Caffeine and You
•
0 likes•1,453 views
This document discusses caffeine and its effects on the body. It summarizes that caffeine is a stimulant that binds to adenosine receptors in the brain, blocking the effects of adenosine and causing increased alertness. However, prolonged caffeine consumption can lead to side effects like anxiety, sleep disorders, and addiction. The document also examines how caffeine crosses the blood-brain barrier, is metabolized in the body, and investigates potential medical uses of caffeine and related compounds as analgesics and in treating Parkinson's disease.
Recommended
More Related Content
What's hot
What's hot (20)
Viewers also liked
Viewers also liked (20)
Similar to Caffeine and You
Similar to Caffeine and You (15)
More from David Ardiansyah
Recently uploaded
Recently uploaded (20)
Caffeine and You
- 2. CAFFEINE & YOU david ardiansyah & koh jia lei
- 3. Caffeine noun caf·feine ka-ˈfēn, ˈka-ˌ German Kaffein, from Kaffee coffee, from French café
- 4. Caffeine noun caf·feine ka-ˈfēn, ˈka-ˌ German Kaffein, from Kaffee coffee, from French café the world consumes 2 billion cups of coffee daily!
- 5. a sharpened focus extra boost of energy warding off drowsiness sleep disorders anxiety addiction and withdrawal syndrome PROLONGED consumptions STIMULANTS
- 6. STRUCTURE
- 8. purine ring two ketone purine xanthine 1,3,7-trimethylxanthine CAFFEINE
- 9. causes drowsiness dilation of blood vessels (vasodilation) slowing down cerebral cell activity ADENOSINE
- 11. adenosine tri-phospate (ATP) adenine building blocks of DNA (‘A’ ’T’ ‘C’ ‘G’) energy storage for biochemical process adenosine induces sleep
- 12. Adenosine docking at Adenosine A2a receptor π bond interaction
- 13. RESONANCE Glu169A Asn253A His278A resonance effect strengthens the hydrogen bonds glutamic acid asparagine histidine
- 15. CROSSING BLOOD-BRAIN BARRIER highly lipophilic
- 16. Caffeine has a value of approx. -0.25 to -0.55 Partition-coefficient (P) To cross the blood-brain barrier, the log P value is < 3 Passive diffusion of caffeine Ride on Adenosine transport mechanism
- 17. Caffeine docking at Adenosine A2a receptor π bond interaction
- 18. CaffeineAdenosine π bond interaction π bond interaction
- 20. increases the rate of lipolysis process Paraxanthine dilation in the blood vessels increases urine production Theobromine induces bronchodilation Theophylline increased heart rate and contractility
- 21. caffeine crash caffeine resistance caffeine withdrawal symptoms up regulation of receptors increased number of receptor active sites more adenosine can bind into extra receptor actives site higher sensitivity of adenosine in the brain caffeine unbinding once being metabolised adenosine readily binds to active side AFTER EFFECT
- 23. four different subtypes: A1, A2a, A2b and A3 purinergic receptors ADENOSINE RECEPTORS decrease the amount of cAMP (cyclic Adenosine Mono-Phosphate) inhibiting enzyme Adenylate Cyclase A1 and A2a play a complementary role
- 24. ADENOSINE A2a RECEPTOR AGONISTS ligand that binds into a receptor and begins to activate the receptor strict requirements esp. structure and stereochemistry of the ribose group 1 2 3 tolerated modifications are shown at (1), (2) and (3).
- 25. adenosine A2a receptor agonists 5’-hydroxyl group of the ribose ring, 2- and N-6 position of the purine group
- 26. Ki value for Adenosine A2a Agonists
- 27. NECA and Adenosine docking at Adenosine A2a Agonists
- 28. ADENOSINE A2a RECEPTOR ANTAGONISTS ligand that binds to a receptors and causes the blocking of the agonist- mediated response a planar configuration, aromatic or π electron rich and nitrogen containing heterocycle lack of ribose group N1, N3, N7 and C8
- 29. xanthine antagonists at adenosine A2a receptor modification at N1, N3, N7 and C8
- 30. non-xanthine antagonists at adenosine A2a receptor
- 31. Ki value for Adenosine A2a Antagonists Ki value for Caffeine is 4,5000, 18,000 and 13,000 at A1, A2a and A3 respectively
- 32. Caffeine and XAC docking at Adenosine A2a Agonists
- 33. ADENOSINE A2a RECEPTOR PARTIAL AGONISTS less than half the intrinsic activity a combination of an antagonistic substituent of purine ring and the unchanged agonistic ribose group modifications on the purine group Theophylline-7-riboside 1,3-dibutylxanthine-7-riboside
- 35. ANALGESICS synergistic effect with paracetamol caffeine on its own has no analgesic effects adenosine often detected in migraine attacks competitive inhibition of the adenosine receptors
- 36. PARKINSONS caffeine may have beneficial effect in treatment of Parkinson up-regulation of adenosine receptors changes adenosine-dopamine proportions dopamine pathway would be stimulated theophylline may also achieve similar effect dopamine pathway has similar mechanism of action to that of Anti- Parkinsonian drugs induces
- 37. PARKINSONS adenosine A2a receptor is found co-localised with the Dopamine D2 receptor dopamine receptors are known to be obligatory synergistic adenosine-receptor binding decreases the affinity of the D2 receptors agonists
- 38. MÉRCI
- 39. KOPITALK