This document discusses brachial plexus injuries, including anatomy, classification, risk factors, diagnosis, and treatment approaches. It covers both pediatric obstetric brachial plexus injuries as well as adult traumatic injuries. Key points include the Narakas classification system for pediatric injuries, signs and symptoms of preganglionic versus postganglionic injuries, imaging and electrodiagnostic testing, conservative treatment protocols, surgical reconstruction options like nerve grafting and nerve transfers, and secondary reconstruction procedures.
Tendoachilles rupture and its managementRohan Vakta
Achilles tendon is the strongest tendon of body. There are many causes of its rupture. It can be acute or chronic rupture. Management of chronic rupture by semitendinosus tendon is mentioned here.
Tendoachilles rupture and its managementRohan Vakta
Achilles tendon is the strongest tendon of body. There are many causes of its rupture. It can be acute or chronic rupture. Management of chronic rupture by semitendinosus tendon is mentioned here.
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Thoracic outlet syndrome
Neurovascular symptoms in the upper extremities due to pressure on the nerves and vessels in the thoracic outlet area
The specific structures compressed are usually the nerves of the branchial plexus and occasionally the subclavian artery or subclavian vein
Anatomy
Thoracic outlet
Entrance/ Exit region of the upper limb
The thoracic outlet is defined as the interval from the supraclavicular fossa to the axilla that passes between the clavicle and the first rib
Anatomy - Scalane triangle
Anatomy of the costoclavicular space
Pectoralis minor space
Located inferior to the coracoid process
anterior to the second through fourth ribs
posterior to the pectoralis minor muscle
The cords of the brachial plexus
Axillary artery
Axillary vein.
Soft-tissue Causes (70%)
Scalene muscle
Variations in insertion
Hypertrophy
Accessory scalenus minimus muscle
Anomalous ligaments or bands
Soft-tissue tumors
Osseous Causes
Cervical rib
Prominent C7 transverse process
Displacement or callus from first rib fracture
Malunited clavicle or first rib fracture
AC or SC joint injury or dislocation
Osseous tumor
Poor posture
Drooping the shoulders
Holding the head in a forward position
Repetitive activity
Athletes and swimmers
Neurogenic TOS
Compression – scalene triangle and costoclavicular space
May be associated with normal anatomy
Traction of the lowest trunk of the brachial plexus
Often in association with arterial TOS
Features of Lower brachial plexus compression - Common
Female predominance
Appearance of Amedio Modigliani painting
Complains of pain and paresthesia extending from the shoulder /down the ulnar aspect of the arm into the medial two fingers
Neurogenic TOS
Upper brachial plexus compression C5,C6 and C7
Less common
Compression mainly occurs in scalene triangle
Symptoms
Unilateral occipito-frontal headache
Facial or jaw pain
The Gilliatt-Sumner hand
A characteristic finding of neurogenic TOS, is described as atrophy of the abductor pollicis brevis and, to a lesser degree, the hypothenar musculature and the interossei.
Venous TOS
Causes
Hypertrophy of the subclavius muscle,
Chondroma formation
Clinical presentation
Most patients are sportsmen, musicians or manual workers undertaking repetitive arm movements.
The condition occurs more commonly in the dominant limb
Male predominance
Clinical presentation
Acute presentation -
Swollen and tensed upper limb
Upper limb aching pain
blueish- purple arm due to venous engorgement
Collateral veins may be visible
Feeling of heaviness that is worse after activity
Symptoms are precipitated by working with the arms elevated and are relieved by dependency, a pathognomonic feature of vTOS.
Arterial TOS
Rare but has more devastating consequences
Caused by
Intermittent subclavian arterial compression - Costoclavicular compression with normal anatomy.
Spinal Tuberculosis by Dr. Monsif IqbalMonsif Iqbal
This is the case presentation of a middle aged lady who presented with severe backache for the last one month with topic review after the case presentation
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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8. NARAKAS CLASSIFICATION
GROUPS NERVE ROOT DYSFUNCTION PROGNOSIS
I C5 C6 (ERBs) SHOULDER
ABDUCTION AND
EXTERNAL
ROTATION
ELBOW FLEXION
AND FOREARM
SUPINATION
SPONTANEOUS
RECOVERY IN 90%
II C5 C6 C7 WITH ABSENCE OF
WRIST EXTENSION
(WAITERS TIP)
POOR
III C5—T1 FLIAL EXTREMITY
WITHOUT
HORNERS
POOR
IV C5—T1 WITH
PREGANGLIONIC
AVULSION
HORNERS WITH
PHRENIC NERVE
POOR
15. Upper plexus
• Physical Exam
• Most common obstetric brachial plexopathy
• Best prognosis
• Clinically, arm will be adducted, internally
rotated, at shoulder; pronated, extended at
elbow (“waiter’s tip”)
• C5 deficiency
– axillary nerve deficiency
– suprascapular nerve deficiency
– musculocutaneous nerve deficiency
• C6 deficiency
– radial nerve deficiency
Lower plexus
•Rare in obstetric
palsy
•Usually avulsion
injuries
•Frequently
associated with a
preganglion injury
and Horner's
Syndrome
•Poor prognosis
Deficit of all of the
small muscles of
the hand (ulnar and
median nerves)
•Clinically, presents
as “claw hand
16. 2)IMAGING
• Plain X ray of shoulder: clavicle and humerus #
and chest : Diaphragm palsy
• CT/MRI: Not indicated
20. TREATMENT PROTOCOL
CLINICALLY
ASSESS
Discuss with
parents and
reassurance
No mobilisation for 3
weeks
Gentle
manipulation Baseline EMG at
6 weeks and
Reasses at 6
weeks
3 Months Re
examine
EMG MUST
BICEPS FUCTION MUST
RETURN TO NORMAL
(If Not)
IF NOT OPERATE
21. WHY 3 MONTHS?
• Muscle Survives Denervation For 1.5 years
• Nerve Grows at 3cm/month
32. Post op Care
• Splinting for 4 weeks
• Passive ROM of Elbow 4 times a day with
supination and pronation
• Night times A Plastic Splint Maintaining
Forearm in Full Pronation and Elbow in 30 deg
Flexion
49. BURNER-STINGER SYNDROME
• Also known as "dead
arm syndrome" or
brachial plexopathy
– refers to transient
brachial plexus
neuropraxi
50. • Presentation
• Symptoms
– unilateral tingling in arm not typically isolated to a single
dermatome
– usually resolve quickly in 1-2 minutes
• Physical exam
– full cervical ROM
– no tenderness
– unilateral transient weakness in C5, C6 muscles (deltoid,
biceps)
• Investigations:
• Xray : C spine
• MRI: Only in Bilateral cases
• Treatment:
• Conservative
55. Indications for Surgical management
• Pre ganglionic Avulsion at 6 weeks
• Post Ganglionic after 3 months
56. AIMS OF SURGERY
• Shoulder Stability : Abduction and External
rotation
• Elbow Flexion
• Median Nerve Sensations
• Finger Flexion
57. • C5 6 7 –can repair
• C8 T1 – Inaccessible,close to Major vessels
very short and direct repair is difficult
58. Primary Nerve Reconstruction
• Neurolysis:Neuroma In Continuity
• Direct Nerve repair-Rarely Possible
• Nerve Grafting
• Nerve Transfer
• Functioning Free Muscle transfer (FFMT)
60. Nerve Grafting
• Indications : Post ganglionic rupture
• Prerequisites : Proximal nerve available
Muscle targets Not Distal
Graft Length (<10cm)
61.
62. Nerve Transfer
• Def: Transfer of normal fascicle or nerve
branch to a important motor/sensory that has
sustained irreparable damage
• Indications:
• Irreparable preganglionic
• Selected post ganglionic
• Reinnervation of FFMTs
63. Spinal Accessory to Suprascapular
• Indications:C5 6 7 and Complete plexus injury
<6-9 months
Post op care:
Shoulder immobilsation 3 weeks
EMG at 6 months
64.
65.
66. Ulnar to Musculocutaneous
• Indications:Elbow flexion with C5 6
Occassionally for C5-7 with
preserved ulnar/median nerve
Post op care:Immobilisation for 3 weeks
Reinnervation at 6 months
67.
68.
69. Intercostal Nerve Transfer to
Musculocutaneous
• Indications:C5-7
• 3-6 intercostal nerves
• Risk of pleural tear
70.
71. FFMT(Functioning Free Muscle
transfer)
• Definition:Microvascular transfer of muscle with
its nerve to restore function
• Prerequisites:
• First 3-6 months
• Restoration of Shoulder stability
• Antagonist muscle—Normal (eg;In elbow Triceps
should be Normal)
72. Selection of Donor Muscle
• Must have Vascular
Pedicle
• Sufficient Length
• Sufficient Excursion
• Adequate Force
• Expendable
• GRACILIS
• Latissimus Dorsi
• Rectus Femoris
75. Post op Protocol
• Elbow immobilised in 100 deg flexion and
neutral supination for 6 weeks
• After 6 weeks—Passive Mobilisation
• Extension avoided beyond 30 deg for 3
months
76. SAHA TRAPEZIUS TRANSFER
• Indications for trapezius transfer:
Failure of nerve repair
• Late brachial plexus injuries
• Trapezius full strength against resistance
• A normal glenohumeral joint and Passive abduction of at
least 80°
Contraindications for trapezius transfer:
Trapezius strength less than M4 on MRC scale
• Advanced degenerative arthritis of glenohumeral joint
• Old unreduced shoulder dislocation
79. SHOULDER ARTHRODESIS
Indications
• Neglected/Failed cases with Gleno-humeral
instability.
• Total/upper Plexus Palsy
• Good strength of Trapezius/Rhomboid
Complications
Post op Fracture of Humerus
Risk of Non-union