Vitamin D is synthesized in the skin upon exposure to sunlight and is hydroxylated sequentially in the liver and kidneys to produce the active form of vitamin D. It regulates calcium and phosphate levels in the blood and promotes bone health by enhancing intestinal calcium absorption and stimulating bone mineralization. Vitamin D supplements in the form of cholecalciferol tablets or sachets are used to treat osteoporosis and fractures by helping to maintain calcium levels and supporting bone mineral density and structure.

2. VITAMIN-D BIOSYNTHESIS
-The major natural source of the vitamin D
is synthesis of cholecalciferol in the skin
from cholesterol through a chemical
reaction that is dependent on sun
exposure (specifically UVB radiation).
-Cholecalciferol is converted in the liver to
Calcidiol (25-hydroxycholecalciferol)
-Calcidiol is further hydroxylated by the
kidneys to form calcitriol(also known as1,2
5-dihydroxycholecalcifero),the biologically
active form of vitamin D.
-Vitamin D is converted to Calcidiol in the
liver. Part of the Calcidiol is converted by
the kidneys to calcitriol, the biologically
active form of vitamin D. It circulates as a
hormone in the blood, regulating the
concentration of calcium and phosphate in
the bloodstream and promoting the healthy
growth and remodeling of bone.

3. REGULATION OF CALCIUM HOMEOSTASIS

4. CALCIUM HOMEOSTASIS PROCESS

5. ROLE OF VITAMIN D IN CALCIUM HOMEOSTASIS

6. ROLE OF VITAMIN D IN CALCIUM HOMEOSTASIS

7. CHOLECALCIFEROL(VITAMIN-D3)
COMPOSITION
Cholecalciferol chewable tablets 60,000 IU
Cholecalciferol 60,000 IU/1gm Sachet
INDICATIONS
Fractures
Osteoporosis
DOSE/DOSAGES
1Tab or Sachet per week for 3 Months

8. CHOLECALCIFEROL(VITAMIN-D3)
-Helps in maintaining calcium level in blood.
-Decreases risk of low BMD.
-Enhances calcium absorption from intestine.
-Stimulates absorption of phosphate and magnesium ions.
-Stimulates differentiation of osteoclasts.
-Provide proper balance of calcium and phosphorus in bone
to support mineralization.
-Facilitates calcium absorption in the kidney.

9. SOURCES OF VITAMIN D

10. AVAILABLE BRANDS IN INDIA
BRANDS
-CALCIROL(CADILA)
-D RISE(USV)
-VITOMIN D3(CIPLA)
-CALDIKIND(MANKIND)
-ROCKBON(ABOTT)
-TORFLASH(TORRENT)
-GEN D3(MACLEODS)
-CALSHINE(ERIS)