Hyperthermia is a cancer treatment that involves exposing the body or tumor to high temperatures in order to damage and kill cancer cells. It is usually used in combination with other treatments like radiation therapy or chemotherapy. There are different methods of hyperthermia depending on the location of the tumor, including local, regional, and whole-body hyperthermia. While it can help make other treatments more effective, maintaining the right temperature is difficult and there is a risk of side effects like burns, pain, and nausea. Overall, hyperthermia is a promising technique for cancer treatment when used in conjunction with other therapies.
This slide includes physical, biological properties of proton and its advantage over the photon. It also provides information from beam production to treatment planning system of proton therapy, its potential applications, cost effectiveness and demerits.
Introduction
Time dose & fractionation
Therapeutic index
Four R’s Of Radiobiology
Radiation response
Survival Curves Of Early & Late Responding Cells
Various fractionation schedules
Clinical trials of altered fractionation
This slide includes physical, biological properties of proton and its advantage over the photon. It also provides information from beam production to treatment planning system of proton therapy, its potential applications, cost effectiveness and demerits.
Introduction
Time dose & fractionation
Therapeutic index
Four R’s Of Radiobiology
Radiation response
Survival Curves Of Early & Late Responding Cells
Various fractionation schedules
Clinical trials of altered fractionation
LET, Linear Energy Transfer, Relative Biologic Effectiveness, Oxygen enhancement ratio,
Dr. Vandana, KGMU, CSMMU, Lucknow, Radiation Oncology, Radiotherapy
It describes relationship between radiation dose and the fraction of cells that “survive” that dose.
This is mainly used to assess biological effectiveness of radiation.
To understand it better, we need to know about a few basic things e.g.
Cell Death
Estimation of Survival / Plating Efficiency
Nature of Cell killing etc.
A cell survival curve is the relationship between the fraction of cells retaining their reproductive integrity and absorbed dose.
Conventionally, surviving fraction on a logarithmic scale is plotted on the Y-axis, the dose is on the X-axis . The shape of the survival curve is important.
The cell-survival curve for densely ionizing radiations (α-particles and low-energy neutrons) is a straight line on a log-linear plot, that is survival is an exponential function of dose.
The cell-survival curve for sparsely ionizing radiations (X-rays, gamma-rays has an initial slope, followed by a shoulder after which it tends to straighten again at higher doses.
A primer of oncology basics for nursing students. Includes basic oncology, understanding cancer and understanding radiation therapy in an easy to comprehend manner.
Radioisotopes and dose rates used for brachytherapySubhash Thakur
Radioisotopes and dose rates used for brachytherapy
This is the seminar about different radioisotopes used in brachytherapy beginning from radium to iradium and different dose rates, low dose rate, high dose rate used in brachytherapy. The significance of different dose rates and its radiobiology along with the clinical results.
LET, Linear Energy Transfer, Relative Biologic Effectiveness, Oxygen enhancement ratio,
Dr. Vandana, KGMU, CSMMU, Lucknow, Radiation Oncology, Radiotherapy
It describes relationship between radiation dose and the fraction of cells that “survive” that dose.
This is mainly used to assess biological effectiveness of radiation.
To understand it better, we need to know about a few basic things e.g.
Cell Death
Estimation of Survival / Plating Efficiency
Nature of Cell killing etc.
A cell survival curve is the relationship between the fraction of cells retaining their reproductive integrity and absorbed dose.
Conventionally, surviving fraction on a logarithmic scale is plotted on the Y-axis, the dose is on the X-axis . The shape of the survival curve is important.
The cell-survival curve for densely ionizing radiations (α-particles and low-energy neutrons) is a straight line on a log-linear plot, that is survival is an exponential function of dose.
The cell-survival curve for sparsely ionizing radiations (X-rays, gamma-rays has an initial slope, followed by a shoulder after which it tends to straighten again at higher doses.
A primer of oncology basics for nursing students. Includes basic oncology, understanding cancer and understanding radiation therapy in an easy to comprehend manner.
Radioisotopes and dose rates used for brachytherapySubhash Thakur
Radioisotopes and dose rates used for brachytherapy
This is the seminar about different radioisotopes used in brachytherapy beginning from radium to iradium and different dose rates, low dose rate, high dose rate used in brachytherapy. The significance of different dose rates and its radiobiology along with the clinical results.
Learn how hyperthermia treatments (thermal therapy) can dramatically improve your response to radiation or chemotherapy. There are several mechanisms for action with how this treatment works biologically, and some cancers respond better than others. Contact Cyrus Rafie at (888) 580-5900 or visit http://www.bhthermalmedicine.com
Cyrus Rafie is a pioneer in the field of hyperthermia for cancer treatment. He has been involved with treatment of more 3000 cancer patients using hyperthermia.
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The Center for Thermal Oncology is cancer treatment center offering thermal therapy heat treatments, also known as hyperthermia, in coordination with the patient’s physician to optimize their outcome. The coupling of thermal heat therapy with traditional cancer healing modalities has scientifically proven to improve treatment efficacy and response by up to 44% - without side effects.
The Center for Thermal Oncology is the only freestanding center to employ hyperthermia cancer treatments, allowing patient’s to keep the physician they love. We are happy to coordinate care with a chosen physician, or recommend one to the patient.
The idea of using heat as a curative modality is not new, and is based on the natural response of the body to disease. In fact, Hippocrates, the “father of medicine” said, “What is not cured by the knife, may be cured by fire.” The ancient Egyptians also recorded using heat for healing in their hieroglyphic texts. And now, 30 years of modern scientific research has determined that the combination of heat treatment with radiation and/or chemotherapy dramatically improves cancer treatment response rates by as much as 44% - without side effects.
Thermal therapy is FDA approved and covered by most insurance, and has proven to be effective on a variety of different types of cancer and has exhibited marked results. In some studies, it has doubled a patient's response rate to radiation therapy: increasing survival, eliminating tumor sites, shrinking tumors and offering palliation. Increased survival and improved response rate has been clinically shown in these areas: Head and neck, thyroid, prostate, breast, axilla, chest, cervical and gynecological, colon, throat, melanoma, base of tongue, among others.
The Center for Thermal Oncology is a unique and innovative cancer treatment clinic that operates with only one goal in mind - positive results. We are uniquely qualified to succeed with each patient’s treatment. Our mission is to help our patients utilize every integrated and traditional method to assist them in regaining health and beating cancer.
Thermo-sensitization of tumor to radiation therapy through a process now as Radio-thermotherapy (hyperthermia and radiation therapy) to treat cancer cells.
Hyperthermia, a non-invasive gentle cancer treatment, raises tumor temperature to approximately 110 degrees Fahrenheit, a temperature similar to a high fever.
The Center for Thermal Oncology 888-580-5900
There are many types of cancer treatment. The types of treatment that patient receive will depend on the type of cancer, stage of cancer and how advanced it is.
Some people with cancer will have only one treatment. But most people have a combination of treatments, such as surgery with chemotherapy and/or radiation therapy.
Cancer treatment comes in a variety of forms. Rapid growth of technology is giving people living with cancer new hope. Dr. Kanury Rao and his colleagues are at the forefront of this transition and are committed to developing improved cancer therapies and cures.
We know that mesothelioma patients would rather stay local when receiving treatment,rnso we will review options for private medical centers, surgical consultants, clinical trials,rnand match you up with friendly, local physicians wherever we can.
We know that mesothelioma patients would rather stay local when receiving treatment,rnso we will review options for private medical centers, surgical consultants, clinical trials,rnand match you up with friendly, local physicians wherever we can.
We know that mesothelioma patients would rather stay local when receiving treatment,rnso we will review options for private medical centers, surgical consultants, clinical trials,rnand match you up with friendly, local physicians wherever we can.
We know that mesothelioma patients would rather stay local when receiving treatment,rnso we will review options for private medical centers, surgical consultants, clinical trials,rnand match you up with friendly, local physicians wherever we can.
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The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
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The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
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2. Overview
• What is Hyperthermia ?
• How is hyperthermia used to treat cancer ?
• What are the method’s use of hyperthermia cancer treatment ?
• Treatment planning and simulation process of Hyperthermia
cancer treatment.
• Hyperthermia Equipment
• Side Effect Of Hyperthermia cancer treatment
• Hyperthermia in combination with other modalities
• Advantage and Disadvantage of Hyperthermia cancer treatment
• Conclusion
10/6/2017 2Hyperthermia Cancer Treatment
3. What is Hyperthermia ?
• Hyperthermia (also called thermal therapy or thermotherapy) is a type of cancer
treatment in which body tissue is exposed to high temperatures (up to 113°F).
Research has shown that high temperatures can damage and kill cancer cells,
usually with minimal injury to normal tissues.
10/6/2017
3
Hyperthermia Cancer Treatment
4. How is hyperthermia used to treat cancer ?
• Hyperthermia is almost always used with other forms of cancer therapy, such as
radiation therapy and chemotherapy. Hyperthermia may make some cancer
cells more sensitive to radiation or harm other cancer cells that radiation cannot
damage. When hyperthermia and radiation therapy are combined, they are
often given within an hour of each other. Hyperthermia can also enhance the
effects of certain anticancer drugs.
• Numerous clinical trials have studied hyperthermia in combination with
radiation therapy and/or chemotherapy. These studies have focused on the
treatment of many types of cancer, including sarcoma, melanoma, and cancers
of the head and neck, brain, lung, esophagus, breast, bladder, rectum, liver,
appendix, and cervix .
10/6/2017 4Hyperthermia Cancer Treatment
5. What are the method’s use of hyperthermia cancer treatment ?
• Depending on the organ bearing the cancerous tissue three kinds of hyperthermia
techniques are recognized these types are-
Local Hyperthermia- In local hyperthermia, heat is applied to a small area, such as a
tumor, using various techniques that deliver energy to heat the tumor. Depending on
the tumor location, there are several approaches to local hyperthermia:
External approaches are used to treat tumors that are in or just below the skin.
Intraluminal or endocavitary methods may be used to treat tumors within or near body
cavities.
Interstitial techniques are used to treat tumors deep within the body, such as brain
tumor.
10/6/2017 5Hyperthermia Cancer Treatment
6. What are the method’s use of hyperthermia cancer treatment ?
Regional Hyperthermia- In regional hyperthermia, various approaches may be
used to heat large areas of tissue, such as a body cavity, organ, or limb.
Deep tissue approaches may be used to treat cancers within the body, such as
cervical or bladder cancer .
Regional perfusion techniques can be used to treat cancers in the arms and
legs, such as melanoma .
Continuous hyperthermic peritoneal perfusion (CHPP) is a technique used to
treat cancers within the peritoneal cavity.
Whole-body hyperthermia is used to treat metastatic cancer that has spread
throughout the body. This can be accomplished by several techniques that raise
the body temperature to 107-108°F, including the use of thermal chambers
(similar to large incubators) or hot water blankets.
10/6/2017 6Hyperthermia Cancer Treatment
7. Treatment planning and Simulation Process of Hyperthermia
Cancer Treatment ?
10/6/2017
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Hyperthermia Cancer Treatment
9. Side Effect Of Hyperthermia
• The possible side effects of hyperthermia depend of the technique being used and
the part of the body being treated. Pain, thermal burns or blisters are the limiting
adverse events of the techniques .
• In case of thermo chemotherapy ( TCHT) during the first days after the main
treatment, the occurrence of fever up to 39 °C can be observed as an expression of a
strong immunostimulation and is desirable in most cases. At this time though,
exhaustion,weakness, nausea, vomiting, headaches, diarrhoea and herpes labialis
(blisters on the lips) can also occur .
• During the TCHT main treatment, a moderate anaesthesia is given. The patient is
unable to drive for at least three days after the main treatment. In the following days,
due to various reasons (e.g. after-effects of the chemotherapy or additional
medications), reaction times can be deteriorated and, therefore, driving ability is
considerably limited. Most of these side effects are temporary .
10/6/2017 9Hyperthermia Cancer Treatment
10. Hyperthermia in combination with other modalities
• As an adjunct to traditional cancer therapy, hyperthermia has been shown to enhance cytotoxicity of
chemotherapy agents. Since adequate heating of the whole tumor volume is difficult except for
superficially located small tumors, and in general the reported response duration is short, the use of
hyperthermia alone is not recommended .
10/6/2017 10Hyperthermia Cancer Treatment
11. Advantage and Disadvantage of Hyperthermia cancer treatment
• The major advantage of regional and whole-body hyperthermia is that they
seem to make other forms of cancer treatment work better. Heating cancer
cells to temperatures above normal makes them easier to destroy using
radiation and certain chemotherapy drugs.
• For the success of hyperthermia therapy is very important careful
temperature control. Scientists almost unanimously agree that hyperthermia
works best when for a certain period of time to maintain a stable temperature
of the target site. But to achieve this is not always easy. Currently there is no
way to accurately measure the temperature inside the tumor. Maintain a
constant temperature, without affecting the surrounding tissue, it is also very
difficult. In addition, not all tissues in the body react to the rise in temperature
the same way - in some areas of the tissue is more sensitive than others. For
example, the brain is very sensitive to heat.
10/6/2017 11Hyperthermia Cancer Treatment
12. Conclusion
• Although basically an old and historic approach for treatment of cancer,
hyperthermia is not a well-known modality among patients and medical experts.
On the other hand, it has proved a very successful therapy method in
combination with radiation therapy and / or chemotherapy.
• Hyperthermia is currently under study in many clinical trials, particularly in
Europe, Japan and the US, to improve and better understand this promising
technique. Future areas of challenge and opportunity for hyperthermia include:
improved understanding of thermal biology; improved technologies for delivery
and monitoring of heat treatments in patients; successful high-quality clinical
trials; and combination of hyperthermia with emerging cancer therapies .
10/6/2017 12Hyperthermia Cancer Treatment