The fibrous skeleton of the heart:
1. Lies between the atria and ventricles.
2. Is composed of dense connective tissue that forms fibrous rings around the four heart valves.
3. Acts as an electrical insulator to prevent direct spread of electrical impulses from the atria to the ventricles, ensuring impulses pass through the bundle of His for coordinated ventricular contraction.
Right Atrium of human heart
This PPT help to understand the external and internal structures of right atrium.
sulcus terminalis on external surface of rt atrium,
crista terminalis on internal side of rt. atrium,
interior is divided into rough anterior part and smooth posterior part ( sinus venarum)
superior and inferior venae cavae drains deoxygenated blood into rt. atrim
there is Eustachian valve to guard the opening of IVC and Thebesian valve to guard the opening of coronary sinus
septal wall presents fossa ovalis with its border limbus fossa ovalis
right ventricle internal and external features-
interior is divided into inflowing and outflowing parts (infundibulum)
inflowing part is rough due to trabeculae corneae, - ridges, bridges, pillars. Chordae tendineae- are attached to pillars and cusps of tricuspid valve.
outflowing part is smooth, semilunar valve guards opening of pulmonary valve
Right Atrium of human heart
This PPT help to understand the external and internal structures of right atrium.
sulcus terminalis on external surface of rt atrium,
crista terminalis on internal side of rt. atrium,
interior is divided into rough anterior part and smooth posterior part ( sinus venarum)
superior and inferior venae cavae drains deoxygenated blood into rt. atrim
there is Eustachian valve to guard the opening of IVC and Thebesian valve to guard the opening of coronary sinus
septal wall presents fossa ovalis with its border limbus fossa ovalis
right ventricle internal and external features-
interior is divided into inflowing and outflowing parts (infundibulum)
inflowing part is rough due to trabeculae corneae, - ridges, bridges, pillars. Chordae tendineae- are attached to pillars and cusps of tricuspid valve.
outflowing part is smooth, semilunar valve guards opening of pulmonary valve
Cardiovascular physiology for university studentsItsOnyii
A detailed pdf document on cardiovascular physiology for university students including structure and functions of heart, Electrocardiogram, echocardiography, chest and limb leads, Diseases and disorders of the heart.
Your heart is divided into four chambers. You have two chambers on the top (atrium, plural atria) and two on the bottom (ventricles), one on each side of the heart. Right atrium: Two large veins deliver oxygen-poor blood to your right atrium. The superior vena cava carries blood from your upper body.
Your heart is the main organ of your cardiovascular system, a network of blood vessels that pumps blood throughout your body. It also works with other body systems to control your heart rate and blood pressure. Your family history, personal health history and lifestyle all affect how well your heart works.
What is the heart?
The heart is a fist-sized organ that pumps blood throughout your body. It's the primary organ of your circulatory system.
Your heart contains four main sections (chambers) made of muscle and powered by electrical impulses. Your brain and nervous system direct your heart’s function.
What is the heart’s function?
Your heart’s main function is to move blood throughout your body. Your heart also:
Controls the rhythm and speed of your heart rate.
Maintains your blood pressure.
How does your heart work with other organs?
Your heart works with other body systems to control your heart rate and other body functions. The primary systems are:
Nervous system: Your nervous system helps control your heart rate. It sends signals that tell your heart to beat slower during rest and faster during stress.
Endocrine system: Your endocrine system sends out hormones. These hormones tell your blood vessels to constrict or relax, which affects your blood pressure. Hormones from your thyroid gland can also tell your heart to beat faster or slower.
Where is your heart located?
Your heart is located in the front of your chest. It sits slightly behind and to the left of your sternum (breastbone). Your ribcage protects your heart.
Where is your heart located?
Your heart is located in the front of your chest. It sits slightly behind and to the left of your sternum (breastbone). Your ribcage protects your heart.
What side is your heart on?
Your heart is slightly on the left side of your body. It sits between your right and left lungs. The left lung is slightly smaller to make room for the heart in your left chest.
On average, an adult’s heart weighs about 10 ounces. Your heart may weigh a little more or a little less, depending on your body size and sex.
What are the parts of the heart’s anatomy?
The parts of your heart are like the parts of a house. Your heart has:
Walls.
Chambers (rooms).
Valves (doors).
Blood vessels (plumbing).
Electrical conduction system (electricity).
Heart walls
Your heart walls are the muscles that contract (squeeze) and relax to send blood throughout your body. A layer of muscular tissue called the septum divides your heart walls into the left and right sides.
Your heart walls have three layers:
Endocardium: Inner layer.
Myocardium: Muscular middle layer.
Epicardium: Protective outer layer.
The epicardium is one layer of your
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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2. FIBROUS SKELETON OF THE
HEARTA] composed of dense
connective tissue.
B] lies in the plane
between the atria
and the ventricles.
C] This plane
corresponds to
atrioventricular
groove/ orifices of
heart.
RV RVLV LV
3. D] is Present in the
form of circular
fibrous ring,,
interconnected by
intervening
fibrous tissue.
E] surrounds the
four valves
4. F] There are four such
rings-- ,, for four orifice
of heart
i & ii- - Atrioventricular
rings– for tricuspid
opening & for bicuspid
opening. It is 8-shaped
iii- aortic ring ---------- at
root of aorta
iv-pulmonary ring------ at
root of pulmonary trunk
superior view of AV-
plane
(Front)
posterior
5. G] Rings are
interconnected
1] AV-ring is connected to
AORTIC ring by a large
mass of fibrous tissue
called trigonum fibrosum
dextrum.
2] Mitral ring is connected
to aortic ring by small
mass of fibrous tissue
called trigonum fibrosum
sinistrum
3] Pulmonary ring & aortic
ring are connected by
tendon of infundibulum.
m
m
8. 1.It forms the central
support of the heart
2.Provides attachment to
i- bicuspid & tricuspid
valves directly
ii-cardiac muscle fibres
of atria & ventricles
iii- membranous part of
interventricular
septum
3. Keeps the cardiac
valves competent
4. Acts as an electrical
insulator
• It blocks the direct spread of
electrical impulses from the
atria to the ventricles.
Impulses go only through
bundle of His.
5.prevents overdilation of
the valve openings
H] FUNCTION OF FIBROUS SKELETON
Applied– weakening of it may lead
to cardiac valves incompetence---
means incomplete closure
leading to mitral regurgitation,
aortic regurgitation, tricuspid
regurgitation, ..
9. NOTE
• tricuspid valves & mitral valves are directly
attached to ring
• semilunar valves are directly attached to
wall of vessel ,, not to ring
10. Conductive system of the heart
• Conductive system of the heart is ----
--made up of specialised cardiac muscle fibres,,
-- responsible for initiation and conduction of
cardiac impulse/A.P ,, by its own.
---- these impulses cause cardiac muscle
contraction
11. Components of Conducting
Systemare:
1] Sinoatrial
node/SA node
2]Atrioventricular
node/AV node
3]Atrioventricular
bundle [bundle of
His]
4] Right and left
branches of AV
bundle (of His)
5] Purkinje fibers
12. SA node• Also k/a node of Keith &
Flack
• Situated in the wall of Rt.
Atrium ,in the upper part
of sulcus terminalis just
below the opening of SVC.
• It is called PACEMAKER
of the heart bcz it
generates impusle
&initiates the contraction
of cardiac muscle
producing heart beat.
• Impulse travels through
atrial wall to reach the AV
node
• impulse or heart beat or
heart rate=70-100
beat/min. [average
approx.70/min.]
13. Atrioventricular node/ AV node
• Also k/a node of
Tawara
• Smaller than SA node
• Located in the traingle
of Koch /or / in the
lower & dorsal part of
the atrial septum just
above the opening of
coronary sinus
• It generates impulse at
the rate of 40-60 beat
/min.
14. Atrioventricular bundle [bundle of
His]
• It begins from AV
node &crosses the AV
ring & travel along
the interventricular
septum.[membranous
part].
• Divides at the upper
part of muscular part
of IV-septum.
• Divides into two
branches– Rt. & Lt.
Bundle branch
15. Bundle branch
• Right branch of AV
bundle—
• Passes down on right
side of
interventricular
septum.
• Large part of it enters
the moderator band
to reach anterior wall
of Rt. Ventricle ,
• where it divides into
purkinje fibres.
• Likewise,,Left
branch of AV
bundle— goes on
left side in left
ventricle.
16. Purkinje fibres
• These are terminal
branches of Rt. &
Lt. Branches of
Bundle of His.
• Form sub-
endocardial plexus.
• They generates
impulse at the rate
of 20-35 beat /min.
applied--- arrhythmia– it is loss of
normal rhythm of contraction/ heart
beat.
-- due to damage of conductive
system.
blood supply –nearly whole
conductive system except left branch
AV bundle –is supplied by RCA.
Left br. Of AV bundle by LCA.
17. Heart is myogenic
1] Means A.P. is
generated by muscle
itself,, not by nerve.
2] Conductive system
of heart is made up
of cardiac muscles.
3] Nerves supplying
the heart, can only
influence / modify
the rate of impulse
production or A.P.
4] If all nerves are cut
even then heart will
continue to beat.[d/t
impulse from SA node]
5] Sympathetic nerve
stimulation increase
the rate of impulse
generation.
6] Para-Sympathetic
[vagus] nerve
stimulation decrease
the rate of impulse
generation.
18.
19. • Conductive system of the heart is made up
of specialised cardiac muscle fibres,, which
is responsible for initiation and conduction
of cardiac impulse/A.P ,, by its own.
• [ process of impulse generation /A.P.
independent of nerve supply.]MEANS----
• if all nerve connections to the heart are cut ,
even then the heart continues to produce A.P.
& beat/CONTRACT rhythmically. Hence our
heart is myogenic.
20. • BUT sympathetic & parasympathetic nerves
can modify the heart rate & force of
contraction.
• Sympathetic stimulation increase heart rates &
force of contraction
• Para-Sympathetic stimulation decrease heart
rates & force of contraction
•
21. Innervation
• Although the heart’s
inherent rate of
contraction is set by the
SA node, this rate can be
altered by extrinsic
neural controls
22. Innervation
• The nerves to the heart
consist of visceral
sensory fibers
• Parasympathetic fibers
that slow heart rate
• Sympathetic fibers that
increase the rate and
force of heart
contractions
25. 1. Sinoatrial
(SA) node
Right
atrium
2. Internodal
pathway
5a. Right
branch
of bundle
of His
Right
ventricle
6. Purkinje
fibers
Left
ventricle
5b. Left branch
of bundle of His
4. Bundle of His or
AV bundle
3. Atrioventricular
(AV) node
Interatrial
pathway
19-25
26. Interatrial pathway
Right atrium Left atrium
SA node
Internodal
pathway
AV node
Purkinje
fibers
Right ventricle Left ventricle
Bundle
of His
1st
beat
2nd
beat
19-26
28. • The fibrous skeleton of the heart lies in the
plane between the atria and the ventricles
• Muscles of atria is not in continuity with
muscles of ventricle [d/t fibrous skeleton]
• This fibrous skeleton is bad conductor of
electrical impulse. So it prevents direct entry
of electrical impulse from atria to ventricle.
4. ACTS AS AN ELECTRICAL INSULATOR:
29. • Electrical impulse from atria to ventricle goes
through bundle of Hiss only.
• Although each cardiac muscle has capacity to
generate & conduct (carry) electrical impulse.
• Thus fibrous skeleton helps in coordinated
conduction of A.P. or electrical impulse to
ventricle.-------- coordinated ventricular
contraction.