
• Investigate for renal osteodystrophy
• Encourage meticulous oral hygiene
Renal transplant patient
Problem Precaution
• High prevalence of arterial
hypertension
• Immune suppression due to
immunosuppressants
• Long term steroids – adrenal crises
if drug stopped suddenly or in
stress
• Cyclosporine – gingival overgrowth
• Monitor BP pre & post op
• Hemostatic investigations is a must
• Drugs excreted by kidney – modify
• Antibiotic prophylaxis – if
nephrologist recommends
• Prevent adrenal crisis by –
decreasing stress, supplement
steroids, morning appointments
• Gingival overgrowth – surgical
excision, good oral hygiene & drug
modification
ENDOCRINE DISORDERS
Diabetes
Problem Precaution
• Main hazard – hypoglycemia
• Uncontrolled diabetes –
delayed wound healing
• Periodontal disease, dry
mouth, glossitis & candidiasis
• Physician’s consent if:
• Complications like heart/ renal disease
• Difficulty in controlling diabetes in spite
of high insulin dosage
• Check blood sugar level
• Early morning appointments
• Safe to use LA with adrenaline
• Avoid - drugs disturbing diabetic
control
• Orofacial infections – treated
Management of hypoglycemia
Condition Treatment
• Awake & can take oral foods • 15 g carbohydrates
• 125-175 mL fruit juice/ soda
• 3-4 tsp sugar
• Hard candy
• Unable to tale oral foods &
has iv line
• 25-50 mL D50 (50% dextrose)/ 1 mg
glucagon
• Unable to tale oral foods & no
iv line
• 1 mg glucagon sc/ im at any body site
Hypothyroidism
Problem Precaution
• Tiredness, weakness, difficulty in
concentration, poor memory & intolerance
to cold
• Delayed eruption, short roots, thin lamina
dura
• Mild – exaggerated effect of analgesics &
sedatives in routine doses
• Has pre-existing CNS depression – sensitive
to drugs with CNS depressing side effects
• Increased subcutaneous
mucopolysaccharides – decreased ability of
small vessel to constrict – increased bleeding
• Short appointments
• Warm environment
• Use LA with adrenaline
• Atraumatic procedure
• Avoid Lithium, amiodarone, etc –
induce hypothyroidism
• Uncontrolled – respirator
depression, semi reclined position,
• Narcotics & Sedatives – precipitate
CVS & respiratory depression
Hyperthyroidism
Problem Precaution
• Alveolar atrophy in advanced
cases due to osteoporosis
• Increases CVS & RS function
• Infection, trauma, stroke, DKA,
thyroid surgery may precipitate
– thyroid crisis/ storm
• Elective dental care is deferred
• Stress management & short
appointments
• catecholamines + dental stress =
precipitate thyroid storm & exacerbate
underlying CVS pathology
• Epinephrine is contraindicated
• Extended local pressure to arrest bleeding
• NSAIDs – increase circulating T4 &
decrease effect if B-blockers
• Propranolol, KI, anti-thyroid drugs,
Hyperparathyroidism
Problem Precaution
• Generalized osteoporosis
• Thinning & loss of cortical bone
• Spontaneous mandibular
fracture
• Brown’s tumor
• Monitor serum Ca level
• Avoid iatrogenic jaw fractures
• Asses bone density
Adrenal insufficiency
MANAGEMENT PROTOCOL
 Through medical history
 Postponing elective dental surgery
 Emergency steroid should be readily available
 Procedure done early morning
 Steroid supplement on the day of surgery
 Pain & stress reduction
 Long-acting LA
 Monitor BP regularly
Patient under steroid therapy
MANAGEMENT PROTOCOL
 Minimize anxiety
 Glucocorticoid level – increased prior to stressful situation
 ‘RULE OF TWO’ – 20 mg, 2 weeks, 2 times the dose
Supplemental corticosteroid
Risk category Procedure Regimen
• Negligible • Non-surgical dental procedures • No supplementation
required
• Mild • Minor oral surgery:
a. Simple extraction
b. Biopsy
• Minor periodontal surgery
• Glucocorticoid target – 25
mg hydrocortisone on the
day of surgery
• Moderate -
major
• Major oral surgery:
• Multiple extractions
• Impaction
• Osseous surgery
• Cancer surgery
• Procedures involving GA
• Procedures involving significant blood
• Glucocorticoid target – 50
– 100 mg on the day of
surgery & 1 post op day
CNS
Epilepsy
• Flat on floor
• Lateral decubitus
• Remove all materials from oral cavity
• Diazepam 5-10 mg iv
• Lorazepam 2 mg im
QUESTIONS ???

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Management of medically compromised patients

  • 1. MANAGEMENT OF MEDICALLY COMPROMISED PATIENTS DR. NANDHINI, M.D.S.,
  • 2.  Management of patients in whom dental treatment may need modification according to their medical condition.  Necessary steps should be taken before & during any dental treatment to avoid any possible complications, which may occur due to patients systemic conditions.
  • 4. Hypertension Problem Precaution • Stress & anxiety – increased BP, angina, MI or CVA • Antihypertensive drugs – nauseated or hypotensive or may develop postural hypotension • Excessive vasopressors – increase BP • Stress, anxiety, duration of procedure – minimized • Short appointments & friendly atmosphere • Preoperative reassurance & sedation with 5 mg diazepam may be helpful • If over stressed – terminate the treatment • Low dose epinephrine • Avoid gingival retraction cords with epinephrine • Epinephrine + non-selective beta-blockers – hypertension & cardiac complications • Epinephrine + TCA – acute hypertensive changes • Epinephrine + diuretics – dysrhythmias
  • 5. Angina pectoris Problem Precaution • Stress & anxiety – precipitate angina in dental office • If not managed properly – MI may occur • Sudden death • Primary concern – prevent recurrence of ischemia or infarction • Reduce anxiety & determine vitals prior • Effective anesthesia is a must • Dental care – late morning or early noon • Avoid epinephrine • Increased HR, BP – terminate the procedure • 0.3-0.6 mg sublingual nitroglycerin. If pain persists > 3 mins, additional dose up to 3 mg every 5 mins & sought medical help • 300 mg chewable Aspirin • Morphine iv – relieves pain & anxiety
  • 6. Myocardial infarction Problem Precaution • Recent history of MI can precipitate • Cardiac arrest • Bleeding tendency secondary to anticoagulant • No routine dental care in first 6 months • Consult physician before starting dental care to know the current status • Avoid gingival retraction cords with epinephrine • Terminate appointment if – fatigue, short of breath or change in pulse rate or rhythm. Inform physician
  • 7. Rheumatic heart disease/ valvular heart disease Problem Precaution • Risk of infective endocarditis from dental treatment • Bacteremia can be introduced by dental treatment • Antibiotic prophylaxis
  • 8. When to & not to give antibiotic prophylaxis ??? Required Not required • Extraction • Periodontal surgery, sub- gingival scaling & root planning • Implant • Tooth reimplantation • Orthodontic bands • Endodontic instrumentation beyond apex • Periapical surgery • Intraligamentary injections • Prophylactic scaling where bleeding is anticipated • Operative & prosthodontic procedures without retraction cord • LA (non-intraligamentary) • Intracanal endodontic procedures including post & core • Removable prostho & ortho appliance • Orthodontic appliance adjustments • Impression taking • Exfoliation of primary teeth • Oral radiography • Fluoride treatment • Rubber dam placement
  • 9. Antibiotic prophylaxis Situation Drug Adults Children • Can take orally • Amoxicillin • 2g, 1hr before procedure • 50 mg/ kg, 1 hr before procedure • Cannot take orally • Ampicillin • 2g, im/ iv, ½ hr before procedure • 50 mg/ kg, 1/2 hr before procedure • Cefazolin or Ceftriaxone • 1 g im/iv, 1/2 hr before procedure • 50 mg/ kg, 1/2 hr before procedure • Allergy to penicillin & can take orally • Cephalexin or Cefadroxil • 2 g, 1 hr before procedure • 50 mg/ kg, 1 hr before procedure • Clindamycin • 600 mg, 1 hr before procedure • 20 mg/ kg, 1 hr before procedure • Azithromycin or Clarithromyci n • 500 mg, 1 hr before procedure • 15 mg/ kg, 1 hr before procedure • Allergy to penicillin & cannot • Cefazolin or Ceftriaxone • 1 g im/ iv 1/2 hr before procedure • 50 mg/ kg, 1/2 hr before procedure • Clindamycin • 600 mg im/ iv, 1 hr before • 20 mg/ kg, 1 hr before
  • 11. Asthma Problem Precaution • Dental materials may exacerbate – pit & fissure sealants, methyl methacrylate, tooth paste • Aggravation or worsening of compromised respiratory function • Airway obstruction by dental procedure • Sometime it may be a life threatening medical emergency • Avoid anxiety • Advised to bring their regular medication • Elective dental care must be deferred in severe cases until they are in a better phase • Appointments – late morning or later • Avoid inhalation anesthetics or NSAIDs • Should not be treated during sickness • Epinephrine, Clindamycin & Azithromycin – contraindicated for patients on Theophylline • Epinephrine + B2 agonist – increase BP & arrhymias • Steroid inhalers – oral & pharyngeal thrush
  • 12. Chronic obstructive pulmonary disease Problem Precaution • Aggravation or worsening of compromised respiratory function • Airway obstruction by dental procedure • Avoid long treatment sessions • Avoid partial airway obstructing devices – rubber dam • Avoid Diazepam, Midazolam – respiratory depression • Avoid GA
  • 13. Tuberculosis Problem Precaution • Infected patients pose risk to dentist & dental office employees a) Before treatment: • Medical evaluation before elective dental procedures • Physician consult – if history or treatment details are unclear b) During treatment: • Do dental emergencies only under controlled environment
  • 15. Peptic, duodenal, gastric ulcers Problem Precaution • Stress – increased acid stimulation & epigastric pain • Chances of peptic ulcer if NSAIDs is given • Avoid drugs that exacerbate ulceration & cause GI distress • If patient reacts in a stressful way sedate before the procedure • Avoid lengthy procedures
  • 16. Jaundice Problem Precaution • Clotting factor deficiency might lead to prolonged bleeding • Physicians consent • Advise BT, CT, INR, LFT
  • 17. Hepatitis • Clotting factor deficiency might lead to prolonged bleeding • Physicians consent • Advise BT, CT, INR, LFT, etc Problem Precaution • Clotting factor deficiency might lead to prolonged bleeding • High chances of cross contamination to dentist through blood or saliva • Advise BT, CT, INR, LFT • Control cross contamination & follow proper sterilization
  • 20. Renal failure/ Dialysis Problem Precaution • Heparin on dialysis day – prolonged bleeding if procedure done on the same day • High prevalence of arterial hypertension • Aspirin, Ibuprofen, Erythromycin not removed by malfunctioned kidney • Renal osteodystrophy – pathological fractures & complicate extraction • Elective dental procedures done during non-dialysis day & early in dialysis cycle • Monitor BP pre & post op • BP cuff not on the dialysis vascular access arm • Hemostatic investigations is a must • Allow to stand/ walk intermittently • Drugs excreted by kidney – modify • Investigate for renal osteodystrophy • Encourage meticulous oral hygiene
  • 21. Renal transplant patient Problem Precaution • High prevalence of arterial hypertension • Immune suppression due to immunosuppressants • Long term steroids – adrenal crises if drug stopped suddenly or in stress • Cyclosporine – gingival overgrowth • Monitor BP pre & post op • Hemostatic investigations is a must • Drugs excreted by kidney – modify • Antibiotic prophylaxis – if nephrologist recommends • Prevent adrenal crisis by – decreasing stress, supplement steroids, morning appointments • Gingival overgrowth – surgical excision, good oral hygiene & drug modification
  • 23. Diabetes Problem Precaution • Main hazard – hypoglycemia • Uncontrolled diabetes – delayed wound healing • Periodontal disease, dry mouth, glossitis & candidiasis • Physician’s consent if: • Complications like heart/ renal disease • Difficulty in controlling diabetes in spite of high insulin dosage • Check blood sugar level • Early morning appointments • Safe to use LA with adrenaline • Avoid - drugs disturbing diabetic control • Orofacial infections – treated
  • 24. Management of hypoglycemia Condition Treatment • Awake & can take oral foods • 15 g carbohydrates • 125-175 mL fruit juice/ soda • 3-4 tsp sugar • Hard candy • Unable to tale oral foods & has iv line • 25-50 mL D50 (50% dextrose)/ 1 mg glucagon • Unable to tale oral foods & no iv line • 1 mg glucagon sc/ im at any body site
  • 25. Hypothyroidism Problem Precaution • Tiredness, weakness, difficulty in concentration, poor memory & intolerance to cold • Delayed eruption, short roots, thin lamina dura • Mild – exaggerated effect of analgesics & sedatives in routine doses • Has pre-existing CNS depression – sensitive to drugs with CNS depressing side effects • Increased subcutaneous mucopolysaccharides – decreased ability of small vessel to constrict – increased bleeding • Short appointments • Warm environment • Use LA with adrenaline • Atraumatic procedure • Avoid Lithium, amiodarone, etc – induce hypothyroidism • Uncontrolled – respirator depression, semi reclined position, • Narcotics & Sedatives – precipitate CVS & respiratory depression
  • 26. Hyperthyroidism Problem Precaution • Alveolar atrophy in advanced cases due to osteoporosis • Increases CVS & RS function • Infection, trauma, stroke, DKA, thyroid surgery may precipitate – thyroid crisis/ storm • Elective dental care is deferred • Stress management & short appointments • catecholamines + dental stress = precipitate thyroid storm & exacerbate underlying CVS pathology • Epinephrine is contraindicated • Extended local pressure to arrest bleeding • NSAIDs – increase circulating T4 & decrease effect if B-blockers • Propranolol, KI, anti-thyroid drugs,
  • 27. Hyperparathyroidism Problem Precaution • Generalized osteoporosis • Thinning & loss of cortical bone • Spontaneous mandibular fracture • Brown’s tumor • Monitor serum Ca level • Avoid iatrogenic jaw fractures • Asses bone density
  • 28. Adrenal insufficiency MANAGEMENT PROTOCOL  Through medical history  Postponing elective dental surgery  Emergency steroid should be readily available  Procedure done early morning  Steroid supplement on the day of surgery  Pain & stress reduction  Long-acting LA  Monitor BP regularly
  • 29. Patient under steroid therapy MANAGEMENT PROTOCOL  Minimize anxiety  Glucocorticoid level – increased prior to stressful situation  ‘RULE OF TWO’ – 20 mg, 2 weeks, 2 times the dose
  • 30. Supplemental corticosteroid Risk category Procedure Regimen • Negligible • Non-surgical dental procedures • No supplementation required • Mild • Minor oral surgery: a. Simple extraction b. Biopsy • Minor periodontal surgery • Glucocorticoid target – 25 mg hydrocortisone on the day of surgery • Moderate - major • Major oral surgery: • Multiple extractions • Impaction • Osseous surgery • Cancer surgery • Procedures involving GA • Procedures involving significant blood • Glucocorticoid target – 50 – 100 mg on the day of surgery & 1 post op day
  • 31. CNS
  • 32. Epilepsy • Flat on floor • Lateral decubitus • Remove all materials from oral cavity • Diazepam 5-10 mg iv • Lorazepam 2 mg im

Editor's Notes

  1. non-selective beta-blockers – propranolol, sotalol, timolol, labetalol, carvedilol TCA – amitriptyline, nortriptyline, doxepin – CVS changes, tachycardia Diuretics – furosemide, hydrochlorothiazide, spironolactone, mannitol. Isosorbide, glycerol
  2. Most eventa occur between 6 am - noon
  3. Possibility of asthmatic attack due to bronchospasm Nitrous oxide may irritate the airway B2 agonist – salbutamol, terbutaline O2 & bronchodilators – salbutamol, salmeterol, terbutaline, isoprenaline Narcotics – bronchospasm Antihistamines – diphenhydramine – drying effect & increases tenacious mucous
  4. Blood – free from heparin & toxins are removed Antacids – milk of magnesia NSAIDs Tetracyclin Cephalosporins
  5. Minimize stress-induced hypoglycemia Antifungal – azoles, Aspirin, erythromycin & steroids Always remind to take food to avoid peri op hypoglycemia
  6. confusion., sweating, tremors, agitation, anxiety, dizziness, tingling or numbness & tachycardia
  7. Sedatives – barbiturates – diazepam, lorazepam
  8. Hyperpyrexia, tachycardia, extreme restlessness, vomiting, diarrhoea, cardiac failure & liver dysfunction Adernaline Anti-thyroid – carbimazole, methimazole, propylthiouracil – agranulocytosis or leukopenia
  9. Bones, stones, abdominal groans – constipation, weight loss, nausea, vomiting, peptic ulcer, weight loss. Psychic moans – lethargy, fatigue, depression, loss of memory, neurosis confusion, coma
  10. Cortisol – high in morning
  11. Cortisol – high in morning
  12. 5 mg prednisolone
  13. Cortisol – high in morning