An educational presentation on basics of neuroanatomy. It defines various cells of nervous tissue. the structure and function is well defined. It also covers various scientific terminologies and lastly their is graphical representation of action potential generation.
An educational presentation on basics of neuroanatomy.
it define the scientific terminologies and various cells of nervous tissue. structure and function of all nervous tissue is explained. action potential generation is graphically represented.
A medical educational presentation on Brachial plexus. In this presentation formation of plexus has been explained. Branches with their nerve root value is mentioned. brachial supply to upper limb muscles is briefly explained. clinical anatomy is explained in detail
An educational presentation on basics of neuroanatomy.
it define the scientific terminologies and various cells of nervous tissue. structure and function of all nervous tissue is explained. action potential generation is graphically represented.
A medical educational presentation on Brachial plexus. In this presentation formation of plexus has been explained. Branches with their nerve root value is mentioned. brachial supply to upper limb muscles is briefly explained. clinical anatomy is explained in detail
well describes the development of nervous system from basic to advanced concept including neural tube defects. the concepts are presented in graphical form for easy understanding of concepts.
an easy introduction of nervous system. Detail theoretical information purposefully avoided. At the beginning of medical course, also biology student need to know about nervous system. Within short time this presentation give a simple overview of NS.
Nervous system - Arun Kumar Beborta, Tutor, SON, Christian Hospital Mungeli ruhiarun
This presentation was prepared for the GNM 1st year students with objectives: they will be able to:
1. define nervous system
2. describe neurones
3. explain different parts of brain and their function
4. list down types of nerves and their functions
5. differentiate between sympathetic and parasympathetic nervous system.
well describes the development of nervous system from basic to advanced concept including neural tube defects. the concepts are presented in graphical form for easy understanding of concepts.
an easy introduction of nervous system. Detail theoretical information purposefully avoided. At the beginning of medical course, also biology student need to know about nervous system. Within short time this presentation give a simple overview of NS.
Nervous system - Arun Kumar Beborta, Tutor, SON, Christian Hospital Mungeli ruhiarun
This presentation was prepared for the GNM 1st year students with objectives: they will be able to:
1. define nervous system
2. describe neurones
3. explain different parts of brain and their function
4. list down types of nerves and their functions
5. differentiate between sympathetic and parasympathetic nervous system.
1.Organization of the Nervous System.pptxSana67616
CNS physiology general description and introduction
Brain and spinal cord
Brain is covered by meninges, CSF is fluid present in subarachnoid space
It has a protective function
Peripheral nervous system consists of cranial nerves and spinal nerves
There are 12 pairs of cranial and 31 pairs of spinal nerves Spinal cord is present in the vertebral canal of vertebral column, surrounded by the meninges and there is CSF present in subarachnoid space.
- It is almost cylindrical but in cervical and lower thoracic and lumbar regions it contains fusiform shaped enlargements called cervical enlargements and lumbar enlargements.
In the cervical segments there is more gray matter and also there is more gray matter in the lower thoracic and lumbar region. Cervical segments supply the upper limb i.e. it supplies more muscles, so more gray matter is present. Similarly the lumbar region supplies the lower limb so more gray matter is present in this region.
Just below the lumbar enlargements, spinal cord abruptly tapers, this tapering part is called conus medularis, and it gives attachment to a fibrous thread called filum terminale, which is attached to the back of coccvx.
In the spinal cord on the anterior surface there is anterior median fissure and on the posterior surface is posterior median sulcus. Fissure is much deeper than the sulcus.
Spinal nerves arise from the spinal cord and each spinal nerve has two roots.
1. Ventral (anterior root); which is motor and it contains both somatic and autonomic fibers.
2. Dorsal (Posterior root); is sensory and in the dorsal root there is dorsal root ganglia. It contains sensory neurons which give rise to cell fibers.
Nervous system ( anatomy and physiology)Ravish Yadav
the topic contain function of nervous system, classification of nervous system, neurons anatomy, structural classification of neurons, functional classification of neurons, nerve impulse
An educational, informative presentation on psoriasis. It covers the latest pathogenesis of the disease and treatment guidelines. the differential diagnosis is well defined.
An Educational presentation on a rare hereditary or acquired disorder of skin - Epidermolysis Bullosa wherein their is increase tendency to develop blister on slight trauma. The variants are explained with differentiating point.
An educational presentation describing a hereditary disorder of Skin "Ichthyosis". in the presentation anatomy of affected layers are explained. Ichthyosis classification is done. and differential diagnosis of each Ichthyosis is briefly explained. UNANI as well as currently available treatment is described briefly
This is an educational presentation that describes methods of studying skull. Various Normas has been explained with diagrams. The presentation is the continuation of previously uploaded matter wherein major bones of the skull was explained. link to previous ppt is https://www.slideshare.net/AyshahHashimi/skull-copy
This is an educational presentation on skull anatomy. It features the structure of various bones of the skull, their exact location their characteristics features and various muscles attached to it.
An educational presentation that consists of general complaint of skin diseases, history taking and examining various lesions and differentiating it and lastly tools required and investigation to be done to diagnose the skin manifestations
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
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2. Nervous System
• Large
• Complex organ
• Serve as center for nervous system
• Located in head
Two parts
• CNS
Brain
Spinal cord
• PNS
Sensory
Motor
3. Brain
• Main part of nervous system
• It integrates the received information and coordinates and influences the activity of all parts of the bodies
Brain 3 parts
• Forebrain/ Prosencephalon
• Midbrain/ Mesencephalon
• Hindbrain/ Rhombencephalon
Or
• Cerebrum
• Cerebellum
• Brainstem (Midbrain + Pons + Medulla)
Cerebrum
Cerebellum
Brainstem
Forebrain
Hindbrain
Midbrain
5. Midbrain consist of
• Tectum
• Cerebral peduncle
• Substantia nigra
Hindbrain/ Rhombencephalon
• Metencephalon (Pons and Cerebellum)
• Myelencephalon (medulla oblongata)
6. Nervous system
• Neurons concern with communication signal
• Glial cells/ Supporting cells
What are Gyri and Sulci?
Gyrus are ridges on the cerebral cortex surrounded by sulci. They create folded appearance of a brain
Now anatomically CNS has 2 parts
• Grey matter
• White matter
Grey matter is collection of cell bodies of neurons within the CNS
White matter is collection of axons within the CNS
7. Division of grey matter
• Cortex (grey matter at periphery)
• Nucleus (pieces of grey matter that are embedded or surrounded by white matter )
Division of White matter
• Tracts : they take information within the CNS upward or downward
Ascending tracts
Descending tracts
• Commissural fibres: they connect or transmit information from right to left within the CNS (corpus callosum)
• Association fibres: they connect anterior to posterior
8. Reticular formation
• In brain grey matter is at periphery mainly while in spinal cord they are in centre so in brain stem grey
matter lies in centre.
• Motor sense/tract from cortex and sensory sense/tract from spinal cord criss-cross at brainstem
fragmenting its grey matter into small pieces. This structure is called as reticular formation. Many nucleus
arises from brainstem.
9. Peripheral Nervous System
• It is one of the two components that makeup the nervous system.
• Consists of nerves and ganglia outside the brain and spinal cord
• It serves as a relay between the CNS and the body
• Sensory PNS is classified into
1. Special senses ( vision, olfaction, taste, hearing, balance)
2. General senses are of two types
A. Somatic sensation (skin, locomotor system(pain, temp., vibration proprioception-sense of position))
B. Visceral sensation (pain or discomfort)
Other type of senses
1. Conscious sense
2. Unconscious sense (BP, peristalsis)
10. Motor response
• Somatic motor responses (controlled by us)
• Visceral/Autonomic motor response (uncontrollable) 2 types
Sympathetic Nervous system
Stimulate on fight and flight response
Two kind of neurons preganglionic and postganglionic neurons
Originate from thoracolumbar division of spinal cord (T1-L2/L3)
Parasympathetic Nervous system
Stimulate on rest and digest or feed and breed
Originate from central nervous system as cranial nerves and sacral division (S2-S4) of spinal
cord (Craniosacral outflow)
11. Structure of Neuron
Neuron is a fundamental unit of nervous system that generate electrical signals called
action potential which allows them to quickly transmit information over long distances
It consist of 3 parts – Cell body, Dendrites and Axon
Dendrites
• Multiple extensions that extrude from cell body of neuron that communicate
with other neurons to collect information or receive information
• Increase the surface area of the neuron and act as sensory receptor.
• They tend to taper
• The dendrites have ligand gated ion channels and G protein coupled receptor
for the production of EPSP (excitatory postsynaptic potential) and IPSP
• on its surface
12. Cell Body/Soma/Cyton
• A compact structure that contains nucleus and in cytoplasm have Nissl’s granules
(present in both soma and dendrites but not in axon)
• Its function is to synthesize and release proteins that are important for neuronal
growth and regeneration of axons and could be neurotransmitter, enzymes etc.
Axon Hillock is junction between soma and axon
Axon
• Large single extension that conducts the processed information from neuron to
the axon terminal in the form of action potential (depolarization and
repolarization wave)
• Kinesin is a special protein present inside the axon that transfer these enzymes,
neurotransmitters and certain protein from the cell body towards the terminal
axon
13. • Dynein are proteins that transport in opposite direction i.e. from synaptic end to cell body and this
transport is called as Retrograde Axonal transport (nerve growth factors, mitochondria)
• Apart from this axonal transport, various infections like polio, rabies, varicella zoster, herpes simplex etc.
are using this machinery for their movement to cell body from axon terminal and back to it
• Voltage gated ion channels (Sodium and potassium)
• They have special insulating substance called myelin
Axon terminal
• Have voltage gated calcium channel
• Synoptic knobs contains neurotransmitter that are released to carry out the concerned function in
response to cacium
• Reuptake of neurotransmitters
• Myelin sheath an insulating layer around the axon and is not continuous to increase the saltatory
conduction of neuron. Schwann cells in PNS and Oligodendrites in CNS wrap over the axon to form myelin
sheath
14. Structural classification of neurons
• Unipolar are found in skin
• Bipolar in retina and olfactory cells
• Pseudo-unipolar in dorsal root ganglia of spinal cord, 5th cranial nerve nuclei
• Multipolar in most part of the body
15. Functional Types
• Sensory neuron carries the afferent information to the brain they are mainly pseudounipolar
General visceral afferent neurons (from viscera)
General Somatic afferent neurons (from locomotor system)
Special senses afferent neurons (from eyes and ears etc.)
• Motor neurons carries motor impulses from brain or spinal cord to tissue level. They are of two types upper
& lower motor neurons
General visceral efferent neurons (towards viscera)
General Somatic efferent neurons (towards locomotor system)
• Interneurons connect sensory neurons to mo tor neurons
16. Supporting cells of brain
• There are six glial cell in nervous system
• Four in CNS and two in PNS
CNS PNS
Astrocyte Satellite cell
Oligodendrocyte Schwann cell
Microglia
Ependymal cell
17. Astrocytes (Star cell)
• Astrocyte are star shaped glial cells in brain and spinal cord. It interacts with up to 2 million neurons at a
time. They are the most abundant cells in the brain
• Have central body and some processes with foot plates in the end
2 types
• Fibrous astrocyte
Long processes mostly unbranched and have vascular feet.
Found in white matter of brain & spinal cord
• Protoplasmic astrocyte
Short processes but are branched and have abundant of organelles and cytoplasm
Seen in grey matter of brain and spinal cord
18. Functions
• Scaffold (covering neurons forming a meshwork around it)
The number of astrocytes are more as compared to neurons
Ratio of astrocytes to neurons is 5:1
The astrocytes are present in CNS in the form of network
They interlink with the help of footplates
• Reservoir of Glycogen
In case of decrease ATP production in neurons, the astrocytes feeds neuron (contain glycogen and are
capable of gluconeogenesis and glycogenolysis) and provide nutrients
• Recycle neurotransmitters
Excessive neurotransmitters are reuptake by axonal endings but at one point it is saturated
Astrocytes now takes the charge and takes the excessive neurotransmitters and further supply it back to the
neurons
19. • Regulate neuronal communication by developing & stabilizing synapses (thrombosaponins I & II, Hevin,
Glypicans 4 & 6 – help in recruiting ampa receptors that makes synapses more active)
• Promote myelinating activity of oligodendrocytes
• Forms BBB
The foot processes of astrocytes binds the junction of endothelium and prevent passage of various
substances forming blood brain barrier
Mostly lipid soluble substances are permeable to this barrier
Protein are not allowed to enter as they may stimulate any neuron
There are places in the brain where blood brain barrier is absent is
Area Postrema in medulla is devoid of BBB because in presence
of toxins it stimulate chemotactic centre in midbrain and causes vomiting
Osmoreceptors around the hypothalamus checks hydrogen ion level,
electrolyte imbalance and accordingly stimulate posterior pituitary
Hypothalamic-Pituitary axis
20. • Glial scar (repairs the damage)
In case of injury, the astrocytes reaches the affected site and prevents blood loss
• Homeostasis (balance ion concentration in the brain)
Rich in hydrogen ions
Astrocytes can efflux and influx hydrogen ion
• Potassium buffer
Membrane of the neuron has potassium channel that leaks out the potassium
Sodium-potassium ATPase to counter balance the loss where in there is influx of two potassium ion and
efflux of 3 sodium ion
Increase of potassium outside the cell, brings the potassium inside, exiting the neuronal cell
In order to prevent this, astrocytes takes up the extra potassium and stores it
21. Microglia
• Microglia are the macrophages of the brain that broadly function to destroy pathogens and scavenge dead or
dying cells
• They form the main form of active immune defence in CNS. They travel within the CNS & perform different job
according to the need.
• Types: 1. Resting/Ramified microglia stays at one place and has a small cell body and a thin projections that r
monitoring or sensing the local environment. (express to IL10 & TGFß)
• 2. Reactive/activated microglia are highly motile (express to IL-1ß)
• 3. Phagocytic microglia
• Microglia dysfunction (area of research in Alzheimer’s disease)
22. • Synaptic Pruning- Clean up xtra synapses in early childhood
Receptors usually have sialic acid to protect them from phagocytosis but an enzyme released by microglia c/a
neuraminidase cleaves it and through series of reaction leads to phagocytosis. It also chews neurons that have
no CD200 or CD47 molecules.
• Scavenging property/ housekeepers
Very sensitive to small change in the environment. Sense any foreign material, damaged cells, apoptotic cells,
plaques, cleans dead cells or debris or engulf any foreign material
• Phagocytosis and promote inflammation
During the inflammation or injury to brain there is rise in microglia that pull their branches and increase their
cell body and multiply to increase its no. to fight against infection by secreting IFN-ɤ.
23. • Cytotoxicity
Apart from phagocytosis it releases variety of cytotoxic substances eg. ROS H2O2, NO, that directly damages cell.
Protease cytokine like IL1 causes demyelination of neuronal axons. Also IL1 inhibits IL10 and TGFß
• Antigen presenting cell and releases protein called cytokines (IL8) that help T cell to enter brain and fight
infection.
• Promotion of repair
Finally, they signal astrocyte to repair and heal the tissue, astrocyte releases IL10 and TGFß which is sensed by
resting microglia that stops further inflammation
24. Ependymal cells
• Neuroepithelial lining of the ventricular system of the brain and the central canal of the spinal cord.
• Contains cilia and microvilli on its surfaces. Cilia helps in moving CSF while microvilli helps in reabsorption of
CSF.
• Ependymal cells surrounded by blood vessels are called as Choroid Plexus that produces and regulates CSF.
• Neuro-regeneration: a recent study observed that ependymal lining might be a source of cells which can be
transplanted into the cochlea to reverse hearing loss.
• SATELLITE GLIAL CELL
These are the astrocytes of PNS
25. OLIGODENDROCYTES
Signals are needed to send at farthest tissue within a given limit of time and myelin sheath helps in the same.
From where does this myelin comes from?
Again Glial cell – Oligodendrocyte are the last cells to form in our brain (25-30yrs).
• They produce certain proteins (BDNF, IGF1) that helps neuron grow and forms synapses.
• These cells have a special lipid membrane that helps in forming myelin sheath around neurons.
• This myelin sheath provide support and insulation to axons
• 1 oligodendrocyte extends its process to approx. 50 neurons
SCHWANN CELLS
• Glia of PNS
• Wrap around axons in PNS i.e. does myelination
26. Na/K ATPase
Leaky K ion Channel
Leaky Na ion Channel
Resting potential
• Na/K ATPase
It efflux 3 Na ions and influx 2 K ions
Net change is loss of 1 cation
Responsible for minor change in electronegativity
(approx. -5mV)
• Leaky Na ion channel
Concentration of sodium ion is more outside the cell
so there is less efflux of Na+ ion, thus less change in
electronegativity
• Leaky K ion channel
Potassium ion are usually present with anion
Concentration gradient is also favourable
Efflux of K+ ion results in generating electronegativity
3 Na+
2 K+
K+
K+
K+
K+
Anions
Anions
Anions
Anions
Na +
Na +
Na +
Na +
27. G- Protein coupled
Receptor
Ligand gated K/Cl ion
channel
Ligand gated Na/Ca
ion channel
Graded Potential
• Ligand gated Na/Ca ion channel (excitatory postsynaptic
potential) stimulate under the influence of glutamate
• Ligand gated K/Cl ion channel (Inhibitory postsynaptic potential)
stimulate under the influence of GABA
• G Protein coupled receptor stimulate under the influence of
protein, lipids etc.
Na +
Na +
Na +
-70mV
↓
-55mV
28. Voltage gated Ca ion
channel
Voltage gated K ion
channel
Voltage gated Na ion
channel
Action Potential
• Voltage gated Na ion channel (responsible for depolarization)
• Voltage gated K ion channel (responsible for repolarization)
• Voltage gated Ca ion channel (release of neurotransmitter)
+30
↑
-10mV
↑
-55mV
↑
-70mV
+30
↓
-10mV
↓
-55mV
↓
-70mV
Editor's Notes
Forebrain consist of cerebrum (2/3 of the brain)
Level of consciousness is processed at cerebral cortex
SNS is activated on stress
PNS is activated on rest
Einstein brain had more astrocyte than normal individual brain,
stabilizes synapses meaning there r 3 imp things when we talk about synapse- presynaptic terminal post synaptic terminal and astrocytic process this process monitors neuron signaling and also it releases certain proteins that influence receptors in synapse.
In 1997, Dr Fletcher showed that RGCs (retinal ganglion cell) are well grown and functioned in presence of astrocyte.
Disorders like autism, schizophrenia affect synapse formation or they aren’t communicating properly.
Amyloid beta plaques are potent activators of microglia
BBB does not allow any infectious agent to enter CNS neither they allow any lymphocyte.
Synaptic pruning- During the development of the brain there is development of more than required synapse that weakens afterward and dies.
inflammation causes
Reactive oxygen species
Ventricular system is a set of 4 interconnected cavities in the brain. Each ventricle consists of choroid plexus(modified ependymal cells) that produces CSF
BDNF- brain derived neurotrophic factor; IGF- insulin like growth factor 1
Myelination occurs until u r 20
Myelination is an important component of intelligence