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Diuretices
A diuretic is any substance that promotes the
production of urine.
Use:-
In medicine diuretics are used to treat Heart failure,
Liver cirrhosis, Hyper tension , water poisoning and
certain Kidney diseases .
Example:-
Some diuretics such as Acetazolamide help to make the
urine more alkaline and helpful in increasing
excretion of substance such as aspirin in case of
overdose or poisoning.
 Carbonic anhydrase
inhibition, results in:
 Decreased H+
formation inside PCT
cell
 Decreased Na+/H+
antiport
 Increased Na+ and
HC03
- in lumen
 Increased diuresis
Carbonic anhydrous inhibitors
 Acetazolamide
 Methazolamide
 Systemic acidosis
 Kidney stone
 Drowsiness
 Rudranil Bhowmik
CARBONIC ANHYDRASE  INHIBITOR: DIURETICS ACT ON PCT(proximal  convoluted tubule)

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CARBONIC ANHYDRASE INHIBITOR: DIURETICS ACT ON PCT(proximal convoluted tubule)

  • 1.
  • 2. Diuretices A diuretic is any substance that promotes the production of urine. Use:- In medicine diuretics are used to treat Heart failure, Liver cirrhosis, Hyper tension , water poisoning and certain Kidney diseases . Example:- Some diuretics such as Acetazolamide help to make the urine more alkaline and helpful in increasing excretion of substance such as aspirin in case of overdose or poisoning.
  • 3.
  • 4.  Carbonic anhydrase inhibition, results in:  Decreased H+ formation inside PCT cell  Decreased Na+/H+ antiport  Increased Na+ and HC03 - in lumen  Increased diuresis
  • 5. Carbonic anhydrous inhibitors  Acetazolamide  Methazolamide
  • 6.  Systemic acidosis  Kidney stone  Drowsiness
  • 7.