Hyperthermia Cancer Treatment by Cyrus Rafie, The Center for Thermal Oncology, March 2014
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Learn how hyperthermia treatments (thermal therapy) can dramatically improve your response to radiation or chemotherapy. There are several mechanisms for action with how this treatment works biologically, and some cancers respond better than others. Contact Cyrus Rafie at (888) 580-5900 or visit http://www.bhthermalmedicine.com
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Hyperthermia Cancer Treatment by Cyrus Rafie, The Center for Thermal Oncology, March 2014
- 1. (888) 580-5900 www.BHThermalMedicine.com Focusing on Life BHThermalMedicine.com 1
- 2. Hyperthermia Hyperthermia, a generally non- invasive gentle treatment, raises tumor temperature to approximately 108 degrees Fahrenheit, a temperature similar to high fever
- 4. Hyperthermia Improves Response Rates When Used As A Combined Therapy t% Clinical Trial Results ¹Valdagni et al., 1993 ²Overgaard et al., 1995 ³Issels et al., 2010 ⁴Colombo et al., 2010 ⁵Van der Zee., 2000 ⁶Vernon et al., 1996 ⁷Hurwitz et al., 2011 ⁸Kakehi et al., 1990 ⁹Jones et al., 2005 ¹ Vernon et al., 1996⁰
- 5. Long-Term Follow up- Randomized Trial comparing RT and RT & HT to Metastatic Lymph Nodes in Stage IV Head & Neck Patients
- 6. Melanoma 15X3 Gy, 6 hyperthermia
- 7. Coley’s Toxin Mixture of dead bacteria First attempts to utilize the immune system to counteract cancer. Adjuvant to conventional surgery, chemotherapy and radiation Effective in lymphomas William Bradley Coley (1862-1936) surgeon and oncologist
- 8. Treatment Sites Skin Chest Wall Lymph Nodes Breast Head and Neck Axilla Extremities Bladder Prostate Pancreas Vagina Lower Pelvic Region Rectum 8
- 9. Hyperthermia Treatments Stand Alone Chemotherapy Radiation Therapy 9
- 10. Hyperthermia Compliments and Enhances Other Therapies Hyperthermia is useful for pre-surgical down-staging Hyperthermia sensitizes tumor cells to ionizing radiation Hyperthermia is useful as a ‘trigger’ for targeting chemotherapy Hyperthermia stimulates immune response 10
- 11. Hyperthermia Treatments Direct Kill Activating the Immune System Heat Shock Proteins 11
- 12. Heat Shock Proteins Discovered in 1962 Conserved Thermotolerance Chaperone Protection of cells Heat upregulates expression of the HSP genes Hyperthermia increase HSP 70 KD
- 13. Hyperthermia and Radiation Therapy Improve Oxygenation of Tumors Sub-lethal Radiation Damage S Phase 13
- 14. Tumor Vascular System Defective Leakey Sympathetic nerve ending missing Dilated and compressed regions Irregular branching Hammersen, 1985
- 15. Tumor Vascular System Inefficient orientation Relative sparse arterioles Large flow variation Large Diameter Shunts Increased metabolic demand Packing density Dewhirst, 2008 Minchiton, 2006
- 16. Hypoxia Correlates with Negative Prognosis Cervix Cancer Pancreatic Cancer Head and Neck Prostate Breast Soft Tissue Sarcoma Hocekel, 1993, 1996 Ide, 2007 Brizel, 1999 Movsas, 2002 Vaupel, 2001, Lungren, 2007 Brizel, 1996
- 18. Hyperthermia Improves Chemotherapy Treatments Improves Drug Delivery to the Tumors Increases Permeability of the Cell Wall Interfering of Sub-lethal Chemo Damage repair 18
- 19. Hyperthermia Research Review 19 Response of matched superficial lesions Complete Response Tumors Radiation Radiation Author Treated Alone Plus Hyperthermia % Kim, et al 99 46% 70% Arcangeli 123 39% 76% Overgaard (summary) 186 31% 74% Scott 62 39% 83%
- 20. Hyperthermia Treatment External Superficial Deep Interstitial Intracavitary Whole Body 20
- 21. Hyperthermia Process Patient Selection Insurance Authorization Records 21
- 22. Hyperthermia Process (2) Scheduling Cyrus Rafie Medical Oncologist Radiation Oncologist Same Day Scheduling Labs CT, PET CT, MRI Biopsy 22
- 23. Hyperthermia Process (3) Review medical records Review diagnostic images Review with Radiologist Review with Radiation or Medical Oncologist 23
- 24. Hyperthermia Process (4) Size of the tumor Depth of tumor Normal tissue Blood flow Nerves Skin folds Surgical suture lines Pace maker 24
- 28. SONOTHERM ® Hyperthermia … the Procedure 28 1. The tumor is first located and examined by mammography. 2. A biopsy is analyzed to determine the tissue make-up of the tumor. 3. An analysis of the tumor’s exterior shape and depth is made. 4. An energy pattern of ultrasound matching the tumor shape is programmed to the 16 transducer sections for optimal treatment.
- 29. SONOTHERM ® Hyperthermia … the Process Within the Body 29 1. Transducer emits ultrasound. 2. Ultrasound energy is absorbed by the tumor and converted to heat. 3. Heat penetrates tumor for therapeutic effect. Normal blood flow cools organs and other body tissue. Underdeveloped blood circulation makes tumors more vulnerable to heat.
- 31. Hyperthermia Devices Regional Microwave 31
- 35. Hyperthermia Codes 77600 External, 4 cm 77605 External, more than 5 cm 77610 Interstitial, 4 or less 77615 Interstitial, more than 4 77620 Intracavitary 35
- 36. Adverse Effects There are no known complications of hyperthermia. Skin discomfort, irritation or local pain. Blisters 36
- 37. Hyperthermia Research Review 37 The effect of adjunctive hyperthermia on the radiation response in human tumors Frequency of Complete Response Radiation Radiation Study No. of Patients / Tumors Alone % Plus Hyperthermia % Arcangeli, et al 163 38 74 Overgaard 101 39 62 Kim, et al 238 39 72 Hiraoka, et al 33 25 71 Kochegarov, et al 161 16 63 Lindholm, et al 85 25 46 Scott, et al 44 64 86 Li, et al 124 29 54 Val dagni, et al 78 36 73 Vernon, et al 315 40 60 1,342 35% 66%
- 38. Beverly Hills Thermal Medicine For more information, please visit our comprehensive and informative website: BHThermalMedicine.com 38
- 39. 39
Editor's Notes
- Heat shock protein are produced when cells are exposed to 3 to 7 degree centigrade. All protein synthesis stops for cell to produce only these proteins, as much a 90%. From very low to very high as much 1000 times. They are for protection of against denaturation of proteins by the elevated temperature.
- No nerve ending Thin walled and fragile, lacking neural and muscular components S phase and early G phase of cell division is most sensitive to hyperthermia DNA damage is reversible and occurs at 80 to 90 C
- Increase tumor fluid pressure puts pressure on blood vessesls Oxygen and nutrients are used up by cells closed to the blood vessels limiting diffusions to the deeper cells. Tumor that survive this condition are more aggerssive and more resistant to therapies Teciher, 2009. Prostate cancer cells exposed to chronic hypoxia caused the tumor cells to be more aggessive and displayed higer invasion acitivity than prostate cells grown under normal conditions.