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BTC 506
PHYLOGENETIC TREE
TYPES AND APPLICATIONS
WHAT IS A PHYLOGENETIC TREE USED
FOR?
• A phylogenetic tree or evolutionary tree is a branching diagram or
tree showing the inferred evolutionary relationships among
various biological species or other entities their phylogeny based
upon similarities and differences in their physical or genetic
characteristics. The taxa joined together in the tree are implied to
have descended from a common ancestor. Phylogenetic trees are
central to the field of phylogenetic.
• A phylogenetic tree is used to help represent evolutionary
relationships between organisms that are believed to have some
common ancestry.
• The name “ dendogram ” is the broad term for trees.
WHERE DID THE IDEA FOR A TREE COME
FROM?
• Charles Darwin (1859) is credited with the earliest representation of
a phylogenetic tree published in his book The Origin of Species. Over a
century later
, evolutionary biologists still use tree diagrams to
depict evolution.
PURPOSES OF PHYLOGENETIC
TREE
• Understanding human origin
• Understanding biogeography
• Understanding the origin of particular traits
• Understanding the process of molecular evaluation
• O rigin of disease
• The aim ofphylogenetic tree construction, is to find the tree which
best describes the relationships between objects in a set. Usually the
objects are species.
WHAT DOES THIS TREE LOOK LIKE?
• There are many different ways to represent the information found in a
phylogenetic tree.
• The basic format of a tree is generally in one of the two forms shown,
although there are other ways to represent the data.
WHAT DO THE LINES REPRESENT?
• Eachline on the tree represents one particular organism of interest.
• The distanceof the lines is usedto determine how closely two
organismsarerelatedto oneanotheror how longagothemayhave
had acom
m
onancestor
.
• The line that connect all the other lines is the representation of the
com
m
onancestor that isbeinglooked at to com
pare other
organism
sto.
ROOTED PHYLOGENETIC TREE
• A rooted phylogenetic tree serves asauseful diagram which
shows the evolutionary history. It hasabasal node which is
called the root, representing the common ancestor of all
the groups of the tree.The root of atree isconsidered as
the oldest point in the tree which represents the last
common ancestor of all groups included in the tree. Hence,
arooted tree shows the direction of evolutionary time.
Since the rooted tree depicts the direction of evolutionary
time, it iseasyto find the older or newer groupsit has.A
rooted tree canbe used to study the entire groups of
organisms.
UN ROOTED PHYLOGENETIC
TREE
• An un rooted phylogenetic tree is aphylogenetic diagram
which lacks acommon ancestor or abasal node. This type
of atree does not indicate the origin of evolution of the
groups of interest. It depicts only therelationship
between organisms irrespective of the direction of the
evolutionary time line
THE “ROOTED” VS. “UNROOTED”
TREE
• A rooted tree isused to make inferences about the m
ost
common ancestor of the leaves or branchesof the tree.
• An un rooted tree is used to makeanillustration about
the leaves or branches, but not makeassumption
regardingacommon ancestor
.
THE BIFURCATING TREE
• A tree that bifurcates hasamaximumof 2descendantsarising
fromeachof the interior nodes.
THE MULTI-FURCATING TREE
• A tree that multi-furcates has multiple descendants arising
from each of the interior nodes.
WHAT CRITERIA IS IMPORTANT
WHEN BUILDING A TREE?
• There are many different things that you should consider
as you get set to build your tree.
• Some examples are;
• Efficiency
• Power
• Consistency/Reliability
• Robustness
• Are underlying assumptions ever violated
WHERE DO I GO TO MAKE A
TREE?
• Many computational biology programs have dendogram
programs.
• An example of a free program that is available via the
EMBL-EBI (European Bioinformatics Institute) called
ClutsalW or ClustalX.
APPLICATIONS OF
PHYLOGENETIC TREE
• The inference of phylogenies with computational methods
has many important applications in medical and biological
research, such as drug discovery and conservation
biology.
• Phylogenetic trees have already witnessed applications in
numerous practical domains,such as in conservation
biology (illegal whale hunting), epidemiology (predictive
evolution), forensics (dental practice HIV transmission),
gene function prediction and drug development.
APPLICATIONS OF
PHYLOGENETIC TREE
• O ther applications of phylogenies include multiple
sequence alignment, protein structure prediction, gene
and protein function prediction and drug design.
• The computation of the tree-of life containing
representatives of all living beings on earth is considered
to be one of the grand challenges in Bioinformatics.
LIMITATIONS TO THE USE OF
TREES
• It isimportant to remember that trees do have
lim
itations. For exam
ple, trees are meant to provide
insight into aresearch questionandnot intendedto
represent anentire species history.
• Several factors, like genetransfers, mayaffect the output
placed into atree.
• All knowledge of limitations related to DNA degradation
over time mustbe considered, especially in the case of
evolutionary trees aimedat ancient or extinct organisms.

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BTC 506 Phylogenetic Tree.pptx

  • 2. WHAT IS A PHYLOGENETIC TREE USED FOR? • A phylogenetic tree or evolutionary tree is a branching diagram or tree showing the inferred evolutionary relationships among various biological species or other entities their phylogeny based upon similarities and differences in their physical or genetic characteristics. The taxa joined together in the tree are implied to have descended from a common ancestor. Phylogenetic trees are central to the field of phylogenetic. • A phylogenetic tree is used to help represent evolutionary relationships between organisms that are believed to have some common ancestry. • The name “ dendogram ” is the broad term for trees.
  • 3. WHERE DID THE IDEA FOR A TREE COME FROM? • Charles Darwin (1859) is credited with the earliest representation of a phylogenetic tree published in his book The Origin of Species. Over a century later , evolutionary biologists still use tree diagrams to depict evolution.
  • 4. PURPOSES OF PHYLOGENETIC TREE • Understanding human origin • Understanding biogeography • Understanding the origin of particular traits • Understanding the process of molecular evaluation • O rigin of disease • The aim ofphylogenetic tree construction, is to find the tree which best describes the relationships between objects in a set. Usually the objects are species.
  • 5. WHAT DOES THIS TREE LOOK LIKE? • There are many different ways to represent the information found in a phylogenetic tree. • The basic format of a tree is generally in one of the two forms shown, although there are other ways to represent the data.
  • 6. WHAT DO THE LINES REPRESENT? • Eachline on the tree represents one particular organism of interest. • The distanceof the lines is usedto determine how closely two organismsarerelatedto oneanotheror how longagothemayhave had acom m onancestor . • The line that connect all the other lines is the representation of the com m onancestor that isbeinglooked at to com pare other organism sto.
  • 7. ROOTED PHYLOGENETIC TREE • A rooted phylogenetic tree serves asauseful diagram which shows the evolutionary history. It hasabasal node which is called the root, representing the common ancestor of all the groups of the tree.The root of atree isconsidered as the oldest point in the tree which represents the last common ancestor of all groups included in the tree. Hence, arooted tree shows the direction of evolutionary time. Since the rooted tree depicts the direction of evolutionary time, it iseasyto find the older or newer groupsit has.A rooted tree canbe used to study the entire groups of organisms.
  • 8. UN ROOTED PHYLOGENETIC TREE • An un rooted phylogenetic tree is aphylogenetic diagram which lacks acommon ancestor or abasal node. This type of atree does not indicate the origin of evolution of the groups of interest. It depicts only therelationship between organisms irrespective of the direction of the evolutionary time line
  • 9. THE “ROOTED” VS. “UNROOTED” TREE • A rooted tree isused to make inferences about the m ost common ancestor of the leaves or branchesof the tree. • An un rooted tree is used to makeanillustration about the leaves or branches, but not makeassumption regardingacommon ancestor .
  • 10. THE BIFURCATING TREE • A tree that bifurcates hasamaximumof 2descendantsarising fromeachof the interior nodes.
  • 11. THE MULTI-FURCATING TREE • A tree that multi-furcates has multiple descendants arising from each of the interior nodes.
  • 12. WHAT CRITERIA IS IMPORTANT WHEN BUILDING A TREE? • There are many different things that you should consider as you get set to build your tree. • Some examples are; • Efficiency • Power • Consistency/Reliability • Robustness • Are underlying assumptions ever violated
  • 13. WHERE DO I GO TO MAKE A TREE? • Many computational biology programs have dendogram programs. • An example of a free program that is available via the EMBL-EBI (European Bioinformatics Institute) called ClutsalW or ClustalX.
  • 14. APPLICATIONS OF PHYLOGENETIC TREE • The inference of phylogenies with computational methods has many important applications in medical and biological research, such as drug discovery and conservation biology. • Phylogenetic trees have already witnessed applications in numerous practical domains,such as in conservation biology (illegal whale hunting), epidemiology (predictive evolution), forensics (dental practice HIV transmission), gene function prediction and drug development.
  • 15. APPLICATIONS OF PHYLOGENETIC TREE • O ther applications of phylogenies include multiple sequence alignment, protein structure prediction, gene and protein function prediction and drug design. • The computation of the tree-of life containing representatives of all living beings on earth is considered to be one of the grand challenges in Bioinformatics.
  • 16. LIMITATIONS TO THE USE OF TREES • It isimportant to remember that trees do have lim itations. For exam ple, trees are meant to provide insight into aresearch questionandnot intendedto represent anentire species history. • Several factors, like genetransfers, mayaffect the output placed into atree. • All knowledge of limitations related to DNA degradation over time mustbe considered, especially in the case of evolutionary trees aimedat ancient or extinct organisms.